Deletion of voltage-gated calcium channels in astrocytes decreases neuroinflammation and demyelination in a murine model of multiple sclerosis by G. E. Denaroso, Z. Smith, C. G. Angeliu, V. T. Cheli, C. Wang, P. M. Paez

Subjects: Get full text

Anti-Neurofascin Antibodies Associated with White Matter Diseases of the Central Nervous System: A Red Flag or a Red Herring? by Navnika Gupta, Afsaneh Shirani, Lakshman Arcot Jayagopal, Ezequiel Piccione, Elizabeth Hartman, Rana Khalil Zabad

Subjects: Get full text

A case of anti-myelin oligodendrocyte glycoprotein (MOG)-immunoglobulin G (IgG) associated disorder (MOGAD) with clinical manifestations of acute disseminated encephalomyelitis: Se... by Xiangui Huang, Rui Guo, Chunhong Li, Xingjiang Long, Tong Yang, Xianliang Hou, Xiaohong Wei, Minglin Ou

Subjects: Get full text

Editorial: Demyelinating neurological syndromes: The role of autoimmunity by Maria Eleftheria Evangelopoulos, Robert Hoepner, Clio Mavragani

Subjects: “…demyelinating diseases…”
Get full text

High level of agreement in a fixed vs. live cell-based assay for antibodies to myelin oligodendrocyte glycoprotein in a real-world clinical laboratory setting by Tammy L. Smith, Tammy L. Smith, Tammy L. Smith, Tammy L. Smith, Tammy L. Smith, Thomas R. Haven, Lauren M. Zuromski, Kyphuong Luong, Stacey L. Clardy, Stacey L. Clardy, Lisa K. Peterson, Lisa K. Peterson

Subjects: Get full text

Nerve Growth Factor Neutralization Promotes Oligodendrogenesis by Increasing miR-219a-5p Levels by Rossella Brandi, Marietta Fabiano, Corinna Giorgi, Ivan Arisi, Federico La Regina, Francesca Malerba, Sabrina Turturro, Andrea Ennio Storti, Flavia Ricevuti, Susanna Amadio, Cinzia Volontè, Simona Capsoni, Raffaella Scardigli, Mara D’Onofrio, Antonino Cattaneo

Subjects: Get full text

Anti-MOG Antibody-Associated Unilateral Cortical Encephalitis with Bilateral Meningeal Involvement: A Case Report by Bo Ren, Shiying Li, Bin Liu, Jinxia Zhang, Yaqing Feng

Subjects: Get full text

Developing Hypoimmunogenic Human iPSC‐Derived Oligodendrocyte Progenitor Cells as an Off‐The‐Shelf Cell Therapy for Myelin Disorders by Lizhao Feng, Jianfei Chao, Peng Ye, Qui Luong, Guoqiang Sun, Wei Liu, Qi Cui, Sergio Flores, Natasha Jackson, Afm Nazmul Hoque Shayento, Guihua Sun, Zhenqing Liu, Weidong Hu, Yanhong Shi

Subjects: Get full text

Reduced serum IgG galactosylation is associated with increased inflammation during relapses of neuromyelitis optica spectrum disorders by Shiyu Gao, Shiyu Gao, Shiyu Gao, Xin Jiao, Xin Jiao, Xin Jiao, Ruoyi Guo, Ruoyi Guo, Ruoyi Guo, Xiujuan Song, Xiujuan Song, Xiujuan Song, Bin Li, Bin Li, Bin Li, Li Guo, Li Guo, Li Guo

Subjects: Get full text

MRI and laboratory features and the performance of international criteria in the diagnosis of multiple sclerosis in children and adolescents: a prospective cohort study by Fadda, G, Brown, R, Longoni, G, Castro, D, O'Mahony, J, Verhey, L, Branson, H, Waters, P, Bar-Or, A, Marrie, R, Yeh, E, Narayanan, S, Arnold, D, Banwell, B, Canadian Pediatric Demyelinating Disease Network

