Clinical, Pathological, and Molecular Characteristics of CpG Island Methylator Phenotype in Colorectal Cancer: A Systematic Review and Meta-analysis by Shailesh M. Advani, Pragati Advani, Stacia M. DeSantis, Derek Brown, Helena M. VonVille, Michael Lam, Jonathan M. Loree, Amir Mehrvarz Sarshekeh, Jan Bressler, David S. Lopez, Carrie R. Daniel, Michael D. Swartz, Scott Kopetz

“…Evidence of an activated immune response was seen with high rates of tumor-infiltrating lymphocytes (but not peritumoral lymphocytes), Crohn-like infiltrates, and infiltration with Fusobacterium nucleatum bacteria. …”
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Knowledge in Inflammatory Bowel Disease: Translation to Portuguese, Validation, and Clinical Application of the IBD-KNOW Questionnaire by Cristiana Sequeira, Mariana Coelho, Inês Costa Santos, Sara Ramos Lopes, Cristina Teixeira, João Mangualde, Isabelle Cremers, Ana Paula Oliveira

“…One hundred and one patients with IBD (54 with ulcerative colitis and 47 with Crohn’s disease) completed the questionnaire at baseline. …”
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Gp96 Peptide Antagonist gp96-II Confers Therapeutic Effects in Murine Intestinal Inflammation by Claudia A. Nold-Petry, Claudia A. Nold-Petry, Marcel F. Nold, Marcel F. Nold, Ofer Levy, Yossef Kliger, Anat Oren, Itamar Borukhov, Christoph Becker, Stefan Wirtz, Manjeet K. Sandhu, Manjeet K. Sandhu, Markus Neurath, Charles A. Dinarello

“…BackgroundThe expression of heat shock protein gp96 is strongly correlated with the degree of tissue inflammation in ulcerative colitis and Crohn’s disease, thereby leading us to the hypothesis that inhibition of expression via gp96-II peptide prevents intestinal inflammation.MethodsWe employed daily injections of gp96-II peptide in two murine models of intestinal inflammation, the first resulting from five daily injections of IL-12/IL-18, the second via a single intrarectal application of TNBS (2,4,6-trinitrobenzenesulfonic acid). …”
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Ambient air pollution and the risk of pediatric-onset inflammatory bowel disease: A population-based cohort study by Michael Elten, Eric I. Benchimol, Deshayne B. Fell, M. Ellen Kuenzig, Glenys Smith, Hong Chen, Gilaad G. Kaplan, Eric Lavigne

“…Keywords: Inflammatory bowel disease, Crohn’s disease, Ulcerative colitis, Ozone, Oxidant capacity…”
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ADSCs stimulated by VEGF-C alleviate intestinal inflammation via dual mechanisms of enhancing lymphatic drainage by a VEGF-C/VEGFR-3-dependent mechanism and inhibiting the NF-κB pa... by Lei Zhang, Chen Ye, Peng Li, Chuanding Li, Weigang Shu, Yujie Zhao, Xiaolei Wang

“…Abstract Background Adipose-derived stem cells (ADSCs) have provided promising applications for Crohn’s disease (CD). However, the practical efficacy of ADSCs remains controversial, and their mechanism is still unclear. …”
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Case Report: Proteinase 3 Antineutrophil Cytoplasmic Antibody-Associated Ulcerative Colitis Presenting as Recurrent Intestinal Pseudo-Obstruction in a Teenage Patient With in situ... by Ching-Wen Yang, Ching-Wen Yang, Yu-Chien Kao, Pei-Chun Lin, Hsi-Yuan Chien, Hsi-Yuan Chien, Sheng-Chieh Lin, Sheng-Chieh Lin, Yu-Hsien Lee, Yen-Lin Huang, Shiuh-Bin Fang, Shiuh-Bin Fang, Shiuh-Bin Fang

“…Recent studies have demonstrated proteinase 3 antineutrophil cytoplasmic antibody (PR3-ANCA) to be a serological marker for differentiating UC from Crohn's disease in children and for detecting disease activity and nonresponse to steroid therapy and antitumor necrotizing factor-α agents. …”
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Downregulated Mucosal Autophagy, Alpha Kinase-1 and IL-17 Signaling Pathways in Active and Quiescent Ulcerative Colitis by Moraes Holst L, Halfvarson J, Carlson M, Hedin C, Kruse R, Lindqvist CM, Bergemalm D, Almér S, Bresso F, Ling Lundström M, Repsilber D, D'Amato M, Keita Å, Hjortswang H, Söderholm J, Sundin J, Törnblom H, Simrén M, Strid H, Magnusson MK, Öhman L

