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241
Peripherally derived macrophages as major phagocytes in MOG encephalomyelitis
Published 2019“…<p>An inflammatory demyelinating disease of the CNS with antibody against myelin oligodendrocyte glycoprotein (MOG-IgG) is now accepted as a discrete disease category of MOG encephalomyelitis (MOG-EM). 1 Previous case studies described abundant accumulation of phagocytic cells (either Iba1 + and/or CD68 + ) at the active demyelinating lesions of MOG-EM. 2 , – , 5 However, both Iba1 and CD68 can be expressed in either the microglia or macrophage. 6 Recently, transmembrane protein 119 (TMEM119) has been proposed to be a reliable microglial marker that discriminates resident microglia from blood-derived macrophages in the inflamed human brain. 6 Here, we discuss the immunohistochemical findings in a patient with MOG-EM using a specific marker for microglia, TMEM119. 6</p>…”
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242
A clinical conundrum: the detrimental effect of TNF antagonists in multiple sclerosis.
Published 2013“…Although TNF antagonists are efficacious in treating a range of autoimmune conditions, they exacerbate or even promote multiple sclerosis (MS)--a clinical finding that has been a conundrum for over a decade and has been a source of debate regarding the role of these drugs and of TNF signaling in the development of demyelinating disease. Recent work investigating the functional consequences of MS-associated genetic variation in the gene encoding TNFR1 has demonstrated that genetic risk drives the production of a novel, endogenous TNF antagonist. …”
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243
Treatment of Neuromyelitis Optica: Review and Recommendations.
Published 2012“…Neuromyelitis optica (NMO) is an autoimmune demyelinating disease preferentially targeting the optic nerves and spinal cord. …”
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244
Serial anti–myelin oligodendrocyte glycoprotein antibody analyses and outcomes in children with demyelinating syndromes
Published 2019“…<p><strong>Importance</strong> Identifying the course of demyelinating disease associated with myelin oligodendrocyte glycoprotein (MOG) autoantibodies is critical to guide appropriate treatment choices.…”
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245
Serial anti–myelin oligodendrocyte glycoprotein antibody analyses and outcomes in children with demyelinating syndromes
Published 2019“…<p><strong>Importance</strong> Identifying the course of demyelinating disease associated with myelin oligodendrocyte glycoprotein (MOG) autoantibodies is critical to guide appropriate treatment choices.…”
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246
The Importance of Managing Modifiable Comorbidities in People with Multiple Sclerosis: A Narrative Review
Published 2023-10-01“…Multiple sclerosis (MS) is a chronic, inflammatory, degenerative demyelinating disease of the central nervous system (CNS) of unknown etiology that affects individuals in their early adulthood. …”
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247
Recent progress in epidemiology, clinical features, and therapy of multiple sclerosis in China
Published 2023-09-01“…Multiple sclerosis (MS) is a demyelinating disease of the central nervous system characterized by inflammation, demyelination, and neurodegeneration. …”
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248
Progressive multifocal leukoencephalopathy
Published 2008-12-01“…Progressive multifocal leukoencephalopathy is a demyelinating disease of the central nervous system caused by the reactivation of latent JC virus. …”
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249
Demyelinating syndrome in SLE: review of different disease subtypes and report of a case series
Published 2017-12-01“…A recent study described 5 different patterns of demyelinating disease presentation, characterised by specific clinical, laboratory and brain and spine magnetic resonance imaging abnormalities: 1) neuromyelitis optica; 2) neuromyelitis optica spectrum disorders; 3) DS prevalently involving the brain; 4) DS prevalently involving the brainstem; 5) clinically isolated syndrome. …”
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250
Novel Drugs in a Pipeline for Progressive Multiple Sclerosis
Published 2022-06-01“…Multiple sclerosis (MS) is a widely known inflammatory, demyelinating disease of the central nervous system. The pathogenesis of progressive multiple sclerosis (PMS) is a complex, multi-level process that causes therapeutic difficulties. …”
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251
What Guides Peripheral Immune Cells into the Central Nervous System?
Published 2021-08-01“…Multiple sclerosis (MS), an immune-mediated demyelinating disease of the central nervous system (CNS), initially presents with a relapsing-remitting disease course. …”
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252
An anti-inflammatory approach to the dietary management of multiple sclerosis: a condensed review
Published 2018-07-01“…Multiple sclerosis (MS) is a chronic, inflammatory, neurodegenerative demyelinating disease of the central nervous system (CNS). …”
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253
Multiple sclerosis: 2023 update
Published 2023-03-01“… Multiple sclerosis (MS) is the most frequent inflammatory and demyelinating disease of the Central Nervous System (CNS). …”
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254
Neuromyelitis Optica: Case Report
Published 2008-06-01“…OBJECTIVES: Neuromyelitis optica (Devic’s syndrome) is an uncommon but severe form of demyelinating disease. This syndrome is characterized by acute or relapsing inflammatory demyelination restricted to the optic nerves and spinal cord. …”
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255
Treatment of neuromyelitis optica: Review and recommendations
Published 2012“…Neuromyelitis optica (NMO) is an autoimmune demyelinating disease preferentially targeting the optic nerves and spinal cord. …”
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256
Bickerstaff brainstem encephalitis: A case report
Published 2023-08-01“…Bickerstaff brainstem encephalitis (BBE) is a rare inflammatory, demyelinating disease that generally has a good prognosis. …”
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257
Oligodendrocyte Development and Regenerative Therapeutics in Multiple Sclerosis
Published 2021-04-01“…We will focus on MS as a pathological condition, the most common chronic inflammatory demyelinating disease of the CNS in young adults.…”
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258
Successful Treatment of Acute Disseminated Encephalomyelitis (ADEM) by Prompt Usage of Immunoglobulins – Case Report and Review of the Literature
Published 2019-01-01“…Acute disseminated encephalomyelitis (ADEM) is an inflammatory demyelinating disease of the central nervous system that usually affects children and young adults. …”
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259
Clinical and epidemiological profiles of non-traumatic myelopathies
Published 2016-02-01“…Results The most prevalent diagnosis was subacute combined degeneration (11.4%), followed by cervical spondylotic myelopathy (9.6%), demyelinating disease (9%), tropical spastic paraparesis (8.4%) and hereditary spastic paraparesis (8.4%). …”
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260
Combination of Probiotics and Natural Compounds to Treat Multiple Sclerosis via Warburg Effect
Published 2022-05-01“…Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system (CNS).It is an auto-immune disorder. …”
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