Rapid high-resolution measurement of DNA replication timing by droplet digital PCR by Batrakou, D, Heron, E, Nieduszynski, C

“…Here, we use droplet digital PCR to study DNA replication timing at multiple loci in budding yeast and human cells. …”

Monitoring DNA replication in fission yeast by incorporation of 5-ethynyl-2'-deoxyuridine by Hua, H, Kearsey, S

Understanding the role of C16orf72 in the DNA replication stress response by Kosmin, J

Subjects: “…DNA replication…”

Cohesin-Mediated Genome Architecture Does Not Define DNA Replication Timing Domains by Oldach, P, Nieduszynski, C

“…3D genome organization is strongly predictive of DNA replication timing in mammalian cells. This work tested the extent to which loop-based genome architecture acts as a regulatory unit of replication timing by using an auxin-inducible system for acute cohesin ablation. …”

Mitogenic growth signalling, DNA replication licensing, and survival are linked in prostate cancer. by Dudderidge, T, McCracken, SR, Loddo, M, Fanshawe, T, Kelly, J, Neal, D, Leung, H, Williams, G, Stoeber, K

“…In this study we have investigated linkages between the MEK5/ERK5 pathway and DNA replication licensing during prostate carcinogenesis. …”

Monitoring DNA replication in fission yeast by incorporation of 5-ethynyl-2'-deoxyuridine. by Hua, H, Kearsey, S

Clonal Decomposition and DNA Replication States Defined by Scaled Single-Cell Genome Sequencing

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Clonal Decomposition and DNA Replication States Defined by Scaled Single-Cell Genome Sequencing by Boyden, Edward

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Characterization of two Bacillus subtilis proteins required for the initiation, restart, and control of DNA replication by Rokop, Megan E., 1978-

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Modularity of the Bacterial Cell Cycle Enables Independent Spatial and Temporal Control of DNA Replication by Jonas, Kristina, Chen, Y. Erin, Chen, Y. Erin, Laub, Michael T., Laub, Michael T

“…DNA replication control involves DnaA, which promotes initiation, and CtrA, which silences initiation. …”
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Nutritional Control of DNA Replication Initiation through the Proteolysis and Regulated Translation of DnaA by Leslie, David J., Heinen, Christian, Schramm, Frederic D., Aakre, Christopher David, Murray, Sean M., Laub, Michael T., Jonas, Kristina, Thuring, Marietta

“…Instead, we demonstrate that decreased nutrient availability downregulates dnaA translation by a mechanism involving the 5' untranslated leader region of the dnaA transcript; Lon-dependent proteolysis of DnaA then outpaces synthesis, leading to the elimination of DnaA and the arrest of DNA replication. Our results demonstrate how regulated translation and constitutive degradation provide cells a means of precisely and rapidly modulating the concentration of key regulatory proteins in response to environmental inputs.…”
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Adefovir dipivoxil induces DNA replication stress and augments ATR inhibitor-related cytotoxicity by Patel, A, Seraia, E, Ebner, D, Ryan, AJ

“…ATR delays cell cycle progression and prevents DNA replication fork collapse, which prohibits cell death and promotes proliferation. …”

Replication stress and chromatin context link ATM activation to a role in DNA replication. by Olcina, M, Foskolou, I, Anbalagan, S, Senra, J, Pires, I, Jiang, Y, Ryan, A, Hammond, E

“…Most significantly, we describe a stress-specific role for ATM in maintaining DNA replication rates in a background of increased H3K9me3. …”

PCNA directs type 2 RNase H activity on DNA replication and repair substrates. by Bubeck, D, Reijns, M, Graham, S, Astell, K, Jones, E, Jackson, A

“…Mutation in RNASEH2 causes Aicardi-Goutières syndrome, an auto-inflammatory disorder that may arise from nucleic acid byproducts generated during DNA replication. Here, we report the crystal structures of Archaeoglobus fulgidus RNase HII in complex with PCNA, and human PCNA bound to a C-terminal peptide of RNASEH2B. …”

Inter-Fork Strand Annealing causes genomic deletions during the termination of DNA replication by Morrow, C, Nguyen, M, Fower, A, Wong, I, Osman, F, Bryer, C, Whitby, M

“…Problems that arise during DNA replication can drive genomic alterations that are instrumental in the development of cancers and many human genetic disorders. …”

SPRTN protease and checkpoint kinase 1 cross-activation loop safeguards DNA replication by Halder, S, Torrecilla, I, Burkhalter, MD, Popović, M, Fielden, J, Vaz, B, Oehler, J, Pilger, D, Lessel, D, Wiseman, K, Singh, AN, Vendrell, I, Fischer, R, Philipp, M, Ramadan, K

“…Simultaneously, CHK1 full length and its N-terminal fragments phosphorylate SPRTN at the C-terminal regulatory domain, which stimulates SPRTN recruitment to chromatin to promote unperturbed DNA replication fork progression and DPC repair. Our data suggest that a SPRTN-CHK1 cross-activation loop plays a part in DNA replication and protection from DNA replication stress. …”

PARP1 resolves DNA replication defects in PCNA-associated DNA repair disorder by Wang, L

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Investigating break induced replication and template switching in fission yeast by Laksir, Y

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Cellular and biochemical characterisation of ERCC6L2 by Armstrong, L

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Mechanism and timing of Mcm2–7 ring closure during DNA replication origin licensing by Ticau, Simina, Friedman, Larry J, Champasa, Kanokwan, Corrêa, Ivan R, Gelles, Jeff, Bell, Stephen P

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