Inhibition of Topoisomerases by Metal Thiosemicarbazone Complexes by Xiaohua Jiang, Lauren A. Fielding, Hunter Davis, William Carroll, Edward C. Lisic, Joseph E. Deweese

“…Topoisomerases, common targets for anti-cancer therapeutics, are crucial enzymes for DNA replication, transcription, and many other aspects of DNA metabolism. The potential anti-cancer effects of thiosemicarbazones (TSC) and metal–TSC complexes have been demonstrated to target several biological processes, including DNA metabolism. …”
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The binary protein interactome of Treponema pallidum--the syphilis spirochete. by Björn Titz, Seesandra V Rajagopala, Johannes Goll, Roman Häuser, Matthew T McKevitt, Timothy Palzkill, Peter Uetz

“…To derive further biological insights from our data, we constructed an integrated network of proteins involved in DNA metabolism. Combining our data with additional evidences, we provide improved annotations for at least 18 proteins (including TP0004, TP0050, and TP0183 which are suggested to be involved in DNA metabolism). …”
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Directed Evolution of RecA Variants with Enhanced Capacity for Conjugational Recombination. by Taejin Kim, Sindhu Chitteni-Pattu, Benjamin L Cox, Elizabeth A Wood, Steven J Sandler, Michael M Cox

“…RecA regulation by RecX protein is important in maintaining an optimal balance between recombination and other aspects of DNA metabolism.…”
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The p14ARF alternate reading frame protein enhances DNA binding of topoisomerase I by interacting with the serine 506-phosphorylated core domain. by Keya Bandyopadhyay, Pingchuan Li, Ruth A Gjerset

“…Because the ARF-topo I interaction could be highly relevant to DNA metabolism and cancer treatment, we identified the regions of topo I involved in ARF binding and characterized the effects of ARF binding on topo I function. …”
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Unlocking the antibacterial potential of xanthone from calophyllum species: inhibition of nucleic acid synthesis by Abang Heilman, Dayang Nurul Anisa, Hui, Audrey Yong Chee, Mian, Vivien Jong Yi, Ahmad, Fasihuddin Badruddin

“…Topoisomerase enzymes (DNA gyrase and topoisomerase IV) are DNA metabolism enzymes that possess distinct roles as unlinking enzymes during DNA replication. …”

Active DNA end processing in micronuclei of ovarian cancer cells by Zizhi Tang, Juan Yang, Xin Wang, Ming Zeng, Jing Wang, Ao Wang, Mingcai Zhao, Liandi Guo, Cong Liu, Dehua Li, Jie Chen

“…We also show that MN compartments do not halt controlled DNA metabolism as sequestered nuclear repair factors are enriched at DNA breaks in MN compartments and efficiently process DNA ends to generate single-stranded DNA (ssDNA) structures. …”
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DNA ligase 1 deficient plants display severe growth defects and delayed repair of both DNA single and double strand breaks by Bray Clifford M, Provost Claire M, Kozak Jaroslav, Waterworth Wanda M, Angelis Karel J, West Christopher E

“…Eukaryotes possess multiple DNA ligases with distinct roles in DNA metabolism, with clear differences in the functions of DNA ligase orthologues between animals, yeast and plants. …”
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High atomic weight, high-energy radiation (HZE) induces transcriptional responses shared with conventional stresses in addition to a core DSB response specific to clastogenic treat... by Victor eMissirian, Phillip A Conklin, Kevin M Culligan, Neil D Huefner, Anne Bagg Britt

“…The ATM-dependent, DNA metabolism-related transcripts of the DSB response were also induced by other DNA damaging agents, but were not induced by conventional stresses. …”
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A bibliometric analysis of researches on flap endonuclease 1 from 2005 to 2019 by Qiaochu Wei, Jiming Shen, Dongni Wang, Xu Han, Jing Shi, Lei Zhao, Yuee Teng

“…Abstract Background Flap endonuclease 1 (FEN1) is a structure-specific nuclease that plays a role in a variety of DNA metabolism processes. FEN1 is important for maintaining genomic stability and regulating cell growth and development. …”
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Fanconi-Anemia-Associated Mutations Destabilize RAD51 Filaments and Impair Replication Fork Protection by Karina Zadorozhny, Vincenzo Sannino, Ondrej Beláň, Jarmila Mlčoušková, Mário Špírek, Vincenzo Costanzo, Lumír Krejčí

