Transcriptome-wide association study identified candidate genes associated with gut microbiota by Chuyu Pan, Yujie Ning, Yumeng Jia, Shiqiang Cheng, Yan Wen, Xuena Yang, Peilin Meng, Chun’e Li, Huijie Zhang, Yujing Chen, Jingxi Zhang, Zhen Zhang, Feng Zhang

“…For instance, SFTPD for an unclassified genus of Proteobacteria was related to atherosclerosis, and FUT2 for Bifidobacterium was associated with Crohn’s disease. Conclusions Our study results provided novel insights for understanding the genetic mechanism of gut microbiota, and attempted to provide clues for revealing the influence of genetic factors on gut microbiota for the occurrence and development of diseases.…”
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Serological Response to BNT162b2 and ChAdOx1 nCoV-19 Vaccines in Patients with Inflammatory Bowel Disease on Biologic Therapies by Mohammad Shehab, Fatema Alrashed, Ahmad Alfadhli, Khazna Alotaibi, Abdullah Alsahli, Hussain Mohammad, Preethi Cherian, Irina Al-Khairi, Thangavel Alphonse Thanaraj, Arshad Channanath, Hamad Ali, Mohamed Abu-Farha, Jehad Abubaker, Fahd Al-Mulla

“…<b>Results:</b> A total of 126 patients were enrolled (mean age, 31 years; 60% male; 71% Crohn’s disease, 29% ulcerative colitis). Of these, 92 patients were vaccinated with the BNT162b2 vaccine (73%) and 34 patients with the ChAdOx1 nCoV-19 vaccine (27%). …”
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Mucin O-glycans facilitate symbiosynthesis to maintain gut immune homeostasisResearch in context by Takahiro Yamada, Shingo Hino, Hideki Iijima, Tomomi Genda, Ryo Aoki, Ryuji Nagata, Kyu-Ho Han, Masato Hirota, Yusuke Kinashi, Hiroyuki Oguchi, Wataru Suda, Yukihiro Furusawa, Yumiko Fujimura, Jun Kunisawa, Masahira Hattori, Michihiro Fukushima, Tatsuya Morita, Koji Hase

“…Methods: To elucidate relationships among dysbiosis, abnormal mucin utilisation, and microbial metabolic dysfunction, we analysed short-chain fatty acids (SCFAs) and mucin components in stool samples of 40 healthy subjects, 49 ulcerative colitis (UC) patients, and 44 Crohn's disease (CD) patients from Japan. Findings: Levels of n-butyrate were significantly lower in stools of both CD and UC patients than in stools of healthy subjects. …”
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Infectious and digestive complications in glycogen storage disease type Ib: Study of a French cohort by Camille Wicker, Célina Roda, Ariane Perry, Jean Baptiste Arnoux, Anais Brassier, Martin Castelle, Aude Servais, Jean Donadieu, Juliette Bouchereau, Bénédicte Pigneur, Philippe Labrune, Frank M. Ruemmele, Pascale de Lonlay

“…Glycogenosis type Ib (GSD1B) causes not only hypoglycemia but also infections and “Crohn's disease like” inflammatory bowel disease (IBD) that can significantly impair patient's quality of life. …”
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Control of anterior GRadient 2 (AGR2) dimerization links endoplasmic reticulum proteostasis to inflammation by Marion Maurel, Joanna Obacz, Tony Avril, Yong‐Ping Ding, Olga Papadodima, Xavier Treton, Fanny Daniel, Eleftherios Pilalis, Johanna Hörberg, Wenyang Hou, Marie‐Claude Beauchamp, Julien Tourneur‐Marsille, Dominique Cazals‐Hatem, Lucia Sommerova, Afshin Samali, Jan Tavernier, Roman Hrstka, Aurélien Dupont, Delphine Fessart, Frédéric Delom, Martin E Fernandez‐Zapico, Gregor Jansen, Leif A Eriksson, David Y Thomas, Loydie Jerome‐Majewska, Ted Hupp, Aristotelis Chatziioannou, Eric Chevet, Eric Ogier‐Denis

