Strategies for detecting colon cancer in patients with inflammatory bowel disease by Bye, W, Nguyen, T, Parker, C, Jairath, V, East, J

“… <h4>Background</h4> <p>Patients with longstanding ulcerative colitis and colonic Crohn’s disease have an increased risk of colorectal cancer (CRC) compared with the general population. …”

Comparison Of iNfliximab and ciclosporin in STeroid Resistant Ulcerative Colitis: pragmatic randomised Trial and economic evaluation (CONSTRUCT) by John G Williams, M Fasihul Alam, Laith Alrubaiy, Clare Clement, David Cohen, Michelle Grey, Mike Hilton, Hayley A Hutchings, Mirella Longo, Jayne M Morgan, Frances L Rapport, Anne C Seagrove, Alan Watkins

“…The primary outcome was quality-adjusted survival (QAS): the area under the curve (AUC) of scores derived from Crohn’s and Ulcerative Colitis Questionnaires completed by participants at 3 and 6 months, and then 6-monthly over 1–3 years, more frequently after surgery. …”
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Differential Effects of Anti-TNFα and Anti-α4β7 Drugs on Circulating Dendritic Cells Migratory Capacity in Inflammatory Bowel Disease by Irene Soleto, Samuel Fernández-Tomé, Irene Mora-Gutiérrez, Montserrat Baldan-Martin, Cristina Ramírez, Cecilio Santander, José Andrés Moreno-Monteagudo, María José Casanova, Fernando Casals, Sergio Casabona, Irene Becerro, María Chaparro, David Bernardo, Javier P. Gisbert

“…Inflammatory bowel disease (IBD) is an idiopathic and chronic disorder that includes ulcerative colitis (UC) and Crohn’s disease (CD). Both diseases show an uncontrolled intestinal immune response that generates tissue inflammation. …”
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Fatigue-Related Changes of Daily Function: Most Promising Measures for the Digital Age by Walter Maetzler, Leonor Correia Guedes, Kirsten Nele Emmert, Jennifer Kudelka, Hanna Luise Hildesheim, Emma Paulides, Hayley Connolly, Kristen Davies, Valentina Dilda, Teemu Ahmaniemi, Luisa Avedano, Raquel Bouça-Machado, Michael Chambers, Meenakshi Chatterjee, Peter Gallagher, Johanna Graeber, Corina Maetzler, Hanna Kaduszkiewicz, Norelee Kennedy, Victoria Macrae, Laura Carrasco Marín, Anusha Moses, Alessandro Padovani, Andrea Pilotto, Natasha Ratcliffe, Ralf Reilmann, Madalena Rosario, Stefan Schreiber, Dina De Sousa, Geert Van Gassen, Lori Ann Warring, Klaus Seppi, C. Janneke van der Woude, Joaquim J. Ferreira, Wan-Fai Ng

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Functional Characterization of Novel Faecalibacterium prausnitzii Strains Isolated from Healthy Volunteers: A Step Forward in the Use of F. prausnitzii as a Next-Generation Probiot... by Rebeca Martín, Sylvie Miquel, Sylvie Miquel, Leandro Benevides, Leandro Benevides, Chantal Bridonneau, Véronique Robert, Sylvie Hudault, Florian Chain, Olivier Berteau, Vasco Azevedo, Jean M. Chatel, Harry Sokol, Harry Sokol, Harry Sokol, Luis G. Bermúdez-Humarán, Muriel Thomas, Philippe Langella

“…F. prausnitzii depletion has been reported in several intestinal disorders, and more consistently in Crohn's disease (CD) patients. Despite its importance in human health, only few microbiological studies have been performed to isolate novel F. prausnitzii strains in order to better understand the biodiversity and physiological diversity of this beneficial commensal species. …”
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Functional outcomes in patients submitted to restorative proctocolectomy with ileal pouch anal anastomosis in a single tertiary center by Ana Cristina Silva, Mónica Sampaio, Ricardo Marcos-Pinto, Paula Lago, Anabela Rocha, Eduarda Matos, Marisa D. Santos

