Conception and reality: Outcome of SARS-CoV-2 infection and vaccination among Hungarian IBD patients on biologic treatments by Tamás Resál, Mária Matuz, Csilla Keresztes, Péter Bacsur, Kata Szántó, Anett Sánta, Mariann Rutka, Diána Kolarovszki-Erdei, Renata Bor, Anna Fábián, Zoltán Szepes, Pál Miheller, Patrícia Sarlós, Anita Zacháry, Klaudia Farkas, Tamás Molnár

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Estimation of Performance Characteristics of Analytical Methods for Mycobacterium avium subsp. paratuberculosis Detection in Dairy Products by Sophie Butot, Matteo Ricchi, Iker A. Sevilla, Lise Michot, Elena Molina, Maitane Tello, Simone Russo, Norma Arrigoni, Joseba M. Garrido, David Tomas

“…MAP is also suspected to be involved in the etiology of some human diseases, like Crohn’s disease and others. In surveillance studies, different analytical methodologies were employed to detect MAP, showing different results and incidence in dairy products. …”
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A Novel Remote Patient and Medication Monitoring Solution to Improve Adherence and Persistence With Inflammatory Bowel Disease Therapy (ASSIST Study): Protocol for a Randomized Con... by Jordan Axelrad, Millie Long, Sara Horst, Anita Afzali, Tamar Sapir, Kristina Fajardo, Kara De Felice, Robert Sandler, Raymond Cross

“…The system will prompt patients to complete a two-item assessment of symptoms monthly using the PRO-2 scales for UC and Crohn disease, from which increased symptoms will be alerted to providers. …”
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Primary Hyperparathyroidism with a Predominant Lesion of the Gastrointestinal Tract by E. Yu. Kudashkina, E. G. Gavrilenko, A. A. Yakushev, G. G. Totolyan, N. N. Petrenko, L. Yu. Ilchenko, I. G. Fedorov, I. G. Nikitin

“…A differential diagnosis was made with small intestine lymphoma and Crohn’s disease. In addition, there were General cerebral symptoms in the form of lethargy, rapid exhaustion. …”
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Deep-Learning and Device-Assisted Enteroscopy: Automatic Panendoscopic Detection of Ulcers and Erosions by Miguel Martins, Miguel Mascarenhas, João Afonso, Tiago Ribeiro, Pedro Cardoso, Francisco Mendes, Hélder Cardoso, Patrícia Andrade, João Ferreira, Guilherme Macedo

“…Endoscopic observation of ulcers or erosions is frequent and can be associated with many nosological entities, namely Crohn’s disease. Although the application of artificial intelligence (AI) is growing exponentially in various imaged-based gastroenterology procedures, there is still a lack of evidence of the AI technical feasibility and clinical applicability of DAE. …”
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Prevalence of Zinc Deficiency in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis by Roberta Zupo, Annamaria Sila, Fabio Castellana, Roberto Bringiotti, Margherita Curlo, Giovanni De Pergola, Sara De Nucci, Gianluigi Giannelli, Mauro Mastronardi, Rodolfo Sardone

“…Two independent investigators assessed the 152 retrieved articles for inclusion criteria, met by only nine, that included 17 prevalence entries for Crohn’s disease (CD) (<i>n</i> = 9) and ulcerative colitis (UC) (<i>n</i> = 8). …”
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IFN-γ and TNF-α drive a CXCL10+ CCL2+ macrophage phenotype expanded in severe COVID-19 lungs and inflammatory diseases with tissue inflammation by Fan Zhang, Joseph R. Mears, Lorien Shakib, Jessica I. Beynor, Sara Shanaj, Ilya Korsunsky, Aparna Nathan, Accelerating Medicines Partnership Rheumatoid Arthritis and Systemic Lupus Erythematosus (AMP RA/SLE) Consortium, Laura T. Donlin, Soumya Raychaudhuri

“…Using this approach, we integrated > 300,000 single-cell transcriptomic profiles from COVID-19-affected lungs and tissues from healthy subjects and patients with five inflammatory diseases: rheumatoid arthritis (RA), Crohn’s disease (CD), ulcerative colitis (UC), systemic lupus erythematosus (SLE), and interstitial lung disease. …”
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Differential diagnosis of pulmonary sarcoidosis: a review by Dominique Valeyre, Dominique Valeyre, Michel Brauner, Jean-François Bernaudin, Jean-François Bernaudin, Etienne Carbonnelle, Boris Duchemann, Boris Duchemann, Cécile Rotenberg, Cécile Rotenberg, Ingrid Berger, Antoine Martin, Hilario Nunes, Hilario Nunes, Jean-Marc Naccache, Florence Jeny, Florence Jeny

