Human DNA2 possesses a cryptic DNA unwinding activity that functionally integrates with BLM or WRN helicases by Cosimo Pinto, Kristina Kasaciunaite, Ralf Seidel, Petr Cejka

“…The nuclease of hDNA2 is involved in a variety of DNA metabolic processes. Little is known about the role of the hDNA2 helicase. …”
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Risk prediction and marker selection in nonsynonymous single nucleotide polymorphisms using whole genome sequencing data by Young-Sup Lee, KyeongHye Won, Donghyun Shin, Jae-Don Oh

“…In the gene ontology analysis encompassing the 16,100 nsSNPs, DNA metabolic process, chemokine- and immune-related, and reproduction were the most enriched terms. …”
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Role of p97/VCP (Cdc48) in genome stability. by Vaz, B, Halder, S, Ramadan, K

“…PICHROS directly and negatively affects multiple DNA metabolic processes, including replication, damage responses, mitosis, and transcription, leading to genotoxic stress and genome instability. …”

A matter of delicate balance: Loss and gain of Cockayne syndrome proteins in premature aging and cancer by Elena Paccosi, Adayabalam S. Balajee, Luca Proietti-De-Santis

“…DNA repair genes are critical for preserving genomic stability and it is well established that mutations in DNA repair genes give rise to progeroid diseases due to perturbations in different DNA metabolic activities. Cockayne Syndrome (CS) is an autosomal recessive inheritance caused by inactivating mutations in CSA and CSB genes. …”
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Mechanisms and Regulation of DNA-Protein Crosslink Repair During DNA Replication by SPRTN Protease by Megan Perry, Gargi Ghosal, Gargi Ghosal

“…Unrepaired DPCs are blockades to all DNA metabolic processes. Specifically, during DNA replication, replication forks stall at DPCs and are vulnerable to fork collapse, causing DNA breakage leading to genome instability and cancer. …”
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Replication protein A plays multifaceted roles complementary to specialized helicases in processing G-quadruplex DNA by Yi-Ran Wang, Ting-Ting Guo, Ya-Ting Zheng, Chang-Wei Lai, Bo Sun, Xu-Guang Xi, Xi-Miao Hou

“…Summary: G-quadruplexes (G4s) are non-canonical DNA structures with critical roles in DNA metabolisms. To resolve those structures that can cause replication fork stalling and genomic instability, single-stranded DNA-binding proteins and helicases are required. …”
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Comparative transcriptome analysis in Triticum aestivum infecting wheat dwarf virus reveals the effects of viral infection on phytohormone and photosynthesis metabolism pathways... by Yu Liu, Yan Liu, Carl Spetz, Li Li, Xifeng Wang

“…Genomes ontology (GO) annotation revealed a number of DEGs associated with different biological processes, such as phytohormone metabolism, photosynthesis, DNA metabolic process, response to biotic stimulus and defense response. …”
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Acetylation regulates WRN catalytic activities and affects base excision DNA repair. by Meltem Muftuoglu, Rika Kusumoto, Elzbieta Speina, Gad Beck, Wen-Hsing Cheng, Vilhelm A Bohr

“…The Werner protein (WRN), defective in the premature aging disorder Werner syndrome, participates in a number of DNA metabolic processes, and we have been interested in the possible regulation of its function in DNA repair by post-translational modifications. …”
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AGO2-RIP-Seq reveals miR-34/miR-449 cluster targetome in sinonasal cancers. by Marco Tomasetti, Federica Monaco, Corrado Rubini, Marzia Rossato, Concetta De Quattro, Cristina Beltrami, Giacomo Sollini, Ernesto Pasquini, Monica Amati, Gaia Goteri, Lory Santarelli, Massimo Re

“…Using this approach, we identified direct target genes (targetome), which were involved in regulation of RNA-DNA metabolic, transcript and epigenetic processes. In particular, the STK3, C9orf78 and STRN3 genes were the direct targets of both miR-34c and miR-449a, and their regulation are predictive of tumour progression. …”
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Inhibitory Effect and Mechanism of Dill Seed Essential Oil on <i>Neofusicoccum parvum</i> in Chinese Chestnut by Tian-Tian Liu, Lin-Jing Gou, Hong Zeng, Gao Zhou, Wan-Rong Dong, Yu Cui, Qiang Cai, Yu-Xin Chen

“…Transcriptomics analysis showed DSEO treatment induced differently expressed genes most related to replication, transcription, translation, and lipid, DNA metabolic process. Furthermore, in vivo experiments showed that DSEO and DSEO emulsion can inhibit the growth of fungi and prolong the storage period of chestnuts. …”
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Replication-independent endogenous DNA double-strand breaks in Saccharomyces cerevisiae model. by Jirapan Thongsroy, Oranart Matangkasombut, Araya Thongnak, Prakasit Rattanatanyong, Siwanon Jirawatnotai, Apiwat Mutirangura

“…Using a collection of mutant yeast strains, we investigated various DNA metabolic and DNA repair pathways that might be involved in the maintenance of RIND-EDSB levels. …”
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A real-time fluorescent gp32 probe-based assay for monitoring single-stranded DNA-dependent DNA processing enzymes by Senthil K. Perumal