“…Keywords: Ileal pouch anal anastomosis, Functional results, Familial adenomatous polyposis, Ulcerative colitis, Crohn's disease, Palavras-chave: Anastomose íleoanal e bolsa ileal, Resultados funcionais, Polipose adenomatosa familiar, Colite ulcerativa, Doença de Crohn…”
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Investigating the Causal Relationship of C-Reactive Protein with 32 Complex Somatic and Psychiatric Outcomes: A Large-Scale Cross-Consortium Mendelian Randomization Study. by Bram P Prins, Ali Abbasi, Anson Wong, Ahmad Vaez, Ilja Nolte, Nora Franceschini, Philip E Stuart, Javier Guterriez Achury, Vanisha Mistry, Jonathan P Bradfield, Ana M Valdes, Jose Bras, Aleksey Shatunov, PAGE Consortium, International Stroke Genetics Consortium, Systemic Sclerosis consortium, Treat OA consortium, DIAGRAM Consortium, CARDIoGRAMplusC4D Consortium, ALS consortium, International Parkinson’s Disease Genomics Consortium, Autism Spectrum Disorder Working Group of the Psychiatric Genomics Consortium, CKDGen consortium, GERAD1 Consortium, International Consortium for Blood Pressure, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Inflammation Working Group of the CHARGE Consortium, Chen Lu, Buhm Han, Soumya Raychaudhuri, Steve Bevan, Maureen D Mayes, Lam C Tsoi, Evangelos Evangelou, Rajan P Nair, Struan F A Grant, Constantin Polychronakos, Timothy R D Radstake, David A van Heel, Melanie L Dunstan, Nicholas W Wood, Ammar Al-Chalabi, Abbas Dehghan, Hakon Hakonarson, Hugh S Markus, James T Elder, Jo Knight, Dan E Arking, Timothy D Spector, Bobby P C Koeleman, Cornelia M van Duijn, Javier Martin, Andrew P Morris, Rinse K Weersma, Cisca Wijmenga, Patricia B Munroe, John R B Perry, Jennie G Pouget, Yalda Jamshidi, Harold Snieder, Behrooz Z Alizadeh

“…The CRP GRSGWAS showed that a 10% increase in genetically determined CRP level was significantly associated with coronary artery disease (OR 0.88 [95% CI 0.84-0.94]; p < 2.4 × 10-5) and was nominally associated with the risk of inflammatory bowel disease (OR 0.85 [95% CI 0.74-0.98]; p < 0.03), Crohn disease (OR 0.81 [95% CI 0.70-0.94]; p < 0.005), psoriatic arthritis (OR 1.36 [95% CI 1.00-1.84]; p < 0.049), knee osteoarthritis (OR 1.17 [95% CI 1.01-1.36]; p < 0.04), and bipolar disorder (OR 1.21 [95% CI 1.05-1.40]; p < 0.007) and with an increase of 0.72 (95% CI 0.11-1.34; p < 0.02) mm Hg in systolic blood pressure, 0.45 (95% CI 0.06-0.84; p < 0.02) mm Hg in diastolic blood pressure, 0.01 ml/min/1.73 m2 (95% CI 0.003-0.02; p < 0.005) in estimated glomerular filtration rate from serum creatinine, 0.01 g/dl (95% CI 0.0004-0.02; p < 0.04) in serum albumin level, and 0.03 g/dl (95% CI 0.008-0.05; p < 0.009) in serum protein level. …”
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Multispectral optoacoustic tomography enables assessment of disease activity in paediatric inflammatory bowel disease by Adrian P. Regensburger, Markus Eckstein, Matthias Wetzl, Roman Raming, Lars-Philip Paulus, Adrian Buehler, Emmanuel Nedoschill, Vera Danko, Jörg Jüngert, Alexandra L. Wagner, Alexander Schnell, Aline Rückel, Ulrich Rother, Oliver Rompel, Michael Uder, Arndt Hartmann, Markus F. Neurath, Joachim Woelfle, Maximilian J. Waldner, André Hoerning, Ferdinand Knieling