“…Alternative granulomatous diseases that must be ruled out include infections (notably tuberculosis, nontuberculous mycobacterial infections, and histoplasmosis), chronic beryllium disease, hypersensitivity pneumonitis, granulomatous talcosis, drug-induced granulomatosis (notably due to TNF-a antagonists, immune checkpoint inhibitors, targeted therapies, and interferons), immune deficiencies, genetic disorders (Blau syndrome), Crohn’s disease, granulomatosis with polyangiitis, eosinophilic granulomatosis with polyangiitis, and malignancy-associated granulomatosis. …”
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The Presence of Genotoxic and/or Pro-inflammatory Bacterial Genes in Gut Metagenomic Databases and Their Possible Link With Inflammatory Bowel Diseases by Abiel Roche-Lima, Kelvin Carrasquillo-Carrión, Ramón Gómez-Moreno, Ramón Gómez-Moreno, Juan M. Cruz, Dayanara M. Velázquez-Morales, Igor B. Rogozin, Abel Baerga-Ortiz, Abel Baerga-Ortiz

“…The selected sequences were searched in three different mWGS datasets accessed through the Human Microbiome Project (HMP): a healthy cohort (N = 251), a Crohn’s disease cohort (N = 60) and an ulcerative colitis cohort (N = 17).Results: Firstly, the sequences for the murB housekeeping genes from Enterobacteriaceae and Enterococci were more frequently found in the IBD cohorts (32% E. coli in IBD vs. 12% in healthy; 13% E. faecalis in IBD vs. 3% in healthy) than in the healthy cohort, confirming earlier reports of a higher presence of both of these taxa in IBD. …”
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The change of healthcare service in Chinese patients with inflammatory bowel disease during the pandemic: a national multicenter cross-sectional study by Xiaofei Li, Fang Wang, Yizhen Jia, He Zhou, Yanting Shi, Feng Tian, Yan Chen, Jie Liang

“…Totally 463 were from ulcerative colitis (UC) patients and 538 from Crohn’s disease (CD) patients were included in the study. …”
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Associations between participation in, intensity of, and time spent on leisure time physical activity and risk of inflammatory bowel disease among older adults (PA-IBD): a prospect... by Nathalie Fogh Rasmussen, Bodil Hammer Bech, Katrine Hass Rubin, Vibeke Andersen

“…The outcome IBD was defined as having at least two main diagnoses of Crohn’s disease or ulcerative colitis registered in the National Patient Registry from the period between December 1993 and May 1997 with an average follow-up of 25 years. …”
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Long-term Temporal Stability of Peripheral Blood DNA Methylation Profiles in Patients With Inflammatory Bowel DiseaseSummary by Vincent Joustra, Andrew Y.F. Li Yim, Ishtu Hageman, Evgeni Levin, Alex Adams, Jack Satsangi, Wouter J. de Jonge, Peter Henneman, Geert D’Haens

“…Methods: We followed a cohort of 46 adult patients with IBD (36 Crohn’s disease [CD], 10 ulcerative colitis [UC]; median age, 44 years; interquartile range [IQR] 27–56 years; 50% female) that received standard care follow-up at the Amsterdam University Medical Centers. …”
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Characteristics and outcome of primary sclerosing cholangitis associated with inflammatory bowel disease in Asian children by Way Seah Lee, Sivaramakrishnan Venkatesh Karthik, Ruey Terng Ng, Sik Yong Ong, Christina Ong, Fang K. Chiou, Shin Yee Wong, Seng Hock Quak, Marion Margaret Aw

“…Results: Of 24 patients (boys, 58%; median age at diagnosis: 6.3 years) with primary sclerosing cholangitis-inflammatory bowel disease (ulcerative colitis, n = 21; Crohn's disease, n = 1; undifferentiated, n = 2), 63% (n = 15) were diagnosed during follow-up for colitis, and 21% (n = 5) presented with acute or chronic hepatitis, 17% (n = 4) presented simultaneously. …”
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Macrophages, Nitric Oxide and microRNAs Are Associated with DNA Damage Response Pathway and Senescence in Inflammatory Bowel Disease by Sohn, Jane J., Schetter, Aaron J., Yfantis, Harris G., Ridnour, Lisa A., Horikawa, Izumi, Kahn, Mohammed A., Robles, Ana I., Hussain, S. Perwez, Goto, Akiteru, Bowman, Elise D., Hofseth, Lorne J., Bartkova, Jirina, Bartek, Jiri, Wogan, Gerald N., Wink, David A., Harris, Curtis C.

