Sedation practices and clinical outcomes in mechanically ventilated patients in a prospective multicenter cohort di Romina E. Aragón, Alvaro Proaño, Nicole Mongilardi, Aldo de Ferrari, Phabiola Herrera, Rollin Roldan, Enrique Paz, Amador A. Jaymez, Eduardo Chirinos, Jose Portugal, Rocio Quispe, Roy G. Brower, William Checkley

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Circulating bioactive adrenomedullin as a marker of sepsis, septic shock and critical illness di Oscar H. M. Lundberg, Maria Lengquist, Martin Spångfors, Martin Annborn, Deborah Bergmann, Janin Schulte, Helena Levin, Olle Melander, Attila Frigyesi, Hans Friberg

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The impact of unexpected intensive care unit admission after cancer surgery on long-term symptom burden among older adults: a population-based longitudinal analysis di Bourke W. Tillmann, Julie Hallet, Rinku Sutradhar, Matthew P. Guttman, Natalie Coburn, Tyler R. Chesney, Jesse Zuckerman, Alyson Mahar, Wing C. Chan, Barbara Haas, members of the REcovery after Surgical Therapy for Older adults REsearch –Cancer (RESTORE-C) group

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Comparing fiberoptic bronchoscopy- and a tracheal tube-mounted camera-guided percutaneous dilatational tracheostomy di Fu-Shan Xue, Chao Wen, Ya-Yang Liu

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Intravenous vitamin C in adults with sepsis in the intensive care unit: still LOV’IT? di Christian Stoppe, Jean-Charles Preiser, Daniel de Backer, Gunnar Elke

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A significant p value is not equivalent to the superiority of one test index over another di Qiaoying Ji, Weimin Li

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Association between afterhours admission to the intensive care unit, strained capacity, and mortality: a retrospective cohort study di Adam M. Hall, Henry T. Stelfox, Xioaming Wang, Guanmin Chen, Danny J. Zuege, Peter Dodek, Allan Garland, Damon C. Scales, Luc Berthiaume, David A. Zygun, Sean M. Bagshaw

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Letter on “Pre-hospital transthoracic echocardiography for early identification of non-ST-elevation myocardial infarction in patients with acute coronary syndrome” di Guido Tavazzi, Aleksandar N Neskovic, Bogdan A Popescu, Gabriele Via

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An overview of positive cultures and clinical outcomes in septic patients: a sub-analysis of the Prehospital Antibiotics Against Sepsis (PHANTASi) trial di Rishi S. Nannan Panday, Eline M. J. Lammers, Nadia Alam, Prabath W. B. Nanayakkara

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Assessing the SAfety and FEasibility of bedside portable low-field brain Magnetic Resonance Imaging in patients on ECMO (SAFE-MRI ECMO study): study protocol and first case series... di Sung-Min Cho, Christopher Wilcox, Steven Keller, Matthew Acton, Hannah Rando, Eric Etchill, Katherine Giuliano, Errol L. Bush, Haris I. Sair, John Pitts, Bo Soo Kim, Glenn Whitman

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Neurofilament light chains to assess sepsis-associated encephalopathy: Are we on the track toward clinical implementation? di Barbora Bircak-Kuchtova, Ha-Yeun Chung, Jonathan Wickel, Johannes Ehler, Christian Geis

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Neurologic manifestations of COVID-19 in critically ill patients: results of the prospective multicenter registry PANDEMIC di Konstantinos Dimitriadis, Jan Meis, Hermann Neugebauer, Kristian Barlinn, Bernhard Neumann, Georg Gahn, Piergiorgio Lochner, Benjamin Knier, Sarah Lindemann, Kurt Wolfram Sühs, Kristina Szabo, Thomas Pfefferkorn, Ingo Schirotzek, Tobias Freilinger, Bassa Burc, Albrecht Günther, Matthias Wittstock, Patrick Schramm, Gernot Reimann, Jana Godau, Gabor Nagy, Fatima B. Koenig, Fabian Essig, Hartwig Klinker, Christian Hartmann, Moritz L. Schmidbauer, Tim Steinberg, Lora Lefterova, Christina Klose, Julian Bösel, for the IGNITE study group

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Ketanserin as potential additive drug to improve V/Q mismatch in COVID-19? di M. Kuindersma, P. E. Spronk

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Fluid-limiting treatment strategies among sepsis patients in the ICU: a retrospective causal analysis di Zach Shahn, Nathan I. Shapiro, Patrick D. Tyler, Daniel Talmor, Li-wei H. Lehman

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Effects of hyperoxia on vascular tone in animal models: systematic review and meta-analysis di Bob Smit, Yvo M. Smulders, Etto C. Eringa, Heleen M. Oudemans - van Straaten, Armand R. J. Girbes, Kimberley E. Wever, Carlijn R. Hooijmans, Angelique M. E. Spoelstra - de Man

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Time-varying intensity of oxygen exposure is associated with mortality in critically ill patients with mechanical ventilation di Zhu Zhu, Mingqin Zhou, Yao Wei, Hui Chen

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Impact of post-traumatic stress symptoms on the health-related quality of life in a cohort study with chronically critically ill patients and their partners: age matters di Gloria-Beatrice Wintermann, Katja Petrowski, Kerstin Weidner, Bernhard Strauß, Jenny Rosendahl

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N-terminal pro-brain natriuretic peptide levels during the acute phase of sepsis may be a useful indicator of higher risk of long-term impairments: some confounders to consider di Patrick M. Honore, Cristina David, Aude Mugisha, Rachid Attou, Sebastien Redant, Andrea Gallerani, David De Bels

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Increasing angiotensin-converting enzyme concentrations and absent angiotensin-converting enzyme activity are associated with adverse kidney outcomes in pediatric septic shock di Naomi Pode-Shakked, Giovanni Ceschia, James E. Rose, Stuart L. Goldstein, Natalja L. Stanski, the Genomics of Pediatric Septic Shock Investigators

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Resuscitative endovascular balloon occlusion of the aorta performed by emergency physicians for traumatic hemorrhagic shock: a case series from Japanese emergency rooms di Ryota Sato, Akira Kuriyama, Rei Takaesu, Nobuhiro Miyamae, Wataru Iwanaga, Hayato Tokuda, Takehiro Umemura

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