Nerve Growth Factor Prevents Demyelination, Cell Death and Progression of the Disease in Experimental Allergic Encephalomyelitis by Azita Parvaneh Tafreshi

“…Experimental allergic encephalomyelitis (EAE), a demyelinating disease induced in the animals parallels multiple sclerosis in human in several aspects, provides a useful model to investigate multiple sclerosis. …”
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Guillain-Barré Syndrome with Incomplete Oculomotor Nerve Palsy after Traumatic Brain Injury: Case Report and Literature Review by Jinsheng Liu, Feng Tang, Xinjun Chen, Zhiqiang Li

“…Guillain-Barré syndrome (GBS) is a severe peripheral neuroinflammatory demyelinating disease characterized by symmetrical progressive limb weakness, which can be accompanied by cranial nerve and sensory disturbances. …”
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Optic Neuritis in Multiple Sclerosis—A Review of Molecular Mechanisms Involved in the Degenerative Process by Manuela Andreea Ciapă, Delia Lidia Șalaru, Cristian Stătescu, Radu Andy Sascău, Camelia Margareta Bogdănici

“…Multiple sclerosis is a central nervous system inflammatory demyelinating disease with a wide range of clinical symptoms, ocular involvement being frequently marked by the presence of optic neuritis (ON). …”
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Hepatotoxicity of Drugs Used in Multiple Sclerosis, Diagnostic Challenge, and the Role of HLA Genotype Susceptibility by Lucy Meunier, Dominique Larrey

“…Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system and the association with other autoimmune diseases is well-documented. …”
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Exploring the Pro-Phagocytic and Anti-Inflammatory Functions of PACAP and VIP in Microglia: Implications for Multiple Sclerosis by Margo I. Jansen, Sarah Thomas Broome, Alessandro Castorina

“…Multiple sclerosis (MS) is a chronic neuroinflammatory and demyelinating disease of the central nervous system (CNS), characterised by the infiltration of peripheral immune cells, multifocal white-matter lesions, and neurodegeneration. …”
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The Cuprizone Model: Dos and Do Nots by Jiangshan Zhan, Teresa Mann, Sarah Joost, Newshan Behrangi, Marcus Frank, Markus Kipp

“…Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system. Various pre-clinical models with different specific features of the disease are available to study MS pathogenesis and to develop new therapeutic options. …”
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Metabolomics as a promising tool for improving understanding of multiple sclerosis: A review of recent advances by Zhicheng Liu, Jeffrey Waters, Bin Rui

“…Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system that usually affects young adults. …”
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CADASIL syndrome and demyelination: dual pathology? (a case report) by I. O. Shtang, A. S. Kotov

“…In the presented clinical case, in addition to the genetically proven CADASIL syndrome, the patient had symptoms (awkwardness in her right hand, retrobulbar neuritis), which made us suspect a demyelinating disease. Magnetic resonance imaging revealed foci in the white matter of the brain without the accumulation of contrast and without infratentorial and stem foci. …”
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Neuromyelitis optica spectrum disorder by Simon Broadley, Elham Khalili, Saman Heshmat, Laura Clarke

“…Over the past 13 years neuromyelitis optica spectrum disorder (NMOSD) has emerged as a discrete form of demyelinating disease of the central nervous system in which antibodies against a water channel found in high concentration on astrocytes are frequently found. …”
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Heterogeneity in multiple sclerosis: scratching the surface of a complex disease. by Disanto, G, Berlanga, A, Handel, A, Para, A, Burrell, A, Fries, A, Handunnetthi, L, De Luca, G, Morahan, J

“…Multiple Sclerosis (MS) is the most common demyelinating disease of the central nervous system. Although the etiology and the pathogenesis of MS has been extensively investigated, no single pathway, reliable biomarker, diagnostic test, or specific treatment have yet been identified for all MS patients. …”

Differentiating central nervous system demyelinating disorders: The role of clinical, laboratory, imaging characteristics and peripheral blood type I interferon activity by Dimitris K. Karathanasis, Anna Rapti, Adrianos Nezos, Charalampos Skarlis, Constantinos Kilidireas, Clio P. Mavragani, Clio P. Mavragani, Clio P. Mavragani, Maria Eleftheria Evangelopoulos