“…This study therefore aimed to provide a comprehensive mucosal characterization with emphasis on immunological host response of patients with active ulcerative colitis (UC active), UC during remission (UC remission) and active colonic Crohn’s disease (CD active).Methods: Colonic biopsies from 47 study subjects were collected for gene expression and pathway analyses using the NanoString host-response panel, including 776 genes and 56 immune-related pathways.Results: The majority of mucosal gene expression and signaling pathway scores were increased in active IBD (n=27) compared to healthy subjects (n=10). …”
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Macrophage and neutrophil heterogeneity at single-cell spatial resolution in human inflammatory bowel disease by Alba Garrido-Trigo, Ana M. Corraliza, Marisol Veny, Isabella Dotti, Elisa Melón-Ardanaz, Aina Rill, Helena L. Crowell, Ángel Corbí, Victoria Gudiño, Miriam Esteller, Iris Álvarez-Teubel, Daniel Aguilar, M. Carme Masamunt, Emily Killingbeck, Youngmi Kim, Michael Leon, Sudha Visvanathan, Domenica Marchese, Ginevra Caratù, Albert Martin-Cardona, Maria Esteve, Ingrid Ordás, Julian Panés, Elena Ricart, Elisabetta Mereu, Holger Heyn, Azucena Salas

“…Abstract Ulcerative colitis and Crohn’s disease are chronic inflammatory intestinal diseases with perplexing heterogeneity in disease manifestation and response to treatment. …”
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Sedentary lifestyle, physical activity, and gastrointestinal diseases: evidence from mendelian randomization analysisResearch in context by Jie Chen, Xixian Ruan, Tian Fu, Shiyuan Lu, Dipender Gill, Zixuan He, Stephen Burgess, Edward L. Giovannucci, Susanna C. Larsson, Minzi Deng, Shuai Yuan, Xue Li

“…Findings: Genetically proxied longer LST was associated with an increased risk of gastrointestinal reflux, gastric ulcer, duodenal ulcer, chronic gastritis, irritable bowel syndrome, diverticular disease, Crohn’s disease, ulcerative colitis, non-alcoholic fatty liver disease, alcoholic liver disease, cholangitis, cholecystitis, cholelithiasis, acute pancreatitis, chronic pancreatitis, and acute appendicitis. …”
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Sucralose Promotes Colitis-Associated Colorectal Cancer Risk in a Murine Model Along With Changes in Microbiota by Xueting Li, Yuanli Liu, Yan Wang, Xue Li, Xinran Liu, Mengru Guo, Yiwei Tan, Xiaofa Qin, Xiuhong Wang, Mingshan Jiang

“…Studies by us and others revealed that sucralose exacerbated gut damage and inflammation in animal models for inflammatory bowel disease (IBD), including those for both ulcerative colitis, and Crohn's disease. Our study demonstrated that sucralose greatly aggravated dextran sulfate sodium (DSS)-induced colitis along with causing changes in gut microbiota, the gut barrier and impaired inactivation of digestive proteases mediated by deconjugated bilirubin. …”
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Role of Interventional Inflammatory Bowel Disease (IBD) in the Management of Complex IBD: Initial Prospective Experience from a Tertiary Center in India by Partha Pal, Mohan Ramchandani, Rupa Banerjee, Pradev Inavolu, Zaheer Nabi, Hardik Rughwani, Aniruddha Pratap Haripal Singh, Rajendra Patel, Polina Vijayalaxmi, Jagdeesh Rampal Singh, Pradeep Rebala, Guduru Venkat Rao, D Nageshwar Reddy, Manu Tandan