“…In contrast to UC, we noted in Crohn’s disease (CD) that senescence (HP1γ; P<0.001) and DDR (γH2A.X; P<0.05, phospho-Chk2; P<0.001) were higher, and macrophages were not associated with senescence. …”
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Enhancing surgical precision: unveiling the impact of preoperative colonoscopy in anal fistula patients by Shumin Xu, Luo Zhang, Zhi Li, Kaiping Wang, Fang Liu, Bo Cao

“…Subsequently, the analysis of the subgroup (groups A and C) revealed a significant disparity in intestinal endoscopic detection rates (P < 0.01) and statistically significant differences in detecting IBD (P < 0.05) and Crohn's disease (P < 0.05) between the two anal fistula subgroups. …”
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Molecular Docking Identifies 1,8-Cineole (Eucalyptol) as A Novel PPARγ Agonist That Alleviates Colon Inflammation by Balaji Venkataraman, Saeeda Almarzooqi, Vishnu Raj, Bhoomendra A. Bhongade, Rajesh B. Patil, Veedamali S. Subramanian, Samir Attoub, Tahir A. Rizvi, Thomas E. Adrian, Sandeep B. Subramanya

“…Inflammatory bowel disease, comprising Crohn’s disease (CD) and ulcerative colitis (UC), is often debilitating. …”
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Safety of Ixekizumab Treatment for up to 5 Years in Adult Patients with Moderate-to-Severe Psoriasis: Results from Greater Than 17,000 Patient-Years of Exposure by April Armstrong, Carle Paul, Luis Puig, Wolf Henning Boehncke, Michael Freeman, Hideshi Torii, Kim Papp, Christopher E. M. Griffiths, Andrew Blauvelt, Kristian Reich, Melinda Gooderham, Tadashi Terui, Lisa Renda, Noah Agada, Wen Xu, Gaia Gallo, Mark G. Lebwohl

“…When compared across years of exposure, rates for AEs remained largely stable or declined, including TEAEs leading to discontinuation (3.8/100 p-y in year 1, declining to 2.0/100 p-y in year 5); SAEs (range 6.2–7.0/100 p-y); serious infections (range 1.3–1.7/100 p-y); nonmelanoma skin cancer (ranging from 0.5/100 p-y in year 1 to 0.2/100 p-y in years 4–5); other malignancies (range 0.4–0.6/100 p-y); inflammatory bowel disease including ulcerative colitis and Crohn’s disease (IR 0.2/100 p-y); and major adverse cardiovascular events (MACE) (range 0.3–0.7/100 p-y). …”
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MiRNA-374b-5p and miRNA-106a-5p are related to inflammatory bowel disease via regulating IL-10 and STAT3 signaling pathways by Dongjie Li, Liyuan Liu, Xiancai Du, Wen Ma, Jing Zhang, Wenhua Piao

“…Abstract Background Inflammatory bowel disease (IBD), including Crohn’s disease and ulcerative colitis, is one of the most frequent gastrointestinal disorders worldwide. …”
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The gut microbiome dysbiosis and regulation by fecal microbiota transplantation: umbrella review by Xianzhuo Zhang, Xufei Luo, Liang Tian, Ping Yue, Mengyao Li, Kefeng Liu, Daoming Zhu, Chongfei Huang, Qianling Shi, Liping Yang, Zhili Xia, Jinyu Zhao, Zelong Ma, Jianlong Li, Joseph W. Leung, Yanyan Lin, Jinqiu Yuan, Wenbo Meng, Xun Li, Yaolong Chen, Yaolong Chen, Yaolong Chen, Yaolong Chen

“…Evidence was high quality for rCDI and moderate to high quality for ulcerative colitis and Crohn’s disease but low to very low quality for other diseases.ConclusionGut microbiome dysbiosis may be implicated in numerous diseases. …”
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Vitamin D as a predictor of severe course of inflammatory bowel diseases in children by T.V. Sorokman, S.V. Sokolnyk, N.O. Popelyuk, O.V. Makarova

“…Lower vitamin D levels were associated with female sex, Crohn’s disease, and ulcerative colitis, as well as disease duration of more than 3 years, activity level, and severity, supporting the role of vitamin D as a possible predictor of severity of these diseases in childhood.…”
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