DNA lesions and repair in trypanosomatids infection by Bruno M. Repolês, Carlos Renato Machado, Pilar T.V. Florentino

“…The effects of the host response on the parasite lead to several kinds of DNA damage, causing alterations in the parasite’s metabolism; the reaction and sensitivity of the parasite to these responses are related to the DNA metabolism and life cycle of each parasite. The present review will discuss the survival strategies developed by host cells and Trypanosoma cruzi, focusing on the DNA repair mechanisms of these organisms throughout infection including the relationship between DNA damage, stress response features, and the unique characteristics of these diseases.…”
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Role of the Checkpoint Clamp in DNA Damage Response by Mihoko Kai

“…As PCNA is required for multiple pathways of DNA metabolism, the checkpoint clamp has also been implicated in direct roles in DNA repair, as well as in coordination of the pathways. …”
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R-loop mediated transcription-associated recombination in trf4Δ mutants reveals new links between RNA surveillance and genome integrity. by Sandra Gavaldá, Mercedes Gallardo, Rosa Luna, Andrés Aguilera

“…Altogether our data indicate that Trf4 is necessary for both mRNA surveillance and maintenance of genome integrity, serving as a link between RNA and DNA metabolism in S. cerevisiae.…”
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Impaired DNA replication within progenitor cell pools promotes leukemogenesis.

“…The demonstration that replication-impaired, poorly competitive progenitor cell pools can promote tumorigenesis provides a new rationale for links between tumorigenesis and common human conditions of impaired DNA replication such as dietary folate deficiency, chemotherapeutics targeting dNTP synthesis, and polymorphisms in genes important for DNA metabolism.…”
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Visualizing genetic loci and molecular machines in living bacteria. by Wang, X, Reyes-Lamothe, R, Sherratt, D

“…We review the development and exploitation of new visualization methods and reagents and show how they are contributing to the understanding of bacterial structure, chromosome organization, DNA metabolism and their relationship to the cell cycle.…”

Identification and characterization of in vivo attenuated mutants of Brucella melitensis. by Lestrate, P, Delrue, R, Danese, I, Didembourg, C, Taminiau, B, Mertens, P, De Bolle, X, Tibor, A, Tang, C, Letesson, J

“…The sequences disrupted by the transposon in the mutants have homology to genes coding for proteins of different functional classes: transport, amino acid and DNA metabolism, transcriptional regulation, peptidoglycan synthesis, a chaperone-like protein and proteins of unknown function. …”

Asymmetry of DNA replication fork progression in Werner's syndrome. by Rodríguez-López, A, Jackson, D, Iborra, F, Cox, L

“…Although the biochemical properties of WRN protein, which possesses both helicase and exonuclease activities, suggest an involvement in DNA metabolism, its action in cells is not clear. Here, we provide experimental evidence for a role of the WRN protein in DNA replication in normally proliferating cells. …”

QUANTITATIVE PARAMETERS OF NUCLEAR AND FREE CELL DNA IN NEWBORN BABIES WITH CLINICAL MANIFESTATIONS OF ADAPTATION DERANGEMENT IN EARLY NEONATAL PERIOD by V.V. Sofronov, N.O. Tuaeva, V.G. Vinter, V.A. Emikeeva, D.I. Shegurova, E.V. Mavrina

“…In all cases the disorders of a DNA metabolism was obtained. However, the greatest divergence of all investigated parameters was founded in newborns with neonatal pneumo pathy. …”
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Targeting the DNA damage response and repair in cancer through nucleotide metabolism by Thomas Helleday, Sean G. Rudd

“…These same pathways also activate antimetabolites, an important group of chemotherapies that disrupt both nucleotide and DNA metabolism to induce DNA damage in cancer cells. Thus, dNTP metabolic enzymes can also be targeted to refine the use of these chemotherapeutics, many of which remain standard of care in common cancers. …”
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QUANTITATIVE PARAMETERS OF NUCLEAR AND FREE CELL DNA IN NEWBORN BABIES WITH CLINICAL MANIFESTATIONS OF ADAPTATION DERANGEMENT IN EARLY NEONATAL PERIOD by V.V. Sofronov, N.O. Tuaeva, V.G. Vinter, V.A. Emikeeva, D.I. Shegurova, E.V. Mavrina

“…In all cases the disorders of a DNA metabolism was obtained. However, the greatest divergence of all investigated parameters was founded in newborns with neonatal pneumo pathy. …”
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Cell cycle-regulated protein abundance changes in synchronously proliferating HeLa cells include regulation of pre-mRNA splicing proteins. by Karen R Lane, Yanbao Yu, Patrick E Lackey, Xian Chen, William F Marzluff, Jeanette Gowen Cook

