Role of Sleep Restriction in Daily Rhythms of Expression of Hypothalamic Core Clock Genes in Mice by Weitian Li, Zixu Wang, Jing Cao, Yulan Dong, Yaoxing Chen

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Prostaglandin F2α Affects the Cycle of Clock Gene Expression and Mouse Behavior by Yuya Tsurudome, Yuya Yoshida, Kengo Hamamura, Takashi Ogino, Sai Yasukochi, Shinobu Yasuo, Ayaka Iwamoto, Tatsuya Yoshihara, Tomoaki Inazumi, Soken Tsuchiya, Toru Takeo, Naomi Nakagata, Shigekazu Higuchi, Yukihiko Sugimoto, Akito Tsuruta, Satoru Koyanagi, Naoya Matsunaga, Shigehiro Ohdo

“…Prostaglandins are bioactive compounds, and the activation of their receptors affects the expression of clock genes. However, the prostaglandin F receptor (<i>Ptgfr</i>) has no known relationship with biological rhythms. …”
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Daily methylphenidate and atomoxetine treatment impacts on clock gene protein expression in the mouse brain. by Baird, A, Coogan, A, Kaufling, J, Barrot, M, Thome, J

“…In the present study we have examined the effects of daily methylphenidate or atomoxetine treatment across 7 days on circadian clock gene product expression across numerous brain regions in the male mouse to test the potential impact of such compounds on circadian timing. …”

<i>Escherichia coli</i> Affects Expression of Circadian Clock Genes in Human Hepatoma Cells by Urša Kovač, Zala Žužek, Lucija Raspor Dall’Olio, Katka Pohar, Alojz Ihan, Miha Moškon, Damjana Rozman, Marjanca Starčič Erjavec

“…</i> A high percentage of necrotic and apoptotic cells occurred at 72 h, while a correlation between the number of ExPEC genes and the influence on the HepG2 core clock gene expression was observed. Our study reveals that the <i>E. coli</i> genetic background is important for the effect on the mammalian circadian clock genes, indicating possible future use of probiotic <i>E. coli</i> strains to influence the host circadian clock.…”
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Males of Aedes aegypti show different clock gene expression profiles in the presence of conspecific females by Jéssica Rodrigues Assunção Bezerra, Rafaela Vieira Bruno, Luciana Ordunha Araripe

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Expression Patterns of Clock Gene mRNAs and Clock Proteins in Human Psoriatic Skin Samples by Viktória Németh, Szabina Horváth, Ágnes Kinyó, Rolland Gyulai, Zsuzsanna Lengyel

“…In conclusion, in our study a perturbation of clock gene transcripts was observed in uninvolved and lesional psoriatic areas compared to healthy skin. …”
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Integrated RNA-seq Analysis Indicates Asynchrony in Clock Genes between Tissues under Spaceflight by Shin-ichiro Fujita, Lindsay Rutter, Quang Ong, Masafumi Muratani

“…Our results showed that clock gene expressions in spaceflight mice were altered compared with those in ground control mice. …”
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CLOCK and TIMELESS regulate rhythmic occupancy of the BRAHMA chromatin-remodeling protein at clock gene promoters. by Christine A Tabuloc, Yao D Cai, Rosanna S Kwok, Elizabeth C Chan, Sergio Hidalgo, Joanna C Chiu

“…Using chromatin immunoprecipitation, we observed rhythmic BRM binding to clock gene promoters despite constitutive BRM protein expression, suggesting that factors other than protein abundance are responsible for rhythmic BRM occupancy at clock-controlled loci. …”
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Association of eating behaviour with clock gene polymorphism 3111 T > C in children based on nutritional status by M. Valladares, J. P. Chaput, S. Vásquez, C. Pino, A. M. Obregón

“…Background: The CLOCK (circadian locomotor output cycle kaput) gene is a central regulator of circadian rhythm. The CLOCK gene has been related to energy intake and therefore to nutritional status. …”
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Expression and rhythmic modulation of circulating microRNAs targeting the clock gene Bmal1 in mice. by Vikram R Shende, Marianna M Goldrick, Suchitra Ramani, David J Earnest

“…However, specific miRNAs mediating the regulation of essential clock genes remain largely unknown. Because vesicles containing membrane-bound miRNAs are present in the circulatory system, we examined miRNAs predicted to target the clock gene, Bmal1, for evidence of rhythmic fluctuations in circulating levels and modulatory effects on the 3' UTR activity of Bmal1. …”
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PTBP1 Positively Regulates the Translation of Circadian Clock Gene, <i>Period1</i> by Wanil Kim, Jae-Cheon Shin, Kyung-Ha Lee, Kyong-Tai Kim

