Do Vedolizumab trough Levels Predict the Outcome of Subsequent Therapy in Inflammatory Bowel Disease? by Asaf Levartovsky, Ido Cohen, Chaya Mushka Abitbol, Miri Yavzori, Ella Fudim, Orit Picard, Uri Kopylov, Shomron Ben-Horin, Bella Ungar

“…<b>Results</b>: Overall, 86 IBD patients (51 Crohn’s disease, 35 ulcerative colitis) who discontinued vedolizumab were included; of those, 72 (83.7%) were due to LOR. …”
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Causality between inflammatory bowel disease and the cerebral cortex: insights from Mendelian randomization and integrated bioinformatics analysis by Shubei He, Shubei He, Shubei He, Shubei He, Ying Peng, Ying Peng, Ying Peng, Ying Peng, Xiaofang Chen, Xiaofang Chen, Xiaofang Chen, Xiaofang Chen, Ying Ou

“…BackgroundInflammatory bowel disease (IBD), which includes ulcerative colitis (UC) and Crohn’s disease (CD), is a chronic, progressive, and recurrent intestinal condition that poses a significant global health burden. …”
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Metabolomic alterations associated with Behçet’s disease by Wenjie Zheng, Xiuhua Wu, Maryam Goudarzi, Jing Shi, Wei Song, Chaoran Li, Jinjing Liu, Hua Chen, Xuan Zhang, Xiaofeng Zeng, Heng-Hong Li

“…Additionally, serum samples from an independent cohort of BD patients, disease controls including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), Takayasu’s arteritis (TA), Crohn’s disease (CD) patients, and HC were collected for further validation of two potential biomarkers using UPLC-QTOFMS analysis. …”
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MPST deficiency promotes intestinal epithelial cell apoptosis and aggravates inflammatory bowel disease via AKT by Jie Zhang, Li Cen, Xiaofen Zhang, Chenxi Tang, Yishu Chen, Yuwei Zhang, Mengli Yu, Chao Lu, Meng Li, Sha Li, Bingru Lin, Tiantian Zhang, Xin Song, Chaohui Yu, Hao Wu, Zhe Shen

“…Results: MPST expression was markedly decreased in colonic samples from patients with ulcerative colitis (UC) or Crohn's disease (CD) and from mice treated with DSS. …”
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Investigational treatment of rheumatoid arthritis with a vibrotactile device applied to the external ear by Meghan E. Addorisio, Gavin H. Imperato, Alex F. de Vos, Steve Forti, Richard S. Goldstein, Valentin A. Pavlov, Tom van der Poll, Huan Yang, Betty Diamond, Kevin J. Tracey, Sangeeta S. Chavan

“…Implantable bioelectronic devices targeting the inflammatory reflex reduce TNF production and inflammation in preclinical models of inflammatory disease, and in patients with RA and Crohn’s disease. Here, we assessed the effect of applying a vibrotactile device to the cymba concha of the external ear on inflammatory responses in healthy subjects, as well as its effect on disease activity in RA patients. …”
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Flood Control: How Milk-Derived Extracellular Vesicles Can Help to Improve the Intestinal Barrier Function and Break the Gut–Joint Axis in Rheumatoid Arthritis by Joyce Aarts, Annemarie Boleij, Bartijn C. H. Pieters, Anouk L. Feitsma, R. J. Joost van Neerven, R. J. Joost van Neerven, Jean Paul ten Klooster, Laura M’Rabet, Onno J. Arntz, Marije I. Koenders, Fons A. J. van de Loo

“…Enhanced intestinal leakiness, dysbiosis of the gut microbiome, and bowel inflammation are not only associated with intestinal diseases like colitis and Crohn’s disease, but also characteristic for systemic inflammatory diseases such as lupus, multiple sclerosis, and rheumatoid arthritis (RA). …”
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Evaluation of the mechanical properties and clinical application of nickel–titanium shape memory alloy anal fistula clip by Heng Deng, Ming Li, Xiaoli Fang, Jun Zhang, Jianmin Wang, Kun Tang, Ran Tang, Ru Jia, Ying Han, Yang Shi, Yu'ang Dong

