UBR5 interacts with the replication fork and protects DNA replication from DNA polymerase η toxicity by Cipolla, L, Bertoletti, F, Maffia, A, Liang, C, Lehmann, A, Cohn, M, Sabbioneda, S

“…Accurate DNA replication is critical for the maintenance of genome integrity and cellular survival. …”

An Ago2-associated capped transcriptional start site small RNA suppresses adenovirus DNA replication by Kamel, W, Akusjärvi, G

“…As a consequence of this, the MLP-TSS-sRNA has an inhibitory effect on the efficiency of viral DNA replication. Collectively, our results suggest that this novel sRNA may serve a regulatory function controlling viral genome replication during a lytic and/or persistent adenovirus infection in its natural host.…”

Regulation of DNA replication through Sld3-Dpb11 interaction is conserved from yeast to humans. by Boos, D, Sanchez-Pulido, L, Rappas, M, Pearl, L, Oliver, A, Ponting, C, Diffley, J

“…Cyclin-dependent kinases (CDKs) play crucial roles in promoting DNA replication and preventing rereplication in eukaryotic cells [1-4]. …”

Analysis of the 16p telomere to examine the relationship between DNA replication, chromosome structure and gene expression by Smith, Z

“…Initially, studies were undertaken to analyse the pattern and timing of DNA replication of the human α globin gene cluster and the surrounding chromosomal region in erythroid and non-erythroid cell-types. …”

7.28 Molecular Biology, Spring 2001 by Baker, Tania A., Bell, Stephen P.

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Identification of a novel role for PARPs in replication stress recovery by Richards, F

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Delineation of the molecular mechanisms underlying DNA replication initiation and changes in gene copy number during Drosophila development by Hua, Brian L

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A Bacterial Toxin Inhibits DNA Replication Elongation through a Direct Interaction with the β Sliding Clamp by Aakre, Christopher David, Phung, Tuyen N., Huang, David, Laub, Michael T

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Keep the ORCs at bay : how eukaryotic cells ensure one round of DNA replication per cell cycle by Amasino, Audra Leigh.

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Tenofovir prodrugs potently inhibit Epstein–Barr virus lytic DNA replication by targeting the viral DNA polymerase by Drosu, Natalia C, Edelman, Elazer R, Housman, David E

“…In the present study, we show that tenofovir disoproxil fumarate (TDF) and tenofovir alafenamide (TAF), drugs with excellent safety profiles used clinically for HIV prevention, inhibit EBV lytic DNA replication, with respective IC50 values of 0.30 μM and 84 nM. …”
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Inhibition of hepatitis B virus DNA replication by imino sugars without the inhibition of the DNA polymerase: therapeutic implications. by Mehta, A, Carrouée, S, Conyers, B, Jordan, R, Butters, T, Dwek, R, Block, T

Repression of DNA replication licensing in quiescence is independent of geminin and may define the cell cycle state of progenitor cells. by Kingsbury, SR, Loddo, M, Fanshawe, T, Obermann, E, Prevost, A, Stoeber, K, Williams, G

“…The DNA replication (or origin) licensing machinery ensures precise duplication of the genome and contributes to the regulation of proliferative capacity in metazoa. …”

Functional nuclear organization of transcription and DNA replication: a topographical marriage between chromatin domains and the interchromatin compartment. by Markaki, Y, Gunkel, M, Schermelleh, L, Beichmanis, S, Neumann, J, Heidemann, M, Leonhardt, H, Eick, D, Cremer, C, Cremer, T

“…We studied the nuclear topography of RNA transcription and DNA replication in mammalian cell types with super-resolution fluorescence microscopy, which offers a resolution beyond the classical Abbe/Raleigh limit. …”

Set2 methyltransferase facilitates DNA replication and promotes genotoxic stress responses through MBF-dependent transcription by Pai, C, Kishkevich, A, Deegan, R, Keszthelyi, A, Folkes, L, Kearsey, S, De León, N, Soriano, I, de Bruin, R, Carr, A, Humphrey, T

“…Here, we describe a role for Set2-dependent H3K36 methylation in facilitating DNA replication and the transcriptional responses to both replication stress and DNA damage through promoting …”

Human SIRT1 regulates DNA binding and stability of the Mcm10 DNA replication factor via deacetylation by Fatoba, S, Tognetti, S, Berto, M, Leo, E, Mulvey, C, Godovac-Zimmermann, J, Pommier, Y, Okorokov, A

Structural and functional insights into the DNA replication factor Cdc45 reveal an evolutionary relationship to the DHH family of phosphoesterases. by Krastanova, I, Sannino, V, Amenitsch, H, Gileadi, O, Pisani, F, Onesti, S

“…Cdc45 is an essential protein conserved in all eukaryotes and is involved both in the initiation of DNA replication and the progression of the replication fork. …”

A Bacterial Chromosome Structuring Protein Binds Overtwisted DNA to Stimulate Type II Topoisomerases and Enable DNA Replication by Guo, Monica S, Haakonsen, Diane Laure, Zeng, Wenjie, Schumacher, Maria A., Laub, Michael T

“…Further, we show that GapR stimulates gyrase and topo IV to relax positive supercoils, thereby enabling DNA replication. Analogous chromosome structuring proteins that locate to the overtwisted DNA in front of replication forks may be present in other organisms, similarly helping to recruit and stimulate topoisomerases during DNA replication. …”
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Drosophila E2F and DP genes : their role in the regulation of G1-S progression and the activity of DNA replication origins by Royzman, Irena, 1970-

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C. elegans MCM-4 is a general DNA replication and checkpoint component with an epidermis-specific requirement for growth and viability by Korzelius, Jerome, The, Inge, Ruijtenberg, Suzan, Portegijs, Vincent, Xu, Huihong, van den Heuvel, Sander, Horvitz, Howard Robert

“…DNA replication and its connection to M phase restraint are studied extensively at the level of single cells but rarely in the context of a developing animal. …”
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Genome-wide analysis reveals extensive functional interaction between DNA replication initiation and transcription in the genome of Trypanosoma brucei. by Tiengwe, C, Marcello, L, Farr, H, Dickens, N, Kelly, S, Swiderski, M, Vaughan, D, Gull, K, Barry, J, Bell, S, McCulloch, R

“…To understand how DNA replication occurs in the context of such organization, we have performed genome-wide mapping of the binding sites of the replication initiator ORC1/CDC6 and have identified replication origins, revealing that both localize to the boundaries of the transcription units. …”