A semi-tryptic peptide centric metaproteomic mining approach and its potential utility in capturing signatures of gut microbial proteolysis by Zhixiang Yan, Feixiang He, Fei Xiao, Huanhuan He, Dan Li, Li Cong, Lu Lin, Huijin Zhu, Yanyan Wu, Ru Yan, Xiaofeng Li, Hong Shan

“…However, alterations of gut microbial proteolytic signatures under complex disease status such as inflammatory bowel disease (IBD, including Crohn’s disease (CD) and ulcerative colitis (UC)), have not been investigated. …”
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Non-coding Class Switch Recombination-Related Transcription in Human Normal and Pathological Immune Responses by Helena Kuri-Magaña, Helena Kuri-Magaña, Leonardo Collado-Torres, Leonardo Collado-Torres, Andrew E. Jaffe, Andrew E. Jaffe, Andrew E. Jaffe, Andrew E. Jaffe, Humberto Valdovinos-Torres, Marbella Ovilla-Muñoz, Juan Téllez-Sosa, Laura C. Bonifaz, Jesús Martínez-Barnetche

“…Additionally, significantly increased Iδ transcription in ileal mucosa in Crohn's disease with ulceration was found. In conclusion, CSRnc transcription occurs in multiple anatomical locations beyond classical secondary lymphoid organs, representing a potentially useful marker of effector B cell responses in normal and pathological immune responses. …”
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Biological Therapy in Inflammatory Bowel Disease Patients Partly Restores Intestinal Innate Lymphoid Cell Subtype Equilibrium by Brecht Creyns, Brecht Creyns, Inge Jacobs, Bram Verstockt, Bram Verstockt, Jonathan Cremer, Jonathan Cremer, Vera Ballet, Roselien Vandecasteele, Tim Vanuytsel, Tim Vanuytsel, Marc Ferrante, Marc Ferrante, Séverine Vermeire, Séverine Vermeire, Gert Van Assche, Gert Van Assche, Jan L. Ceuppens, Christine Breynaert, Christine Breynaert

“…Patients with Crohn disease (CD) and ulcerative colitis (UC) suffer from chronic relapsing intestinal inflammation. …”
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Multi-omic insight into the molecular networks of mitochondrial dysfunction in the pathogenesis of inflammatory bowel diseaseResearch in context by Jie Chen, Xixian Ruan, Yuhao Sun, Shiyuan Lu, Shixian Hu, Shuai Yuan, Xue Li

“…At circulating protein level, genetically predicted higher levels of PARK7 (OR 0.36, 95% CI 0.25–0.52) and HINT1 (OR 0.47, 95% CI 0.30–0.74) were inversely associated with IBD risk; genetically predicted higher level of HINT1 was associated with a decreased risk of Crohn's disease (CD) (OR 0.26, 95% CI 0.14–0.49) and a higher level of ACADM (OR 0.67, 95% CI 0.55–0.83), PDK1 (OR 0.63, 95% CI 0.49–0.81), FIS1 (OR 0.63, 95% CI 0.47–0.83) was associated with a decreased risk of UC. …”
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Fatty Acids of Erythrocyte Membranes and Blood Serum in Differential Diagnosis of Inflammatory Bowel Diseases by M. V. Kruchinina, I. O. Svetlova, M. F. Osipenko, N. V. Abaltusova, A. A. Gromov, M. V. Shashkov, A. S. Sokolova, I. N. Yakovina, A. V. Borisova

“…Aim: to study fatty acid levels in erythrocyte membranes (RBC) and blood serum (BS) in patients with inflammatory bowel diseases (IBDs) to develop differential diagnostic models including fatty acids as biomarkers to distinguish between nosological entities of IBDs (ulcerative colitis — UC, Crohn's disease — CD, unclassified colitis — UCC).Materials and methods. …”
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New Approach to Addison Disease: Oral Manifestations Due to Endocrine Dysfunction and Comorbidity Burden by Narcis Mihăiţă Bugălă, Mara Carsote, Loredana Elena Stoica, Dana Maria Albulescu, Mihaela Jana Ţuculină, Smaranda Adelina Preda, Ancuta-Ramona Boicea, Dragoș Ovidiu Alexandru

“…Anemia-related mucosal pallor is related to DM, hypothyroidism, hypogonadism, corresponding gastroenterological diseases (Crohn’s disease also presents oral ulceration (OU), mucogingivitis, and a 2–3 times higher risk of PD; Biermer anemia might cause hyperpigmentation by itself), and rheumatologic diseases (lupus induces OU, honeycomb plaques, keratotic plaques, angular cheilitis, buccal petechial lesions, and PD). …”
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The persistence of anti-Spike antibodies following two SARS-CoV-2 vaccine doses in patients on immunosuppressive therapy compared to healthy controls—a prospective cohort study by Ingrid Egeland Christensen, Ingrid Jyssum, Anne Therese Tveter, Joseph Sexton, Trung T. Tran, Siri Mjaaland, Grete Birkeland Kro, Tore K. Kvien, David John Warren, Jørgen Jahnsen, Ludvig A. Munthe, Espen A. Haavardsholm, John Torgils Vaage, Gunnveig Grødeland, Fridtjof Lund-Johansen, Kristin Kaasen Jørgensen, Silje Watterdal Syversen, Guro Løvik Goll, Sella Aarrestad Provan