“…Results IIBD procedures were performed in total 54 patients (61% males, median age: 37.5 years, range: 21–74 years, Crohn's disease [CD]: 42, ulcerative colitis [UC]: 12 between September 2021 and April 2022). …”
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Denosumab Regulates Gut Microbiota Composition and Cytokines in Dinitrobenzene Sulfonic Acid (DNBS)-Experimental Colitis by Azin Khafipour, Nour Eissa, Nour Eissa, Nour Eissa, Nour Eissa, Peris M. Munyaka, Peris M. Munyaka, Peris M. Munyaka, Mohammad F. Rabbi, Mohammad F. Rabbi, Mohammad F. Rabbi, Mohammad F. Rabbi, Kunal Kapoor, Kunal Kapoor, Kunal Kapoor, Laetitia Kermarrec, Laetitia Kermarrec, Laetitia Kermarrec, Ehsan Khafipour, Charles N. Bernstein, Charles N. Bernstein, Jean-Eric Ghia, Jean-Eric Ghia, Jean-Eric Ghia, Jean-Eric Ghia

“…Genome-wide association meta-analysis for Crohn’s disease (CD) identified a variant near the TNFSF11 gene that encodes RANKL and CD risk allele increased expression of RANKL in specific cell lines. …”
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Identification of novel pathogenic MSH2 mutation and new DNA repair genes variants: investigation of a Tunisian Lynch syndrome family with discordant twins by Amira Jaballah-Gabteni, Haifa Tounsi, Maria Kabbage, Yosr Hamdi, Sahar Elouej, Ines Ben Ayed, Mouna Medhioub, Moufida Mahmoudi, Hamza Dallali, Hamza Yaiche, Nadia Ben Jemii, Afifa Maaloul, Najla Mezghani, Sonia Abdelhak, Lamine Hamzaoui, Mousaddak Azzouz, Samir Boubaker

“…He has a monozygotic twin diagnosed at the age of 35 years with crohn disease. Forty-seven years-old was the onset age of his paternal uncle withCRC. …”
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Smoking, alcohol consumption, and 24 gastrointestinal diseases: Mendelian randomization analysis by Shuai Yuan, Jie Chen, Xixian Ruan, Yuhao Sun, Ke Zhang, Xiaoyan Wang, Xue Li, Dipender Gill, Stephen Burgess, Edward Giovannucci, Susanna C Larsson

“…Results: Genetic predisposition to smoking initiation was associated with increased risk of 20 of 24 gastrointestinal diseases, including 7 upper gastrointestinal diseases (gastroesophageal reflux, esophageal cancer, gastric ulcer, duodenal ulcer, acute gastritis, chronic gastritis, and gastric cancer), 4 lower gastrointestinal diseases (irritable bowel syndrome, diverticular disease, Crohn’s disease, and ulcerative colitis), 8 hepatobiliary and pancreatic diseases (non-alcoholic fatty liver disease, alcoholic liver disease, cirrhosis, liver cancer, cholecystitis, cholelithiasis, and acute and chronic pancreatitis), and acute appendicitis. …”
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Bacteroides thetaiotaomicron-derived outer membrane vesicles promote regulatory dendritic cell responses in health but not in inflammatory bowel disease by Lydia Durant, Régis Stentz, Alistair Noble, Johanne Brooks, Nadezhda Gicheva, Durga Reddi, Matthew J. O’Connor, Lesley Hoyles, Anne L. McCartney, Ripple Man, E. Tobias Pring, Stella Dilke, Philip Hendy, Jonathan P. Segal, Dennis N. F. Lim, Ravi Misra, Ailsa L. Hart, Naila Arebi, Simon R. Carding, Stella C. Knight

“…Here, we have examined the interaction between Bt OMVs and blood or colonic mucosa-derived dendritic cells (DC) from healthy individuals and patients with Crohn’s disease (CD) or ulcerative colitis (UC). Results In healthy individuals, Bt OMVs stimulated significant (p < 0.05) IL-10 expression by colonic DC, whereas in peripheral blood-derived DC they also stimulated significant (p < 0.001 and p < 0.01, respectively) expression of IL-6 and the activation marker CD80. …”
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Integrative analysis of Paneth cell proteomic and transcriptomic data from intestinal organoids reveals functional processes dependent on autophagy by Emily J. Jones, Zoe J. Matthews, Lejla Gul, Padhmanand Sudhakar, Agatha Treveil, Devina Divekar, Jasmine Buck, Tomasz Wrzesinski, Matthew Jefferson, Stuart D. Armstrong, Lindsay J. Hall, Alastair J. M. Watson, Simon R. Carding, Wilfried Haerty, Federica Di Palma, Ulrike Mayer, Penny P. Powell, Isabelle Hautefort, Tom Wileman, Tamas Korcsmaros

