PIF-independent regulation of growth by an evening complex in the liverwort Marchantia polymorpha by Ulf Lagercrantz, Anja Billhardt, Sabine N. Rousku, Katarina Landberg, Mattias Thelander, D. Magnus Eklund

“…Previous inventories of orthologs to Arabidopsis clock genes in various plant lineages showed that there is high levels of structural differences between clocks of different plant lineages. …”
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Constructing a feedback loop with circadian clock molecules from the silkmoth, Antheraea pernyi. by Chang, D, Mcwatters, H, Williams, J, Gotter, A, Levine, J, Reppert, S

“…Our analysis sheds light on the molecular function and evolution of clock genes in the animal kingdom.…”

Application and limitation of a biological clock-based method for estimating time of death in forensic practices by Akihiko Kimura, Yuko Ishida, Mizuho Nosaka, Akiko Ishigami, Hiroki Yamamoto, Yumi Kuninaka, Satoshi Hata, Mitsunori Ozaki, Toshikazu Kondo

“…We analyzed the expression of the clock genes, BMAL1 and NR1D1, in 318 dead hearts with defined time of death by real-time RT-PCR. …”
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Attention to Innate Circadian Rhythm and the Impact of Its Disruption on Diabetes by Da Young Lee, Inha Jung, So Young Park, Ji Hee Yu, Ji A Seo, Kyeong Jin Kim, Nam Hoon Kim, Hye Jin Yoo, Sin Gon Kim, Kyung Mook Choi, Sei Hyun Baik, Nan Hee Kim

“…In this review, we summarized various circadian misalignments, such as altered light-dark, sleep-wake, rest-activity, fasting-feeding, shift work, evening chronotype, and social jetlag, as well as mutations in clock genes that could contribute to the development of diabetes and poor glycemic status in patients with diabetes. …”
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Role of Non-Coding RNAs in Lung Circadian Clock Related Diseases by Srinivasan Chinnapaiyan, Rajib Kumar Dutta, Dinesh Devadoss, Hitendra S Chand, Irfan Rahman, Hoshang Jehangir Unwalla

“…Dysregulation of these non-coding RNAs have been shown to impact the expression of core clock genes as well as clock output genes in many organs. …”
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Full-Length Transcriptome Maps of Reef-Building Coral Illuminate the Molecular Basis of Calcification, Symbiosis, and Circadian Genes by Tingyu Han, Xin Liao, Yunchi Zhu, Yunqing Liu, Na Lu, Yixin Li, Zhuojun Guo, J.-Y. Chen, Chunpeng He, Zuhong Lu

“…Finally, a phylogenetic analysis of key circadian clock genes among 40 evolutionarily representative species indicates that there are four key members in early metazoans, including <i>cry</i> genes; <i>Clock</i> or <i>Npas2</i>; <i>cyc</i> or <i>Arntl</i>; and <i>tim</i>, while <i>per</i>, as the fifth member, occurs in Bilateria. …”
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Circadian Disruption and Consequences on Innate Immunity and Inflammatory Response by Viera Jerigova, Michal Zeman, Monika Okuliarova

“…Here, we first discuss the immune consequences of genetic circadian disruption induced by mutation or deletion of specific clock genes. Next, we evaluate experimental research into the effects of disruptive light/dark regimes, particularly light-phase shifts, dim ALAN, and constant light on the innate immune mechanisms under steady state and acute inflammation, and in the pathogenesis of common lifestyle diseases. …”
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Uterine Deletion of <i>Bmal1</i> Impairs Placental Vascularization and Induces Intrauterine Fetal Death in Mice by Masanori Ono, Natsumi Toyoda, Kyosuke Kagami, Takashi Hosono, Takeo Matsumoto, Shin-ichi Horike, Rena Yamazaki, Mitsuhiro Nakamura, Yasunari Mizumoto, Tomoko Fujiwara, Hitoshi Ando, Hiroshi Fujiwara, Takiko Daikoku

“…To investigate the pathological roles of uterine clock genes during pregnancy, we produced conditional deletion of uterine <i>Bmal1</i> (cKO) mice and found that cKO mice could receive embryo implantation but not sustain pregnancy. …”
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Quantitative analysis of regulatory flexibility under changing environmental conditions by Kieron D Edwards, Ozgur E Akman, Kirsten Knox, Peter J Lumsden, Adrian W Thomson, Paul E Brown, Alexandra Pokhilko, Laszlo Kozma‐Bognar, Ferenc Nagy, David A Rand, Andrew J Millar

“…A simple, quantitative measure, Dusk Sensitivity, was introduced to compare the behaviour of clock models with varying loop complexity. Evening‐expressed clock genes showed photoperiod‐dependent dusk sensitivity, as predicted by the three‐loop model, whereas the one‐ and two‐loop models tracked dawn and dusk, respectively. …”
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Transcriptome profiling based on Illumina- and SMRT-based RNA-seq reveals circadian regulation of key pathways in flower bud development in walnut. by Kai Ma, Xiang Luo, Liqun Han, Yu Zhao, Aisajan Mamat, Ning Li, Chuang Mei, Peng Yan, Rui Zhang, Jianfang Hu, Jixun Wang

