Different Biomarkers of Response to Treatment with Selective Jak-1 Inhibitors in Rheumatoid Arthritis by Maurizio Benucci, Francesca Li Gobbi, Paola Fusi, Arianna Damiani, Edda Russo, Serena Guiducci, Mariangela Manfredi, Valentina Grossi, Maria Infantino, Amedeo Amedei

“…All patients were evaluated for clinimetry with DAS28 and Crohn’s Disease Activity Index (CDAI), number of tender and swollen joints, Visual Analogic Scale (VAS), Physician Global Assessment (PhGA), and Health Assessment Questionnaire (HAQ), at baseline and at the 12th week of treatment. …”
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Polygenic risk score for ulcerative colitis predicts immune checkpoint inhibitor-mediated colitis by Pooja Middha, Rohit Thummalapalli, Michael J. Betti, Lydia Yao, Zoe Quandt, Karmugi Balaratnam, Cosmin A. Bejan, Eduardo Cardenas, Christina J. Falcon, David M. Faleck, Princess Margaret Lung Group, Matthew A. Gubens, Scott Huntsman, Douglas B. Johnson, Linda Kachuri, Khaleeq Khan, Min Li, Christine M. Lovly, Megan H. Murray, Devalben Patel, Kristin Werking, Yaomin Xu, Luna Jia Zhan, Justin M. Balko, Geoffrey Liu, Melinda C. Aldrich, Adam J. Schoenfeld, Elad Ziv

“…We hypothesize that genetic susceptibility to Crohn’s disease (CD) and ulcerative colitis (UC) predisposes to IMC. …”
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Impact of biological therapy in reducing the risk of arthritis development in inflammatory bowel diseases by Paola Conigliaro, Maria Sole Chimenti, Paola Triggianese, Alberto Bergamini, Mauro Fatica, Benedetta Monosi, Arianna D’Antonio, Sara Essofi, Elisa Cuccagna, Livia Biancone, Giovanni Monteleone, Emma Calabrese

“…Objective Evaluate spondyloarthritis (SpA) incidence in inflammatory bowel diseases (IBD) between patients treated with biological disease-modifying antirheumatic drugs (bDMARDs) and conventional DMARDs (cDMARDs) and define risk factors associated with SpA development.Methods Retrospective cohort study was conducted on patients with Crohn’s disease (CD) or ulcerative colitis (UC) and divided into two cohorts: cDMARDs or bDMARDs/targeted synthetic (ts) DMARDs treated patients. …”
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Survival in elderly patients with breast cancer with and without autoimmune disease by Demitrios Dedousis, Annie L. Zhang, Anastasia N. Vassiliou, Shufen Cao, Deepthi Yammani, Ravi K. Kyasaram, John P. Shanahan, Melissa C. Keinath, Melinda L. Hsu, Pingfu Fu, Afshin Dowlati, Alberto J. Montero

“…Conclusions We found a higher prevalence of rheumatoid arthritis, Crohn's disease, ulcerative colitis, and systemic lupus erythematosus in patients with breast cancer compared to age matched cohorts in the general population. …”
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The causal relationship between multiple autoimmune diseases and nasal polyps by Siyuan Chen, Lu Tan, Danxue Qin, Hao Lv, Kunyu Liu, Yingying Xu, Xiaomin Wu, Jingyu Huang, Yu Xu, Yu Xu, Yu Xu, Yu Xu

“…Then mediation analyses were conducted to further investigate the underlying mechanisms.ResultsFor the first time, we investigated the causal relationships between nine autoimmune diseases and nasal polyps in different genders and found: (1) there was a causal association between adult-onset Still's disease and nasal polyps; (2) sarcoidosis, ulcerative colitis, type 1 diabetes, and Crohn’s disease had no significant associations with nasal polyps; (3) celiac disease showed a suggestive positive association with female nasal polyps, whereas juvenile arthritis and multiple sclerosis showed suggestive positive associations with male nasal polyps. …”
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Transcriptomic analysis of enteropathy in Zambian children with severe acute malnutritionResearch in context by Mubanga Chama, Beatrice C. Amadi, Kanta Chandwe, Kanekwa Zyambo, Ellen Besa, Nurmohammad Shaikh, I. Malick Ndao, Philip I. Tarr, Chad Storer, Richard Head, Paul Kelly

“…Both NOIseq and GSEA identified gene clusters similar to those differentially expressed in pediatric Crohn's disease but to a much lesser degree than those identified in coeliac disease. …”
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Optimal combination of arsenic trioxide and copper ions to prevent autoimmunity in a murine HOCl-induced model of systemic sclerosis by Charlotte Chêne, Charlotte Chêne, Dominique Rongvaux-Gaïda, Marine Thomas, François Rieger, Carole Nicco, Frédéric Batteux, Frédéric Batteux