“…Results A total of 1108 patients (403 rheumatoid arthritis, 195 psoriatic arthritis, 195 spondyloarthritis, 124 ulcerative colitis, 191 Crohn’s disease) and 134 controls provided blood samples within the defined intervals (median 19 days [IQR 15–24] and 97 days [87–105] after second vaccine dose). …”
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Expression of inflammatory cytokine and inducible nitric oxide synthase genes in the small intestine and mesenteric lymph node tissues of pauci- and multibacillary sheep naturally... by Ganesh G Sonawane, Bhupendra Nath Tripathi

“…MAP has also been implicated with human Crohn's disease. There exists a strong correlation between the immune response and development of various types of pathologies in ruminants. …”
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Toll-like Receptors and Cytokine Modulation by Goat Milk Extracellular Vesicles in a Model of Intestinal Inflammation by Chiara Grazia De Ciucis, Floriana Fruscione, Livia De Paolis, Samanta Mecocci, Susanna Zinellu, Lisa Guardone, Giulia Franzoni, Katia Cappelli, Elisabetta Razzuoli

“…IPEC-J2 was exposed for 2 h to pro-inflammatory stimuli as a model of inflammatory bowel disease (IBD), namely LPS for Crohn’s disease (CD) and H₂O₂ for ulcerative colitis (UC); then, cells were treated with goat mEVs for 48 h. …”
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Alteration of microbiota antibody‐mediated immune selection contributes to dysbiosis in inflammatory bowel diseases by Eva Michaud, Louis Waeckel, Rémi Gayet, Roman Goguyer‐Deschaumes, Blandine Chanut, Fabienne Jospin, Katell Bathany, Magali Monnoye, Coraline Genet, Amelie Prier, Caroline Tokarski, Philippe Gérard, Xavier Roblin, Nicolas Rochereau, Stéphane Paul

“…Using stool HPLC‐purified IgA, we show that reverse‐transcytosis is abrogated in ulcerative colitis (UC) while it is extended to IgA1 in Crohn's disease (CD). 16S RNA sequencing of IgA‐bound microbiota in CD and UC showed distinct IgA1‐ and IgA2‐associated microbiota; the IgA1+ fraction of CD microbiota was notably enriched in beneficial commensals. …”
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Nutrición Parenteral Domiciliaria: satisfacción de los pacientes y sus cuidadores con la Unidad de Nutrición Clínica y el Servicio de Farmacia by Paula Arrabal Duran, Rosa María Romero Jiménez, Cristina Cuerda Compes, Miguel Camblor Álvarez, Irene Bretón Lesmes, Ana de Lorenzo Pinto, Silvia Buendía Bravo, Laura Frías Soriano, Pilar García Peris, María Sanjurjo Sáez

“…Las enfermedades de base de los pacientes fueron: enteritis rádica (27,3%), obstrucción intestinal (18,2%), carcinomatosis intestinal (45,5%) y enfermedad de Crohn (9,1%). Con respecto a los ítems que evaluaban la satisfacción con médicos, enfermeros y farmacéuticos, en general tanto pacientes como cuidadores estuvieron satisfechos. …”
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Butyrate reduces adherent-invasive E. coli-evoked disruption of epithelial mitochondrial morphology and barrier function: involvement of free fatty acid receptor 3 by Samira A. Hamed, Armaan Mohan, Saranya Navaneetha Krishnan, Arthur Wang, Marija Drikic, Nicole L. Prince, Ian A. Lewis, Jane Shearer, Åsa V. Keita, Johan D. Söderholm, Timothy E. Shutt, Derek M. McKay

“…ABSTRACTGut bacteria provide benefits to the host and have been implicated in inflammatory bowel disease (IBD), where adherent-invasive E. coli (AIEC) pathobionts (e.g., strain LF82) are associated with Crohn’s disease. E. coli-LF82 causes fragmentation of the epithelial mitochondrial network, leading to increased epithelial permeability. …”
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Fasting-Mimicking Diet Modulates Microbiota and Promotes Intestinal Regeneration to Reduce Inflammatory Bowel Disease Pathology by Priya Rangan, Inyoung Choi, Min Wei, Gerardo Navarrete, Esra Guen, Sebastian Brandhorst, Nobel Enyati, Gab Pasia, Daral Maesincee, Vanessa Ocon, Maya Abdulridha, Valter D. Longo