A cross‐sectional study of MRI features and the gut microbiome in pediatric‐onset multiple sclerosis by Feng Zhu, Yinshan Zhao, Douglas L. Arnold, Amit Bar‐Or, Charles N. Bernstein, Christine Bonner, Morag Graham, Janace Hart, Natalie Knox, Ruth Ann Marrie, Ali I. Mirza, Julia O'Mahony, Gary Van Domselaar, E. Ann Yeh, Brenda Banwell, Emmanuelle Waubant, Helen Tremlett, US Network of Pediatric MS Centers, the Canadian Pediatric Demyelinating Disease Network

“…Methods A cross‐sectional study involving the Canadian Paediatric Demyelinating Disease Network study participants. Gut microbiome features (alpha diversity, phylum‐ and genus‐level taxa) were derived using 16S rRNA sequencing from stool samples. …”
Get full text

Study of the mechanisms by which CD4+ T cells contribute to protection in Theiler's murine encephalomyelitis. by Borrow, P, Welsh, C, Nash, A

“…However, surviving animals had high levels of persisting virus in the CNS and they developed very severe symptoms of chronic demyelinating disease. The appearance of infectious virus was not due to selection of neutralizing antibody-resistant viral variants. …”

A Tumefactive Multiple Sclerosis Case Mimicking a Focal Cerebral Mass by Olcay Unver, Zehra Isik Hasiloglu, Umut Durak, Serap Uysal

“…Tumefactive multiple sclerosis is a rare demyelinating disease presenting with a focal cerebral mass. …”
Get full text

Critical role of TLR activation in viral replication, persistence, and pathogenicity of Theiler’s virus by Byung S. Kim

“…Theiler’s murine encephalomyelitis virus (TMEV) establishes persistent viral infections in the central nervous system and induces chronic inflammatory demyelinating disease in susceptible mice. TMEV infects dendritic cells, macrophages, B cells, and glial cells. …”
Get full text

The role of CD8+T cells in the acute and chronic phases of Theiler's murine encephalomyelitis virus-induced disease in mice. by Borrow, P, Tonks, P, Welsh, C, Nash, A

“…Mice rendered CD8-deficient prior to infection with TMEV were less efficient at clearing virus from the central nervous system compared to intact animals and also suffered demyelinating disease of earlier onset and increased severity. …”

Intracranial Inoculation Is More Potent Than Intranasal Inoculation for Inducing Optic Neuritis in the Mouse Hepatitis Virus-Induced Model of Multiple Sclerosis by Manmeet Singh, Reas S. Khan, Kimberly Dine, Jayasri Das Sarma, Kenneth S. Shindler

“…Intracranial inoculation should continue to be considered a preferred method for studies of MHV-induced optic neuritis and central nervous system (CNS) demyelinating disease.…”
Get full text

A Case Report of Pediatric Patient with Tuberous Sclerosis and Radiologically Isolated Syndrome by Giorgia Sforza, Gabriele Monte, Alessandra Voci, Lorenzo Figà Talamanca, Laura Papetti, Michela Ada Noris Ferilli, Martina Proietti Checchi, Massimiliano Valeriani, Romina Moavero

“…Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the CNS characterized by symptomatic episodes that occur months or years apart and affect different anatomic locations. …”
Get full text

Infection and Activation of B Cells by Theiler’s Murine Encephalomyelitis Virus (TMEV) Leads to Autoantibody Production in an Infectious Model of Multiple Sclerosis by Young-Hee Jin, Charles X. Kim, Jocelin Huang, Byung S. Kim

“…Theiler’s murine encephalomyelitis virus (TMEV) induces immune-mediated inflammatory demyelinating disease in susceptible mice that is similar to human multiple sclerosis (MS). …”
Get full text

Acute Myelopathy in Childhood by Giulia Bravar, Aphra Luchesa Smith, Ata Siddiqui, Ming Lim

“…Assessment should include neuroimaging of the brain and spinal cord, with further investigations targeted based on the most likely differential diagnoses; for example, a child with suspected demyelinating disease may require specialist cerebrospinal fluid and serological testing. …”
Get full text

MOG-IgG1 antibodies in children by Waters, P, Fadda, G, Woodhalli, M, Irani, S, O'Mahony, J, Brown, R, Castro, D, Longoni, G, Yeh, E, Marrie, R, Arnold, D, Banwell, B, Bar-Or, A