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561
Demyelination Lesions Do Not Correlate with Clinical Manifestations by Bordetella pertussis Toxin Concentrations
Published 2022-06-01“…Multiple sclerosis (MS) is an autoimmune disease of the central nervous system, characterized as an inflammatory demyelinating disease. Given the need for improvements in MS treatment, many studies are mainly conducted through preclinical models such as experimental allergic encephalomyelitis (EAE). …”
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562
Hypomyelinating leukodystrophy-associated mutation of RARS leads it to the lysosome, inhibiting oligodendroglial morphological differentiation
Published 2019-12-01“…Pelizaeus-Merzbacher disease (PMD) is a central nervous system (CNS) demyelinating disease in human, currently known as prototypic hypomyelinating leukodystrophy 1 (HLD1). …”
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563
Single-cell profiling reveals periventricular CD56bright NK cell accumulation in multiple sclerosis
Published 2022-05-01“…Multiple sclerosis (MS) is a chronic demyelinating disease characterised by immune cell infiltration resulting in lesions that preferentially affect periventricular areas of the brain. …”
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564
Th1 and Th17 Cells and Associated Cytokines Discriminate among Clinically Isolated Syndrome and Multiple Sclerosis Phenotypes
Published 2017-06-01“…Multiple sclerosis (MS) is a chronic, inflammatory, and demyelinating disease of the central nervous system. It is a heterogeneous pathology that can follow different clinical courses, and the mechanisms that underlie the progression of the immune response across MS subtypes remain incompletely understood. …”
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565
Myelination diseases of the central nervous system: Artificial Axons as in vitro models of chemomechanical cues
Published 2024“…These properties are clinically relevant as prior neuroimaging data from human patients show correlations between demyelinating diseases and changes in brain stiffness, axon diameter, and axon density. …”
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566
Positive Predictive Value of MOG-IgG for Clinically Defined MOG-AD Within a Real-World Cohort
Published 2022-06-01“…Myelin oligodendrocyte glycoprotein antibody associated disease (MOG-AD) is a CNS demyelinating disease, typically presenting with optic neuritis, transverse myelitis, and/or ADEM-like syndromes. …”
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567
N-acetylglucosamine inhibits inflammation and neurodegeneration markers in multiple sclerosis: a mechanistic trial
Published 2023-09-01“…Abstract Background In the demyelinating disease multiple sclerosis (MS), chronic-active brain inflammation, remyelination failure and neurodegeneration remain major issues despite immunotherapy. …”
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568
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569
The benefits of hesperidin in central nervous system disorders, based on the neuroprotective effect
Published 2023-03-01“…The most common CNS diseases include neurodegenerative diseases, mental disorders, demyelinating disease, ischemia-reperfusion injury, and neuroinflammation. …”
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570
Selective Upregulation of SIRT1 Expression in Retinal Ganglion Cells by AAV-Mediated Gene Delivery Increases Neuronal Cell Survival and Alleviates Axon Demyelination Associated wit...
Published 2022-06-01“…Optic neuritis (ON), the most common ocular manifestation of multiple sclerosis, is an autoimmune inflammatory demyelinating disease also characterized by degeneration of retinal ganglion cells (RGCs) and their axons, which commonly leads to visual impairment despite attempted treatments. …”
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571
The systemic inhibition of the terminal complement system reduces neuroinflammation but does not improve motor function in mouse models of CMT1A with overexpressed PMP22
Published 2023-01-01“…Several reports have described patients with co-occurrence of CMT1A with chronic inflammatory demyelinating disease or Guillain-Barré syndrome. We have previously shown in multiple animal models that the innate immune system and specifically the terminal complement system is a driver of inflammatory demyelination. …”
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572
Anesthetic management of a patient with multiple sclerosis – case report
Published 2016-07-01“…Background and objectives: Multiple sclerosis is a demyelinating disease of the brain and spinal cord, characterized by muscle weakness, cognitive dysfunction, memory loss, and personality disorders. …”
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573
Treatment with the Olive Secoiridoid Oleacein Protects against the Intestinal Alterations Associated with EAE
Published 2023-03-01“…Multiple sclerosis (MS) is a CNS inflammatory demyelinating disease. Recent investigations highlight the gut-brain axis as a communication network with crucial implications in neurological diseases. …”
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574
IKKβ deletion from CNS macrophages increases neuronal excitability and accelerates the onset of EAE, while from peripheral macrophages reduces disease severity
Published 2024-01-01“…Abstract Background Multiple sclerosis (MS) is a neuroinflammatory demyelinating disease characterized by motor deficits and cognitive decline. …”
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575
Sera from Patients with NMOSD Reduce the Differentiation Capacity of Precursor Cells in the Central Nervous System
Published 2021-05-01“…Introduction: AQP4 (aquaporin-4)–immunoglobulin G (IgG)-mediated neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory demyelinating disease that affects the central nervous system, particularly the spinal cord and optic nerve; remyelination capacity in neuromyelitis optica is yet to be determined, as is the role of AQP4–IgG in cell differentiation. …”
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576
The Occurrence of Acute Disseminated Encephalomyelitis in SARS-CoV-2 Infection/Vaccination: Our Experience and a Systematic Review of the Literature
Published 2023-07-01“…It is an acute-onset demyelinating disease that involves a rapid evolution and multifocal neurological deficits that develops following a viral or bacterial infection or, less frequently, following vaccination. …”
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577
Investigation of image-derived input functions for non-invasive quantification of myelin density using [11C]MeDAS PET
Published 2022-12-01“…Multiple sclerosis (MS) is an inflammatory demyelinating disease. Current treatments are focussed on immune suppression to modulate pathogenic activity that causes myelin damage. …”
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578
In-silico studies of glutathione peroxidase4 activators as candidate for multiple sclerosis management
Published 2022-11-01“…Multiple sclerosis (MS) is an autoimmune and inflammatory demyelinating disease of the central nervous system (CNS) that affects approximately 2.8 million people worldwide. …”
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579
The Assessment of Structural Changes in MS Plaques and Normal Appearing White Matter Using Quantitative Magnetization Transfer Imaging (MTI)
Published 2007-12-01“…Introduction: Multiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS), affecting mostly young people at a mean age of 30 years. …”
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580
Tools for comprehensive evaluation of sexual function in patients with multiple sclerosis
Published 2023-04-01“…Introduction: Multiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS) that affects young adults, causing a variety of symptoms (motor alterations, visual alterations, loss of sphincter control, gait alterations) that impair the patient’s functional status. …”
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