DNA replication licensing and cell cycle kinetics of normal and neoplastic breast. by Shetty, A, Loddo, M, Fanshawe, T, Prevost, A, Sainsbury, R, Williams, G, Stoeber, K

“…Mcm2-7 (MCM) proteins are part of the origin licensing machinery that regulates initiation of DNA replication. Geminin is a licensing repressor and prevents reinitiation of DNA replication during S-G2-M phase by blocking reloading of Mcm2-7 at replication origins. …”

E2F1: Cause and consequence of DNA replication stress by Fouad, S, Hauton, D, D'Angiolella, V

“…Despite a clear link between dysregulated E2F1 activity and cancer progression, literature on the contribution of E2F1 to DNA replication stress phenotypes is somewhat scarce. …”

DNAReplication: a database of information and resources for the eukaryotic DNA replication community by Cotterill, S, Kearsey, S

“…Replication concepts are defined and a general model of the steps in DNA replication is presented. Links to relevant websites and homepages of replication labs are provided. …”

DNAReplication: a database of information and resources for the eukaryotic DNA replication community. by Cotterill, S, Kearsey, S

“…Replication concepts are defined and a general model of the steps in DNA replication is presented. Links to relevant websites and homepages of replication labs are provided. …”

The role of p97 cofactors SPRTN and FAF1 in DNA replication by Halder, S

“…This thesis explains novel function of two bonafide p97 cofactors SPRTN and FAF1 in DNA replication.</p> <p>Our discovery of a new human syndrome followed by its characterisation that monogenic and biallelic mutations in SPRTN leads to premature aging and juvenile hepatocellular carcinoma, have led us to identify the critical function of SPRTN in DNA replication. …”

Sequential steps in DNA replication are inhibited to ensure reduction of ploidy in meiosis. by Hua, H, Namdar, M, Ganier, O, Gregan, J, Méchali, M, Kearsey, S

“…The absence of licensing is assumed to explain the block to DNA replication, but this has not been formally tested. …”

Developing single molecule methods to study DNA replication dynamics in yeasts by Heron, ELD

Subjects: “…DNA replication…”

DNA Replication and associated repair pathways are involved in the mutagenesis of methylated cytosine by Tomkova, M, McClellan, M, Kriaucionis, S, Schuster-Böckler, P

Ribonucleotide reductase requires subunit switching in hypoxia to maintain DNA replication by Foskolou, I, Jorgensen, C, Leszczynska, K, Olcina, M, Tarhonskaya, H, Haisma, B, D'Angiolella, V, Myers, W, Domene, C, Flashman, E, Hammond, E

“…Cells exposed to hypoxia, experience replication stress but do not accumulate DNA damage, suggesting sustained DNA replication. Ribonucleotide Reductase (RNR) is the only enzyme capable of de novo synthesis of dNTPs. …”

The spatial organization of sequences involved in initiation and termination of eukaryotic DNA replication. by Cook, P, Lang, J

Ribonucleotide reductase requires subunit switching in hypoxia to maintain DNA replication. by Foskolou, IP, Jorgensen, C, Leszczynska, KB, Olcina, MM, Tarhonskaya, H, Haisma, B, D'Angiolella, V, Myers, WK, Domene, C, Flashman, E, Hammond, EM

“…Cells exposed to hypoxia experience replication stress but do not accumulate DNA damage, suggesting sustained DNA replication. Ribonucleotide reductase (RNR) is the only enzyme capable of de novo synthesis of deoxyribonucleotide triphosphates (dNTPs). …”

Factors affecting template switch recombination associated with restarted DNA replication by Jalan, M, Oehler, J, Morrow, CA, Osman, F, Whitby, MC

Mutational signature distribution varies with DNA replication timing and strand asymmetry by Tomkova, M, Tomek, J, Kriaucionis, S, Schuster-Boeckler, PB

“…<strong>Background:</strong> DNA replication plays an important role in mutagenesis, yet little is known about how it interacts with other mutagenic processes. …”

Investigating DNA replication perturbance induced by CRISPR-Cas9 variants by Xu, Y

“…If encountered by the DNA replication machinery, SSBs can be converted into double-stranded DNA breaks (DSBs). …”

Exploring the factors and mechanisms involved in triggering the alternative lengthening of telomeres pathway by Kent, T

Subjects:

Mcm10 regulates DNA replication elongation by stimulating the CMG replicative helicase by Looke, Marko, Maloney, Michael Finnan, Bell, Stephen P

“…Our findings expand the roles of Mcm10 during DNA replication and suggest a new model for Mcm10 function as an activator of the CMG complex throughout DNA replication.…”
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Regulation of DNA replication and cellular responses to perturbations in replication in the bacterium Bacillus subtilis by Goranov, Alexi I

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Architecture of the Saccharomyces cerevisiae origin recognition complex bound to origins of DNA replication by Lee, Daniel Gyejun, 1971-

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Chromatin architectural factors as safeguards against excessive supercoiling during DNA replication by Ahmed, Syed Moiz, Dröge, Peter

“…Here, we reviewed the background of these new findings and described emerging models of how these accessory factors contribute to supercoil homeostasis. We focused on DNA replication and the generation of positive (+) supercoiling in front of replisomes, where two accessory factors—GapR and HMGA2—from pro- and eukaryotic cells, respectively, appear to play important roles as sinks for excessive (+) supercoiling by employing a combination of supercoil constrainment and activation of topoisomerases. …”
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Accurate identification of DNA replication origin by fusing epigenomics and chromatin interaction information by Dao, Fu-Ying, Lv, Hao, Fullwood, Melissa Jane, Lin, Hao

“…DNA replication initiation is a complex process involving various genetic and epigenomic signatures. …”
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