Transcriptomic Analysis of Light-Induced Genes in <i>Nasonia vitripennis</i>: Possible Implications for Circadian Light Entrainment Pathways by Yifan Wang, Leo W. Beukeboom, Bregje Wertheim, Roelof A. Hut

“…Maximal gene induction was found after 2 h of light stimulation (1432 genes), and this included the opsin gene <i>opblue</i> and the core clock genes <i>cry2</i> and <i>npas2</i>. Pathway and cluster analyses revealed light activation of glutamatergic and GABA-ergic neurotransmission, including CREB and AP-1 transcription pathway signaling. …”
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Exploring Hormone Therapy Effects on Reproduction and Health in Transgender Individuals by Efthalia Moustakli, Orestis Tsonis

“…The intricate interplay between hormones, clock genes, and fertility is profound, acknowledging the complexity of reproductive health in transgender individuals. …”
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Time of day of exercise does not affect the beneficial effect of exercise on bone structure in older female rats by Jay J. Cao, Brian R. Gregoire

“…Background: Circadian clock genes are expressed in bone and biomarkers of bone resorption and formation exhibit diurnal patterns in animals and humans. …”
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Dual Role for FHY3 in Light Input to the Clock by Bruce M. Rhodes, Hamad Siddiqui, Safina Khan, Paul F. Devlin

“…Examination of differences in the rhythmic transcriptome in the fhy3 mutant in red light identified specific disruption of the CCA1-regulated ELF3 and LUX central clock genes, while the CCA1 target TBS element, TGGGCC, was enriched among genes that became arrhythmic. …”
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Mathematical modeling of temperature-induced circadian rhythms by Lingjun Lu, Yannuo Li, Rene Schloss, Ioannis P. Androulakis, Ioannis P. Androulakis

“…The model incorporates a temperature sensing-transduction cascade involving a heat shock transcription factor-1 (HSF1) and heat shock response (HSR) pathway to simulate the entrainment of clock genes. The model is used to investigate the mammalian temperature entrainment and synchronization of cells subject to temperature oscillations of different amplitudes and magnitudes and examine the effects of transitioning between temperature schedules. …”
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Control systems theory revisited: new insights on the brain clocks of time-to-action by Sari Goldstein Ferber, Sari Goldstein Ferber, Aron Weller, Hermona Soreq

“…We employ a thermodynamic perspective, suggest that clock genes calculate free energy versus entropy and derived time-to-action level-wise as a master controller, and show that they are receivers, as well as transmitters of information. …”
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MYC disrupts transcriptional and metabolic circadian oscillations in cancer and promotes enhanced biosynthesis. by Juliana Cazarin, Rachel E DeRollo, Siti Noor Ain Binti Ahmad Shahidan, Jamison B Burchett, Daniel Mwangi, Saikumari Krishnaiah, Annie L Hsieh, Zandra E Walton, Rebekah Brooks, Stephano S Mello, Aalim M Weljie, Chi V Dang, Brian J Altman

“…Deregulated expression of the MYC oncoprotein has been shown to alter expression of molecular clock genes, leading to a disruption of molecular clock oscillation across cancer types. …”
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Biological correlates of altered circadian rhythms, autonomic functions and sleep problems in autism spectrum disorder by Liliana Dell’Osso, Leonardo Massoni, Simone Battaglini, Ivan Mirko Cremone, Claudia Carmassi, Barbara Carpita

“…Among the mechanisms implicated, alteration in genes related to circadian rhythms, such as CLOCK genes, and in melatonin levels were reported. …”
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Diurnal variation of the human adipose transcriptome and the link to metabolic disease by Lamb John, Leonardson Amy, Emilsson Valur, Ferguson Mark, Chalikonda Ira, Morris Mark, Wright Christopher, Yang Xia, He Yudong, Zhang Chunsheng, Nebozhyn Michael, Joseph Jeffrey, Fine Bernard, Kraft Walter K, Loboda Andrey, Dai Hongyue, Schadt Eric, Greenberg Howard E, Lum Pek

“…The mRNA expression levels of core clock genes at a specific time of day were consistent across multiple subjects on different days in all three arms, indicating robust diurnal regulation irrespective of potential confounding factors. …”
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Peculiarities of circadian regulation of the thyroid gland by T.M. Boichuk, I.S. Popova

“…In thyroid pathology, there is a violation of circadian rhythms, a decrease in melatonin levels, and a decrease in the expression of Clock genes.…”
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Dim artificial light at night alters gene expression rhythms and growth in a key seagrass species (Posidonia oceanica) by Dalle Carbonare, L, Basile, A, Rindi, L, Bulleri, F, Hamedeh, H, Iacopino, S, Shukla, V, Weits, DA, Lombardi, L, Sbrana, A, Benedetti-Cecchi, L, Giuntoli, B, Licausi, F, Maggi, E

“…We first monitored the fluctuations of putative circadian-clock genes over a period of 24 h along the ALAN gradient. …”

Effect of exposure to electromagnetic fields on brain function and behaviour in mice by Lundberg, L

