Photoperiod Genes Contribute to Daylength-Sensing and Breeding in Rice by Leilei Qiu, Peng Zhou, Hao Wang, Cheng Zhang, Chengxing Du, Shujun Tian, Qinqin Wu, Litian Wei, Xiaoying Wang, Yiming Zhou, Rongyu Huang, Xi Huang, Xinhao Ouyang

“…Here, we determined that mutations in the photoreceptor and circadian clock genes can generate different daylength-sensing processes. …”
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Stable Expression of dmiR-283 in the Brain Promises Positive Effects in Endurance Exercise on Sleep–Wake Behavior in Aging <i>Drosophila</i> by Qiufang Li, Lingxiao Wang, Yurou Cao, Xiaoya Wang, Chao Tang, Lan Zheng

“…This study varied the expression pattern of dmiR-283 in <i>Drosophila</i> and the result showed that the aging decline in sleep–wake behavior was caused by the accumulation of brain dmiR-283 expression, whereas the core clock genes <i>cwo</i> and Notch signaling pathway might be suppressed, which regulate the aging process. …”
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A Computational Analysis in a Cohort of Parkinson’s Disease Patients and Clock-Modified Colorectal Cancer Cells Reveals Common Expression Alterations in Clock-Regulated Genes by Müge Yalçin, Deeksha Malhan, Alireza Basti, Ana Rita Peralta, Joaquim J. Ferreira, Angela Relógio

“…Notably, our results pointed to alterations in the core-clock network in IPD patients when compared to healthy controls and revealed variations in the expression profile of PD-associated genes (e.g., <i>HRAS</i> and <i>GBA</i>) upon disruption of the core-clock genes. Our study characterizes changes at the transcriptomic level following circadian clock disruption on common cellular pathways associated with cancer and neurodegeneration (e.g., immune system, energy metabolism and RNA processing), and it points to a significant influence on the overall survival of colon cancer patients for several genes resulting from our analysis (e.g., <i>TUBB6</i>, <i>PAK6</i>, <i>SLC11A1</i>).…”
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The Circadian Nobiletin-ROR Axis Suppresses Adipogenic Differentiation and IκBα/NF-κB Signaling in Adipocytes by Eunju Kim, Kazuaki Mawatari, Seung-Hee Yoo, Zheng Chen

“…Here, we show that NOB enhanced the oscillation of core clock genes in differentiated 3T3-L1 adipocytes, including ROR target genes such as <i>Bmal1</i>, <i>Cry1</i>, <i>Dec1</i>, and <i>Dec2</i>. …”
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Gene Expression Monotonicity across Bladder Cancer Stages Informs on the Molecular Pathogenesis and Identifies a Prognostic Eight-Gene Signature by Rafael Stroggilos, Maria Frantzi, Jerome Zoidakis, Marika Mokou, Napoleon Moulavasilis, Emmanouil Mavrogeorgis, Anna Melidi, Manousos Makridakis, Konstantinos Stravodimos, Maria G. Roubelakis, Harald Mischak, Antonia Vlahou

“…Wnt, MTORC1 signaling, and MYC activity were monotonically increased with increasing stage, while an opposite trend was detected for the catabolism of fatty acids, circadian clock genes, and the metabolism of heme. Co-expression network analysis highlighted stage- and cell-type-specific genes of potentially synergistic therapeutic value. …”
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Genes related to circadian rhythm are involved in regulating tuberization time in potato by Yumeng Niu, Guangcun Li, Yinqiao Jian, Shaoguang Duan, Ju Liu, Jianfei Xu, Liping Jin

“…A total of 3 085 DEGs were specifically identified and analyzed according to Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment, and DEGs involved in starch and sucrose metabolism, plant hormone signal transduction and plant circadian clock were significantly enriched. The circadian clock genes were significantly differentially expressed between Z3 and Z18, revealing an important role for the plant circadian pathway in regulating TT. …”
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The Daily Expression of ABCC4 at the BCSFB Affects the Transport of Its Substrate Methotrexate by André Furtado, Rafael Mineiro, Ana Catarina Duarte, Isabel Gonçalves, Cecília R. Santos, Telma Quintela

“…It has already been shown that sex hormones regulate several CP functions, including the oscillations of its clock genes. However, it is less explored how the circadian rhythm regulates CP functions. …”
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CRS: a circadian rhythm score model for predicting prognosis and treatment response in cancer patients by Yuwei Liu, Shuang Guo, Yue Sun, Caiyu Zhang, Jing Gan, Shangwei Ning, Junwei Wang

“…Results Transcriptomic and genomic analyses of 48 CRGs revealed that most core clock genes are up-regulated, while clock control genes are down-regulated. …”
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Regulatory Effect of High-Protein Diet on Circadian Rhythm of Lipid Metabolism in Obese Mice by JIANG Zhiqing, DENG Guoliang, ZENG Fanhang, SHAO Ru, ZHU Rongxiang, TANG Xue

“…Further analysis showed that the improvement effects of high-protein intervention on circadian rhythm disorders of lipid metabolism caused by high-fat diet were closely related to the regulation of the expression of two clock genes in liver, circadian locomotor output cycle kaput (CLOCK) and brain and muscle-Arnt-like protein 1 (BMAL1). …”
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Circadian Oscillation Pattern of Endoplasmic Reticulum Quality Control (ERQC) Components in Human Embryonic Kidney HEK293 Cells by Yalcin Erzurumlu, Deniz Catakli, Hatice Kubra Dogan