“…In this prospective pilot-study, we investigated, whether increased levels of MSOT haemoglobin parameters corresponded to inflammatory activity in paediatric IBD patients, too. 23 children with suspected IBD underwent MSOT of the terminal ileum and sigmoid colon with standard validation (e.g. endoscopy). In Crohn`s disease (CD) and ulcerative colitis (UC) patients with endoscopically confirmed disease activity, MSOT total haemoglobin (HbT) signals were increased in the terminal ileum of CD (72.1 ± 13.0 a.u. vs. 32.9 ± 15.4 a.u., p = 0.0049) and in the sigmoid colon of UC patients (62.9 ± 13.8 a.u. vs. 35.1 ± 16.3 a.u., p = 0.0311) as compared to controls, respectively. …”
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Visualization of Inflammation in Experimental Colitis by Magnetic Resonance Imaging Using Very Small Superparamagnetic Iron Oxide Particles by Laura Golusda, Laura Golusda, Laura Golusda, Anja A. Kühl, Malte Lehmann, Katja Dahlke, Katja Dahlke, Susanne Mueller, Susanne Mueller, Philipp Boehm-Sturm, Philipp Boehm-Sturm, Jessica Saatz, Heike Traub, Joerg Schnorr, Christian Freise, Matthias Taupitz, Karina Biskup, Véronique Blanchard, Oliver Klein, Ingolf Sack, Britta Siegmund, Daniela Paclik, Daniela Paclik

“…Inflammatory bowel diseases (IBD) comprise mainly ulcerative colitis (UC) and Crohn´s disease (CD). Both forms present with a chronic inflammation of the (gastro) intestinal tract, which induces excessive changes in the composition of the associated extracellular matrix (ECM). …”
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TRIM33 deficiency in monocytes and macrophages impairs resolution of colonic inflammationResearch in context by Vanessa Petit, Aude Parcelier, Cecile Mathé, Vilma Barroca, Claire Torres, Daniel Lewandowski, Federica Ferri, Anne-Sophie Gallouët, Marion Dalloz, Océane Dinet, Gilles Boschetti, Marie-Catherine Vozenin, Paul-Henri Roméo

“…Background: Mature myeloid cells play a crucial role in Crohn's disease (CD) but the molecular players that regulate their functions in CD are not fully characterized. …”
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Investigating the causal relationship of c-reactive protein with 32 complex somatic and psychiatric outcomes: a large-scale cross-consortium mendelian randomization study by Prins, B, Abbasi, A, Wong, A, Vaez, A, Nolte, I, Franceschini, N, Stuart, P, Guterriez Achury, J, Mistry, V, Bradfield, J, Valdes, A, Bras, J, Shatunov, A, Lu, C, Han, B, Raychaudhuri, S, Bevan, S, Mayes, M, Tsoi, L, Evangelou, E, Nair, R, Grant, S, Polychronakos, C, Radstake, T, van Heel, D, Dunstan, M, Wood, N, Al-Chalabi, A, Dehghan, A, Hakonarson, H, Markus, H, Elder, J, Knight, J, Arking, D, Spector, T, Koeleman, B, van Duijn, C, Martin, J, Morris, A, Weersma, R, Wijmenga, C, Munroe, P, Perry, J, Pouget, J, Jamshidi, Y, Snieder, H, Alizadeh, B

“…The CRP GRS_GWAS showed that a 10% increase in genetically determined CRP level was significantly associated with coronary artery disease (OR 0.88 [95% CI 0.84–0.94]; <em>p</em> &lt; 2.4 × 10⁻⁵) and was nominally associated with the risk of inflammatory bowel disease (OR 0.85 [95% CI 0.74–0.98]; <em>p</em> &lt; 0.03), Crohn disease (OR 0.81 [95% CI 0.70–0.94]; <em>p</em> &lt; 0.005), psoriatic arthritis (OR 1.36 [95% CI 1.00–1.84]; <em>p</em> &lt; 0.049), knee osteoarthritis (OR 1.17 [95% CI 1.01–1.36]; <em>p</em> &lt; 0.04), and bipolar disorder (OR 1.21 [95% CI 1.05–1.40]; <em>p</em> &lt; 0.007) and with an increase of 0.72 (95% CI 0.11–1.34; <em>p</em> &lt; 0.02) mm Hg in systolic blood pressure, 0.45 (95% CI 0.06–0.84; <em>p</em> &lt; 0.02) mm Hg in diastolic blood pressure, 0.01 ml/min/1.73 m2 (95% CI 0.003–0.02; <em>p</em> &lt; 0.005) in estimated glomerular filtration rate from serum creatinine, 0.01 g/dl (95% CI 0.0004–0.02; <em>p</em> &lt; 0.04) in serum albumin level, and 0.03 g/dl (95% CI 0.008–0.05; <em>p</em> &lt; 0.009) in serum protein level. …”

