Evolution of extreme resistance to ionizing radiation via genetic adaptation of DNA repair by Rose T Byrne, Audrey J Klingele, Eric L Cabot, Wendy S Schackwitz, Jeffrey A Martin, Joel Martin, Zhong Wang, Elizabeth A Wood, Christa Pennacchio, Len A Pennacchio, Nicole T Perna, John R Battista, Michael M Cox

“…Of 69 mutations identified in one of our most highly adapted isolates, functional experiments demonstrate that the IR resistance phenotype is almost entirely accounted for by only three of these nucleotide changes, in the DNA metabolism genes recA, dnaB, and yfjK. Four additional genetic changes make small but measurable contributions. …”
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The value of EYA1/3/4 in clear cell renal cell carcinoma: a study from multiple databases by Taobin Liu, Jianqiang Nie, Xiaoming Zhang, Xinxi Deng, Bin Fu

“…Mechanistically, EYAs genes play an essential role in a wide range of biological processes such as DNA metabolism and double-strand break repair in ccRCC. …”
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The Role of <i>S. cerevisiae</i> Sub1/PC4 in Transcription Elongation Depends on the C-Terminal Region and Is Independent of the ssDNA Binding Domain by Alejandro Collin, Araceli González-Jiménez, María del Carmen González-Jiménez, Manuel J. Alfonso, Olga Calvo

“…Recently, PC4/Sub1 orthologues have been elucidated in eukaryotes, prokaryotes, and bacteriophages with functions related to DNA metabolism. Additionally, ScSub1 contains a unique carboxyl–terminal region (CT) of unknown function up to date. …”
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Activation of interferon-α signaling by resveratrol, genistein and quercetin by O. A. Vlasova, A. A. Borunova, A. Safina, I. V. Smetanina, E. A. Lesovaya, G. A. Belitsky, T. N. Zabotina, K. Gurova, K. I. Kirsanov, M. G. Yakubovskaya

“…This process is usually followed by changes in spatial, physical-chemical and structural DNA characteristics that can result in disfunction of DNA metabolism enzymes and chromatin destabilization. …”
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Embryonic thermal manipulation impacts the postnatal transcriptome response of heat-challenged Japanese quails by Anaïs Vitorino Carvalho, Christelle Hennequet-Antier, Aurélien Brionne, Sabine Crochet, Justine Jimenez, Nathalie Couroussé, Anne Collin, Vincent Coustham

“…Gene Ontology terms related to the membrane transport, the endoplasmic reticulum and mitochondrial functions as well as DNA metabolism and repair were also identified in specific comparisons and sexes. …”
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<i>Saccharomyces cerevisiae</i> as a Tool for Studying Mutations in Nuclear Genes Involved in Diseases Caused by Mitochondrial DNA Instability by Alexandru Ionut Gilea, Camilla Ceccatelli Berti, Martina Magistrati, Giulia di Punzio, Paola Goffrini, Enrico Baruffini, Cristina Dallabona

“…Pathological mutations in nuclear genes involved in the mtDNA metabolism may result in a quantitative decrease in mtDNA levels, referred to as mtDNA depletion, or in qualitative defects in mtDNA, especially in multiple deletions. …”
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Biological and Genomic Characteristics of MaMV-DH01, a Novel Freshwater Myoviridae Cyanophage Strain by Li-Hui Meng, Fei Ke, Qi-Ya Zhang, Zhe Zhao

“…These ORFs are related to DNA metabolism, structural proteins, lysis, host-derived metabolic genes, and DNA packaging. …”
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Effects of 5′-3′ Exonuclease Xrn1 on Cell Size, Proliferation and Division, and mRNA Levels of Periodic Genes in <i>Cryptococcus neoformans</i> by Xueru Zhao, Xin Li, Ping Zhang, Chenxi Li, Weijia Feng, Xudong Zhu, Dongsheng Wei

“…RNA-sequencing results showed that the difference was significantly enriched in genes involved in membrane components, DNA metabolism, integration and recombination, DNA polymerase activity, meiotic cell cycle, nuclear division, organelle fission, microtubule-based process and reproduction. …”
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Conserved and Opposite Transcriptome Patterns during Germination in <i>Hordeum vulgare</i> and <i>Arabidopsis thaliana</i> by Yanqiao Zhu, Oliver Berkowitz, Jennifer Selinski, Andreas Hartmann, Reena Narsai, Yan Wang, Peisheng Mao, James Whelan

“…Comparison of orthologous genes revealed more than 3000 orthogroups containing almost 4000 genes that displayed similar expression patterns including functions associated with mitochondrial tricarboxylic acid (TCA) cycle, carbohydrate and RNA/DNA metabolism, autophagy, protein modifications, and organellar function. …”
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A sense of place: transcriptomics identifies environmental signatures in Cabernet Sauvignon berry skins in the late stages of ripening by Grant R. Cramer, Noé Cochetel, Ryan Ghan, Agnès Destrac-Irvine, Serge Delrot

“…Top gene ontology categories for the common transcript sets were translation, photosynthesis, DNA metabolism and catabolism. Top gene ontology categories for the differentially expressed genes at 22°Brix involved response to stimulus, biosynthesis and response to stress. …”
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Metagenomics insights into Cr(VI) effects on structural and functional diversity of bacterial community in chromite mine soils of Sukinda Valley, Odisha by Sukanta Kumar Pradhan, Nihar Ranjan Singh, Hrudayanath Thatoi

