The relationship between DNA modifications and mutations in cancer by Tomkova, M

“…In conclusion, our results suggest that DNA replication or replication-associated DNA repair interacts with most mutagenic processes.…”

Characterisation of DNA polymerase δ exonuclease domain mutations associated with cancer predisposition using fission yeast by Toumazou, SI

“…Pol3(d)L474P had a moderate mutator phenotype, and pol3(d)P327L and pol3(d)G321S did not have increased mutation rates compared to wild type but showed hydroxyurea (HU) sensitivity, suggesting that DNA replication under stressful conditions is defective.…”

Investigating the role of ERCC6L2 in the DNA damage response by Carnie, C

“…Interestingly, ERCC6L2-/- cells also display a profound defect in DNA replication upon genotoxic treatment. Importantly, this defect is rescued by overexpression of wild-type ERCC6L2 but not by overexpression of a catalytic-dead mutant. …”

Cytoplasmic poly(A) polymerases mediate cellular responses to S phase arrest by Read, R, Martinho, R, Wang, S, Carr, A, Norbury, C

“…The S-M checkpoint delays mitosis until DNA replication is complete; cells defective in this checkpoint lose viability when DNA replication is inhibited. …”

Deregulated expression of mammalian lncRNA through loss of SPT6 induces R-Loop formation, replication stress, and cellular senescence by Nojima, T, Tellier, M, Foxwell, J, Ribeiro de Almeida, C, Mei Tan-Wong, S, Dhir, S, Dujardin, G, Dhir, A, Murphy, S, Proudfoot, N

“…Additionally, these deregulated lncRNAs overlap with DNA replication origins leading to localized DNA replication stress and a cellular senescence phenotype. …”

Cid1, a fission yeast protein required for S-M checkpoint control when DNA polymerase delta or epsilon is inactivated. by Wang, S, Toda, T, MacCallum, R, Harris, A, Norbury, C

“…The S-M checkpoint is an intracellular signaling pathway that ensures that mitosis is not initiated in cells undergoing DNA replication. We identified cid1, a novel fission yeast gene, through its ability when overexpressed to confer specific resistance to a combination of hydroxyurea, which inhibits DNA replication, and caffeine, which overrides the S-M checkpoint. …”

Monitoring homologous recombination following replication fork perturbation in the fission yeast Schizosaccharomyces pombe. by Osman, F, Whitby, M

“…Importantly, direct repeat recombinants appear to arise predominantly during DNA replication via sister chromatid interactions and are induced by factors that perturb RFs. …”

BMP signaling promotes zebrafish heart regeneration via alleviation of replication stress by Vasudevarao, MD, Posadas Pena, D, Ihle, M, Bongiovanni, C, Maity, P, Geissler, D, Mohammadi, HF, Rall-Scharpf, M, Niemann, J, Mommersteeg, MTM, Redaelli, S, Happ, K, Wu, C, Beisaw, A, Scharffetter-Kochanek, K, D’Uva, G, Malek Mohammadi, M, Wiesmüller, L, Geiger, H, Weidinger, G

“…Surprisingly, we found that regenerating cardiomyocytes experience DNA replication stress, which represents one reason for declining tissue regeneration during aging in mammals. …”

Cell cycle: who turns the crank? by Tyson, J, Novak, B

“…The oscillating activity of a single CDK-cyclin fusion protein can drive the orderly progression of yeast cells through DNA replication, mitosis and cell division.…”

The role of Orc6 in ORC binding-site switching during helicase loading by Driscoll, David

“…DNA replication is a fundamental cellular process that enables proper maintenance of genomic integrity and cellular identity as cells divide. …”
Get full text
Get full text

Regulation of cell fate asymmetry in Caulobacter crescentus by a complex of two component signaling proteins by Tsokos, Christos G

Get full text

Identification of a functionally relevant adeno-associated virus Rep68 oligomeric interface. by Bardelli, M, Zárate-Pérez, F, Agúndez, L, Linden, R, Escalante, C, Henckaerts, E

“…The Rep68 protein from adeno-associated virus (AAV) combines a DNA binding and endonuclease domain with a helicase-ATPase domain, which together support DNA replication, transcriptional regulation, and site-specific integration. …”

The role of histone modification in DNA double-strand break repair in Schizosaccharomyces pombe by Deegan, R

“…However, this altered progression of DNA replication was not responsible for the repair phenotype seen. …”

Meiosis I: when chromosomes undergo extreme makeover by Amon, Angelika B., Unal, Elcin, Miller, Matthew P.

“…In mitosis, alternating rounds of DNA replication and chromosome segregation preserve the chromosome complement of the progenitor cell. …”
Get full text
Get full text

Chromosome Duplication in Saccharomyces cerevisiae by Labib, K., Bell, Stephen P

“…Here, we review our increasingly molecular understanding of these events and their regulation. Keywords: DNA replication; cell cycle; chromatin; chromosome duplication; genome stability; YeastBook…”
Get full text
Get full text

Activation of a signaling pathway by the physical translocation of a chromosome by Guzzo, Mathilde, Sanderlin, Allen G, Castro, Lennice K, Laub, Michael T

“…Consequently, any disruption to DNA replication initiation prevents ChpT polarization and, in turn, cell division. …”
Get full text

A role for the Speedy gene family in the early stages of mammalian meiosis by Lopez-Molina, Javier

Get full text

Hypomorphic PCNA mutation underlies a human DNA repair disorder. by Baple, E, Chambers, H, Cross, H, Fawcett, H, Nakazawa, Y, Chioza, B, Harlalka, G, Mansour, S, Sreekantan-Nair, A, Patton, M, Muggenthaler, M, Rich, P, Wagner, K, Coblentz, R, Stein, C, Last, J, Taylor, A, Jackson, A, Ogi, T, Lehmann, A, Green, C, Crosby, A

“…PCNA is a highly conserved sliding clamp protein essential for DNA replication and repair. Due to this fundamental role, mutations in PCNA that profoundly impair protein function would be incompatible with life. …”

Cytoplasmic poly(A) polymerases mediate cellular responses to S phase arrest. by Read, R, Martinho, R, Wang, S, Carr, A, Norbury, C

“…The S-M checkpoint delays mitosis until DNA replication is complete; cells defective in this checkpoint lose viability when DNA replication is inhibited. …”

p53 prevents entry into mitosis with uncapped telomeres. by Thanasoula, M, Escandell, J, Martinez, P, Badie, S, Muñoz, P, Blasco, M, Tarsounas, M

“…These results suggest that a p53-dependent pathway monitors telomere capping after DNA replication and delays G2/M progression in the presence of unprotected telomeres. …”