Geochronology, Petrology and Geochemistry of Intermediate and Mafic Rocks of Bornaward Plutonic Complex (Northwest Bardaskan, Iran) by Reza Monazzami Bagherzadeh, Mohammad Hassan Karimpour, G. Lang Farmer, Charles R. Stern, Jose Francisco Santos, Sara Ribeiro, Behnam Rahimi, Mohammad Reza Haidarian Shahri

“…For the Bornaward diorite dating by the U-Pb method, zircon grains of material remaining in the sieve, Bromoform were isolated from light minerals by cleaning and were isolated with a minimum size of 25 microns, and then studies took place in the Crohn's Laser Lab Arizona (Gehrels et al., 2008). …”
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Inflammatory bowel disease evolution in the past two decades: a chronological multinational studyResearch in context by Pezhman Alavinejad, Seyed Jalal Hashemi, Nitin Behl, Ahmad Hormati, Abubakr Elbasuny, Naser Ebrahimi Daryani, Mehdi Pezeshgi Modarres, Masoud Arshadzadeh, Samira Panahande, Dao Viet Hang, Aya Mohammed Mahros, Abazar Parsi, Hazhir Javaherizadeh, Ata Rehman, Katarzyna M. Pawlak, Mitra Ahmadi, Mohammed Hussien Ahmed, Farnaz Farsi, Mohammad Arefi, Afreen Quadri, Quang Trung Tran, Foroogh Alborzi, Seyed Mohammad Amin Alavi, Bahman Cheraghian, Elmira Ramezani, Mohammed Fathi Gouda, Babak Saadati, Ahmed Alam Quadri, Rahim Hirani, Maha Maher, Elsayed Ghoneem

“…Findings: Overall 1430 patients with IBD including 1207 patients with ulcerative colitis (UC) (84.5%) and 205 patients with Crohn's disease (CD; 14.3%) included. Mean age of participants at the first time of diagnosis with IBD was 30 years. …”
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Impact of fibre and red/processed meat intake on treatment outcomes among patients with chronic inflammatory diseases initiating biological therapy: A prospective cohort study by Silja H. Overgaard, Silja H. Overgaard, Silja H. Overgaard, Signe B. Sørensen, Signe B. Sørensen, Heidi L. Munk, Anders B. Nexøe, Anders B. Nexøe, Anders B. Nexøe, Henning Glerup, Rikke H. Henriksen, Tanja Guldmann, Natalia Pedersen, Sanaz Saboori, Lone Hvid, Jens F. Dahlerup, Christian L. Hvas, Mohamad Jawhara, Mohamad Jawhara, Mohamad Jawhara, Karina W. Andersen, Karina W. Andersen, Andreas K. Pedersen, Ole H. Nielsen, Fredrik Bergenheim, Jacob B. Brodersen, Jacob B. Brodersen, Berit L. Heitmann, Berit L. Heitmann, Thorhallur I. Halldorsson, Uffe Holmskov, Anette Bygum, Anette Bygum, Robin Christensen, Robin Christensen, Jens Kjeldsen, Jens Kjeldsen, Torkell Ellingsen, Vibeke Andersen, Vibeke Andersen, Vibeke Andersen

“…However, up to 60% of the patients do not have a sufficient response to treatment and there is a need for optimization of treatment strategies.ObjectiveTo investigate if the treatment outcome of biological therapy is associated with the habitual dietary intake of fibre and red/processed meat in patients with a CID.MethodsIn this multicentre prospective cohort study, we consecutively enrolled 233 adult patients with a diagnosis of Crohn's Disease, Ulcerative Colitis, Rheumatoid Arthritis (RA), Axial Spondyloarthritis, Psoriatic Arthritis and Psoriasis, for whom biologic therapy was planned, over a 3 year period. …”
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MSI2 deficiency in ILC3s attenuates DSS-induced colitis by affecting the intestinal microbiota by Nengneng Li, Nengneng Li, Shiquan Xu, Shiquan Xu, Shuaishuai Zhang, Shuaishuai Zhang, Qiang Zhu, Qiang Zhu, Xiaole Meng, Xiaole Meng, Wenbin An, Wenbin An, Baoqing Fu, Baoqing Fu, Baoqing Fu, Mengya Zhong, Yan Yang, Zeyang Lin, Xueni Liu, Junjie Xia, Jie Wang, Jie Wang, Tingting You, Tingting You, Changxiu Yan, Huamei Tang, Guohong Zhuang, Zhihai Peng, Zhihai Peng, Zhihai Peng