“…Arsenic trioxide (ATO) has been proven to be effective against SSc, sclerodermatous Graft-versus-Host Disease, multiple sclerosis, Crohn’s disease or systemic lupus erythematosus animal models and has demonstrated promising effects in human clinical trials. …”
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Improving the Consent Process With an Informed Consent Video Prior to Outpatient Colonoscopy by Emily W. Lopes, Leo Boneschansker, Jacqueline N. Chu, Jasmine B. Ha, Yousef R. Badran, Paige McLean Diaz, Eric M. Przybyszewski, Johannes F. Scheid, Sathish Subramanian, Christopher Vélez, Robert M. Wilechansky, Meera Changela, James M. Richter, Amiko M. Uchida, Paul Lochhead

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Identification of gene signatures associated with ulcerative colitis and the association with immune infiltrates in colon cancer by Zhaoji Pan, Hao Lin, Yanyan Fu, Fanpeng Zeng, Feng Gu, Guoping Niu, Jian Fang, Bing Gu

“…BackgroundInflammatory bowel diseases, including ulcerative colitis (UC) and Crohn’s disease, are some of the most common inflammatory disorders of the gastrointestinal tract. …”
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Serum Albumin to Globulin Ratio is Associated with the Presence and Severity of Inflammatory Bowel Disease by Wang Y, Li C, Wang W, Wang J, Li J, Qian S, Cai C, Liu Y

“…The primary purpose of the present research was to explore the relationship between serum AGR and inflammatory bowel disease (IBD).Methods: A total of 179 patients with ulcerative colitis (UC), 210 patients with Crohn’s disease (CD), and non-IBD controls (age- and gender-matched controls who have gastrointestinal (GI) symptoms) were enrolled in the research. …”
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The Prevalent Comorbidome at the Onset of Psoriasis Diagnosis by Alessandra Buja, Andrea Miatton, Claudia Cozzolino, Alessandra Rosalba Brazzale, Roberta Lo Bue, Santo Raffaele Mercuri, Fabian Nikolai Proft, Khalaf Kridin, Arnon Dov Cohen, Giovanni Damiani

“…PsO patients’ specific comorbidomes evidenced several pathological cores: autoimmune and inflammatory systemic diseases [i.e., hidradenitis suppurativa (OR 3.55, 95% CI 1.88–7.28) or polymyalgia rheumatica (OR 3.01 95% CI 1.96–4.77)], inflammatory bowel diseases [i.e., Crohn’s disease (OR 2.99 95% CI 2.20–4.13)], pulmonary inflammatory diseases [i.e., chronic obstructive pulmonary disease (OR 1.81 95% CI 1.61–2.04)], hepatological diseases [i.e., cirrhosis (OR 2.00 95% CI 1.36–3.00)], endocrine diseases [dysthyroidisms (OR 1.82 95% CI 1.30–2.59)], mental disorders [i.e., depression (OR 1.72 95% CI 1.57–1.87)], and cardiovascular diseases (i.e., hypertension (OR 1.47 95% CI 1.41–1.53)]. …”
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Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies. by Iris Broce, Celeste M Karch, Natalie Wen, Chun C Fan, Yunpeng Wang, Chin Hong Tan, Naomi Kouri, Owen A Ross, Günter U Höglinger, Ulrich Muller, John Hardy, International FTD-Genomics Consortium, Parastoo Momeni, Christopher P Hess, William P Dillon, Zachary A Miller, Luke W Bonham, Gil D Rabinovici, Howard J Rosen, Gerard D Schellenberg, Andre Franke, Tom H Karlsen, Jan H Veldink, Raffaele Ferrari, Jennifer S Yokoyama, Bruce L Miller, Ole A Andreassen, Anders M Dale, Rahul S Desikan, Leo P Sugrue

“…<h4>Methods and findings</h4>Using large genome-wide association studies (GWASs) (total n = 192,886 cases and controls) and recently developed tools to quantify genetic overlap/pleiotropy, we systematically identified single nucleotide polymorphisms (SNPs) jointly associated with FTD-related disorders-namely, FTD, corticobasal degeneration (CBD), progressive supranuclear palsy (PSP), and amyotrophic lateral sclerosis (ALS)-and 1 or more immune-mediated diseases including Crohn disease, ulcerative colitis (UC), rheumatoid arthritis (RA), type 1 diabetes (T1D), celiac disease (CeD), and psoriasis. …”
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Primary hypertrophic osteoarthropathy related gastrointestinal complication has distinctive clinical and pathological characteristics: two cases report and review of the literature by Qiang Wang, Ying-he Li, Guo-le Lin, Yue Li, Wei-xun Zhou, Jia-ming Qian, Wei-bo Xia, Dong Wu