“…Among them, 22.6% (7) had multiple anal fistula, 16.1% (5) had high anal fistula, and 48.3% (15) had perianal fistula Crohn's disease. In total, 12.9% (4/31) did not achieve primary healing, underwent fistula resection, and eventually recovered. …”
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Natural products targeting Nrf2/ARE signaling pathway in the treatment of inflammatory bowel disease by Botong Li, Yixuan Wang, Xiaolin Jiang, Hongwei Du, Yan Shi, Minghui Xiu, Yongqi Liu, Jianzheng He

“…Inflammatory bowel disease (IBD) is a special chronic intestinal inflammatory disease, which is mainly divided into Crohn's disease (CD) and ulcerative colitis (UC). …”
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Reduced CD27−IgD− B Cells in Blood and Raised CD27−IgD− B Cells in Gut-Associated Lymphoid Tissue in Inflammatory Bowel Disease by Chathyan Pararasa, Na Zhang, Na Zhang, Thomas J. Tull, Ming H. A. Chong, Jacqueline H. Y. Siu, William Guesdon, Konstantia Maria Chavele, Jeremy D. Sanderson, Louise Langmead, Klaartje Kok, Jo Spencer, Anna Vossenkamper

“…Here we analyzed B cells in blood of patients with Crohn's disease (CD) and ulcerative colitis (UC) with a range of disease activities. …”
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Low TREM1 expression in whole blood predicts anti-TNF response in inflammatory bowel diseaseResearch in context by Bram Verstockt, Sare Verstockt, Jonas Dehairs, Vera Ballet, Helene Blevi, Willem-Jan Wollants, Christine Breynaert, Gert Van Assche, Séverine Vermeire, Marc Ferrante

“…Background: With the changed therapeutic armamentarium for Crohn's disease (CD) and ulcerative colitis (UC), biomarkers predicting treatment response are urgently needed. …”
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Reduction of Inflammation and Colon Injury by a Spearmint Phenolic Extract in Experimental Bowel Disease in Mice by Rosa Direito, João Rocha, Ana Lima, Maria Margarida Gonçalves, Maria Paula Duarte, Vanessa Mateus, Catarina Sousa, Adelaide Fernandes, Rui Pinto, Ricardo Boavida Ferreira, Bruno Sepodes, Maria-Eduardo Figueira

“…<b>Background</b>: Inflammatory Bowel Diseases (IBD) encompasses both Crohn&#8217;s Disease and Ulcerative Colitis, known to be connected to an enlarged risk for developing colorectal cancer (CRC). …”
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The expanding clinical spectrum of autoinflammatory diseases with NOD2 variants: a case series and literature review by Anastasios Karamanakos, Anastasios Karamanakos, Olga Vougiouka, Evdoxia Sapountzi, Aliki I. Venetsanopoulou, Maria G. Tektonidou, Anastasios E. Germenis, Petros P. Sfikakis, Katerina Laskari

“…Finally, one patient presented with chronic relapsing urticaria with periorbital edema and inflammatory markers, and another one had a Crohn-like syndrome with good response to anti-IL-1 but refractory to anti-TNF treatment.ConclusionNOD2 variants were detected in 1 out of 7 SAID patients and seem to have an impact on disease phenotype and treatment response. …”
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Anti-Inflammatory Effect and Signaling Mechanism of <i>Glycine max</i> Hydrolyzed with Enzymes from <i>Bacillus velezensis</i> KMU01 in a Dextran-Sulfate-Sodium-Induced Colitis Mou... by Seung-Hyeon Lee, Ha-Rim Kim, Eun-Mi Noh, Jae Young Park, Mi-Sun Kwak, Ye-Jin Jung, Hee-Jong Yang, Myeong Seon Ryu, Hyang-Yim Seo, Hansu Jang, Seon-Young Kim, Mi Hee Park

