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Potency and durability of T and B cell immune responses after homologous and heterologous vector delivery of a trimer-stabilized, membrane-displayed HIV-1 clade ConC Env protein
Published 2023-11-01“…The evaluation of the HIV-1-specific humoral responses induced in the different immunization groups after protein boosts showed that the various prime/boost protocols elicited broad and potent antibody responses, preferentially of a Th1-associated IgG2a subclass, and that the obtained antibody levels remained high at the memory phase.DiscussionIn summary, we provide a feasible strategy to display multiple copies of native-like Env trimers on the cell surface, which translates into efficient priming of sustained CD4+ T cell responses after vector delivery as well as broad, potent, and sustained antibody responses following booster immunizations with the homologous, prefusion-stabilized, close-to-native ConCv5 KIKO* gp140 Env trimer.…”
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6823
Designing a Model for E-Banking Effect on Banking Competitiveness Ability(case study: five Selected banks in Tehran)
Published 2018-05-01“…There is Strong competition among commercial banks .It means even Most innovative products and services are copied by others. Then bank opportunity to protect its competitive ability,will be declined(Al-Alak,2014(. …”
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Sustainable materials from renewable protein feedstock and waste rubber
Published 2020Get full text
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6826
Reflections of Seljuk Bookbinding Style on the 15th Century Ottoman Bindings (Examples of Çorum Hasan Pasha Manuscript Library)
Published 2021-06-01“…Reflections of Seljuk Bookbinding Style on the 15th Century Ottoman Bindings (Examples of Çorum Hasan Pasha Manuscript Library) Abstract Binding is the general name of the book covers, which both have protective qualities and give aesthetic pleasure to the eyes with the decoration applied on it. …”
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A systematic review and individual patient data meta-analysis of prognostic factors for foot ulceration in people with diabetes: the international research collaboration for the pr...
Published 2015-07-01“…Meta-analyses based on data from the entire IPD population found that an inability to feel a 10-g monofilament [odds ratio (OR) 3.184, 95% confidence interval (CI) 2.654 to 3.82], at least one absent pedal pulse (OR 1.968, 95% CI 1.624 to 2.386), a longer duration of a diagnosis of diabetes (OR 1.024, 95% CI 1.011 to 1.036) and a previous history of ulceration (OR 6.589, 95% CI 2.488 to 17.45) were all predictive of risk. Female sex was protective (OR 0.743, 95% CI 0.598 to 0.922). Limitations: It was not possible to perform a meta-analysis using a one-step approach because we were unable to procure copies of one of the data sets and instead accessed data via Safe Haven. …”
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3545 “Sofia Learns about Research”: an interactive storybook to educate children and their families on clinical research with a welcoming and inclusive approach.
Published 2019-03-01“…The book explains basic concepts about research coupled with fun games and the possibility to color. Over 1,000 copies of the activity book have been disseminated to second to fourth graders via afterschool programs, community events, and medical practice waiting rooms. …”
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6831
Strategic delay and information exchange in endogenous social networks
Published 2011Get full text
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