“…We also demonstrate that in IBD and specifically in Crohn's disease, the levels of AGR2 dimerization modulators are selectively deregulated, and this correlates with severity of disease. …”
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Trends in adult Home Parenteral Nutrition in Spain: 1992-2003 Tendencias en nutrición parenteral domiciliaria en pacientes adultos en España: periodo 1992-2003 by J. M. Moreno Villares, C. Cuerda, M. Planas, C. Gómez Candela, M. León-Sanz, A. de Cos, C. Pedrón

“…Excepto el descenso en el número de pacientes con enfermedad de Crohn, el resto de indicaciones sufrió pocas variaciones en el tiempo. …”
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Medicinal Plants, Phytochemicals and Regulation of the NLRP3 Inflammasome in Inflammatory Bowel Diseases: A Comprehensive Review by Rosa Direito, Sandra Maria Barbalho, Maria Eduardo Figueira, Giulia Minniti, Gabriel Magno de Carvalho, Bárbara de Oliveira Zanuso, Ana Rita de Oliveira dos Santos, Natália de Góes Corrêa, Victória Dogani Rodrigues, Ricardo de Alvares Goulart, Elen Landgraf Guiguer, Adriano Cressoni Araújo, Henrique Bosso, Lucas Fornari Laurindo

“…Ongoing research explores the underlying causes of ulcerative colitis and Crohn’s disease. Many experts suggest that dysbiosis in the gut microbiota and genetic, immunological, and environmental factors play significant roles. …”
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Seven days triple therapy for eradication of does not alter the disease activity of patients with inflammatory bowel disease by Shinichiro Shinzaki, Toshimitsu Fujii, Shigeki Bamba, Maiko Ogawa, Taku Kobayashi, Masahide Oshita, Hiroki Tanaka, Keiji Ozeki, Sakuma Takahashi, Hiroki Kitamoto, Kazuhito Kani, Sohachi Nanjo, Takeshi Sugaya, Yuko Sakakibara, Toshihiro Inokuchi, Kazuki Kakimoto, Akihiro Yamada, Hisae Yasuhara, Yoko Yokoyama, Takuya Yoshino, Akira Matsui, Misaki Nakamura, Taku Tomizawa, Ryosuke Sakemi, Noriko Kamata, Toshifumi Hibi

“…Results A total of 429 IBD (378 ulcerative colitis, 51 Crohn’s disease) patients, comprising 144 patients in the eradication group and 285 patients in the non-eradication group, were enrolled at 25 institutions. …”
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MIS416 Enhances Therapeutic Functions of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Against Experimental Colitis by Modulating Systemic Immune Milieu by Byung-Chul Lee, Byung-Chul Lee, Nari Shin, Nari Shin, Jin Young Lee, Jin Young Lee, Insung Kang, Insung Kang, Jae-Jun Kim, Jae-Jun Kim, Seung Eun Lee, Seung Eun Lee, Soon Won Choi, Soon Won Choi, Gill A. Webster, Kyung-Sun Kang, Kyung-Sun Kang

“…In this study, we investigated whether administration of MIS416, a novel microparticle that activates NOD2 and TLR9 signaling, could enhance the therapeutic efficacy of hUCB-MSCs against Crohn’s disease, using dextran sulfate sodium (DSS)-induced colitis model. …”
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Variant-to-Gene-Mapping Analyses Reveal a Role for the Hypothalamus in Genetic Susceptibility to Inflammatory Bowel DiseaseSummary by Chiara Lasconi, Matthew C. Pahl, Diana L. Cousminer, Claudia A. Doege, Alessandra Chesi, Kenyaita M. Hodge, Michelle E. Leonard, Sumei Lu, Matthew E. Johnson, Chun Su, Reza K. Hammond, James A. Pippin, Natalie A. Terry, Louis R. Ghanem, Rudolph L. Leibel, Andrew D. Wells, Struan F.A. Grant

“…Results: We found significant genetic correlations (rg) of 0.122 with an adjusted P (Padj) = 1.4 × 10-4 for IBD: rg = 0.122; Padj = 2.5 × 10-3 for ulcerative colitis and genetic correlation (rg) = 0.094; Padj = 2.5 × 10-3 for Crohn’s disease, and significant approximately 4-fold (P = .005) and approximately 7-fold (P = .03) enrichment of IBD single-nucleotide polymorphisms in HNs and colonoids, respectively. …”
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Single-cell transcriptomics of human gut T cells identifies cytotoxic CD4+CD8A+ T cells related to mouse CD4 cytotoxic T cells by Shun Tanemoto, Tomohisa Sujino, Kentaro Miyamoto, Kentaro Miyamoto, Jonathan Moody, Yusuke Yoshimatsu, Yoshinari Ando, Ikuko Koya, Yosuke Harada, Anna Okuzawa Tojo, Keiko Ono, Yukie Hayashi, Kaoru Takabayashi, Koji Okabayashi, Toshiaki Teratani, Yohei Mikami, Nobuhiro Nakamoto, Naoki Hosoe, Haruhiko Ogata, Chung-Chau Hon, Jay W. Shin, Jay W. Shin, Takanori Kanai