“…We sought to explore whether distinct clinical, laboratory, and imaging characteristics along with quantitation of peripheral blood type I interferon (IFN) activity could aid in differentiating between them.Methods: A total of 193 consecutive patients with imaging features suggesting the presence of CNS demyelinating disease with or without relevant clinical manifestations underwent full clinical, laboratory, and imaging evaluation, including testing for specific antibodies against 15 cellular antigens. …”
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Understanding Progressive Multifocal Leukoencephalopathy Risk in Multiple Sclerosis Patients Treated with Immunomodulatory Therapies: A Bird’s Eye View by Elizabeth A. Mills, Yang Mao-Draayer, Yang Mao-Draayer

“…Similar to MS, PML is a demyelinating disease of the CNS, but it is caused by the JC virus. …”
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Extracellular vesicles in multiple sclerosis: what are they telling us? by Matías eSáenz-Cuesta, Matías eSáenz-Cuesta, Iñaki eOsorio-Querejeta, Iñaki eOsorio-Querejeta, David eOtaegui, David eOtaegui

“…MS is a central nervous system demyelinating disease characterized by relapsing of symptoms followed by periods of remission. …”
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Regulation of Polyomavirus Transcription by Viral and Cellular Factors by June F. Yang, Jianxin You

“…Among several known pathogenic human polyomaviruses, JC polyomavirus (JCPyV) has the potential to cause the demyelinating disease progressive multifocal leukoencephalopathy (PML); BK polyomavirus (BKPyV) can cause nephropathy in kidney transplant recipients, and Merkel cell polyomavirus (MCPyV) is associated with a highly aggressive form of skin cancer, Merkel cell carcinoma (MCC). …”
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Cognitive Impairment in Multiple Sclerosis by Kenneth Maiese

“…Almost three million individuals suffer from multiple sclerosis (MS) throughout the world, a demyelinating disease in the nervous system with increased prevalence over the last five decades, and is now being recognized as one significant etiology of cognitive loss and dementia. …”
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The Possible Role of Neural Cell Apoptosis in Multiple Sclerosis by Peter G. E. Kennedy, Woro George, Xiaoli Yu

“…The etiology of multiple sclerosis (MS), a demyelinating disease affecting the central nervous system (CNS), remains obscure. …”
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Erythropoietin: New Directions for the Nervous System by Shaohui Wang, Yan Chen Shang, Zhao Zhong Chong, Kenneth Maiese

“…EPO and its receptor are present in multiple systems of the body and can impact disease progression in the nervous, vascular, and immune systems that ultimately affect disorders such as Alzheimer’s disease, Parkinson’s disease, retinal injury, stroke, and demyelinating disease. EPO relies upon <em>wingless</em> signaling with Wnt1 and an intimate relationship with the pathways of phosphoinositide 3-kinase (PI 3-K), protein kinase B (Akt), and mammalian target of rapamycin (mTOR). …”
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Long-term outcome of progressive multifocal leukoencephalopathy with recombinant interleukin-2 treatment and an associated increase in the number of HPyV-2-specific T-cells: a case... by Fieke W. Hoff, John Rolwes, Paula A. Hardeman, Molly Perkins, Eugene O. Major, Daniel Douek, Robert H. Collins, Benjamin M. Greenberg

“…Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease caused by reactivation of the human polyomavirus 2 (HPyV-2). …”
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The Role of Non-Selective TNF Inhibitors in Demyelinating Events by Line Buch Kristensen, Kate Lykke Lambertsen, Nina Nguyen, Keld-Erik Byg, Helle H Nielsen

“…Its use in neurological disorders is limited however, due to rare adverse events of demyelination, even in patients without preceding demyelinating disease. We review here the molecular and cellular aspects of this neuroinflammatory process in light of a case of severe monophasic demyelination caused by treatment with infliximab. …”
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Aberrant DNA methylation profile exacerbates inflammation and neurodegeneration in multiple sclerosis patients by Naiara Celarain, Jordi Tomas-Roig

“…Abstract Multiple sclerosis (MS) is an autoimmune and demyelinating disease of the central nervous system characterised by incoordination, sensory loss, weakness, changes in bladder capacity and bowel function, fatigue and cognitive impairment, creating a significant socioeconomic burden. …”
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