“…Moreover, we found that the abundance of 15 microorganisms changed significantly; that of Proteobacteria and <i>Escherichia coli</i>, which are upregulated in patients with Crohn’s disease and ulcerative colitis, decreased after EHG treatment. …”
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Fecal Microbiome Changes and Specific Anti-Bacterial Response in Patients with IBD during Anti-TNF Therapy by Dagmar Schierova, Radka Roubalova, Martin Kolar, Zuzana Stehlikova, Filip Rob, Zuzana Jackova, Stepan Coufal, Tomas Thon, Martin Mihula, Martin Modrak, Miloslav Kverka, Lukas Bajer, Klara Kostovcikova, Pavel Drastich, Jana Hercogova, Michaela Novakova, Martin Vasatko, Milan Lukas, Helena Tlaskalova-Hogenova, Zuzana Jiraskova Zakostelska

“…We found diversity differences between HC, Crohn’s disease, and ulcerative colitis patients. …”
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Serious adverse events reported in placebo randomised controlled trials of oral naltrexone: a systematic review and meta-analysis by Monica Bolton, Alex Hodkinson, Shivani Boda, Alan Mould, Maria Panagioti, Sarah Rhodes, Lisa Riste, Harm van Marwijk

“…Results Eighty-nine randomised controlled trials with 11,194 participants were found, studying alcohol use disorders (n = 38), various psychiatric disorders (n = 13), impulse control disorders (n = 9), other addictions including smoking (n = 18), obesity or eating disorders (n = 6), Crohn’s disease (n = 2), fibromyalgia (n = 1) and cancers (n = 2). …”
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Association of serum lipids with inflammatory bowel disease: a systematic review and meta-analysis by Hongxin Chen, Hongxin Chen, Weiyang Li, Weiyang Li, Jingyi Hu, Jingyi Hu, Feng Xu, Feng Xu, Yizhou Lu, Yizhou Lu, Lei Zhu, Lei Zhu, Hong Shen, Hong Shen

“…Serum lipid levels were compared between IBD patients and Health individuals, Crohn’s (CD) and ulcerative colitis (UC), active and inactive, mild and non-mild patients, respectively. …”
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Breaking through the therapeutic ceiling of inflammatory bowel disease: Dual-targeted therapies by Zelin Feng, Guangbo Kang, Jiewen Wang, Xingjie Gao, Xiaoli Wang, Yulin Ye, Limin Liu, Jingwen Zhao, Xinjuan Liu, He Huang, Xiaocang Cao

“…However, data on the efficacy and safety of DTT on Crohn’s disease and ulcerative colitis are still limited or insufficient. …”
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Enfermedades Autoinmunes, tratamiento con Trichuris suis y otros helmintos by Iñigo Pallardo Fernández

“…Resultados: Actualmente existen resultados prometedores de ensayos clínicos sobre terapias helmínticas aplicadas al tratamiento de enfermedades autoinmunes como son la enfermedad de Crohn y la colitis ulcerosa, resumidos en el apartado de resultados de este artículo. …”
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Lactobacillus paracasei R3 protects against dextran sulfate sodium (DSS)-induced colitis in mice via regulating Th17/Treg cell balance by Juan Huang, Ziyan Yang, Yanyun Li, Xingxing Chai, Yanfang Liang, Bihua Lin, Ziyu Ye, Shaobing Zhang, Zhengping Che, Hailiang Zhang, Xueying Zhang, Zhao Zhang, Tao Chen, Weiqing Yang, Jincheng Zeng

“…Abstract Inflammatory bowel diseases (IBD), mainly comprising ulcerative colitis (UC) and Crohn's Disease, are most often a polygenic disorder with contributions from the intestinal microbiome, defects in barrier function, and dysregulated host responses to microbial stimulation. …”
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Musculoskeletal Ultrasound to Identify Subclinical Joint and Periarticular Involvement in Patients With Inflammatory Bowel Disease: A Systematic Literature Review by Garifallia Sakellariou, Garifallia Sakellariou, Annalisa Schiepatti, Annalisa Schiepatti, Davide Scalvini, Davide Scalvini, Francesca Lusetti, Francesca Lusetti, Erica Fazzino, Erica Fazzino, Federico Biagi, Federico Biagi, Carlomaurizio Montecucco, Carlomaurizio Montecucco

“…There were no differences among Crohn's disease or ulcerative colitis and depending on disease activity, while there were contrasting results on different disease durations. …”
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