“…The percentage of CD4+CD8A+ T cells among the total CD4+ T cells in the inflamed intestine of the patients with Crohn’s disease was significantly reduced compared with that in the noninflamed intestine of the patients. …”
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Evaluating the Effects of Omega-3 Polyunsaturated Fatty Acids on Inflammatory Bowel Disease via Circulating Metabolites: A Mediation Mendelian Randomization Study by Xiaojing Jia, Chunyan Hu, Xueyan Wu, Hongyan Qi, Lin Lin, Min Xu, Yu Xu, Tiange Wang, Zhiyun Zhao, Yuhong Chen, Mian Li, Ruizhi Zheng, Hong Lin, Shuangyuan Wang, Weiqing Wang, Yufang Bi, Jie Zheng, Jieli Lu

“…We applied two-sample Mendelian randomization (MR) to disentangle the effects of omega-3 PUFAs (including total omega-3, α-linolenic acid, eicosapentaenoic acid (EPA), or docosahexaenoic acid (DHA)) on the risk of IBD, Crohn’s disease (CD) and ulcerative colitis (UC). …”
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Immunogenicity and safety of mixed COVID-19 vaccine regimens in patients with immune-mediated inflammatory diseases: a single-centre prospective cohort study by Carol A Hitchon, Charles N Bernstein, Ruth Ann Marrie, John Kim, Sheila F O’Brien, Christine Mesa, Catherine Card

“…Objective Among persons with immune-mediated inflammatory diseases (IMIDs) who received SARS-CoV-2 vaccines, we compared postvaccine antibody responses and IMID disease activity/states.Design Single-centre prospective cohort study.Setting Specialty ambulatory clinics in central Canada.Participants People with inflammatory arthritis (n=78; 77% rheumatoid arthritis), systemic autoimmune rheumatic diseases (n=84; 57% lupus), inflammatory bowel disease (n=93; 43% Crohn’s) and multiple sclerosis (n=72; 71% relapsing-remitting) (female 79.4%, white 84.7%, mean (SD) age 56.0 (14.3) years) received COVID-19 vaccinations between March 2021 and September 2022.Primary outcome Postvaccination anti-spike, anti-receptor binding domain (anti-RBD) and anti-nucleocapsid (anti-NC) IgG antibodies tested by multiplex immunoassays compared across vaccine regimens and with responses in 370 age-matched and sex-matched vaccinated controls.Secondary outcomes COVID-19 infection and self-reported IMID disease activity/state.Results Most (216/327, 66.1%) received homologous messenger RNA (mRNA) (BNT162b2 or mRNA1273) vaccines, 2.4% received homologous ChAdOx1 and 30.6% received heterologous vaccines (23.9% ChAdOx1/mRNA, 6.4% heterologous mRNA) for their first two vaccines (V1, V2). …”
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Registro Nacional de la Nutrición Parenteral Domiciliaria del año 2003 by J. M. Moreno, M. Planas, A. I. de Cos, N. Virgili, P. Gómez-Enterría, J. Ordóñez, C. de la Cuerda, E. Martí, A. Apezetxea, M. T. Forga, A. Pérez de la Cruz, A. Muñoz, A. Rodríguez, D. Cardona, C. Pedrón, L. M. Luengo, C. Garde, R. M. Parés