“…Additionally, six and two differentially expressed clock genes were detected to be regulated by AS events and lncRNAs, respectively. …”
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The EASO new investigator award in clinical research 2021. Role of chronotype in obesity. by Giovanna Muscogiuri

“…The impairment of insulin sensitivity, melatonin, adiponectin and clock genes function along with increase of leptin secretion detected in subjects with evening chronotype could also represent a favorable milieu for the onset of obesity-related cancer. …”
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Reversible suppression of circadian-driven locomotor rhythms in mice using a gradual fragmentation of the day-night cycle by Melissa E. S. Richardson, Chérie-Akilah Browne, Citlali I. Huerta Mazariegos

“…Abstract Circadian rhythms are regulated by molecular clockwork and drive 24-h behaviors such as locomotor activity, which can be rendered non-functional through genetic knockouts of clock genes. Circadian rhythms are robust in constant darkness (DD) but are modulated to become exactly 24 h by the external day-night cycle. …”
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Role of Chronobiology as a Transdisciplinary Field of Research: Its Applications in Treating Mood Disorders by Okan Çalıyurt

“…The master biological clock in the suprachiasmatic nucleus controls daily rhythms of core body temperature, rest-activity cycle, physiological and behavioral functions, psychomotor functions and mood in humans. The clock genes are involved in the generation of the circadian rhythms and the biological clock is synchronized to solar day by direct photic inputs. …”
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Transcriptome Analysis of Ethylene Response in <i>Chrysanthemum moriflolium</i> Ramat. with an Emphasis on Flowering Delay by Hua Cheng, Min Zhou, Yuyang Si, Wenjie Li, Likai Wang, Sumei Chen, Fadi Chen, Jiafu Jiang

“…The identified differentially expressed genes (DEGs) primarily involved ethylene, auxin, and abscisic acid signaling genes; circadian clock genes; genes encoding functional proteins associated with floral transition, such as homologs of <i>AP1/FRUITFUL-like 1</i> (<i>AFL1</i>), <i>TERMINAL FLOWER 1</i> (<i>TFL1</i>), and so on; and genes encoding transcription factors, specifically of the MYB and bHLH families. …”
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Circadian Genes Expression Patterns in Disorders Due to Enzyme Deficiencies in the Heme Biosynthetic Pathway by Maria Savino, Claudio Carmine Guida, Maria Nardella, Emanuele Murgo, Bartolomeo Augello, Giuseppe Merla, Salvatore De Cosmo, Antonio Fernando Savino, Roberto Tarquini, Francesco Cei, Filippo Aucella, Gianluigi Mazzoccoli

“…Herein, we assessed mRNA levels of circadian genes in patients suffering from porphyrias and found several modifications of core clock genes and clock-controlled genes expression, associated with metabolic and electrolytic changes. …”
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Impaired Sleep, Circadian Rhythms and Neurogenesis in Diet-Induced Premature Aging by Alexander J. Stankiewicz, Erin M. McGowan, Lili Yu, Irina V. Zhdanova

“…Here, we show that, similar to normal aging, HCI leads to the reduction in daily amplitude of expression for core clock genes, a decline in sleep duration, an increase in scoliosis, and anxiety-like behavior. …”
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Alternative Splicing Variation: Accessing and Exploiting in Crop Improvement Programs by Sangam L. Dwivedi, Luis Felipe Quiroz, Anireddy S. N. Reddy, Charles Spillane, Rodomiro Ortiz

“…AS contributes to heterosis, enhances plant symbiosis (mycorrhiza and rhizobium), and provides a mechanistic link between the core clock genes and diverse environmental clues.…”
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CNOT1 regulates circadian behaviour through Per2 mRNA decay in a deadenylation-dependent manner by Haytham Mohamed Aly Mohamed, Akinori Takahashi, Saori Nishijima, Shungo Adachi, Iori Murai, Hitoshi Okamura, Tadashi Yamamoto

“…CNOT1 deficiency in mice results in circadian period lengthening and alterations in the mRNA and protein expression patterns of various clock genes, mainly Per2. Per2 mRNA exhibited a longer poly(A) tail and increased mRNA stability in Cnot1+/− mice. …”
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Phytochromes transmit photoperiod information via the evening complex in Brachypodium by Mingjun Gao, Yunlong Lu, Feng Geng, Cornelia Klose, Anne-Marie Staudt, He Huang, Duy Nguyen, Hui Lan, Han Lu, Todd C. Mockler, Dmitri A. Nusinow, Andreas Hiltbrunner, Eberhard Schäfer, Philip A. Wigge, Katja E. Jaeger

“…In cereals, photoperiodic responses are a major adaptive trait, and alleles of clock genes such as PHOTOPERIOD1 (PPD1) and EARLY FLOWERING3 (ELF3) have been selected for in adapting barley and wheat to northern latitudes. …”
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Different levels of circadian (de)synchrony ­– where does it hurt? [version 2; peer review: 2 approved] by Isabel Heyde, Henrik Oster, Ankita AS. Galinde, Faheem Al-Mughales

“…Here, alterations in phase coordination can emerge between cellular clocks of the same tissue or between different clock genes within the single cell. A better understanding of the mechanisms of circadian misalignment and its effects on physiology will help to find effective tools to prevent or treat disorders arising from modern-day chronodisruptive environments.…”
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