“…Keywords: fasting-mimicking diet, gut microbiota, microbiome, inflammatory bowel disease, ulcerative colitis, Crohn’s disease, inflammation, fasting, intermittent fasting…”
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Two-sample Mendelian randomization analysis evaluates causal associations between inflammatory bowel disease and osteoporosis by Zhujiang Dai, Zhujiang Dai, Weimin Xu, Weimin Xu, Rui Ding, Rui Ding, Xiang Peng, Xiang Peng, Xia Shen, Xia Shen, Jinglue Song, Jinglue Song, Peng Du, Peng Du, Zhongchuan Wang, Zhongchuan Wang, Yun Liu, Yun Liu

“…IntroductionOver the past few years, multiple observational studies have speculated a potential association between inflammatory bowel disease (IBD), which includes ulcerative colitis (UC) and Crohn’s disease (CD), and osteoporosis. However, no consensus has been reached regarding their interdependence and pathogenesis. …”
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Use of Tumor Necrosis Factor-α Antagonists Is Associated With Attenuated IgG Antibody Response Against SARS-CoV-2 in Vaccinated Patients With Inflammatory Bowel Disease by Antonius T. Otten, Arno R. Bourgonje, Petra P. Horinga, Hedwig H. van der Meulen, Eleonora A. M. Festen, Hendrik M. van Dullemen, Rinse K. Weersma, Coretta C. van Leer-Buter, Gerard Dijkstra, Marijn C. Visschedijk

“…Subsequently, a chemiluminescent microparticle immunoassay was used for the quantitative determination of IgG antibodies against the receptor-binding domain (RBD) of the S1 subunit of the spike protein of SARS-CoV-2.ResultsThree hundred and twelve (312) patients with IBD were included (172 Crohn’s disease [CD] and 140 ulcerative colitis [UC]). …”
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COVID-19 Vaccine Booster Shot Preserves T Cells Immune Response Based on Interferon-Gamma Release Assay in Inflammatory Bowel Disease (IBD) Patients on Anti-TNFα Treatment by Grazia Pavia, Rocco Spagnuolo, Angela Quirino, Nadia Marascio, Aida Giancotti, Silvio Simeone, Cristina Cosco, Elena Tino, Federico Carrabetta, Gianfranco Di Gennaro, Carmelo Nobile, Aida Bianco, Giovanni Matera, Patrizia Doldo

“…Regarding the IBD patients, 19 were affected by Crohn’s disease and 34 by ulcerative colitis. During the vaccination cycle, half of the patients (53%) were on stable treatment with aminosalicylates, and 32% were on biological therapy. …”
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COVID-19 and Inflammatory Bowel Disease: Patient Knowledge and Perceptions in a Single Center Survey by Rocco Spagnuolo, Tiziana Larussa, Chiara Iannelli, Cristina Cosco, Eleonora Nisticò, Elena Manduci, Amalia Bruno, Luigi Boccuto, Ludovico Abenavoli, Francesco Luzza, Patrizia Doldo

“…</b> Fifty-four individuals (38%) were affected by Crohn disease and 88 (62%) by Ulcerative Colitis. …”
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Assessing the effect of interaction between gut microbiome and inflammatory bowel disease on the risks of depression by Xiaoyue Qin, Chuyu Pan, Qingqing Cai, Yijing Zhao, Dan He, Wenming Wei, Na Zhang, Sirong Shi, Xiaoge Chu, Feng Zhang

“…Methods: Using the individual genotype and depression traits data from the UK Biobank, we calculated the polygenetic risk scores (PRS) of 114 gut microbiome, ulcerative colitis (UC), Crohn's disease (CD), and total IBD (CD + UC) respectively. …”
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Large-scale genome-wide association study to identify causal relationships and potential mediators between education and autoimmune diseases by Yingjie Li, Yingjie Li, Jingwei Zhang, Jingwei Zhang, Jingwei Zhang, Jie Wen, Jie Wen, Jie Wen, Mingren Liu, Mingren Liu, Mingren Liu, Wanyao Liu, Yongzhen Li

“…Higher self-reported math ability showed protective effects on Crohn’s disease (CD) (OR = 0.67, 95% CI = 0.55-0.81, p = 4.96×10-5), RA (OR = 0.76, 95% CI = 0.67-0.87, p = 5.21×10-5), and psoriasis (OR = 0.76, 95% CI = 0.65-0.88, p = 4.08×10-4). …”
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Loss of NOD2 in macrophages improves colitis and tumorigenesis in a lysozyme-dependent manner by Camille Chauvin, Camille Chauvin, Katarina Radulovic, Olivier Boulard, Myriam Delacre, Nadine Waldschmitt, Paul Régnier, Paul Régnier, Gauthier Legris, Clément Bouchez, Mohamed-Yassine Sleimi, Philip Rosenstiel, Guillaume Darrasse-Jèze, Guillaume Darrasse-Jèze, Guillaume Darrasse-Jèze, Mathias Chamaillard, Lionel F. Poulin

“…BackgroundCrohn’s disease (CD) is a complex and poorly understood myeloid-mediated disorder. …”
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