“…Paneth cell abnormalities are unfortunately detrimental to gut health and are often associated with digestive pathologies such as Crohn's disease or infections. Similar alterations are observed in individuals with impaired autophagy, a process that recycles cellular components. …”
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Lamina Propria Phagocyte Profiling Reveals Targetable Signaling Pathways in Refractory Inflammatory Bowel Disease by Gillian E. Jacobsen, Irina Fernández, Maria A. Quintero, Ana M. Santander, Judith Pignac-Kobinger, Oriana M. Damas, Amar R. Deshpande, David H. Kerman, Yuguang Ban, Zhen Gao, Tiago C. Silva, Lily Wang, Ashley H. Beecham, Jacob L. McCauley, Juan F. Burgueño, Maria T. Abreu

“…Results: We found distinct differences in gene expression between CD11b+ cells from the colon vs ileum, as well as in different inflammatory states and, to a lesser degree, IBD types (Crohn’s disease or ulcerative colitis). These genes mapped to targetable immune pathways and metabolic and cancer pathways. …”
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More Positive or More Negative? Metagenomic Analysis Reveals Roles of Virome in Human Disease-Related Gut Microbiome by Mo Li, Mo Li, Chunhui Wang, Chunhui Wang, Qian Guo, Qian Guo, Congmin Xu, Zhongjie Xie, Jie Tan, Jie Tan, Shufang Wu, Shufang Wu, Peihong Wang, Jinyuan Guo, Zhencheng Fang, Zhencheng Fang, Shiwei Zhu, Liping Duan, Xiaoqing Jiang, Xiaoqing Jiang, Huaiqiu Zhu, Huaiqiu Zhu, Huaiqiu Zhu, Huaiqiu Zhu

“…We also retrieved public whole-genome metagenomic datasets of another four diseases (type 2 diabetes, Crohn’s disease, colorectal cancer, and liver cirrhosis), totaling 438 samples including IBS, and performed uniform analysis of the gut viruses in diseases. …”
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Co-expression of fibrotic genes in inflammatory bowel disease; A localized event? by Nikolas Dovrolis, Nikolas Dovrolis, Nikolas Dovrolis, Eirini Filidou, Eirini Filidou, Gesthimani Tarapatzi, Gesthimani Tarapatzi, Georgios Kokkotis, Michail Spathakis, Michail Spathakis, Leonidas Kandilogiannakis, Leonidas Kandilogiannakis, Ioannis Drygiannakis, Vassilis Valatas, Vassilis Valatas, Konstantinos Arvanitidis, Konstantinos Arvanitidis, Ioannis Karakasiliotis, Stergios Vradelis, Vangelis G. Manolopoulos, Vangelis G. Manolopoulos, Vasilis Paspaliaris, Giorgos Bamias, George Kolios, George Kolios

“…It embosses the need for out-of-the-box approaches to identify and target molecular mechanisms of fibrosis.Methods and resultsIn this study, a novel mRNA sequencing dataset of 22 pairs of intestinal biopsies from the terminal ileum (TI) and the sigmoid of 7 patients with Crohn’s disease, 6 with ulcerative colitis and 9 control individuals (CI) served as a validation cohort of a core fibrotic transcriptomic signature (FIBSig), This signature, which was identified in publicly available data (839 samples from patients and healthy individuals) of 5 fibrotic disorders affecting different organs (GI tract, lung, skin, liver, kidney), encompasses 241 genes and the functional pathways which derive from their interactome. …”
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Super Carbonate Apatite-miR-497a-5p Complex Is a Promising Therapeutic Option against Inflammatory Bowel Disease by Naoto Tsujimura, Takayuki Ogino, Masayuki Hiraki, Taisei Kai, Hiroyuki Yamamoto, Haruka Hirose, Yuhki Yokoyama, Yuki Sekido, Tsuyoshi Hata, Norikatsu Miyoshi, Hidekazu Takahashi, Mamoru Uemura, Tsunekazu Mizushima, Yuichiro Doki, Hidetoshi Eguchi, Hirofumi Yamamoto

“…It is reported that TGF-β/Smad signal pathway is inactivated in patients with Crohn’s disease by overexpression of Smad 7. With expectation of multiple molecular targeting by microRNAs (miRNAs), we currently attempted to identify certain miRNAs that activate TGF-β/Smad signal pathway and aimed to prove in vivo therapeutic efficacy in mouse model. …”
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