Crosstalk between chromatin structure, cohesin activity and transcription by Douglas Maya-Miles, Eloísa Andújar, Mónica Pérez-Alegre, Marina Murillo-Pineda, Marta Barrientos-Moreno, María J. Cabello-Lobato, Elena Gómez-Marín, Macarena Morillo-Huesca, Félix Prado

“…However, little is known about these reciprocal interactions, even for cohesin, despite its multiple roles in DNA metabolism. Results We have used genome-wide analyses to address how cohesins and chromatin structure impact each other in yeast. …”
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Previously Unidentified Histone H1-Like Protein Is Involved in Cell Division and Ribosome Biosynthesis in Toxoplasma gondii by Vanessa Severo, Rodolpho Souza, Francisca Vitorino, Julia Cunha, Andréa Ávila, Gustavo Arrizabalaga, Sheila Nardelli

“…H1 is a multifunctional protein and can be involved in different steps of DNA metabolism or associated with protein complexes related to distinct biological processes. …”
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Presence of rare potential pathogenic variants in subjects under 65 years old with very severe or fatal COVID-19 by Rosario López-Rodríguez, Marta Del Pozo-Valero, Marta Corton, Pablo Minguez, Javier Ruiz-Hornillos, María Elena Pérez-Tomás, María Barreda-Sánchez, Esther Mancebo, Cristina Villaverde, Gonzalo Núñez-Moreno, Raquel Romero, The STOP_Coronavirus Study Group, Estela Paz-Artal, Encarna Guillén-Navarro, Berta Almoguera, Carmen Ayuso

“…A network analysis, including the 42 genes with candidate variants, showed three main components, consisting of 25 highly interconnected genes related to immune response and two additional networks composed by genes enriched in carbohydrate metabolism and in DNA metabolism and repair processes. In conclusion, we have detected candidate variants that may potentially influence COVID-19 outcome in our cohort of patients. …”
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SLX4 Assembles a Telomere Maintenance Toolkit by Bridging Multiple Endonucleases with Telomeres by Bingbing Wan, Jinhu Yin, Kent Horvath, Jaya Sarkar, Yong Chen, Jian Wu, Ke Wan, Jian Lu, Peili Gu, Eun Young Yu, Neal F. Lue, Sandy Chang, Yie Liu, Ming Lei

“…SLX4 interacts with several endonucleases to resolve structural barriers in DNA metabolism. SLX4 also interacts with telomeric protein TRF2 in human cells. …”
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<i>Pantoea</i> Bacteriophage vB_PagS_MED16—A Siphovirus Containing a 2′-Deoxy-7-amido-7-deazaguanosine-Modified DNA by Monika Šimoliūnienė, Emilija Žukauskienė, Lidija Truncaitė, Liang Cui, Geoffrey Hutinet, Darius Kazlauskas, Algirdas Kaupinis, Martynas Skapas, Valérie de Crécy-Lagard, Peter C. Dedon, Mindaugas Valius, Rolandas Meškys, Eugenijus Šimoliūnas

“…In total, 35 MED16 ORFs were given a putative functional annotation, including those coding for the proteins responsible for virion morphogenesis, phage–host interactions, and DNA metabolism. In addition, a gene encoding a preQ₀ DNA deoxyribosyltransferase (DpdA) is present in the genome of MED16 and the LC–MS/MS analysis indicates 2′-deoxy-7-amido-7-deazaguanosine (dADG)-modified phage DNA, which, to our knowledge, has never been experimentally validated in genomes of <i>Pantoea</i> phages. …”
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Biological Profiling Enables Rapid Mechanistic Classification of Phenotypic Screening Hits and Identification of KatG Activation-Dependent Pyridine Carboxamide Prodrugs With Activi... by Melissa D. Chengalroyen, Audrey Jordaan, Ronnett Seldon, Ronnett Seldon, Thomas Ioerger, Scott G. Franzblau, Mohamed Nasr, Digby F. Warner, Digby F. Warner, Valerie Mizrahi, Valerie Mizrahi