“…In mammals, molecular clock genes tightly arrange cellular rhythmicity. It has been shown that this circadian clock optimizes various biological processes, including the cell cycle and autophagy. …”
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Clock-Modulating Activities of the Anti-Arrhythmic Drug Moricizine by Chorong Han, Marvin Wirianto, Eunju Kim, Mark J. Burish, Seung-Hee Yoo, Zheng Chen

“…Real-time qPCR analysis in fibroblast cells treated with moricizine revealed significant circadian time- and/or treatment-dependent expression changes in core clock genes, consistent with the above period-lengthening effects. …”
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Effect of clock rhythm on emergence agitation and early postoperative delirium in older adults undergoing thoracoscopic lung cancer surgery: protocol for a prospective, observation... by Linghui Jiang, Jie Wang, Wannan Chen, Zhiyao Wang, Wanxia Xiong

“…Secondary outcomes will include the incidence of early postoperative delirium assessed via the Confusion Assessment Method (CAM) on postoperative day 1, pain status assessed via the numerical rating scale (NRS) in the PACU, sleep quality on postoperative day 1 and changes in perioperative plasma melatonin, clock genes and inflammatory factor levels. Postoperative surgical complications, intensive care unit admission and hospital length of stay will also be evaluated. …”
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Circadian clock does not play an essential role in daylength measurement for growth-phase transition in Marchantia polymorpha by Yuki Kanesaka, Keisuke Inoue, Keisuke Inoue, Yuki Tomita, Shohei Yamaoka, Takashi Araki

“…Then, we compared the timing of gametangiophore formation between wild type and circadian clock mutants in long-day and short-day conditions. Mutations in two clock genes, MpTIMING OF CAB EXPRESSION 1 and MpPSEUDO-RESPONSE REGULATOR, had no significant effects on the timing of gametangiophore formation. …”
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Construction and verification of a novel circadian clock related long non-coding RNA model and prediction of treatment for survival prognosis in patients with hepatocellular carcin... by Zhen Zhang, Wenhui Gao, Xiaoning Tan, Tianhao Deng, Wanshuang Zhou, Huiying Jian, Puhua Zeng

“…Abstract Circadian clock genes are significant in the occurrence and development of HCC and long-non coding RNAs (lncRNAs) are closely related to HCC progression. …”
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The interaction between circadian rhythm and epilepsy by Mingsu Liu, Jing Ding, Xin Wang

“…Sleep influences the epilepsy rhythm, and conversely, epilepsy alters the sleep rhythm through multiple pathways. Clock genes accompanied by two feedback loops of regulation have an important role in cortical excitability and seizure occurrence, which may be involved in the mTORopathy. …”
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Time-Restricted G-Protein Signaling Pathways via GPR176, G_z, and RGS16 Set the Pace of the Master Circadian Clock in the Suprachiasmatic Nucleus by Shumpei Nakagawa, Khanh Tien Nguyen Pham, Xinyan Shao, Masao Doi

“…Genome-wide association studies, employing questionnaire-based evaluations of individual chronotypes, revealed loci near clock genes and in the regions containing <i>RGS16</i> and <i>ALG10B</i>, a gene encoding an enzyme involved in protein <i>N</i>-glycosylation. …”
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昼夜节律紊乱增加卒中风险机制的研究进展 Research Advances on Mechanisms of Increased Stroke Risk by Circadian Rhythm Disruption by 贾慧, 王迪, 所芮, 卫馨雅, 朱雨岚

“…Internal/external factors can lead to central and peripheral circadian clock disorder. Circadian clock genes regulate the expression of almost the entire genome. …”
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Temporal effects on death by suicide: empirical evidence and possible molecular correlates by R. Bhagar, H. Le-Niculescu, K. Roseberry, K. Kosary, C. Daly, A. Ballew, M. Yard, G. E. Sandusky, A. B. Niculescu

“…The biomarkers for suicidality that are predictive of death by suicide during full moon, peak hour of day, and peak month of year, respectively, compared to outside of those periods, appear to be enriched in circadian clock genes. For full moon it is AHCYL2, ACSM3, AK2, and RBM3. …”
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Interplay between retinal light responses and the circadian clock, and their implications for retinal degenerative diseases by Palumaa, T

“…By analysing the circadian transcriptome of wild-type and melanopsin-null retinas, I discovered that the absence of melanopsin leads to dampened rhythmicity in the expression of core clock genes. Furthermore, while the melanopsin-null retinas retained the rhythmic expression of dopamine- related and gap junction genes, the circadian rhythmicity of sphingolipid and phototransduction pathways were aberrant.…”

Circadian profile, daytime activity, and the Parkinson's phenotype: A motion sensor pilot study with neurobiological underpinnings by Massimo Marano, Jessica Rosati, Alessandro Magliozzi, Alessia Casamassa, Alessia Rappa, Gabriele Sergi, Miriam Iannizzotto, Ziv Yekutieli, Angelo Luigi Vescovi, Vincenzo Di Lazzaro

“…Fibroblasts were collected from PD patients (n = 5) and from sex/age matched controls (n = 3) and tested for the circadian expression of clock genes (CLOCK, BMAL1, PER1, CRY1), and for cell morphology, proliferation, and death. …”
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