“…Single-stranded DNA (ssDNA) generated during DNA replication, recombination and damage repair reactions is an important intermediate and ssDNA-binding proteins that binds these intermediates coordinate various DNA metabolic processes. Mechanistic details of these ssDNA-dependent processes can be explored by monitoring the generation and consumption of ssDNA in real time. …”
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Small RNA Analyses of a <i>Ceratobasidium</i> Isolate Infected with Three Endornaviruses by Chi T. H. Cao, Mark C. Derbyshire, Roshan Regmi, Hua Li, Michael G. K. Jones, Stephen J. Wylie

“…Gene target prediction of the differentially expressed Cer-milRNAs was quite ambiguous; however, fungal genes involved in transcriptional regulation, catalysis, molecular binding, and metabolic activities such as gene expression, DNA metabolic processes and regulation activities were differentially expressed in the presence of the mycoviruses.…”
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Meta-Analysis of Transcriptomes in Insects Showing Density-Dependent Polyphenism by Kouhei Toga, Kakeru Yokoi, Hidemasa Bono

“…DNA replication (GO:0006260), DNA metabolic processes (GO:0006259), and mitotic cell cycle (GO:0000278) were enriched in response to crowded conditions. …”
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Reduced stability and increased dynamics in the human proliferating cell nuclear antigen (PCNA) relative to the yeast homolog. by Alfredo De Biasio, Ricardo Sánchez, Jesús Prieto, Maider Villate, Ramón Campos-Olivas, Francisco J Blanco

“…The ring encircles the DNA and acts as a platform where polymerases and other proteins dock to carry out different DNA metabolic processes. The amino acid sequence of human PCNA is 35% identical to the yeast homolog, and the two proteins have the same 3D crystal structure. …”
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Bloom syndrome helicase contributes to germ line development and longevity in zebrafish by Tamás Annus, Dalma Müller, Bálint Jezsó, György Ullaga, Barnabás Németh, Gábor M. Harami, László Orbán, Mihály Kovács, Máté Varga

“…Abstract RecQ helicases—also known as the “guardians of the genome”—play crucial roles in genome integrity maintenance through their involvement in various DNA metabolic pathways. Aside from being conserved from bacteria to vertebrates, their importance is also reflected in the fact that in humans impaired function of multiple RecQ helicase orthologs are known to cause severe sets of problems, including Bloom, Werner, or Rothmund-Thomson syndromes. …”
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ssDNA accessibility of Rad51 is regulated by orchestrating multiple RPA dynamics by Jiawei Ding, Xiangting Li, Jiangchuan Shen, Yiling Zhao, Shuchen Zhong, Luhua Lai, Hengyao Niu, Zhi Qi

“…Abstract The eukaryotic single-stranded DNA (ssDNA)-binding protein Replication Protein A (RPA) plays a crucial role in various DNA metabolic pathways, including DNA replication and repair, by dynamically associating with ssDNA. …”
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Triacontanol Promotes the Fruit Development and Retards Fruit Senescence in Strawberry: A Transcriptome Analysis by Qianqian Pang, Xueqin Chen, Jinhua Lv, Teng Li, Jinggui Fang, Haifeng Jia

“…The results showed that TA treatment caused changes in transcript levels related to cellular processes, hormones and secondary metabolism, such as DNA metabolic processes, flavonoid synthesis, and plant hormone signal transduction. …”
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Research on Werner Syndrome: Trends from Past to Present and Future Prospects by Kyoshiro Tsuge, Akira Shimamoto

“…<i>WRN</i>, the gene responsible for WS, encodes DNA helicase with a 3′ to 5′ exonuclease activity, and numerous studies have revealed that WRN helicase is involved in the maintenance of chromosome stability through actions in DNA, e.g., DNA replication, repair, recombination, and epigenetic regulation via interaction with DNA repair factors, telomere-binding proteins, histone modification enzymes, and other DNA metabolic factors. However, although these efforts have elucidated the cellular functions of the helicase in cell lines, they have not been linked to the treatment of the disease. …”
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3-O-Methylfunicone, a Selective Inhibitor of Mammalian Y-Family DNA Polymerases from an Australian Sea Salt Fungal Strain by Fumio Sugawara, Hiromi Yoshida, Ken Hirano, Toshifumi Takeuchi, Yasuhiro Yamaguchi, Yoshiyuki Mizushina, Hirohisa Motoshima

“…On the other hand, the compound barely influenced the activities of the other families of mammalian pols, such as A-family (i.e., pol γ), B-family (i.e., pols α, δ and ε) or X-family (i.e., pols β, λ and terminal deoxynucleotidyl transferase), and showed no effect on the activities of fish pol δ, plant pols, prokaryotic pols and other DNA metabolic enzymes, such as calf primase of pol α, human immunodeficiency virus type-1 (HIV-1) reverse transcriptase, human telomerase, T7 RNA polymerase, mouse IMP dehydrogenase (type II), human topoisomerases I and II, T4 polynucleotide kinase or bovine deoxyribonuclease I. …”
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