Defects in maintenance of mitochondrial DNA are associated with intramitochondrial nucleotide imbalances by Ashley, N, Adams, S, Slama, A, Zeviani, M, Suomalainen, A, Andreu, A, Naviaux, R, Poulton, J

“…Most are associated with defects in genes involved in mitochondrial deoxynucleotide metabolism or utilization, such as mutations in thymidine kinase 2 (TK2) as well as the mtDNA replicative helicase, Twinkle and gamma polymerase (POLG). …”

Using surface-enhanced Raman spectroscopy and electrochemically driven melting to discriminate Yersinia pestis from Y. pseudotuberculosis based on single nucleotide polymorphisms w... by Papadopoulou, E, Goodchild, S, Cleary, D, Weller, S, Gale, N, Stubberfield, M, Brown, T, Bartlett, P

“…However, manipulation of assay conditions (conducting the electrochemical experiments at 10 °C) resulted in greater discrimination between the complementary and mismatched DNA. Replicate data were collected and analyzed for each duplex on different days, using different batches of PCR product and different sphere segment void (SSV) substrates. …”

Estimation of hepatitis B virus cccDNA persistence in chronic infection using within-host evolutionary rates by Lythgoe, KA, Lumley, SF, McKeating, JA, Matthews, PC

“…We found that cccDNA replicative capacity declined by an order of magnitude between HBeAgPOS and HBeAgNEG phases of infection. …”

Perturbation of PALB2 function by the T413S mutation found in small cell lung cancer by Bleuyard, J, Butler, R, Esashi, F

“…More recently, PALB2 was shown to associate with active genes independently of BRCA1, and through this mechanism, safeguards these regions from DNA replicative stresses. However, it is unknown whether PALB2 tumour suppressor function requires its chromatin association.…”

Molecular and Cellular Studies of Human Hepatitis B Virus Variants by Ong, Hooi Tin

“…These studies showed that single stranded and relaxed circular double stranded HBV DNA replicative intermediates can be eliminated from the cytoplasm of HBV transgenic hepatocytes as a result of the antiviral effect of the interferon-gamma (IFN-γ) and tumour necrosis factor-alpha (TNF-α) released within the transgenic liver primarily by infiltrating HBV-specific CD8+ cells (Guidotti et al., 1996; Heise et al., 1999b) but also CD4+ T cells (Franco et al., 1997). …”
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