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RAD51: beyond the break by Wassing, IE, Esashi, F

“…With recent advances in the understanding of RAD51 function extending beyond DSBs, the importance of RAD51 throughout DNA metabolism has become increasingly clear. Here we review the suggested roles of RAD51 beyond HR, specifically focusing on their interplay with DNA replication and the maintenance of genomic stability, in which RAD51 function emerges as a double-edged sword.…”

The importance of repairing stalled replication forks. by Cox, M, Goodman, M, Kreuzer, K, Sherratt, D, Sandler, S, Marians, K

“…The pathways for fork reactivation involve the homologous recombination systems, are nonmutagenic, and integrate almost every aspect of DNA metabolism. On a frequency-of-use basis, these pathways represent the main function of bacterial DNA recombination systems, as well as the main function of a number of other enzymatic systems that are associated with replication and site-specific recombination.…”

A transgenic cell line with inducible transcription for studying (CGG)n repeat expansion mechanisms by I. V. Grishchenko, A. A. Tulupov, Y. M. Rymareva, E. D. Petrovskiy, A. A. Savelov, A. M. Korostyshevskaya, Y. V. Maksimova, A. R. Shorina, E. M. Shitik, D. V. Yudkin

“…It is proposed that these DNA secondary structures can block various stages of DNA metabolism processes, such as replication, repair and recombination and it is considered as the source of repeat instability. …”
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Genomic Characterisation of UFJF_PfDIW6: A Novel Lytic <i>Pseudomonas fluorescens</i>-Phage with Potential for Biocontrol in the Dairy Industry by Humberto Moreira Hungaro, Pedro Marcus Pereira Vidigal, Edilane Cristina do Nascimento, Felipe Gomes da Costa Oliveira, Marco Túlio Pardini Gontijo, Maryoris Elisa Soto Lopez

“…Nevertheless, UFJF_PfDIW6’s genome was organised into five functional modules: DNA packaging, structural proteins, DNA metabolism, lysogenic, and host lysis. Comparative genome analysis revealed that the UFJF_PfDIW6’s genome is distinct from other viral genomes available at NCBI databases, displaying maximum coverages of 5% among all alignments. …”
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Moonlighting Proteins: Diverse Functions Found in Fungi by Nicole J. Curtis, Krupa J. Patel, Amina Rizwan, Constance J. Jeffery

“…In this mini-review we discuss examples of moonlighting proteins in fungi that illustrate their roles in transcription and DNA metabolism, translation and RNA metabolism, protein folding, and regulation of protein function, and their interaction with other cell types and host proteins.…”
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Remodeler Catalyzed Nucleosome Repositioning: Influence of Structure and Stability by Aaron Morgan, Sarah LeGresley, Christopher Fischer

“…The packaging of the eukaryotic genome into chromatin regulates the storage of genetic information, including the access of the cell’s DNA metabolism machinery. Indeed, since the processes of DNA replication, translation, and repair require access to the underlying DNA, several mechanisms, both active and passive, have evolved by which chromatin structure can be regulated and modified. …”
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Analysis of replication intermediates indicates that Drosophila melanogaster mitochondrial DNA replicates by a strand-coupled theta mechanism. by Priit Jõers, Howard T Jacobs

“…Our findings imply that strand-coupled replication is widespread amongst metazoans, and should inform future research on mtDNA metabolism in D. melanogaster.…”
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Need telomere maintenance? Call 911 by d'Adda di Fagagna Fabrizio, Weiss Robert S, Francia Sofia

“…We recently observed that the Rad9/Hus1/Rad1 (911) complex, previously known for its functions in DNA metabolism and DNA damage responses, is constitutively associated with telomeres and plays an important role in their maintenance. …”
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High-Copy Overexpression Screening Reveals PDR5 as the Main Doxorubicin Resistance Gene in Yeast. by Ayse Banu Demir, Ahmet Koc

“…Our results suggest that many efflux pumps and DNA metabolism genes are upregulated by the drug and required for doxorubicin tolerance.…”
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Data on cell cycle in breast cancer cell line, MDA-MB-231 with ferulic acid treatment by Eunmi Park

“…Inhibition to repair DNA metabolism to respond to damaged DNA can lead to genetic instability, resulting in cancer cell death (Audeh et al., 2010; Bryant et al., 2005; Farmer et al., 2005; Lukas et al., 2003; Tutt et al., 2010) [1,2,6,8,11]. …”
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