Ageing impairs the regenerative capacity of regulatory T cells in mouse central nervous system remyelination by Alerie Guzman de la Fuente, Marie Dittmer, Elise J. Heesbeen, Nira de la Vega Gallardo, Jessica A. White, Andrew Young, Tiree McColgan, Amy Dashwood, Katie Mayne, Sonia Cabeza-Fernández, John Falconer, Francisco Javier Rodriguez-Baena, Christopher E. McMurran, Mohammed Inayatullah, Khalil S. Rawji, Robin J. M. Franklin, James Dooley, Adrian Liston, Rebecca J. Ingram, Vijay K. Tiwari, Rosana Penalva, Yvonne Dombrowski, Denise C. Fitzgerald

“…Abstract Myelin regeneration (remyelination) is essential to prevent neurodegeneration in demyelinating diseases such as Multiple Sclerosis, however, its efficiency declines with age. …”
Get full text

Extracellular Acidic pH Inhibits Oligodendrocyte Precursor Viability, Migration, and Differentiation by Jagielska, Anna, Wilhite, Kristen D., Van Vliet, Krystyn J.

“…Failure of this repair process is characteristic of neurodegeneration in demyelinating diseases such as multiple sclerosis, and it remains unclear how the lesion microenvironment contributes to decreased remyelination potential of oligodendrocytes. …”
Get full text
Get full text

Neuronal activity and remyelination: new insights into the molecular mechanisms and therapeutic advancements by Yiting Zhou, Jing Zhang

“…Research has shown that controlling neuronal excitability may become a new intervention method for the clinical treatment of demyelinating diseases. The article discusses the latest research progress of neuronal activity on myelin regeneration, including direct or indirect stimulation methods, and the related neural signaling pathways, including glutamatergic, GABAergic, cholinergic, histaminergic, purinergic and voltage-gated ion channel signaling pathways, revealing that seeking treatment strategies to promote myelin regeneration through precise regulation of neuronal activity has broad prospects.…”
Get full text

Increased peripheral inflammatory responses in myelin oligodendrocyte glycoprotein associated disease and aquaporin-4 antibody positive neuromyelitis optica spectrum disorder by Angelika Bauer, Angelika Bauer, Dagmar Rudzki, Dagmar Rudzki, Klaus Berek, Alessandro Dinoto, Christian Lechner, Eva-Maria Wendel, Harald Hegen, Florian Deisenhammer, Thomas Berger, Thomas Berger, Romana Höftberger, Romana Höftberger, Kevin Rostasy, Sara Mariotto, Markus Reindl

“…Autoantibody-associated demyelinating diseases of the central nervous system such as myelin oligodendrocyte glycoprotein-antibody associated disease (MOGAD) and aquaporin 4-antibody positive neuromyelitis optica spectrum disorders (AQP4+ NMOSD) are rare diseases but can cause severe disability. …”
Get full text

Testosterone Inhibits Secretion of the Pro-Inflammatory Chemokine CXCL1 from Astrocytes by Malgorzata Turniak-Kusy, Maciej Studzian, Piotr Szpakowski, Piotr Kuchta, Kaja Smietanka, Claudia Mattern, Lukasz Pulaski, Bartosz Bielecki

“…Astrocytes play an important role in the regulation of the inflammatory response in the CNS, e.g., in demyelinating diseases. Since the chemokine CXCL1 is known to be secreted by astrocytes and to have a pro-inflammatory effect on immune cells in the CNS, we verified the effect of testosterone on its secretion in vitro (in the astrocytic cell line DI TNC1). …”
Get full text

From OPC to Oligodendrocyte: An Epigenetic Journey by Assia Tiane, Melissa Schepers, Ben Rombaut, Raymond Hupperts, Jos Prickaerts, Niels Hellings, Daniel van den Hove, Tim Vanmierlo

“…These insights are a crucial starting point for studies that aim to identify the contribution of epigenetics in demyelinating diseases and may thus provide new therapeutic targets to induce myelin repair in the long run.…”
Get full text

β-hydroxybutyrate attenuates demyelination, modulates microglial phenotype and supports blood-brain barrier integrity in a cuprizone-induced mouse model of demyelination by Ning Zhang, Lin Li, Sen Li, Muhammad Akram Khan, Adnan Hassan Tahir, Muhammad Farhan Rahim, Ting Wang, Jiyu Zhao, Ruiyan Zhang

