Inflammatory regulatory network mediated by the joint action of NF-kB, STAT3, and AP-1 factors is involved in many human cancers by Regev, Aviv

“…Conversely, the cancer inflammation index is negatively correlated with the expression of genes involved in DNA metabolism, and transformation is associated with genome instability. …”
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Mesenchymal stem cells preserve their stem cell traits after exposure to antimetabolite chemotherapy by Ramon Lopez Perez, Franziska Münz, Denise Vidoni, Alexander Rühle, Thuy Trinh, Sonevisay Sisombath, Bingwen Zou, Patrick Wuchter, Jürgen Debus, Anca-Ligia Grosu, Rainer Saffrich, Peter E. Huber, Nils H. Nicolay

“…High expression levels of enzymes involved in DNA metabolism and multidrug resistance transporters may contribute to the resistance to antimetabolite chemotherapy. …”
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Metacyclogenesis defects and gene expression hallmarks of histone deacetylase 4-deficient Trypanosoma cruzi cells by Gisele Fernanda Assine Picchi-Constante, Eloise Pavão Guerra-Slompo, Ana Carolina Tahira, Monica Visnieski Alcantara, Murilo Sena Amaral, Arthur Schveitzer Ferreira, Michel Batista, Cassiano Martin Batista, Samuel Goldenberg, Sergio Verjovski-Almeida, Nilson Ivo Tonin Zanchin

“…Chromatin-modifying enzymes have a direct impact on gene expression programs and DNA metabolism. In this work, we have investigated the function of T. cruzi histone deacetylase 4 (TcHDAC4). …”
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Genomic Instability of G-Quadruplex Sequences in <i>Escherichia coli</i>: Roles of DinG, RecG, and RecQ Helicases by Virali J. Parekh, Grzegorz Węgrzyn, Véronique Arluison, Richard R. Sinden

“…Originally identified in sequences from telomeres and oncogene promoters, they can alter DNA metabolism. Indeed, G4-forming sequences represent obstacles for the DNA polymerase, with important consequences for cell life as they may lead to genomic instability. …”
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Quantitative trait loci mapping reveals candidate pathways regulating cell cycle duration in <it>Plasmodium falciparum</it> by Siwo Geoffrey, Wacker Mark A, Reilly Ayala Heather B, Ferdig Michael T

“…Putative functions were assigned to the prioritized genes based on protein interaction networks and expression eQTL from our earlier study. DNA metabolism or antigenic variation functional categories were enriched among our prioritized candidate genes. …”
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Temporal Stability and Genetic Diversity of 48-Year-Old T-Series Phages by Dinesh Subedi, Jeremy J. Barr

“…Genomic analysis predicted nucleotide variations in genes associated with DNA metabolism and structural proteins. We did not, however, observe any differences in growth characteristics or host range between the T4 sublines. …”
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Proteomics of Trypanosoma evansi infection in rodents. by Nainita Roy, Rishi Kumar Nageshan, Rani Pallavi, Harshini Chakravarthy, Syama Chandran, Rajender Kumar, Ashok Kumar Gupta, Raj Kumar Singh, Suresh Chandra Yadav, Utpal Tatu

“…Proteins identified belonged to various functional categories including metabolic enzymes; DNA metabolism; transcription; translation as well as cell-cell communication and signal transduction. …”
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Using Selective Enzymes to Measure Noncanonical DNA Building Blocks: dUTP, 5-Methyl-dCTP, and 5-Hydroxymethyl-dCTP by Éva Viola Surányi, Viktória Perey-Simon, Rita Hirmondó, Tamás Trombitás, Latifa Kazzazy, Máté Varga, Beáta G. Vértessy, Judit Tóth

“…This approach provides a more precise understanding of the composition and noncanonical constituents of dNTP pools, facilitating a deeper comprehension of DNA metabolism and repair. It is also crucial for accurately interpreting mutational patterns generated through the next-generation sequencing of biological samples.…”
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The repair gene <em>BACH1</em> - a potential oncogene by Katheeja Muhseena N, Sooraj Mathukkada, Shankar Prasad Das, Suparna Laha

“…The N-terminus of BACH1 functions in DNA metabolism as DNA-dependent ATPase and helicase. The C-terminus consists of BRCT domain, which interacts with BRCA1 and this interaction is one of the major regulator of BACH1 function. …”
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The yeast mitogen-activated protein kinase Slt2 is involved in the cellular response to genotoxic stress by Soriano-Carot María, Bañó M Carmen, Igual J Carlos

“…However, different observations suggest that <it>SLT2 </it>may also have a role related to DNA metabolism.</p> <p>Results</p> <p>This work consisted in a comprehensive study to connect the Slt2 protein to genome integrity maintenance in response to genotoxic stresses. …”
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DNA ADP-Ribosylation Stalls Replication and Is Reversed by RecF-Mediated Homologous Recombination and Nucleotide Excision Repair by Emeline Lawarée, Gytis Jankevicius, Charles Cooper, Ivan Ahel, Stephan Uphoff, Christoph M. Tang

