Demyelination Lesions Do Not Correlate with Clinical Manifestations by Bordetella pertussis Toxin Concentrations by Maiara Carolina Perussolo, Bassam Felipe Mogharbel, Claudia Sayuri Saçaki, Dilcele Silva Moreira Dziedzic, Seigo Nagashima, Leanderson Franco de Meira, Luiz Cesar Guarita-Souza, Lúcia de Noronha, Katherine Athayde Teixeira de Carvalho

“…Multiple sclerosis (MS) is an autoimmune disease of the central nervous system, characterized as an inflammatory demyelinating disease. Given the need for improvements in MS treatment, many studies are mainly conducted through preclinical models such as experimental allergic encephalomyelitis (EAE). …”
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Hypomyelinating leukodystrophy-associated mutation of RARS leads it to the lysosome, inhibiting oligodendroglial morphological differentiation by Naoto Matsumoto, Natsumi Watanabe, Noriko Iibe, Yuriko Tatsumi, Kohei Hattori, Yu Takeuchi, Hiroaki Oizumi, Katsuya Ohbuchi, Tomohiro Torii, Yuki Miyamoto, Junji Yamauchi

“…Pelizaeus-Merzbacher disease (PMD) is a central nervous system (CNS) demyelinating disease in human, currently known as prototypic hypomyelinating leukodystrophy 1 (HLD1). …”
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Single-cell profiling reveals periventricular CD56bright NK cell accumulation in multiple sclerosis by Sabela Rodríguez-Lorenzo, Lynn van Olst, Carla Rodriguez-Mogeda, Alwin Kamermans, Susanne MA van der Pol, Ernesto Rodríguez, Gijs Kooij, Helga E de Vries

“…Multiple sclerosis (MS) is a chronic demyelinating disease characterised by immune cell infiltration resulting in lesions that preferentially affect periventricular areas of the brain. …”
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Th1 and Th17 Cells and Associated Cytokines Discriminate among Clinically Isolated Syndrome and Multiple Sclerosis Phenotypes by Gabriel Arellano, Eric Acuña, Lilian I. Reyes, Payton A. Ottum, Patrizia De Sarno, Luis Villarroel, Ethel Ciampi, Ethel Ciampi, Reinaldo Uribe-San Martín, Reinaldo Uribe-San Martín, Claudia Cárcamo, Rodrigo Naves

“…Multiple sclerosis (MS) is a chronic, inflammatory, and demyelinating disease of the central nervous system. It is a heterogeneous pathology that can follow different clinical courses, and the mechanisms that underlie the progression of the immune response across MS subtypes remain incompletely understood. …”
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Myelination diseases of the central nervous system: Artificial Axons as in vitro models of chemomechanical cues by Yang, Mingyu

“…These properties are clinically relevant as prior neuroimaging data from human patients show correlations between demyelinating diseases and changes in brain stiffness, axon diameter, and axon density. …”
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Positive Predictive Value of MOG-IgG for Clinically Defined MOG-AD Within a Real-World Cohort by Giovanna S. Manzano, Rebecca Salky, Farrah J. Mateen, Eric C. Klawiter, Tanuja Chitnis, Michael Levy, Marcelo Matiello

“…Myelin oligodendrocyte glycoprotein antibody associated disease (MOG-AD) is a CNS demyelinating disease, typically presenting with optic neuritis, transverse myelitis, and/or ADEM-like syndromes. …”
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N-acetylglucosamine inhibits inflammation and neurodegeneration markers in multiple sclerosis: a mechanistic trial by Michael Sy, Barbara L. Newton, Judy Pawling, Ken L. Hayama, Andres Cordon, Zhaoxia Yu, Jens Kuhle, James W. Dennis, Alexander U. Brandt, Michael Demetriou

“…Abstract Background In the demyelinating disease multiple sclerosis (MS), chronic-active brain inflammation, remyelination failure and neurodegeneration remain major issues despite immunotherapy. …”
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<i>HLA-DPB1*03</i> as Risk Allele and <i>HLA-DPB1*04</i> as Protective Allele for Both Early- and Adult-Onset Multiple Sclerosis in a Hellenic Cohort by Maria Anagnostouli, Artemios Artemiadis, Maria Gontika, Charalampos Skarlis, Nikolaos Markoglou, Serafeim Katsavos, Konstantinos Kilindireas, Ilias Doxiadis, Leonidas Stefanis

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The benefits of hesperidin in central nervous system disorders, based on the neuroprotective effect by Xinyu Li, Wei Huang, Rongrong Tan, Caijuan Xu, Xi Chen, Sixin Li, Ying Liu, Huiwen Qiu, Hui Cao, Quan Cheng

“…The most common CNS diseases include neurodegenerative diseases, mental disorders, demyelinating disease, ischemia-reperfusion injury, and neuroinflammation. …”
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Selective Upregulation of SIRT1 Expression in Retinal Ganglion Cells by AAV-Mediated Gene Delivery Increases Neuronal Cell Survival and Alleviates Axon Demyelination Associated wit... by Ahmara G. Ross, Brahim Chaqour, Devin S. McDougald, Kimberly E. Dine, Thu T. Duong, Ryan E. Shindler, Jipeng Yue, Tehui Liu, Kenneth S. Shindler

