Circadian rhythm as a key player in cancer progression as well as a therapeutic target in HER2-positive advanced gastric cancer treatment by Shihao Wang, Suliman Khan, Ghulam Nabi, Hong-Yu Li

“…To overcome this problem, readjustment of the circadian system may play a crucial role, as dysregulation in the expression of circadian clock genes has been observed in tumors. Therefore, pharmacological modulation of clock components can be considered for better efficacy of trastuzumab. …”
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Network balance via CRY signalling controls the Arabidopsis circadian clock over ambient temperatures by Peter D Gould, Nicolas Ugarte, Mirela Domijan, Maria Costa, Julia Foreman, Dana MacGregor, Ken Rose, Jayne Griffiths, Andrew J Millar, Bärbel Finkenstädt, Steven Penfield, David A Rand, Karen J Halliday, Anthony J W Hall

“…Circadian clocks exhibit ‘temperature compensation’, meaning that they show only small changes in period over a broad temperature range. Several clock genes have been implicated in the temperature‐dependent control of period in Arabidopsis. …”
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Circadian protein TIMELESS regulates synaptic function and memory by modulating cAMP signaling by Estibaliz Barrio-Alonso, Pablo J. Lituma, Michael J. Notaras, Robert Albero, Youcef Bouchekioua, Natalie Wayland, Isidora N. Stankovic, Tanya Jain, Sijia Gao, Diany Paola Calderon, Pablo E. Castillo, Dilek Colak

“…Summary: The regulation of neurons by circadian clock genes is thought to contribute to the maintenance of neuronal functions that ultimately underlie animal behavior. …”
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Circadian rhythms in colonic function by Timothy J. Hibberd, Stewart Ramsay, Phaedra Spencer-Merris, Phil G. Dinning, Phil G. Dinning, Vladimir P. Zagorodnyuk, Nick J. Spencer

“…A rhythmic expression of clock genes occurs within the cells of multiple organs and tissues throughout the body, termed “peripheral clocks.” …”
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Extracellular Vesicles in Young Serum Contribute to the Restoration of Age-Related Brain Transcriptomes and Cognition in Old Mice by Nicholas F. Fitz, Amrita Sahu, Yi Lu, Fabrisia Ambrosio, Iliya Lefterov, Radosveta Koldamova

“…Comparing the differentially expressed genes to recently published chronological aging clock genes reveals a reversal of transcriptomic aging in the choroid plexus. …”
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Role of Chrononutrition in the Antihypertensive Effects of Natural Bioactive Compounds by Néstor Ibarz-Blanch, Diego Morales, Enrique Calvo, Laura Ros-Medina, Begoña Muguerza, Francisca Isabel Bravo, Manuel Suárez

“…Moreover, evidence shows that phenolic compounds can interact with clock genes, which regulate the biological rhythm followed by many physiological processes. …”
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TDP-43 deficiency in suprachiasmatic nucleus perturbs rhythmicity of neuroactivity in prefrontal cortex by Hongxia Zhang, Chen Chen, Eric Erquan Zhang, Xiaotian Huang

“…TDP-43 knockdown induces intracellular arrhythmicity, disrupts transcriptional activation regulation, and diminishes clock genes expression. Moreover, our experiments in adult mouse reveal that TDP-43 knockdown, specifically within the suprachiasmatic nucleus (SCN), induces locomotor arrhythmia, arrhythmic c-Fos expression, and depression-like behavior. …”
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Functional and Molecular Markers for Hearing Loss and Vertigo Attacks in Meniere’s Disease by Chao-Hui Yang, Ming-Yu Yang, Chung-Feng Hwang, Kuang-Hsu Lien

“…Investigations of molecular markers such as autoimmunity, inflammation, protein signatures, vasopressin and circadian clock genes in MD are still underway. This review will summarize these functional and molecular markers, address how these markers are associated with hearing loss and vertigo attacks in MD, and analyze the results of the markers between MD and VM.…”
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miR-277 regulates the phase of circadian activity-rest rhythm in Drosophila melanogaster by Geo Anna, Maria John, Nisha N. Kannan

“…In Drosophila, the circadian clock is composed of mainly four clock genes: period (per), timeless (tim), Clock (Clk) and cycle (cyc) which constitutes the transcription-translation feedback loop. …”
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Enhancement of Arabidopsis growth by non–24 hour day–night cycles by Yuko Yamamoto, Kazufumi Tabata

“…Time course RNA‐seq analysis determined that seedling circadian clock genes had a free‐running period of 22 ± 1 hr. …”
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Adenosine integrates light and sleep signalling for the regulation of circadian timing in mice by Jagannath, A, Varga, N, Dallmann, R, Vasudevan, S, Foster, R, Et al.

