Clinical Effect of Mussel Adhesive Protein with Tongyangxiao Lotion in Grades 1 and 2 Mixed Hemorrhoids by TIAN Maosheng, GAO Jihua, XU Jiancheng, QI Wenyue, WANG Linyue, GAO Ce

“…There were no significant differences between two groups in gender ratio, mean age, distribution of course, and grade of mixed hemorrhoids, VAS score, clinical symptom score, anal mean canal resting pressure, hemorrhoid disease and the Crohn's Anal Fistula Quality of Life (CAF-QoL) score and past history (P>0.05). …”
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Integration of metabolomics, genomics, and immune phenotypes reveals the causal roles of metabolites in disease by Xiaojing Chu, Martin Jaeger, Joep Beumer, Olivier B. Bakker, Raul Aguirre-Gamboa, Marije Oosting, Sanne P. Smeekens, Simone Moorlag, Vera P. Mourits, Valerie A. C. M. Koeken, Charlotte de Bree, Trees Jansen, Ian T. Mathews, Khoi Dao, Mahan Najhawan, Jeramie D. Watrous, Irma Joosten, Sonia Sharma, Hans J. P. M. Koenen, Sebo Withoff, Iris H. Jonkers, Romana T. Netea-Maier, Ramnik J. Xavier, Lude Franke, Cheng-Jian Xu, Leo A. B. Joosten, Serena Sanna, Mohit Jain, Vinod Kumar, Hans Clevers, Cisca Wijmenga, Mihai G. Netea, Yang Li

“…Of these, one locus (rs174584-FADS2) associated with arachidonic acid metabolism is causally associated with Crohn’s disease, suggesting it is a potential therapeutic target. …”
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Treatment strategy changes for inflammatory bowel diseases in biologic era: results from a multicenter cohort in Japan, Far East 1000 by Takashi Taida, Yuki Ohta, Jun Kato, Sadahisa Ogasawara, Yuhei Ohyama, Yukiyo Mamiya, Hayato Nakazawa, Ryosuke Horio, Chihiro Goto, Satsuki Takahashi, Akane Kurosugi, Michiko Sonoda, Wataru Shiratori, Tatsuya Kaneko, Yuya Yokoyama, Naoki Akizue, Yotaro Iino, Junichiro Kumagai, Hideaki Ishigami, Hirotaka Koseki, Kenichiro Okimoto, Keiko Saito, Masaya Saito, Tomoaki Matsumura, Tomoo Nakagawa, Shinichiro Okabe, Hirofumi Saito, Kazuki Kato, Hirotsugu Uehara, Hideaki Mizumoto, Yoshihiro Koma, Ryosaku Azemoto, Kenji Ito, Hidehiro Kamezaki, Yoshifumi Mandai, Yoshio Masuya, Yoshihiro Fukuda, Yoshio Kitsukawa, Haruhisa Shimura, Toshio Tsuyuguchi, Naoya Kato

“…This study analyzed 542 ulcerative colitis (UC) and 186 Crohn’s disease (CD). The biologic era included 53.3% of patients with UC and 76.2% with CD, respectively. …”
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Nutritional Regimes Enriched with Antioxidants as an Efficient Adjuvant for IBD Patients under Infliximab Administration, a Pilot Study by Marina Liso, Annamaria Sila, Giulio Verna, Aurelia Scarano, Rossella Donghia, Fabio Castellana, Elisabetta Cavalcanti, Pasqua Letizia Pesole, Eduardo Maria Sommella, Antonio Lippolis, Raffaele Armentano, Anna Maria Giudetti, Daniele Vergara, Pietro Campiglia, Rodolfo Sardone, Margherita Curlo, Mauro Mastronardi, Katia Petroni, Chiara Tonelli, Angelo Santino, Marcello Chieppa