“…The intestinal pathologic characteristics are distinct from Crohn’s disease but similar to CMUSE. Mutations in SLCO2A1 might be the pathogenic cause of GI involvement of PHO. …”
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Patients With Inflammatory Bowel Disease Show IgG Immune Responses Towards Specific Intestinal Bacterial Genera by Arno R. Bourgonje, Geesje Roo-Brand, Paola Lisotto, Mehdi Sadaghian Sadabad, Rosanne D. Reitsema, Marcus C. de Goffau, Marcus C. de Goffau, Klaas Nico Faber, Gerard Dijkstra, Hermie J. M. Harmsen

“…No differences in IgG-coated bacterial fractions were observed between Crohn’s disease and ulcerative colitis, between active or non-active disease, nor between different disease locations.ConclusionThe IgG immune response is specifically targeted at distinct intestinal bacterial genera that are typically associated with the small intestinal microbiota, whereas responses against more colonic-type commensals are lower, which was particularly the case for patients with IBD. …”
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Skin microbiota signature distinguishes IBD patients and reflects skin adverse events during anti-TNF therapy by Zuzana Reiss, Filip Rob, Martin Kolar, Dagmar Schierova, Jakub Kreisinger, Zuzana Jackova, Radka Roubalova, Stepan Coufal, Martin Mihula, Tomas Thon, Lukas Bajer, Lukas Bajer, Michaela Novakova, Martin Vasatko, Klara Kostovcikova, Natalie Galanova, Milan Lukas, Milan Lukas, Miloslav Kverka, Jana Tresnak Hercogova, Jana Tresnak Hercogova, Helena Tlaskalova-Hogenova, Zuzana Jiraskova Zakostelska

“…Crohn’s disease (CD) and ulcerative colitis (UC) are two forms of inflammatory bowel disease (IBD), where the role of gut but not skin dysbiosis is well recognized. …”
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Adherent-Invasive and Non-Invasive <i>Escherichia coli</i> Isolates Differ in Their Effects on <i>Caenorhabditis elegans’</i> Lifespan by Maria Beatriz de Sousa Figueiredo, Elizabeth Pradel, Fanny George, Séverine Mahieux, Isabelle Houcke, Muriel Pottier, Chantal Fradin, Christel Neut, Catherine Daniel, Antonino Bongiovanni, Benoît Foligné, Marie Titécat

“…The adherent-invasive <i>Escherichia coli</i> (AIEC) pathotype has been implicated in the pathogenesis of inflammatory bowel diseases in general and in Crohn’s disease (CD) in particular. AIEC strains are primarily characterized by their ability to adhere to and invade intestinal epithelial cells. …”
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Identification of Specific Oral and Gut Pathogens in Full Thickness Colon of Colitis Patients: Implications for Colon Motility by Vasudevan Dinakaran, Sammed N. Mandape, Kristina Shuba, Siddharth Pratap, Shruti S. Sakhare, Mohammad Ali Tabatabai, Duane T. Smoot, Cherae M. Farmer-Dixon, Lakshmyya N. Kesavalu, Samuel Evans Adunyah, Janet Hayes Southerland, Pandu R. Gangula

“…Thirty-nine human full thickness colon (diseased colon and adjacent healthy colon) specimens were collected from Crohn's Colitis (CC) or Ulcerative Colitis (UC) patients while they underwent elective colon surgeries. …”
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Impact of tumor necrosis factor antagonist combination and anti-integrin therapies on body mass index in inflammatory bowel disease: A cross-sectional study by Mohammad Shehab, Ali Alali, Ahmed Al-Hindawi, Abdulwahab Alsayegh, Usama Aldallal, Israa Abdullah, Abbas Albaghli, Fatema Alrashed, Ahmad Alfadhli, Talat Bessissow

“…Adult patients, older than 18 years, with a diagnosis of Crohn’s disease (CD) or ulcerative colitis (UC) were recruited. …”
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ÚLCERAS GENITAIS EM ADOLESCENTES DO SEXO FEMININO - DIAGNÓSTICO DIFERENCIAL A PROPÓSITO DE TRÊS CASOS CLÍNICOS by Ana Rita Travassos, Joana Antunes, David Pacheco, João Borges da Costa, Paulo Filipe, Manuel Sacramento Marques

“…Comentários: As úlceras genitais não relacionadas com contacto sexual (úlceras genitais reactivas) estão frequentemente associadas a doenças sistémicas, nomeadamente doença de Crohn ou de Behçet, mas podem aparecer em resposta a uma infecção aguda. …”
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Smad7 Controls Immunoregulatory PDL2/1-PD1 Signaling in Intestinal Inflammation and Autoimmunity by Lucien P. Garo, Amrendra K. Ajay, Mai Fujiwara, Vanessa Beynon, Chantal Kuhn, Galina Gabriely, Supriya Sadhukan, Radhika Raheja, Stephen Rubino, Howard L. Weiner, Gopal Murugaiyan

“…Summary: Smad7, a negative regulator of TGF-β signaling, has been implicated in the pathogenesis and treatment of inflammatory bowel diseases (IBDs), including Crohn's disease (CD) and ulcerative colitis (UC). …”
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