Metabolic and genetic factors guiding hematopoietic cell fate by Do, Brian Tshao

“…Instead, by tracking early transcriptional and epigenetic changes, we find that DNA replication stress appears to preferentially activate primed regulatory loci with pre-existing chromatin accessibility. …”
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Multiple kinases inhibit origin licensing and helicase activation to ensure reductive cell division during meiosis by Berchowitz, Luke E, Phizicky, David Vincent, Bell, Stephen P

“…Meiotic cells undergo a single round of DNA replication followed by two rounds of chromosome segregation (the meiotic divisions) to produce haploid gametes. …”
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Initiation-specific alleles of the Cdc45 helicase-activating protein by Rios-Morales, Ramon Y, Chan, Sze Ham, Bell, Stephen P

“…The committed step in DNA replication initiation is the activation of the Mcm2-7 replicative DNA helicase. …”
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Mutations in CDC45, encoding an essential component of the pre-initiation complex, cause Meier-Gorlin Syndrome and Craniosynostosis by Fenwick, A, Kliszczak, M, Twigg, S, Goriely, A, McGowan, S, Miller, K, Wilkie, A, Niedzwiedz, W, WGS500 Consortium

“…DNA replication precisely duplicates the genome to ensure stable inheritance of genetic information. …”

TEX264 coordinates p97- and SPRTN-mediated resolution of topoisomerase 1-DNA adducts by Fielden, J, Wiseman, K, Torrecilla, I, Li, S, Hume, S, Chiang, SC, Ruggiano, A, Singh, AN, Freire, R, Hassanieh, S, Domingo, E, Vendrell, I, Fischer, R, Kessler, BM, Maughan, TS, El-Khamisy, SF, Ramadan, K

“…TEX264 localises to the nuclear periphery, associates with DNA replication forks, and counteracts TOP1ccs during DNA replication. …”

Termination structures in the Escherichia coli chromosome replication fork trap. by Duggin, I, Bell, S

“…Using two-dimensional agarose gel electrophoresis, we examined DNA replication intermediates at the Ter sites and at dif in wild-type cells. …”

The Beacon Calculus: A formal method for the flexible and concise modelling of biological systems by Boemo, MA, Cardelli, L, Nieduszynski, CA

“…Its breadth is demonstrated by creating models of DNA replication dynamics, the gene expression dynamics in response to DNA methylation damage, and a multisite phosphorylation switch. …”

The DNA fibre technique – tracking helicases at work by Nieminuszczy, J, Schwab, R, Niedzwiedz, W

“…Here we outline how DNA fibre fluorography, a straightforward and inexpensive approach, can be employed to study the in vivo function of helicases in DNA replication and the maintenance of genome stability at a single molecule level. …”

Molecular architecture of the human GINS complex. by Boskovic, J, Coloma, J, Aparicio, T, Zhou, M, Robinson, C, Méndez, J, Montoya, G

“…Chromosomal DNA replication is strictly regulated through a sequence of steps that involve many macromolecular protein complexes. …”

Effects of acute versus chronic hypoxia on DNA damage responses and genomic instability. by Pires, I, Bencokova, Z, Milani, M, Folkes, L, Li, J, Stratford, MR, Harris, A, Hammond, E

“…Questions exist concerning the effects of acute versus chronic hypoxic conditions on DNA replication and genomic stability that may influence tumorigenesis. …”

Mice expressing an error-prone DNA polymerase in mitochondria display elevated replication pausing and chromosomal breakage at fragile sites of mitochondrial DNA. by Bailey, L, Cluett, T, Reyes, A, Prolla, T, Poulton, J, Leeuwenburgh, C, Holt, I

“…Pausing at these sites may be enhanced in the case of exonuclease-deficient POLG owing to delayed resumption of DNA replication, or replisome instability. In either case, the mtDNA replication cycle is perturbed and this might explain the progeroid features of the POLG mutator mouse.…”

Replication-directed sister chromosome alignment in Escherichia coli. by Liu, X, Wang, X, Reyes-Lamothe, R, Sherratt, D

“…We test the hypothesis that the minority <lrrl> and <rllr> patterns arise because of pausing of DNA replication on the right and left replichores respectively. …”

Changing protein-DNA interactions promote ORC binding site exchange during replication origin licensing by Zhang, Annie

“…DNA replication is a fundamental process that ensures the faithful duplication of genetic material in all living organisms. …”
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How do sister DNAs become entrapped within cohesin rings? by Laurent, CM

“…Although cohesin can load onto, and topologically entrap individual DNAs prior to DNA replication, cohesion is established during S-phase in concert with DNA replication. …”

The role of histone H3K36me3 in mammalian cell cycle regulation and genome stability by Armfield, LD

“… <p>Although the molecular genetics regulating DNA replication onset have been studied in great detail, the epigenetic contribution to this step is poorly understood. …”

DNA protein crosslink proteolysis repair: From yeast to premature ageing and cancer in humans by Fielden, J, Ruggiano, A, Popović, M, Ramadan, K

“…DPCs can be bulky and thereby pose a barrier to DNA replication and transcription. The persistence of DPCs during S phase causes DNA replication stress and genome instability. …”

Chromatin binding of the fission yeast replication factor mcm4 occurs during anaphase and requires ORC and cdc18. by Kearsey, S, Montgomery, S, Labib, K, Lindner, K

“…We have applied this method to the DNA replication factor mcm4/cdc21, and find that chromatin association occurs during anaphase B, significantly earlier than is the case in budding yeast. …”

Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1. by Rowbotham, S, Barki, L, Neves-Costa, A, Santos, F, Dean, W, Hawkes, N, Choudhary, P, Will, W, Webster, J, Oxley, D, Green, C, Varga-Weisz, P, Mermoud, J

“…Epigenetic marks such as posttranslational histone modifications specify the functional states of underlying DNA sequences, though how they are maintained after their disruption during DNA replication remains a critical question. We identify the mammalian SWI/SNF-like protein SMARCAD1 as a key factor required for the re-establishment of repressive chromatin. …”

Single-molecule studies of the mechanism of eukaryotic helicase activation by De Jesús-Kim, Lorraine.

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Developmental control of gene copy number by repression of replication initiation and fork progression by Sher, Noa, Bell, George W., Li, Sharon, Nordman, Jared T., Eng, Thomas, Eaton, Matthew Lucas, MacAlpine, David M., Orr-Weaver, Terry L.

“…Precise DNA replication is crucial for genome maintenance, yet this process has been inherently difficult to study on a genome-wide level in untransformed differentiated metazoan cells. …”
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