Design, synthesis, molecular modeling, and biological evaluation of acrylamide derivatives as potent inhibitors of human dihydroorotate dehydrogenase for the treatment of rheumatoi... by Fanxun Zeng, Shiliang Li, Guantian Yang, Yating Luo, Tiantian Qi, Yingfan Liang, Tingyuan Yang, Letian Zhang, Rui Wang, Lili Zhu, Honglin Li, Xiaoyong Xu

Subjects: “…DHODH…”
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Novel Dihydroorotate Dehydrogenase Inhibitors with Potent Interferon-Independent Antiviral Activity against Mammarenaviruses In Vitro by Yu-Jin Kim, Beatrice Cubitt, Yingyun Cai, Jens H. Kuhn, Daniel Vitt, Hella Kohlhof, Juan C. de la Torre

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A novel mitochondria-targeting DHODH inhibitor induces robust ferroptosis and alleviates immune suppression by Yongrui Hai, Renming Fan, Ting Zhao, Ruizhuo Lin, Junyan Zhuang, Aohua Deng, Shanshui Meng, Zhuang Hou, Gaofei Wei

Subjects: “…DHODH inhibitor…”
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Synthesis, Design, and Structure–Activity Relationship of the Pyrimidone Derivatives as Novel Selective Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase by Le Xu, Wenjie Li, Yanyan Diao, Hongxia Sun, Honglin Li, Lili Zhu, Hongchang Zhou, Zhenjiang Zhao

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Dihydroorotate dehydrogenase inhibition acts synergistically with tyrosine kinase inhibitors to induce apoptosis of mantle cell lymphoma cells by May Eriksen‐Gjerstad, Ida Tveit Karlsen, Zinayida Fandalyuk, Susanne Benjaminsen, Fanny Baran‐Marszak, Bela Papp, Frederick Locke, Marcus Ladds, Andrés Pastor‐Fernández, Pascal Gelebart, Emmet Mc Cormack

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A pharmacokinetic drug–drug interaction study between rosuvastatin and emvododstat, a potent anti‐SARS‐CoV‐2 (COVID‐19) DHODH (dihydroorotate dehydrogenase) inhibitor by Terri L. Morton, Oscar L. Laskin, Diksha Kaushik, Lucy Lee, Jiyuan Ma, Allan Kristensen, Kylie O'Keefe, Lee Golden, Matthew Klein, Ronald Kong

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Depletion of SOD2 enhances nasopharyngeal carcinoma cell radiosensitivity via ferroptosis induction modulated by DHODH inhibition by Alvan Amos, Ning Jiang, Dan Zong, Jiajia Gu, Jiawei Zhou, Li Yin, Xia He, Yong Xu, Lirong Wu

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A targetable PRR11-DHODH axis drives ferroptosis- and temozolomide-resistance in glioblastoma by Zong Miao, Lei Xu, Wei Gu, Yimin Ren, Rong Li, Shuai Zhang, Chao Chen, Hongxiang Wang, Jing Ji, Juxiang Chen

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A novel and potent dihydroorotate dehydrogenase inhibitor suppresses the proliferation of colorectal cancer by inducing mitochondrial dysfunction and DNA damage by Xiaowei Yang, Chungen Li, Kun Gou, Xiaocong Liu, Yue Zhou, Jiao Zou, Qiang Chen, Youfu Luo, Yinglan Zhao

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Retinoblastoma vulnerability to combined de novo and salvage pyrimidine ribonucleotide synthesis pharmacologic blockage by Tanzina Mollick, Suhas Darekar, Basile Dalarun, Flavia Plastino, Juan Zhang, Andres Pastor Fernández, Twana Alkasalias, Helder André, Sonia Laín

Subjects: “…Dhodh…”
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17β-oestradiol inhibits ferroptosis in the hippocampus by upregulating DHODH and further improves memory decline after ovariectomy by Ying Tian, Yuan Xie, Zaixin Guo, Penghui Feng, Yang You, Qi Yu

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Safety and Tolerability of KIO-101 Eye Drops in Healthy Volunteers and Patients with Ocular Surface Disease—A Phase I Study by Doreen Schmidl, Nikolaus Hommer, Martin Kallab, Andreas Schlatter, Clemens Nadvornik, Franz Obermayr, Stefan Sperl, Eric J. Daniels, Gerhard Garhöfer

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Cloning and Characterization of Yak <i>DHODH</i> Gene and Its Functional Studies in a Bisphenol S-Induced Ferroptosis Model of Fetal Fibroblasts by Hongmei Xu, Yueyue Li, Qiao Li, Zifeng Ma, Shi Yin, Honghong He, Yan Xiong, Xianrong Xiong, Daoliang Lan, Jian Li, Wei Fu

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Inhibition of pyrimidine biosynthesis targets protein translation in acute myeloid leukemia by Joan So, Alexander C Lewis, Lorey K Smith, Kym Stanley, Rheana Franich, David Yoannidis, Lizzy Pijpers, Pilar Dominguez, Simon J Hogg, Stephin J Vervoort, Fiona C Brown, Ricky W Johnstone, Gabrielle McDonald, Danielle B Ulanet, Josh Murtie, Emily Gruber, Lev M Kats

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Assessment of a novel variation in DHODH gene causing Miller syndrome: The first report in Chinese population by Kai Yang, Li‐Man Fu, Xiao‐Yang Chu, Jing Zhang, Wen‐Qi Chen, You‐Sheng Yan, Yi‐Peng Wang, Dong‐Liang Zhang, Cheng‐Hong Yin, Qing Guo

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DHODH inhibition enhances the efficacy of immune checkpoint blockade by increasing cancer cell antigen presentation by Nicholas J Mullen, Surendra K Shukla, Ravi Thakur, Sai Sundeep Kollala, Dezhen Wang, Nina Chaika, Juan F Santana, William R Miklavcic, Drew A LaBreck, Jayapal Reddy Mallareddy, David H Price, Amarnath Natarajan, Kamiya Mehla, David B Sykes, Michael A Hollingsworth, Pankaj K Singh

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Circulating mitochondria promoted endothelial cGAS-derived neuroinflammation in subfornical organ to aggravate sympathetic overdrive in heart failure mice by Shutian Zhang, Dajun Zhao, Zhaohua Yang, Fanshun Wang, Shouguo Yang, Chunsheng Wang

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Mitochondrial Dysfunction‐Evoked DHODH Acetylation is Involved in Renal Cell Ferroptosis during Cisplatin‐Induced Acute Kidney Injury by Nan‐Nan Liang, Yue‐Yue Guo, Xiao‐Yi Zhang, Ya‐Hui Ren, Yi‐Zhang He, Zhi‐Bing Liu, De‐Xiang Xu, Shen Xu

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Modulating pyrimidine ribonucleotide levels for the treatment of cancer by Tanzina Mollick, Sonia Laín

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Bioinformatics analysis and experimental verification of the cancer-promoting effect of DHODH in clear cell renal cell carcinoma by Songsong Wang, Yan Li, Yilong Lin, Junting Li, Lang Guo, Haoyu Wang, Xinyuan Lin, Ziming Liu, Bingqi Zhang, Zhengming Liao, Zhongmin Zhang

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