“…Optic neuritis (ON), the most common ocular manifestation of multiple sclerosis, is an autoimmune inflammatory demyelinating disease also characterized by degeneration of retinal ganglion cells (RGCs) and their axons, which commonly leads to visual impairment despite attempted treatments. …”
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The systemic inhibition of the terminal complement system reduces neuroinflammation but does not improve motor function in mouse models of CMT1A with overexpressed PMP22 by Iliana Michailidou, Jeroen Vreijling, Matthijs Rumpf, Maarten Loos, Bastijn Koopmans, Nina Vlek, Nina Straat, Cedrick Agaser, Thomas B. Kuipers, Hailiang Mei, Frank Baas, Kees Fluiter

“…Several reports have described patients with co-occurrence of CMT1A with chronic inflammatory demyelinating disease or Guillain-Barré syndrome. We have previously shown in multiple animal models that the innate immune system and specifically the terminal complement system is a driver of inflammatory demyelination. …”
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Anesthetic management of a patient with multiple sclerosis – case report by Eduardo Barbin Zuccolotto, Guilherme Coelho Machado Nunes, Rafael Soares Lopes Nogueira, Eugenio Pagnussatt Neto, José Roberto Nociti

“…Background and objectives: Multiple sclerosis is a demyelinating disease of the brain and spinal cord, characterized by muscle weakness, cognitive dysfunction, memory loss, and personality disorders. …”
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Treatment with the Olive Secoiridoid Oleacein Protects against the Intestinal Alterations Associated with EAE by Beatriz Gutiérrez-Miranda, Isabel Gallardo, Eleni Melliou, Isabel Cabero, Yolanda Álvarez, Marta Hernández, Prokopios Magiatis, Marita Hernández, María Luisa Nieto

“…Multiple sclerosis (MS) is a CNS inflammatory demyelinating disease. Recent investigations highlight the gut-brain axis as a communication network with crucial implications in neurological diseases. …”
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IKKβ deletion from CNS macrophages increases neuronal excitability and accelerates the onset of EAE, while from peripheral macrophages reduces disease severity by Maria Avloniti, Maria Evangelidou, Maria Gomini, Theodore Loupis, Mary Emmanouil, Adamantia Mitropoulou, Theodore Tselios, Hans Lassmann, Agnès Gruart, José M. Delgado-García, Lesley Probert, Vasiliki Kyrargyri

“…Abstract Background Multiple sclerosis (MS) is a neuroinflammatory demyelinating disease characterized by motor deficits and cognitive decline. …”
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Sera from Patients with NMOSD Reduce the Differentiation Capacity of Precursor Cells in the Central Nervous System by Ulises Gómez-Pinedo, Yolanda García-Ávila, Lucía Gallego-Villarejo, Jordi A. Matías-Guiu, María Soledad Benito-Martín, Noelia Esteban-García, Inmaculada Sanclemente-Alamán, Vanesa Pytel, Lidia Moreno-Jiménez, Francisco Sancho-Bielsa, Lucía Vidorreta-Ballesteros, Paloma Montero-Escribano, Jorge Matías-Guiu

“…Introduction: AQP4 (aquaporin-4)–immunoglobulin G (IgG)-mediated neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory demyelinating disease that affects the central nervous system, particularly the spinal cord and optic nerve; remyelination capacity in neuromyelitis optica is yet to be determined, as is the role of AQP4–IgG in cell differentiation. …”
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The Occurrence of Acute Disseminated Encephalomyelitis in SARS-CoV-2 Infection/Vaccination: Our Experience and a Systematic Review of the Literature by Adina Stoian, Zoltan Bajko, Mircea Stoian, Roxana Adriana Cioflinc, Raluca Niculescu, Emil Marian Arbănași, Eliza Russu, Marian Botoncea, Rodica Bălașa

“…It is an acute-onset demyelinating disease that involves a rapid evolution and multifocal neurological deficits that develops following a viral or bacterial infection or, less frequently, following vaccination. …”
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Investigation of image-derived input functions for non-invasive quantification of myelin density using [11C]MeDAS PET by Chris W.J. van der Weijden, Anouk van der Hoorn, Yanming Wang, Antoon T.M. Willemsen, Rudi A.J.O. Dierckx, Adriaan A. Lammertsma, Erik F.J. de Vries

“…Multiple sclerosis (MS) is an inflammatory demyelinating disease. Current treatments are focussed on immune suppression to modulate pathogenic activity that causes myelin damage. …”
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In-silico studies of glutathione peroxidase4 activators as candidate for multiple sclerosis management by Alaa Alnoor Alameen, Mohnad Abdalla, Hanan M. Alshibl, Monerah R. AlOthman, Manal M. Alkhulaifi, Tabyan O. Mirgany, Rasha Elsayim

“…Multiple sclerosis (MS) is an autoimmune and inflammatory demyelinating disease of the central nervous system (CNS) that affects approximately 2.8 million people worldwide. …”
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The Assessment of Structural Changes in MS Plaques and Normal Appearing White Matter Using Quantitative Magnetization Transfer Imaging (MTI) by Masoomeh Fooladi, Nader Riahi Alam, Mohammad Hossein Harirchyan, Kavoos Firuznia, Mohammad Ali Oghabian, Majid Shakiba, Behrooz Rafie, Morteza Bakhtiary

“…Introduction: Multiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS), affecting mostly young people at a mean age of 30 years. …”
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Tools for comprehensive evaluation of sexual function in patients with multiple sclerosis by M. Gaviria Carrillo, P.A. Ortiz Salas, K.P. Rueda Vergara, G.A. Cortes Bernal, M. Nava Mesa, K. Moreno Medina

“…Introduction: Multiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS) that affects young adults, causing a variety of symptoms (motor alterations, visual alterations, loss of sphincter control, gait alterations) that impair the patient’s functional status. …”
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