“…BackgroundThe etiology and pathogenesis of inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn’s disease (CD), are generally believed to be related to immune dysfunction and intestinal microbiota disorder. …”
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Registro Nacional de la nutrición parenteral domiciliaria del año 2002 by J. M Moreno, M Planas, M Lecha, N Virgili, P Gómez-Enterría, J Ordóñez, C de la Cuerda, A Apezetxea, E Martí, P. P García Luna, M. T Forga, A Pérez de la Cruz, A Muñoz, P Bayo, A Rodríguez, J Chamorro, A Bonada, L. M Luengo, C Pedrón, R. M Parés

“…Las enfermedades que motivaron el uso de NPD fueron la isquemia mesentérica (29,7%), seguida de enfermedad neoplásica (16,2%), enteritis rádica (12,2%), alteraciones de la motilidad (8,1%) y enfermedad de Crohn (5,4%). Los catéteres tunelizados fueron empleados en el 52,7% de los casos, frente al 36,5% de reservorios subcutáneos. …”
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A randomized multicenter clinical trial to evaluate the efficacy of melatonin in the prophylaxis of SARS-CoV-2 infection in high-risk contacts (MeCOVID Trial): A structured summary... by Irene García García, Miguel Rodriguez-Rubio, Amelia Rodríguez Mariblanca, Lucía Martínez de Soto, Lucía Díaz García, Jaime Monserrat Villatoro, Javier Queiruga Parada, Enrique Seco Meseguer, María J. Rosales, Juan González, José R. Arribas, Antonio J. Carcas, Pedro de la Oliva, Alberto M. Borobia

“…History of potentially immune derived diseases such as: lupus, Crohn's disease, ulcerative colitis, vasculitis or rheumatoid arthritis. …”
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A pilot controlled trial to determine the feasibility, acceptability and effectiveness of a PAPA-based online intervention to address practical and perceptual barriers to medicatio... by Sarah Chapman, Alice Sibelli, Alastair Forbes, Anja St. Clair-Jones

“…They were recruited via Crohn's and Colitis UK's website, social media and NHS clinics. …”
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Actualización de la guía de práctica clínica PANCCO para el tratamiento de la colitis ulcerativa en población adulta by F. Juliao-Baños, C.F. Grillo-Ardila, I. Alfaro, M.T. Andara-Ramírez, O. Avelar-Escobar, J. Barahona-Garrido, S. Bautista-Martínez, F.J. Bosques-Padilla, J.A. De Paula, K. Ernest-Suárez, M.T. Galiano, B. Iade-Vergara, Patricio-Ibañez, M.L. Jara-Alba, P.G. Kotze, M.C. Miranda-Ojeda, R. Ortuño-Escalante, G. Otoya-Moreno, F.N. Piñol-Jiménez, I.C. Ramos-Polo, A. Sambuelli, M. Toro, E.A. Torres, G.R. Veitia-Velásquez, J.K. Yamamoto-Furusho, C. Zaltman, F. Steinwurz, M. Vallejo-Ortega, J.I. Torres-Castillo, C. Hamon-Pinilla, C.H. Calderón-Franco, A.M. Escobar-Villegas

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The gut microbiota and metabolome are associated with diminished COVID-19 vaccine-induced antibody responses in immunosuppressed inflammatory bowel disease patientsResearch in cont... by James L. Alexander, Benjamin H. Mullish, Nathan P. Danckert, Zhigang Liu, Marton L. Olbei, Aamir Saifuddin, Melissa Torkizadeh, Hajir Ibraheim, Jesús Miguéns Blanco, Lauren A. Roberts, Claire M. Bewshea, Rachel Nice, Simeng Lin, Hemanth Prabhudev, Caroline Sands, Verena Horneffer-van der Sluis, Matthew Lewis, Shaji Sebastian, Charlie W. Lees, Julian P. Teare, Ailsa Hart, James R. Goodhand, Nicholas A. Kennedy, Tamas Korcsmaros, Julian R. Marchesi, Tariq Ahmad, Nick Powell

“…Findings: Forty-three infliximab-treated patients with IBD were recruited (30 Crohn's disease, 12 ulcerative colitis, 1 IBD-unclassified; 26 with concomitant thiopurine therapy). …”
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