“…To verify this possibility, a single-center preliminary study (SI-CURA, Soluzioni Innovative per la gestione del paziente e il follow up terapeutico della Colite UlceRosA) was designed and carried out to evaluate whether a daily administration of purple corn supplement could improve the response to Infliximab (IFX) infusion of IBD patients with both Crohn’s disease (CD) and ulcerative colitis (UC). …”
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A randomized controlled trial of a multicomponent online stress reduction intervention in inflammatory bowel disease by Farhad Peerani, Makayla Watt, Kathleen P Ismond, Reid Whitlock, Lindsy Ambrosio, Naomi Hotte, Nicholas Mitchell, Robert J Bailey, Karen Kroeker, Levinus A Dieleman, Jesse Siffledeen, Allen Lim, Karen Wong, Brendan P Halloran, Daniel C Baumgart, Lorian Taylor, Maitreyi Raman, Karen L Madsen, Puneeta Tandon

“…Results: Of 150 screened patients, 101 were randomized to the intervention ( n  = 49) and control ( n  = 52) groups (mean age: 42.5 ± 14.1 years; M:F 1:3, 48% with ulcerative colitis and 52% with Crohn’s disease). The between-group PSS improved by 22.4% (95% confidence interval, 10.5–34.3, p  < 0.001). …”
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Fibroblast Growth Factor 19 modulates intestinal microbiota and inflammation in presence of Farnesoid X Receptor by Raffaella Maria Gadaleta, Oihane Garcia-Irigoyen, Marica Cariello, Natasha Scialpi, Claudia Peres, Stefania Vetrano, Gionatha Fiorino, Silvio Danese, Brian Ko, Jian Luo, Emanuele Porru, Aldo Roda, Carlo Sabbà, Antonio Moschetta

“…To provide a translational perspective, we also show that circulating FGF19 levels are reduced in patients with Crohn's disease. Interpretation: Reactivation of the FXR-FGF19 axis in a murine model of intestinal inflammation could bona fide provide positive changes in BA metabolism with consequent reduction of intestinal inflammation and modulation of microbiota. …”
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Impact of malnutrition and sarcopenia on quality of life in patients with inflammatory bowel disease: A multicentre study by Yupeng Zhang, Li Zhang, Xuejin Gao, Cong Dai, Yuhong Huang, Yan Wu, Wei Zhou, Qian Cao, Xue Jing, Haitao Jiang, Yong Zhong, Weiming Zhu, Xinying Wang

“…Results A total of 238 IBD patients (177 Crohn's disease [CD] and 61 ulcerative colitis [UC]), 68.5% male, with a mean age of 38.5 ± 14.0 years and a mean BMI of 19.8 ± 3.5 kg/m2, were recruited. …”
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Screening of hub inflammatory bowel disease biomarkers and identification of immune-related functions based on basement membrane genes by Penghang Lin, Jin Hua, Zuhong Teng, Chunlin Lin, Songyi Liu, Ruofan He, Hui Chen, Hengxin Yao, Jianxin Ye, Guangwei Zhu

“…Abstract Background Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), is a chronic, inflammatory, and autoimmune disease, but its specific etiology and pathogenesis are still unclear. …”
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Long-term follow-up of certolizumab pegol in uveitis due to immune-mediated inflammatory diseases: multicentre study of 80 patients by Ricardo Blanco, Alfredo Adan, Ignacio Torre, Vega Jovani, Susana Romero-Yuste, Arantxa Conesa, Vanesa Calvo-Río, Cristina Fernández-Carballido, Emma Beltrán-Catalán, Patricia Fanlo, Miguel Cordero-Coma, Alvaro Garcia Martos, Ines Hernanz, Angel Garcia-Aparicio, Patricia Moya Alvarado, José Luis Martín-Varillas, Lara Sanchez-Bilbao, Adela Gallego-Flores, Sonia Castro-Oreiro, Juan Ramon De Dios, Marisa Hernández-Garfella, Amalia Sánchez-Andrade, Andrea García-Valle, Olga Maiz, Roberto Miguélez, Sergio Rodríguez-Montero, Ana Urruticoechea, Raúl Veroz, Jose J Mondejar, Olga Martínez González, Paula Rubio-Muñoz, Eva Peña-Sainz-Pardo, Marta Garijo-Bufort, Rosalía Demetrio-Pablo, José L Hernández