“…Fourteen of the compounds with in vitro activities in the low micrometer range and a favorable selectivity index were classified using reporter strains of M. tuberculosis which showed that six interfered with cell wall metabolism and one disrupted DNA metabolism. Counter-screening against strains carrying mutations in promiscuous drug targets argued against DprE1 and MmpL3 as hits of any of the cell wall actives and eliminated the cytochrome bc1 complex as a target of any of the compounds. …”
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Cytidine analogs are synthetic lethal with base excision repair default due to MBD4 deficiency by Thomas Chabot, Fariba Nemati, Aurélie Herbette, Alexandre Demeyer, Stéphane Dayot, Olivier Ganier, Samar Alsafadi, Sophie Gardrat, Pascale Mariani, Marie Luporsi, Maxime Corbé, Vincent Servois, Nathalie Cassoux, Didier Decaudin, Sergio Roman Roman, Elaine Del Nery, Sophie Piperno-Neumann, Marc-Henri Stern, Manuel Rodrigues

“…Here, we hypothesize that the difference in DNA metabolism consecutive to MBD4 deficiency may result in specific cytotoxicities in MBD4-deficient tumor cells in a synthetic lethality fashion. …”
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Metagenomic study to evaluate functional capacity of a cyanobacterial bloom during oxidation by Saber Moradinejad, Hana Trigui, Juan Francisco Guerra Maldonado, B. Jesse Shapiro, Yves Terrat, Sébastien Sauvé, Nathalie Fortin, Arash Zamyadi, Sarah Dorner, Michèle Prévost

“…The bloom samples were associated with two functional profile assemblages: that of August 1st (onset of the bloom) characterized by enrichment of genes related to nutrient uptake and that of August 13th-29th (towards the end of the sampling) associated with competition for resources and repair such as Photosynthesis, Protein metabolism and DNA metabolism. Different functional profile responses to oxidation with Cl2, KMnO4 and H2O2 was also identified as two-time points during the bloom (at the August 1st, and August 29th). …”
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The Role of Mitochondria in the Chemoresistance of Pancreatic Cancer Cells by Yibo Fu, Francesca Ricciardiello, Gang Yang, Jiangdong Qiu, Hua Huang, Jianchun Xiao, Zhe Cao, Fangyu Zhao, Yueze Liu, Wenhao Luo, Guangyu Chen, Lei You, Ferdinando Chiaradonna, Lianfang Zheng, Taiping Zhang

“…In addition, according to recent studies, mitochondria may play important roles in the chemoresistance of PC by affecting apoptosis, metabolism, mtDNA metabolism, and mitochondrial dynamics. Interfering with some of these factors in mitochondria may improve the sensitivity of PC cells to chemotherapeutic agents, such as gemcitabine, making mitochondria promising targets for overcoming chemoresistance in PC.…”
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Genome-wide family prediction unveils molecular mechanisms underlying the regulation of agronomic traits in Urochloa ruziziensis by Felipe Bitencourt Martins, Alexandre Hild Aono, Aline da Costa Lima Moraes, Rebecca Caroline Ulbricht Ferreira, Mariane de Mendonça Vilela, Marco Pessoa-Filho, Mariana Rodrigues-Motta, Rosangela Maria Simeão, Anete Pereira de Souza, Anete Pereira de Souza

“…Further exploration with the gene coexpression network uncovered associations with DNA metabolism, stress response, and circadian rhythm. …”
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Isolation and Characterization of the Novel Phages vB_VpS_BA3 and vB_VpS_CA8 for Lysing Vibrio parahaemolyticus by Meiyan Yang, Meiyan Yang, Yongjian Liang, Yongjian Liang, Shixuan Huang, Jumei Zhang, Jumei Zhang, Jing Wang, Hanfang Chen, Hanfang Chen, Yuanming Ye, Yuanming Ye, Xiangyang Gao, Qingping Wu, Qingping Wu, Zhiyuan Tan

“…The ORFs were associated with phage structure, packing, host lysis, DNA metabolism, and additional functions. Furthermore, average nucleotide identity analysis, comparative genomic features and phylogenetic analysis revealed that BA3 and CA8 represented different isolates but novel members of the family, Siphoviridae. …”
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The lichen symbiosis re-viewed through the genomes of Cladonia grayi and its algal partner Asterochloris glomerata by Daniele Armaleo, Olaf Müller, François Lutzoni, Ólafur S. Andrésson, Guillaume Blanc, Helge B. Bode, Frank R. Collart, Francesco Dal Grande, Fred Dietrich, Igor V. Grigoriev, Suzanne Joneson, Alan Kuo, Peter E. Larsen, John M. Logsdon, David Lopez, Francis Martin, Susan P. May, Tami R. McDonald, Sabeeha S. Merchant, Vivian Miao, Emmanuelle Morin, Ryoko Oono, Matteo Pellegrini, Nimrod Rubinstein, Maria Virginia Sanchez-Puerta, Elizabeth Savelkoul, Imke Schmitt, Jason C. Slot, Darren Soanes, Péter Szövényi, Nicholas J. Talbot, Claire Veneault-Fourrey, Basil B. Xavier