“…Las enfermedades que motivaron el uso de NPD fueron la enfermedad neoplásica (21%), seguida de la isquemia mesentérica (20%), enteritis rádica (16,3%), alteraciones de la motilidad (10,5%) y enfermedad de Crohn (4,6%). Se emplearon catéteres tunelizados en el 66,3% de los casos, frente al 29,1% de reservorios subcutáneos. …”
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Activation of Nod2 signaling upon norovirus infection enhances antiviral immunity and susceptibility to colitis by Ghaffar Muharram, Marion Thépaut, Pierre-Emmanuel Lobert, Teddy Grandjean, Olivier Boulard, Myriam Delacre, Emmrich Wakeford, Richard Wheeler, Lionel Franz Poulin, Ivo Gomperts Boneca, Frank Lafont, Marie-Cécile Michallet, Didier Hober, Ken Cadwell, Mathias Chamaillard

“…Hence, our results uncover a previously unidentified virus-host-bacterial interplay that may represent a novel therapeutic target for treating noroviral origin gastroenteritis that may be linked with susceptibility to several common illnesses such as Crohn’s disease.…”
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Evaluation of the use of glucocorticosteroids by athletes in Poland in the light of the amended anti-doping regulations by Andrzej Pokrywka, Daria Berezovska, Sylwia Lewandowska-Pachecka, Michał Rynkowski, Raphael Faiss, Jarosław Krzywański

“…The basic indications for the use of drugs declared by athletes during doping control are bronchial asthma (57% of cases), rhinitis (26%), pain blockade (7%), inflammatory skin diseases (5.5%), Achilles tendinitis (1.5%), Crohn's disease (1.5%), eye infections (1%), and Addison's Disease (0,5%). …”
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RELATO DE CASO: LINFOMA MALT DE CECO by TS Hahn, VT Almeida, AH Schuck, LV Calderan, EW Silva, LM Lorenzini, BK Losch, MFL Pezzi, RD Lorandi

“…Essa patologia pode estar associada a várias outras afecções, principalmente as que alteram o sistema imunológico como o HIV, retocolite ulcerativa, doença de Crohn e doença celíaca. Para fazer a distinção entre linfomas primários do cólon e aqueles com envolvimento secundário utilizam-se os Critérios de Dawson, que consistem em: radiografia de tórax normal, ausência de hepatoesplenomegalia ou linfadenopatia superficial, leucograma normal (sem evidências de processo leucêmico) e massa tumoral intestinal com linfadenopatia exclusivamente regional. …”
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Constructing a prediction model of inflammatory bowel disease recurrence based on factors affecting the quality of life by Maojuan Li, Maojuan Li, Yan Tao, Yan Tao, Yang Sun, Yang Sun, Jing Wu, Jing Wu, Fengrui Zhang, Fengrui Zhang, Yunling Wen, Yunling Wen, Min Gong, Min Gong, Jingxian Yan, Jingxian Yan, Hao Liang, Hao Liang, Xinyu Bai, Xinyu Bai, Junkun Niu, Junkun Niu, Yinglei Miao, Yinglei Miao

“…Disease activity, EIMs, and occupational stress were important factors influencing the IBDQ scores of patients with Crohn's disease, and they accounted for approximately 75.1% of the factors affecting the quality of life. …”
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MANIFESTAÇÕES CLÍNICAS E LABORATORIAIS DOS PACIENTES COM DEFICIÊNCIA DE VITAMINA B12 ACOMPANHADOS EM HOSPITAL TERCIÁRIO DO RIO DE JANEIRO by CR Berto, KG Frigotto, GSB Garcia, VRA Valviesse, LL Bergier

“…Outras etiologias observadas foram: doença celíaca (10%), abuso de inibidor de bomba de prótons (5%), doença de Crohn (5%), pancreatite recorrente (5%), pólipos gástricos (5%), gastrectomia (5%), e colite infecciosa (5%). …”
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Efficacy and Safety in the Continued Treatment With a Biosimilar Drug in Patients Receiving Infliximab: A Systematic Review in the Context of Decision-Making From a Latin-American... by Edward Mezones-Holguin, Rocio Violeta Gamboa-Cardenas, Gadwyn Sanchez-Felix, José Chávez-Corrales, Luis Miguel Helguero-Santin, Luis Max Laban Seminario, Paula Alejandra Burela-Prado, Maribel Marilu Castro-Reyes, Fabian Fiestas

“…In the Peruvian Social Security (EsSalud), infliximab is approved for the treatment of rheumatoid arthritis, psoriasis, psoriatic arthropathy, ankylosing spondylitis, ulcerative colitis and Crohn’s disease (in cases refractory to conventional treatment). …”
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