“…The IMID included were: spondyloarthritis (n=43), Behçet’s disease (n=10), psoriatic arthritis (n=8), Crohn’s disease (n=4), sarcoidosis (n=2), juvenile idiopathic arthritis (n=1), reactive arthritis (n=1), rheumatoid arthritis (n=1), relapsing polychondritis (n=1),Conclusions CZP seems to be effective and safe in uveitis related to different IMID, even in patients refractory to previous biological drugs.…”
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Biomedical risk assessment as an aid for smoking cessation by Clair, C, Mueller, Y, Livingstone-Banks, J, Burnand, B, Camain, J, Cornuz, J, Rège‐Walther, M, Selby, K, Bize, R

“…Feedback on smoking-related disease risk, including four studiestesting feedback on genetic markers for cancer risk and one study with feedback on genetic markers for risk of Crohn’s disease, didnot show a benefit in smoking cessation (RR 0.80, 95% CI 0.63 to 1.01; I2= 0%; n = 2064). …”

Early and innate host reponses to enteric fever by Barton, A

“…These changes were validated in two independent challenge studies, and correlated with gene expression changes following in vitro infection of cell lines (ρ = 0.7 and p = 1 x 10^-48 for Hep2 cells, Pearson correlation coefficient) and inflammatory bowel disease (ρ = 0.3 and p = 3 x 10-5 with Crohn’s disease, Pearson correlation coefficient). …”

Premio Revista Médica del Uruguay - Laboratorio Roemmers 2004-2005 by Consejo Editorial

“…Análisis crítico de su aplicación en un servicio quirúrgico 29)      Características clínicas de presentación y seguimiento de una cohorte de 121 pacientes con colitis ulcerosa crónica en Uruguay 30)      Características clínicas de presentación y evolutivas de una cohorte de 48 pacientes con enfermedad de Crohn en Uruguay 31)     Traumatismos y perforaciones de esófago: diez años de experiencia 32)     Estrategias para el diagnóstico de sepsis neonatal tardía          Nota del Editor Se eliminaron cuatro artículos por no cumplir con los requisitos del reglamento, podrá eliminarse alguno más de confirmarse lo mismo que los anteriores. …”
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Gender Differences in Psychological Symptoms and Quality of Life in Patients with Inflammatory Bowel Disease in China: A Multicenter Study by Chuan Liu, Jixiang Zhang, Min Chen, Ping An, Jiankang Xiang, Rong Yu, Suqi Zeng, Shuchun Wei, Beiying Deng, Zhongchun Liu, Changqing Jiang, Jie Shi, Kaichun Wu, Weiguo Dong

“…Results: A total of 2478 IBD patients (1371 patients with ulcerative colitis (UC) and 1107 patients with Crohn’s disease (CD)) were investigated, including 1547 males (62.4%) and 931 females (37.6%). …”
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The miR-7/EGFR axis controls the epithelial cell immunomodulation and regeneration and orchestrates the pathology in inflammatory bowel disease by Juanjuan Zhao, Mengmeng Guo, Yaping Yan, Ya Wang, Xu Zhao, Jing Yang, Jing Chen, Chao Chen, Lin Tang, Wenhuan Zeng, Yiting Liu, Ming Qin, Ya Zhou, Lin Xu

