Evaluating the sensitivity of hybridization-based epigenotyping using a methyl binding domain protein by Shatova, Tatyana A., Lee, Jungkyu K., Kaastrup, Kaja, Heimer, Brandon Walter, Sikes, Hadley

“…Hypermethylation of CpG islands in gene promoter regions has been shown to be a predictive biomarker for certain diseases. …”
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Analysis of archaic human haplotypes suggests that 5hmC acts as an epigenetic guide for NCO recombination by Lee, Bernett, Cyrill, Samantha Leeanne, Lee, Wendy, Melchiotti, Rossella, Andiappan, Anand Kumar, Poidinger, Michael, Rötzschke, Olaf

“…Results: We detected a strong correlation between NCO recombination rates and the function of the respective region: low NCO rates were evident in introns and quiescent intergenic regions but high rates in splice sites, exons, 5′- and 3′-UTRs, as well as CpG islands. Correlations with ChIP-Seq data from ENCODE and other public sources further identified epigenetic modifications that associated directly with these recombination events. …”
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Tracing Dynamic Changes of DNA Methylation at Single-Cell Resolution by Stelzer, Yonatan, Soldner, Frank, Markoulaki, Styliani, Shivalila, Chikdu Shakti, Jaenisch, Rudolf

“…We show that insertion of RGM proximal to promoter-associated CpG islands reports the gain or loss of DNA methylation. …”
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DNA repair enzymes ALKBH2, ALKBH3, and AlkB oxidize 5-methylcytosine to 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxylcytosine in vitro by Bian, Ke, Lenz, Stefan A P, Tang, Qi, Chen, Fangyi, Qi, Rui, Jost, Marco, Drennan, Catherine L, Essigmann, John M, Wetmore, Stacey D, Li, Deyu

“…5-Methylcytosine (5mC) in DNA CpG islands is an important epigenetic biomarker for mammalian gene regulation. …”
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Genome-wide programmable transcriptional memory by CRISPR-based epigenome editing by Nuñez, James K, Chen, Jin, Pommier, Greg C, Cogan, J Zachery, Replogle, Joseph M, Adriaens, Carmen, Ramadoss, Gokul N, Shi, Quanming, Hung, King L, Samelson, Avi J, Pogson, Angela N, Kim, James YS, Chung, Amanda, Leonetti, Manuel D, Chang, Howard Y, Kampmann, Martin, Bernstein, Bradley E, Hovestadt, Volker, Gilbert, Luke A, Weissman, Jonathan S

“…We identify single guide RNAs (sgRNAs) capable of silencing the large majority of genes including those lacking canonical CpG islands (CGIs) and reveal a wide targeting window extending beyond annotated CGIs. …”
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The mechanism of action of the negative Regulators of jak/stat singnaling pathway in Resistant FLT-ITD acute myeloid leukaemia cells by Johan, Muhammad Farid

“…There was significant hypomethylation (p=0.002) in CpG islands of SHP-1 and PRG2, associated with their re-expressions. …”
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Epigenome-wide DNA methylation profiling in colorectal cancer and normal adjacent colon using Infinium human methylation 450K by Rashidah Baharudin, Muhiddin Ishak, Azliana Muhamad Yusof, Sazuita Saidin, Saiful Effendi Syafruddin, Wan Fahmi Wan Mohamad Nazarie, Lee, Learn-Han, Nurul-Syakima Ab Mutalib

“…Hypermethylated sites were common in CpG islands, while hypomethylated sites were in open sea. …”
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The regulation of premature termination at divergent promoters by Chiu, Anthony Chun-yin.

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Qualitative and Quantitative Analyses Of SMN 2 Gene Expression Upon Exposure with Histone De-acetylase Inhibitors and Polyphenols by Sasongko, Teguh Haryo

“…This study aimed to elucidate the effects of two hydroxamate-based HDACIs, SAHA and Dacinostat, and SRT1720, a synthetic SIRT1 activator with polyphenolic structure, on the SMN2 expression , CpG Islands (CGI) methylation and SMN protein levels in fibroblasts taken from SMA Type 1 and Type 11 patients. …”
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Aberrant Chloride Intracellular Channel 4 Expression Is Associated With Adverse Outcome in Cytogenetically Normal Acute Myeloid Leukemia by Huang, Sai, Huang, Zhi, Chen, Ping, Feng, Cong

“…Multi-omics analysis presented the overexpression of CLIC4 as associated with the co-expression of the different gene sets in leukemia, up/downregulation of the immune-related pathways, dysregulation of microRNAs, and hypermethylation around the CpG islands, in open sea regions, and in different gene structural fragments including TSS1500, gene body, 5′UTR region, 3′UTR region, and the first exon. …”
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