“…Pharmacological and genetic approaches demonstrate that adenosine acts upon the circadian clockwork via adenosine A₁/A_2A&nbsp;receptor signalling through the activation of the Ca²⁺&thinsp;-ERK-AP-1 and CREB/CRTC1-CRE pathways to regulate the clock genes&nbsp;<em>Per1</em>&nbsp;and&nbsp;<em>Per2</em>. …”

Timing Is Important—Management of Metabolic Syndrome According to the Circadian Rhythm by Ksenija Zečević, Nataša Popović, Aleksandra Vuksanović Božarić, Mihailo Vukmirović, Manfredi Rizzo, Emir Muzurović

“…It consists of the core clock genes, Circadian Locomotor Output Cycles Protein Kaput (CLOCK) and Brain and Muscle Arnt-Like protein 1 (BMAL1), and their products, the period (PER) and cryptochrome (CRY) proteins, as well as an interlocked feedback loop which includes reverse-strand avian erythroblastic leukemia (ERBA) oncogene receptors (REV-ERBs) and retinoic acid-related orphan receptors (RORs). …”
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Synechocystis: A model system for expanding the study of cyanobacterial circadian rhythms by Chi Zhao, Yao Xu, Bo Wang, Carl Hirschie Johnson

“…Moreover, we analyse the complex organization of clock genes in Synechocystis and identify which genes are essential for circadian rhythmicity and adaptive fitness for entrainment and optimal phase alignment to environmental cycles (and which genes are not). …”
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Chronotype, circadian rhythm, and psychiatric disorders: Recent evidence and potential mechanisms by Haowen Zou, Haowen Zou, Hongliang Zhou, Rui Yan, Rui Yan, Zhijian Yao, Zhijian Yao, Zhijian Yao, Qing Lu, Qing Lu

“…Furthermore, the underlying mechanisms or influence factors are described in detail, including clock genes, brain characteristics, neuroendocrinology, the light/dark cycle, social factors, psychological factors, and sleep disorders. …”
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Targeting NR1D1 in organ injury: challenges and prospects by Zi-Yin Zhang-sun, Xue-Zeng Xu, Germaine Escames, Wang-Rui Lei, Lin Zhao, Ya-Zhe Zhou, Ye Tian, Ya-Nan Ren, Darío Acuña-Castroviejo, Yang Yang

“…In addition to repressing the transcription of multiple clock genes associated with circadian rhythms, NR1D1 has a wide range of downstream target genes that are intimately involved in many physiopathological processes, including autophagy, immunity, inflammation, metabolism and aging in multiple organs. …”
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Regulation of per and cry genes reveals a central role for the D-box enhancer in light-dependent gene expression. by Philipp Mracek, Cristina Santoriello, M Laura Idda, Cristina Pagano, Zohar Ben-Moshe, Yoav Gothilf, Daniela Vallone, Nicholas S Foulkes

“…Direct illumination of most fish tissues and cell lines induces expression of a broad range of genes including DNA repair, stress response and key clock genes. We have previously identified D- and E-box elements within the promoter of the zebrafish per2 gene that together direct light-induced gene expression. …”
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Free access to a running-wheel advances the phase of behavioral and physiological circadian rhythms and peripheral molecular clocks in mice. by Yuki Yasumoto, Reiko Nakao, Katsutaka Oishi

“…The temporal expression of E-box-dependent circadian clock genes such as Per1, Per2, Nr1d1 and Dbp were slightly, but significantly phase-advanced in the liver and white adipose tissue, but not in brown adipose tissue and skeletal muscle. …”
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Evidence of ancestral nocturnality, locomotor clock regression, and cave zone-adjusted sleep duration modes in a cave beetle by Sonya Royzenblat, Jasmina Kulacic, Markus Friedrich

“…Previous studies revealed negative phototaxis and the expression of biological clock genes in this microphthalmic cave beetle. Here we present results from probing P. hirtus for the entrainment of locomotor rhythms using the TriKinetics activity monitor setup. …”
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Time of Day Analysis over a Field Grown Developmental Time Course in Rice by Todd P. Michael

“…All the core circadian clock genes display consistent TOD expression over the season with the interesting exception that the two grass paralogs of <i>EARLY FLOWERING 3</i> (<i>ELF3</i>) display a distinct phasing based on the interaction between thermo- and photo-cycles. …”
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Circadian rhythm dysfunction in bipolar affective disorder by M.T. Valadas, R. Mota Freitas

“…Results Irregularity of the sleep–wake rhythm, eveningness chronotype, abnormality of melatonin secretion, vulnerability of clock genes, and the irregularity of social time cues are circadian rhythm markers disrupted in bipolar affective disorder. …”
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