“…As for the mechanism, EGFR, a miR-7 target gene, was downregulated in colonic IECs in colitis model and Crohn's disease patients. Furthermore, miR-7 also controlled the proliferation and inflammatory-cytokine secretion of IECs in response to inflammatory-signals through EGFR/NF-κB/AKT/ERK pathway. …”
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Mouse Model of Mutated in Colorectal Cancer Gene Deletion Reveals Novel Pathways in Inflammation and CancerSummary by Nicola Currey, Zeenat Jahan, C. Elizabeth Caldon, Phuong N. Tran, Fahad Benthani, Penelope De Lacavalerie, Daniel L. Roden, Brian S. Gloss, Claudia Campos, Elaine G. Bean, Amanda Bullman, Saskia Reibe-Pal, Marcel E. Dinger, Mark A. Febbraio, Stephen J. Clarke, Jane E. Dahlstrom, Maija R.J. Kohonen-Corish

“…Results: Transcriptome profiling of the lesions showed a strong response to colon barrier destruction, such as up-regulation of key inflammation and cancer-associated genes as well as 28 interferon γ–induced guanosine triphosphatase genes, including the homologs of Crohn’s disease susceptibility gene IRGM. These features were shared by both Mcc-expressing and Mcc-deficient mice and many of the altered gene expression pathways were similar to the mesenchymal colorectal cancer subtype known as consensus molecular subtype 4 (CMS4). …”
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Clinicogenomic factors of biotherapy immunogenicity in autoimmune disease: A prospective multicohort study of the ABIRISK consortium. by Signe Hässler, Delphine Bachelet, Julianne Duhaze, Natacha Szely, Aude Gleizes, Salima Hacein-Bey Abina, Orhan Aktas, Michael Auer, Jerôme Avouac, Mary Birchler, Yoram Bouhnik, Olivier Brocq, Dorothea Buck-Martin, Guillaume Cadiot, Franck Carbonnel, Yehuda Chowers, Manuel Comabella, Tobias Derfuss, Niek De Vries, Naoimh Donnellan, Abiba Doukani, Michael Guger, Hans-Peter Hartung, Eva Kubala Havrdova, Bernhard Hemmer, Tom Huizinga, Kathleen Ingenhoven, Poul Erik Hyldgaard-Jensen, Elizabeth C Jury, Michael Khalil, Bernd Kieseier, Anna Laurén, Raija Lindberg, Amy Loercher, Enrico Maggi, Jessica Manson, Claudia Mauri, Badreddine Mohand Oumoussa, Xavier Montalban, Maria Nachury, Petra Nytrova, Christophe Richez, Malin Ryner, Finn Sellebjerg, Claudia Sievers, Dan Sikkema, Martin Soubrier, Sophie Tourdot, Caroline Trang, Alessandra Vultaggio, Clemens Warnke, Sebastian Spindeldreher, Pierre Dönnes, Timothy P Hickling, Agnès Hincelin Mery, Matthieu Allez, Florian Deisenhammer, Anna Fogdell-Hahn, Xavier Mariette, Marc Pallardy, Philippe Broët, ABIRISK consortium

“…<h4>Methods and findings</h4>The European consortium ABIRISK (Anti-Biopharmaceutical Immunization: prediction and analysis of clinical relevance to minimize the RISK) conducted a clinical and genomic multicohort prospective study of 560 patients with multiple sclerosis (MS, n = 147), rheumatoid arthritis (RA, n = 229), Crohn's disease (n = 148), or ulcerative colitis (n = 36) treated with 8 different biopharmaceuticals (etanercept, n = 84; infliximab, n = 101; adalimumab, n = 153; interferon [IFN]-beta-1a intramuscularly [IM], n = 38; IFN-beta-1a subcutaneously [SC], n = 68; IFN-beta-1b SC, n = 41; rituximab, n = 31; tocilizumab, n = 44) and followed during the first 12 months of therapy for time to ADA development. …”
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Anti-Inflammatory and Chemopreventive Effects of Bryophyllum pinnatum (Lamarck) Leaf Extract in Experimental Colitis Models in Rodents by Anderson Wilbur Lopes Andrade, Anderson Wilbur Lopes Andrade, Gerlane Coelho Bernardo Guerra, Daline Fernandes de Souza Araújo, Raimundo Fernandes de Araújo Júnior, Raimundo Fernandes de Araújo Júnior, Aurigena Antunes de Araújo, Thaís Gomes de Carvalho, Júlia Morais Fernandes, Patrícia Diez-Echave, Patrícia Diez-Echave, Laura Hidalgo-García, Laura Hidalgo-García, Maria Elena Rodriguez-Cabezas, Maria Elena Rodriguez-Cabezas, Julio Gálvez, Julio Gálvez, Silvana Maria Zucolotto