“…In in situ soil, the bacterial genes are involved in membrane transport, DNA metabolism, Iron acquisition and metabolism, secondary metabolism, motility and chemotaxis. …”
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An Oral Fluorouracil Prodrug, Capecitabine, Mitigates a Gram-Positive Systemic Infection in Mice by Jack R. McLeod, Pamela A. Harvey, Corrella S. Detweiler

“…The nine drugs identified all disrupt DNA metabolism in bacteria and eukaryotes. One of the hit compounds, capecitabine, is a well-tolerated oncology drug that is administered orally, a preferred treatment route. …”
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Effects of removing in-feed antibiotics and zinc oxide on the taxonomy and functionality of the microbiota in post weaning pigs by Juan M. Ortiz Sanjuán, Héctor Argüello, Raúl Cabrera-Rubio, Fiona Crispie, Paul D. Cotter, Juan J. Garrido, Daniel Ekhlas, Catherine M. Burgess, Edgar G. Manzanilla

“…Differential microbiota functions of pigs treated with ZnO were related to sulphur and DNA metabolism, as well as mechanisms of antimicrobial and heavy metal resistance, whereas Ab treated animals exhibited functions related to antimicrobial resistance and virulence. …”
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Life without dUTPase by Csaba Kerepesi, Judit E Szabó, Judit E Szabó, Veronika Papp-Kádár, Veronika Papp-Kádár, Orsolya Dobay, Dóra Szabó, Vince Grolmusz, Beata G Vertessy, Beata G Vertessy

“…We discuss potential survival strategies in lack of dUTPases, such as simultaneous lack or inhibition of UNG and possession of exogenous or alternate metabolic enzymes involved in uracil-DNA metabolism. The potential that genes previously not associated with dUTPase activity may still encode enzymes capable of hydrolyzing dUTP is also discussed. …”
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Multimolecular characteristics and role of BRCA1 interacting protein C-terminal helicase 1 (BRIP1) in human tumors: a pan-cancer analysis by Ruohuang Wang, Jisheng Zhang, Xin Cui, Shun Wang, Ting Chen, Yanfang Niu, Xiaoyun Du, Jingwen Kong, Lin Wang, Yan Jiang

“…“Basal transcription factors,” “homologous recombination,” “nucleotide excision repair,” and DNA metabolism pathways may play a role in the functional mechanisms of BRIP1. …”
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The antibacterial mechanism of oridonin against methicillin-resistant Staphylococcus aureus (MRSA) by Zhongwei Yuan, Ping Ouyang, Kexin Gu, Tayyab Rehman, Tianyi Zhang, Zhongqiong Yin, Hualin Fu, Juchun Lin, Changliang He, Gang Shu, Xiaoxia Liang, Zhixiang Yuan, Xu Song, Lixia Li, Yuanfeng Zou, Lizi Yin

“…Conclusions: Oridonin antibacterial mechanism was related to changes in cell membrane and cell wall permeability, disturbance in protein and DNA metabolism, and influence on bacterial morphology. …”
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Analysis of LexA binding sites and transcriptomics in response to genotoxic stress in Leptospira interrogans by Schons-Fonseca, Luciane, da Silva, Josefa B., Milanez, Juliana S., Domingos, Renan H., Smith, Janet L., Nakaya, Helder I., Ho, Paulo L., da Costa, Renata MA, Grossman, Alan Davis

“…In response to DNA damage, Leptospira induced expression of genes involved in DNA metabolism, in mobile genetic elements and defective prophages. …”
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Novel interaction interfaces mediate the interaction between the NEIL1 DNA glycosylase and mitochondrial transcription factor A by Nidhi Sharma, Marlo K. Thompson, Jennifer F. Arrington, Dava M. Terry, Srinivas Chakravarthy, Peter E. Prevelige, Aishwarya Prakash

“…In the current work, we scrutinized the interaction between NEIL1 and mitochondrial transcription factor A (TFAM), a protein that is essential for various aspects of mtDNA metabolism. We note, for the first time, that both the N- and C- terminal domains of NEIL1 interact with TFAM revealing a unique NEIL1 protein-binding interface. …”
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Characterization and Genomic Analysis of Novel <i>Vibrio parahaemolyticus</i> Phage vB_VpaP_DE10 by Yuanming Ye, Hanfang Chen, Qiaolan Huang, Shixuan Huang, Jiaxin He, Jumei Zhang, Qingping Wu, Xueling Li, Wenfeng Hu, Meiyan Yang

“…The genome of phage vB_VpaP_DE10 is a 42,871-bp-long dsDNA molecule with a G + C content of 49.19% and is predicted to contain 46 open reading frames, 26 of which are predicted to be related to functions such as phage structure, packaging, host lysis, and DNA metabolism. Sequence comparisons suggested that vB_VpaP_DE10 is a member of the genus <i>Maculvirus</i> within the family <i>Autographiviridae</i>. …”
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Life at Home and on the Roam: Genomic Adaptions Reflect the Dual Lifestyle of an Intracellular, Facultative Symbiont by Ilia Burgsdorf, Kim M. Handley, Rinat Bar-Shalom, Patrick M. Erwin, Laura Steindler

“…These include genes related to cell surface structures, genetic regulation, and responses to environmental stress, as well as the composition of photosynthetic genes and DNA metabolism. We speculate that the presence of these genes confers on “Ca. …”
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