“…Exposure at 580 μT for 24 hours had only minor transient effects on the rhythmic expression of the core clock genes.</p> <p>In summary, exposure to 50 Hz or 1800 MHz fields caused subtle and transient changes to some molecular mechanisms and cells involved in cognitive function and circadian rhythm control.…”

The role of epigenetic modulators on circadian rhythms and metabolism by Mosneagu, DI

“…IBET-762, a selective and potent bromodomain inhibitor, is shown to enhance the expression of several clock genes including Bmal1 and Per2, via BRD4 and Specificity Protein 1 (SP1), a transcription factor with widespread metabolic effects, and impact on metabolic pathophysiology at least partially through SP1.…”

A high-fat diet disrupts the hepatic and adipose circadian rhythms and modulates the diurnal rhythm of gut microbiota-derived short-chain fatty acids in gestational mice by Lu Ding, Jieying Liu, Jieying Liu, Liyuan Zhou, Xinmiao Jia, Shunhua Li, Qian Zhang, Miao Yu, Xinhua Xiao

“…Furthermore, the HF significantly disrupted the rhythmic pattern of hepatic and adipose circadian clock genes and downstream metabolic genes. Importantly, our results revealed that the HF altered the diurnal rhythm of the gut microbiota in a diverse manner, which was assessed across three categories: phase shift, loss rhythmicity, and gained rhythmicity. …”
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Relationship between Night Shifts and Risk of Breast Cancer among Nurses: A Systematic Review by Javier Fagundo-Rivera, Juan Gómez-Salgado, Juan Jesús García-Iglesias, Carlos Gómez-Salgado, Selena Camacho-Martín, Carlos Ruiz-Frutos

“…Among the associated factors, the alteration of the circadian rhythm influenced the expression of peripheral clock genes, which was the same as reproductive hormones. …”
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Clocks do not tick in unison: isolation of Clock and vrille shed new light on the clockwork model of the sand fly Lutzomyia longipalpis by João Silveira Moledo Gesto, Gustavo Bueno da Silva Rivas, Marcio Galvão Pavan, Antonio Carlos Alves Meireles-Filho, Paulo Roberto de Amoretty, Nataly Araújo de Souza, Rafaela Vieira Bruno, Alexandre Afranio Peixoto

“…This study aims to characterize, within an evolutionary perspective, two important circadian clock genes, Clock and vrille. Findings We have cloned and isolated the coding sequence of L. longipalpis’ genes Clock and vrille. …”
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Targeted screening and identification of chlorhexidine as a pro-myogenic circadian clock activator by Tali Kiperman, Weini Li, Xuekai Xiong, Hongzhi Li, David Horne, Ke Ma

“…This action was mediated by the targeted CLOCK structure via augmented interaction with heterodimer partner Bmal1, leading to enhanced CLOCK/Bmal1-controlled transcription with upregulation of core clock genes. Consistent with its clock-activating function, CHX displayed robust effects on stimulating myogenic differentiation in a clock-dependent manner. …”
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Stx2 Induces Differential Gene Expression and Disturbs Circadian Rhythm Genes in the Proximal Tubule by Fumiko Obata, Ryo Ozuru, Takahiro Tsuji, Takashi Matsuba, Jun Fujii

“…Moreover, circadian clock genes were differentially expressed, suggesting Stx2-induced renal circadian rhythm disturbance. …”
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GUN4 Affects the Circadian Clock and Seedlings Adaptation to Changing Light Conditions by Tao Li, Rui Wu, Zhixin Liu, Jiajing Wang, Chenxi Guo, Yaping Zhou, George Bawa, Xuwu Sun

“…RNA-seq analysis indicated that the expression of genes for light signaling and the circadian clock is altered in <i>gun4</i> compared with (WT). qPCR analysis confirmed that the expression of the clock genes <i>CLOCK-RELATED 1</i> (<i>CCA1</i>), <i>LATE ELONGATION HYPOCOTYL</i> (<i>LHY</i>), <i>TIMING OF CAB EXPRESSION 1</i> (<i>TOC1</i>) and <i>PSEUDO RESPONSE REGULATOR 7</i> (<i>PRR7</i>) is significantly changed in the <i>gun4</i> and <i>srp54</i> mutants under normal and medium strong light conditions. …”
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Deciphering the Molecular Basis of Melatonin Protective Effects on Breast Cells Treated with Doxorubicin: TWIST1 a Transcription Factor Involved in EMT and Metastasis, a Novel Targ... by Javier Menéndez-Menéndez, Francisco Hermida-Prado, Rocío Granda-Díaz, Alicia González, Juana María García-Pedrero, Nagore Del-Río-Ibisate, Alicia González-González, Samuel Cos, Carolina Alonso-González, Carlos Martínez-Campa

“…Combined with doxorubicin, melatonin inhibited the activation of p70S6K and modulated the expression of breast cancer, angiogenesis and clock genes. Moreover, melatonin regulates the levels of TWIST1-related microRNAs, such as miR-10a, miR-10b and miR-34a. …”
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