Rif1 inhibits replication fork progression and controls DNA copy number in Drosophila by Alexander Munden, Zhan Rong, Amanda Sun, Rama Gangula, Simon Mallal, Jared T Nordman

“…Rif1 has many roles in DNA metabolism and regulates the replication timing program. …”
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The cumulative effects of polymorphisms in the DNA mismatch repair genes and tobacco smoking in oesophageal cancer risk. by Matjaz Vogelsang, Yabing Wang, Nika Veber, Lamech M Mwapagha, M Iqbal Parker

“…The DNA mismatch repair (MMR) enzymes repair errors in DNA that occur during normal DNA metabolism or are induced by certain cancer-contributing exposures. …”
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Protein-tyrosine phosphorylation interaction network in Bacillus subtilis reveals new substrates, kinase activators and kinase cross-talk. by Lei eShi, Lei eShi, Nathalie ePigeonneau, Magali eVentroux, Abderahmane eDerouiche, Abderahmane eDerouiche, Vladimir eBidnenko, Ivan eMijakovic, Ivan eMijakovic, Marie-Françoise eNoirot-Gros

“…Our study highlighted the role of tyrosine and serine/threonine kinases and phosphatases in DNA metabolism, transcriptional control and cell division. …”
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Understanding “Atmosome”, the Personal Atmospheric Exposome: Comprehensive Approach by Hari Bhimaraju, Nitish Nag, Vaibhav Pandey, Ramesh Jain

“…The atmosome plays a pivotal role in health and has significant effects on DNA, metabolism, skin integrity, and lung health. …”
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Escherichia coli Can Eat DNA as an Excellent Nitrogen Source to Grow Quickly by Lili Huang, Yehui Zhang, Xinmei Du, Ran An, Xingguo Liang, Xingguo Liang

“…This study is of great significance to study DNA metabolism and utilization in organisms. It also lays a foundation to understand the nutritional function of DNA in intestinal flora and human health.…”
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Impact of Chromosomal Context on Origin Selection and the Replication Program by Lilian Lanteri, Anthony Perrot, Diane Schausi-Tiffoche, Pei-Yun Jenny Wu

“…Interestingly, the impact of genome reorganization on replication initiation is highly comparable in the post-quiescent and pre-meiotic S phases, despite the differences in DNA metabolism in these two physiological states. Our findings therefore shed new light on how origin selection and the replication program are governed by chromosomal architecture.…”
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Replication Protein A Presents Canonical Functions and Is Also Involved in the Differentiation Capacity of Trypanosoma cruzi. by Raphael Souza Pavani, Marcelo Santos da Silva, Carlos Alexandre Henrique Fernandes, Flavia Souza Morini, Christiane Bezerra Araujo, Marcos Roberto de Mattos Fontes, Osvaldo Augusto Sant'Anna, Carlos Renato Machado, Maria Isabel Cano, Stenio Perdigão Fragoso, Maria Carolina Elias

“…Replication Protein A (RPA), the major single stranded DNA binding protein in eukaryotes, is composed of three subunits and is a fundamental player in DNA metabolism, participating in replication, transcription, repair, and the DNA damage response. …”
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Rad51 Nucleoprotein Filament Disassembly Captured Using Fluorescent Plasmodium falciparum SSB as a Reporter for Single-Stranded DNA. by Eric Parker Davenport, Derek F Harris, Sofia Origanti, Edwin Antony

“…These studies showcase the utility of the Pf-SSB probe in mechanistic investigation of enzymes that function in DNA metabolism.…”
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Revealing genetic diversity, population structure, and selection signatures of the Pacific oyster in Dalian by whole-genome resequencing by Junxia Mao, Ying Tian, Qian Liu, Danyang Li, Xinfan Ge, Xubo Wang, Zhenlin Hao

“…Investigation of genome-wide selection signatures of these populations identified many selected genes involved in the biological processes related to DNA metabolism and stability, shell formation, and environmental stress response, which may be critical for oysters to adapt to the stressful environments.DiscussionThis study laid theoretical basis for the subsequent germplasm conservation, management and genetic breeding of the indigenous Pacific oysters, and provided novel insights for the adaptive evolutionary mechanism of oysters.…”
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Hypomorphic PCNA mutation underlies a human DNA repair disorder by Baple, E, Chambers, H, Cross, H, Fawcett, H, Nakazawa, Y, Chioza, B, Harlalka, G, Mansour, S, Sreekantan-Nair, A, Patton, M, Muggenthaler, M, Rich, P, Wagner, K, Coblentz, R, Stein, C, Last, J, Taylor, A, Jackson, A, Ogi, T, Lehmann, A, Green, C, Crosby, A

“…The p.Ser228Ile change also profoundly altered PCNA's interaction with Flap endonuclease 1 and DNA Ligase 1, DNA metabolism enzymes. Together, our findings detail a mutation of PCNA in humans associated with a neurodegenerative phenotype, displaying clinical and molecular features common to other DNA repair disorders, which we showed to be attributable to a hypomorphic amino acid alteration.…”