“…Circadian oscillations of mRNAs and proteins are the main features of circadian clock genes. Among them, <i>Period1</i> (<i>Per1</i>) is a key component in negative-feedback regulation, which shows a robust diurnal oscillation and the importance of circadian rhythm and translational regulation of circadian clock genes has been recognized. …”
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Biphasic Roles of Clock Genes and Bone Morphogenetic Proteins in Gonadotropin Expression by Mouse Gonadotrope Cells by Yoshiaki Soejima, Nahoko Iwata, Yasuhiro Nakano, Koichiro Yamamoto, Atsuhito Suyama, Takahiro Nada, Fumio Otsuka

“…Roles of Clock genes and the bone morphogenetic protein (BMP) system in the regulation of gonadotropin secretion by gonadotropin-releasing hormone (GnRH) were investigated using mouse gonadotropin LβT2 cells. …”
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Clock genes regulate mating activity rhythms in the vector mosquitoes, Aedes albopictus and Culex quinquefasciatus. by Shuang Liu, Jiayong Zhou, Ling Kong, Yiquan Cai, Hongkai Liu, Zhensheng Xie, Xiaolin Xiao, Anthony A James, Xiao-Guang Chen

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The <i>BrGI</i> Circadian Clock Gene Is Involved in the Regulation of Glucosinolates in Chinese Cabbage by Nan Sun Kim, Su Jeong Kim, Jung Su Jo, Jun Gu Lee, Soo In Lee, Dong Hwan Kim, Jin A. Kim

“…We report that the <i>BrGI</i> circadian clock gene is required for the biosynthesis of GSLs in Chinese cabbage plants.…”
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Gene copy number and negative feedback differentially regulate transcriptional variability of segmentation clock genes by Oriana Q.H. Zinani, Kemal Keseroğlu, Supravat Dey, Ahmet Ay, Abhyudai Singh, Ertuğrul M. Özbudak

“…Here, we studied the transcriptional variability of two paired zebrafish segmentation clock genes (her1 and her7) in multiple genetic backgrounds. …”
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Role of Clock Genes and Circadian Rhythm in Renal Cell Carcinoma: Recent Evidence and Therapeutic Consequences by Matteo Santoni, Javier Molina-Cerrillo, Giorgio Santoni, Elaine T. Lam, Francesco Massari, Veronica Mollica, Giulia Mazzaschi, Bernardo L. Rapoport, Enrique Grande, Sebastiano Buti

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The core clock gene Per1 phases molecular and electrical circadian rhythms in SCN neurons by Jeff R. Jones, Douglas G. McMahon

“…Importantly, the concordant phasing of gene and neural rhythms is disrupted in the absence of the homologous clock gene Per1, but persists in the absence of the core clock gene Per2. …”
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EXPRESSION PROFILE OF MOLECULAR CIRCADIAN CLOCK GENES PREDICTS RISK STRATIFICATION IN ACUTE MYELOID LEUKEMIA by M Brandão, SCG Lima, DT Covas, LEB Souza

“…The expression levels of remaining clock genes were not associated with risk groups defined by cytogenetic classification for AML. …”
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The clock gene Bmal1 inhibits macrophage motility, phagocytosis, and impairs defense against pneumonia by Kitchen, G, Cunningham, P, Poolman, TM, Iqbal, M, Maidstone, R, Baxter, M, Bagnall, J, Begley, N, Saer, B, Hussell, T, Matthews, L, Dockrell, D, Durrington, H, Gibbs, J, Blaikley, J, Loudon, A, Ray, DW

Epidermal retinol dehydrogenases cyclically regulate stem cell markers and clock genes and influence hair composition by Kelli R. Goggans, Olga V. Belyaeva, Alla V. Klyuyeva, Jacob Studdard, Aja Slay, Regina B. Newman, Christine A. VanBuren, Helen B. Everts, Natalia Y. Kedishvili

“…The HF cycle is known to be regulated by steroid hormones, growth factors and circadian clock genes. Recent data also suggest a role for a vitamin A derivative, all-trans-retinoic acid (ATRA), the activating ligand of transcription factors, retinoic acid receptors, in the regulation of the HF cycle. …”
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