“…Despite increasing examples of DNA ADP-ribosylation, the impact of this modification on DNA metabolism and cell physiology is unknown. Here, we show that the DarTG toxin-antitoxin system from enteropathogenic Escherichia coli (EPEC) catalyzes reversible ADP-ribosylation of single-stranded DNA (ssDNA). …”
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Development and Properties of <i>Francisella tularensis</i> Subsp. <i>holarctica</i> 15 NIIEG Vaccine Strain without the <i>recD</i> Gene by Vitaly Pavlov, Galina Vakhrameeva, Alexander Mokrievich, Mikhail E. Platonov, Galina Titareva, Raisa Mironova, Tatiana Kombarova, Tatiana Gapelchenkova, Ivan Dyatlov

“…To date, the role of the <i>recD</i> gene in <i>F. tularensis</i>, which encodes the alpha chain of exonuclease V, in DNA metabolism processes, has not been studied either in vitro or in vivo. …”
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The Multifaceted Roles of Ku70/80 by Sayma Zahid, Murielle Seif El Dahan, Florence Iehl, Paloma Fernandez-Varela, Marie-Helene Le Du, Virginie Ropars, Jean Baptiste Charbonnier

“…Beyond its DNA repair function, Ku is also involved in several other DNA metabolism processes. Here, we review the structural and functional data on the DNA and RNA recognition properties of Ku implicated in DNA repair and in telomeres maintenance.…”
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Quantitative Trait Locus Mapping Combined with RNA Sequencing Reveals the Molecular Basis of Seed Germination in Oilseed Rape by Kunjiang Yu, Yuqi He, Yuanhong Li, Zhenhua Li, Jiefu Zhang, Xiaodong Wang, Entang Tian

“…Transcriptome analysis revealed that the differences in sugar, protein, lipid, amino acid, and DNA metabolism and the TCA cycle, electron transfer, and signal transduction potentially determined the higher germination rate of ‘Holly’ seeds. …”
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iPSC reprogramming of fibroblasts from a patient with a Rothmund-Thomson syndrome RTS by Vincent Gatinois, Romain Desprat, Lydiane Pichard, Fabienne Becker, Alice Goldenberg, Xavier Balguerie, Franck Pellestor, Jean-Marc Lemaitre

“…RECQL4 belongs to the RECQ DNA helicase family which has been shown to participate in many aspects of DNA metabolism. To be able to study the cellular defects related to the pathology, we derived an induced pluripotent cell line from RTS patient fibroblasts, with the ability to re-differentiate into the three embryonic germ layers.…”
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Target genes of myostatin loss-of-function in muscles of late bovine fetuses by Hocquette Jean-François, Léger Jean, Bernard Carine, Passelaigue Florent, Cassar-Malek Isabelle

“…The genes up-regulated in DM fetuses were mainly involved in the regulation of transcription, cell cycle/apoptosis, translation or DNA metabolism. These data highlight features indicating that DM muscle is shifted towards a more glycolytic metabolism, and has an altered extracellular matrix composition (e.g. down-regulation of <it>COL1A1 </it>and <it>COL1A2</it>, and up-regulation of <it>COL4A2</it>) and decreased adipocyte differentiation (down-regulation of <it>C1QTNF3</it>). …”
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A functional oriT in the Ptw plasmid of Burkholderia cenocepacia can be recognized by the R388 relaxase TrwC by Esther eFernandez-Gonzalez, Sawsane eBakioui, Margarida eGomes, David eO'Callaghan, Annette eVergunst, Felix eSangari, Matxalen eLlosa

“…However, genes in the adjacent region shared stronger homology with the R388 genes involved in conjugative DNA metabolism. This region included the putative relaxase ptwC, a putative coupling protein and accessory nicking protein, and a DNA segment with high number of inverted repeats and elevated AT content, suggesting a possible oriT. …”
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Survival-related genes are diversified across cancers but generally enriched in cancer hallmark pathways by Po-Wen Wang, Yi-Hsun Su, Po-Hao Chou, Ming-Yueh Huang, Ting-Wen Chen

“…While these SRGs were unique to each cancer type, they were found mostly enriched in cancer hallmark pathways, e.g., cell proliferation, cell differentiation, DNA metabolism, and RNA metabolism. We also analyzed the association between cancer driver genes and SRGs and did not find significant over-representation amongst most cancers. …”
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Concentration-dependent exchange of replication protein A on single-stranded DNA revealed by single-molecule imaging. by Bryan Gibb, Ling F Ye, Stephanie C Gergoudis, YoungHo Kwon, Hengyao Niu, Patrick Sung, Eric C Greene

“…Replication protein A (RPA) is a ubiquitous eukaryotic single-stranded DNA (ssDNA) binding protein necessary for all aspects of DNA metabolism involving an ssDNA intermediate, including DNA replication, repair, recombination, DNA damage response and checkpoint activation, and telomere maintenance. …”
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SUMO: A Swiss Army Knife for Eukaryotic Topoisomerases by Yilun Sun, John L. Nitiss, Yves Pommier

“…Topoisomerases play crucial roles in DNA metabolism that include replication, transcription, recombination, and chromatin structure by manipulating DNA structures arising in double-stranded DNA. …”
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