Thirty Years with ERH: An mRNA Splicing and Mitosis Factor Only or Rather a Novel Genome Integrity Protector? by Piotr Kozlowski

“…There are, however, some common themes in this wide range of processes and partners, such as: (a) ERH homodimerizes to form a scaffold for several complexes involved in the metabolism of nucleic acids, (b) all these RNAs are RNA polymerase II transcripts, (c) pre-mRNAs, whose splicing depends on ERH, are enriched in transcripts of DNA damage response and DNA metabolism genes, and (d) heterochromatin is formed to silence unwanted transcription, e.g., from repetitive elements. …”
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Evolutionary genomics of APSE: a tailed phage that lysogenically converts the bacterium Hamiltonella defensa into a heritable protective symbiont of aphids by Bret M. Boyd, Germain Chevignon, Vilas Patel, Kerry M. Oliver, Michael R. Strand

“…Gene content and order were near-fully conserved in modules 1 and 2, which encode predicted DNA metabolism genes, and module 4, which encodes predicted virion assembly genes. …”
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Topoisomerase 3alpha and RMI1 suppress somatic crossovers and are essential for resolution of meiotic recombination intermediates in Arabidopsis thaliana. by Frank Hartung, Stefanie Suer, Alexander Knoll, Rebecca Wurz-Wildersinn, Holger Puchta

“…Topoisomerases are enzymes with crucial functions in DNA metabolism. They are ubiquitously present in prokaryotes and eukaryotes and modify the steady-state level of DNA supercoiling. …”
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RNA profiles of porcine embryos during genome activation reveal complex metabolic switch sensitive to in vitro conditions. by Olga Østrup, Gayla Olbricht, Esben Østrup, Poul Hyttel, Philippe Collas, Ryan Cabot

“…Following EGA an increase in the abundance of transcripts involved in transcription, translation, DNA metabolism, histone and chromatin modification, as well as protein catabolism was detected. …”
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RECQL5 plays an essential role in maintaining genome stability and viability of triple‐negative breast cancer cells by Jin Peng, Lichun Tang, Mengjiao Cai, Huan Chen, Jiemin Wong, Pumin Zhang

“…Consequently, we found that RECQL5, which encodes a RecQ family DNA helicase involved in many aspects of DNA metabolism including replication and repair, was essential for TNBC cells to survive and proliferate in vitro and in vivo. …”
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Long term culture of mesenchymal stem cells in hypoxia promotes a genetic program maintaining their undifferentiated and multipotent status by de Carvalho Marcelo, de Isla Natalia, Foliguet Bernard, Nemos Christophe, Basciano Leticia, Tran Nguyen, Dalloul Ali

“…In parallel, MSC displayed (>4 fold) inhibition of genes involved in DNA metabolism, cell cycle progression and chromosome cohesion whereas transcripts involved in adhesion and metabolism (CD93, ESAM, VWF, PLVAP, ANGPT2, LEP, TCF1) were stimulated. …”
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NMR Structure and Biophysical Characterization of Thermophilic Single-Stranded DNA Binding Protein from <i>Sulfolobus Solfataricus</i> by Min June Yang, Jinwoo Kim, Yeongjoon Lee, Woonghee Lee, Chin-Ju Park

“…The single-stranded DNA (ssDNA) binding protein of <i>S. solfataricus</i> (SsoSSB) is overexpressed to protect ssDNA during DNA metabolism. Although SsoSSB has the potential to be applied in various areas, its structural and ssDNA binding properties at high temperatures have not been studied. …”
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Telomere length regulation by Rif1 protein from Hansenula polymorpha by Alexander N Malyavko, Olga A Petrova, Maria I Zvereva, Vladimir I Polshakov, Olga A Dontsova

“…Rif1 is a large multifaceted protein involved in various processes of DNA metabolism – from telomere length regulation and replication to double-strand break repair. …”
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Topoisomerase 3β interacts with RNAi machinery to promote heterochromatin formation and transcriptional silencing in Drosophila by Seung Kyu Lee, Yutong Xue, Weiping Shen, Yongqing Zhang, Yuyoung Joo, Muzammil Ahmad, Madoka Chinen, Yi Ding, Wai Lim Ku, Supriyo De, Elin Lehrmann, Kevin G. Becker, Elissa P. Lei, Keji Zhao, Sige Zou, Alexei Sharov, Weidong Wang

“…Topoisomerases solve topological problems during DNA metabolism, but their role in RNA metabolism remains unclear. …”
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A Retrospective Study on Genetic Heterogeneity within Treponema Strains: Subpopulations Are Genetically Distinct in a Limited Number of Positions. by Darina Čejková, Michal Strouhal, Steven J Norris, George M Weinstock, David Šmajs

“…Heterogeneous sites were mostly strain-specific and were identified in four tpr genes (tprC, GI, I, K), in genes involved in bacterial motility and chemotaxis (fliI, cheC-fliY), in genes involved in cell structure (murC), translation (prfA), general and DNA metabolism (putative SAM dependent methyltransferase, topA), and in seven hypothetical genes.Heterogeneous sites likely represent both the selection of adaptive changes during infection of the host as well as an ongoing diversifying evolutionary process.…”
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