“…Results A) In coculture, the fungus upregulated small secreted proteins, membrane transport proteins, signal transduction components, extracellular hydrolases and, notably, a ribitol transporter and an ammonium transporter, and the alga activated DNA metabolism, signal transduction, and expression of flagellar components. …”
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SAMHD1 agit sur les fourches de réplication bloquées pour empêcher l’induction d’interféron by Coquel, F., Silva, M. J., Técher, H., Zadorozhny, K., Sharma, S., Nieminuszczy, J., Mettling, C., Dardillac, E., Barthe, A., Schmitz, A. L., Promonet, A., Cribier, A., Sarrazin, A., Niedzwiedz, W., Lopez, B., Costanzo, V., Krejci, L., Chabes, A., Benkirane, M., Lin, Y. L., Pasero, P.

“…DNA fragments resulting from genomic DNA metabolism (repair, retrotransposition) can diffuse into the cytoplasm and activate this pathway. …”
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Melatonin inhibits HCC progression through regulating the alternative splicing of NEMO by Lu Bai, Siwen Sun, Wenmei Su, Chaoqun Chen, Yuesheng Lv, Jinrui Zhang, Jinyao Zhao, Man Li, Yangfan Qi, Wenjing Zhang, Yang Wang, Yang Wang

“…Mechanistically, melatonin induced transcriptional alterations of genes, which are involved in DNA replication, DNA metabolic process, DNA repair, response to wounding, steroid metabolic process, and extracellular matrix functions. …”
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The Toll-like receptor gene family is integrated into human DNA damage and p53 networks. by Daniel Menendez, Maria Shatz, Kathleen Azzam, Stavros Garantziotis, Michael B Fessler, Michael A Resnick

“…Expression of all TLR genes, TLR1 to TLR10, in blood lymphocytes and alveolar macrophages from healthy volunteers can be induced by DNA metabolic stressors. However, there is considerable inter-individual variability. …”
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Growth Inhibition of Two Prenylated Chalcones on Prostate Cancer Cells through the Regulation of the Biological Activity and Protein Translation of Bloom Helicase by Bao-Fei Sun, Xu-Hui Zhu, Jing Hou, Lan-Lan Li, Yuan-Kun Qin, Jia Yu, Sha Cheng, Bi-Xue Xu, Fa-Jun Song, Heng Luo

“…The predisposition to cancer caused by BLM helicase is due to defects in important DNA metabolic pathways such as replication, recombination, and repair. …”
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Molecular Complexes at Euchromatin, Heterochromatin and Centromeric Chromatin by Olivia Morrison, Jitendra Thakur

“…Chromatin consists of a complex of DNA and histone proteins as its core components and plays an important role in both packaging DNA and regulating DNA metabolic pathways such as DNA replication, transcription, recombination, and chromosome segregation. …”
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From Processivity to Genome Maintenance: The Many Roles of Sliding Clamps by Meenakshi Mulye, Manika Indrajit Singh, Vikas Jain

“…They also serve as an interacting platform for a plethora of other proteins, which have an important role in other DNA metabolic processes, including DNA repair. In other words, clamps have evolved, as has been correctly referred to, into a mobile “tool-belt” on the DNA, and provide a platform for several proteins that are involved in maintaining genome integrity. …”
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Single-molecule fluorescence imaging techniques reveal molecular mechanisms underlying deoxyribonucleic acid damage repair by Yujin Kang, Soyeong An, Duyoung Min, Ja Yil Lee, Ja Yil Lee

“…These techniques have been broadly utilized for studying DNA metabolic events such as replication, transcription, and DNA repair, which are fundamental biological reactions. …”
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RAD52: Viral Friend or Foe? by Eric A. Hendrickson

“…In the past decade, RAD52, which was thought to be dispensable for most DNA repair and recombination reactions in mammals, has been shown to be important for a bevy of DNA metabolic pathways. One of these processes is termed break-induced replication (BIR), a mechanism that can be used to re-start broken replication forks and to elongate the ends of chromosomes in telomerase-negative cells. …”
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