“…Cell proliferation involves dramatic changes in DNA metabolism and cell division, and control of DNA replication, mitosis, and cytokinesis have received the greatest attention in the cell cycle field. …”
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Targeting the BRCA1/2 deficient cancer with PARP inhibitors: Clinical outcomes and mechanistic insights by Ashwin Ragupathi, Manrose Singh, Alexis M. Perez, Dong Zhang

“…BRCA1 and BRCA2 play a critical role in a variety of molecular processes related to DNA metabolism, including homologous recombination and mediating the replication stress response. …”
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Evolution of the Insertion-Deletion Mutation Rate Across the Tree of Life by Way Sung, Matthew S. Ackerman, Marcus M. Dillon, Thomas G. Platt, Clay Fuqua, Vaughn S. Cooper, Michael Lynch

“…Given the substantial differences in DNA metabolism pathways that give rise to these two types of mutations, this consistency of results raises the possibility that refinement of other molecular and cellular traits may be inversely related to species-specific levels of random genetic drift.…”
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The Intriguing Mystery of RPA Phosphorylation in DNA Double-Strand Break Repair by Valerie J. Fousek-Schuller, Gloria E. O. Borgstahl

“…RPA is now known to be involved in all DNA metabolism pathways that involve single-stranded DNA (ssDNA). …”
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Sequencing of seven haloarchaeal genomes reveals patterns of genomic flux. by Erin A Lynch, Morgan G I Langille, Aaron Darling, Elizabeth G Wilbanks, Caitlin Haltiner, Katie S Y Shao, Michael O Starr, Clotilde Teiling, Timothy T Harkins, Robert A Edwards, Jonathan A Eisen, Marc T Facciotti

“…Analysis of genes encoding machinery for DNA metabolism reveals genera-specific expansions of the general transcription factor TATA binding protein as well as a history of extensive duplication and horizontal transfer of the proliferating cell nuclear antigen. …”
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Characterisation and distribution of a cryptic Salmonella typhi plasmid pHCM2. by Kidgell, C, Pickard, D, Wain, J, James, K, Nga, D, Diep, T, Levine, M, O'Gaora, P, Prentice, M, Parkhill, J, Day, N, Farrar, J, Dougan, G

“…Bioinformatic analysis revealed that 57% of the coding sequences (CDSs) encoded on pHCM2 display over 97% DNA sequence identity to the virulence-associated plasmid of Yersinia pestis, pFra. pHCM2 encodes no obvious virulence-associated determinants or antibiotic resistance genes but does encode a wide array of putative genes directly related to DNA metabolism and replication. PCR analysis of a series of S. typhi isolates from Vietnam detected pHCM2-related DNA sequences in some S. typhi isolated before, but not after, 1994. …”

ATR activation and replication fork restart are defective in FANCM-deficient cells by Schwab, R, Blackford, A, Niedzwiedz, W

“…Among the 13 identified FA gene products only one, the DNA translocase FANCM, has homologues in lower organisms, suggesting a conserved function in DNA metabolism. However, a precise role for FANCM in DNA repair remains elusive. …”

ATR activation and replication fork restart are defective in FANCM-deficient cells. by Schwab, R, Blackford, A, Niedzwiedz, W

“…Among the 13 identified FA gene products only one, the DNA translocase FANCM, has homologues in lower organisms, suggesting a conserved function in DNA metabolism. However, a precise role for FANCM in DNA repair remains elusive. …”

DNA ADP-ribosylation stalls replication and is reversed by RecF-mediated homologous recombination and nucleotide excision repair by Lawarée, E, Jankevicius, G, Cooper, C, Ahel, I, Uphoff, S, Tang, CM

“…Despite increasing examples of DNA ADP-ribosylation, the impact of this modification on DNA metabolism and cell physiology is unknown. Here, we show that the DarTG toxin-antitoxin system from enteropathogenic Escherichia coli (EPEC) catalyzes reversible ADP-ribosylation of single-stranded DNA (ssDNA). …”

The dual nature of mismatch repair as antimutator and mutator: for better or for worse by Sara Thornby Bak, Despoina eSakellariou, Javier ePena-Diaz

“…Besides this key corrective role, MMR proteins are involved in other pathways of DNA metabolism such as mitotic and meiotic recombination and processing of oxidative damage. …”
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