“…Inflammatory bowel diseases, mainly ulcerative colitis and Crohn’s disease are characterized by chronic inflammation in the intestine. …”
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Regulation of CEACAM Family Members by IBD-Associated Triggers in Intestinal Epithelial Cells, Their Correlation to Inflammation and Relevance to IBD Pathogenesis by Gonzalo Saiz-Gonzalo, Gonzalo Saiz-Gonzalo, Gonzalo Saiz-Gonzalo, Naomi Hanrahan, Naomi Hanrahan, Naomi Hanrahan, Valerio Rossini, Raminder Singh, Raminder Singh, Mary Ahern, Maebh Kelleher, Maebh Kelleher, Shane Hill, Shane Hill, Ruairi O’Sullivan, Ruairi O’Sullivan, Aine Fanning, Patrick T. Walsh, Patrick T. Walsh, Seamus Hussey, Seamus Hussey, Fergus Shanahan, Ken Nally, Ken Nally, Caitriona M. O’Driscoll, Caitriona M. O’Driscoll, Silvia Melgar

“…Biopsies from patients with pediatric Crohn’s disease (CD) and adult ulcerative colitis (UC, active/inactive disease) showed a significant increase in CEACAM3, -5, -6 expression, while CEACAM5 expression was reduced in adult CD patients (active/inactive disease). …”
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Dysfunctional metacognitive beliefs and gastrointestinal disorders. Beyond an ‘organic’/‘functional’ categorization in the clinical practice by Maria Catena Quattropani, Vittorio Lenzo, Walter Fries, Alessandra Belvedere

“…</span></p><p class="MsoNormal" style="line-height: normal;"><strong style="mso-bidi-font-weight: normal;"><span style="font-size: 12.0pt; font-family: 'Times New Roman'; mso-ansi-language: EN-US;" lang="EN-US"> </span></strong></p><p class="MsoNormal" style="line-height: normal;"><strong style="mso-bidi-font-weight: normal;"><span style="font-size: 12.0pt; font-family: 'Times New Roman'; mso-ansi-language: EN-US;" lang="EN-US">Keywords:</span></strong><span style="font-size: 12.0pt; font-family: 'Times New Roman'; mso-ansi-language: EN-US;" lang="EN-US"> alexithymia; Crohn’s disease; IBS; <span style="mso-spacerun: yes;"> </span>metacognition; ulcerative colitis.…”
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Regulation of Intestinal Inflammation by Dietary Fats by Abigail R. Basson, Abigail R. Basson, Abigail R. Basson, Abigail R. Basson, Christy Chen, Filip Sagl, Ashley Trotter, Ashley Trotter, Ashley Trotter, Ilya Bederman, Adrian Gomez-Nguyen, Adrian Gomez-Nguyen, Adrian Gomez-Nguyen, Mark S. Sundrud, Sanja Ilic, Fabio Cominelli, Fabio Cominelli, Fabio Cominelli, Fabio Cominelli, Alex Rodriguez-Palacios, Alex Rodriguez-Palacios, Alex Rodriguez-Palacios, Alex Rodriguez-Palacios, Alex Rodriguez-Palacios

“…We provide a scoping overview of the most studied diseases mechanisms associated with the induction or prevention of Inflammatory Bowel Disease in rodent models relevant to Crohn’s Disease and Ulcerative Colitis after feeding either high-fat diet (HFD) or feed containing specific fatty acid or other target dietary molecule. …”
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