“…Thus, these findings suggest that BHB may be a therapeutic approach for preventing demyelinating diseases.…”
Get full text

Effect of Cholesterol and Myelin Basic Protein (MBP) Content on Lipid Monolayers Mimicking the Cytoplasmic Membrane of Myelin by Jennica Träger, Katharina Widder, Andreas Kerth, George Harauz, Dariush Hinderberger

“…By interacting with lipid membranes, it is responsible for compaction of the myelin sheath in the central nervous system, which is weakened in demyelinating diseases. The lipid composition of the myelin leaflet has a high impact on the interaction between the membrane and MBP. …”
Get full text

Aquaporin-4 in Neuromyelitis Optica Spectrum Disorders: A Target of Autoimmunity in the Central Nervous System by Yoichiro Abe, Masato Yasui

“…NMO-IgG is an excellent marker for distinguishing the disease from other inflammatory demyelinating diseases, such as multiple sclerosis. The unique higher-order structure of AQP4—called orthogonal arrays of particles (OAPs)—as well as its subcellular localization may play a crucial role in the pathogenesis of the disease. …”
Get full text

Microfiber drug/gene delivery platform for study of myelination by Ong, William, Lin, Junquan, Bechler, Marie E., Wang, Kai, Wang, Mingfeng, ffrench-Constant, Charles, Chew, Sing Yian

“…Our ability to rescue functional deficits after demyelinating diseases or spinal cord injuries is limited by our lack of understanding of the complex remyelination process, which is crucial to functional recovery. …”
Get full text
Get full text

Filtering property of myelinated internode can change neural information representability and might trigger a compensatory action during demyelination by Sarbani Das, Koushik Maharatna

“…Consequently, we showed how the representability of a neural signal could be altered with myelin loss in pathological conditions involving demyelinating diseases. Contrary to the traditionally held viewpoint that myelin geometry of an INS is optimised for maximising Conduction Velocity (CV) of Action Potential (AP), our theory provides an alternative viewpoint that myelin geometry of an INS is optimised for maximizing representability of the stimuli a fibre is meant to carry. …”
Get full text

Fast generation of forebrain oligodendrocyte spheroids from human embryonic stem cells by transcription factors by Ling Ma, Yuting Mei, Peibo Xu, Yan Cheng, Zhiwen You, Xiaoli Ji, Deyi Zhuang, Wenhao Zhou, Yuejun Chen, Man Xiong

“…Summary: Oligodendrocyte spheroids (OL-spheroids) containing oligodendrocytes and neurons provide an accessible system to dissect demyelinating diseases and test therapeutic treatment. However, generation of human OL-spheroids is still technically challenging and time-consuming until now. …”
Get full text

Optical Coherence Tomography Angiography of Peripapillary Vessel Density in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder: A Comparative Study by Małgorzata Rogaczewska, Sławomir Michalak, Marcin Stopa

“…Multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) are demyelinating diseases of the central nervous system, which differ in the pathogenic mechanism. …”
Get full text

Evidence That DDR1 Promotes Oligodendrocyte Differentiation during Development and Myelin Repair after Injury by Ruyi Mei, Wanwan Qiu, Yingying Yang, Siyu Xu, Yueyu Rao, Qingxin Li, Yuhao Luo, Hao Huang, Aifen Yang, Huaping Tao, Mengsheng Qiu, Xiaofeng Zhao

“…Taken together, the current study described, for the first time, the role of <i>Ddr1</i> in myelin development and repair in the CNS, providing a novel molecule target for the treatment of demyelinating diseases.…”
Get full text

The Effects of Insulin on Immortalized Rat Schwann Cells, IFRS1 by Tomokazu Saiki, Nobuhisa Nakamura, Megumi Miyabe, Mizuho Ito, Tomomi Minato, Kazunori Sango, Tatsuaki Matsubara, Keiko Naruse

“…Schwann cells play an important role in peripheral nerve function, and their dysfunction has been implicated in the pathogenesis of diabetic neuropathy and other demyelinating diseases. The physiological functions of insulin in Schwann cells remain unclear and therefore define the aim of this study. …”
Get full text

Oligodendrocyte-lineage cell exocytosis and L-type prostaglandin D synthase promote oligodendrocyte development and myelination by Lin Pan, Amelia Trimarco, Alice J Zhang, Ko Fujimori, Yoshihiro Urade, Lu O Sun, Carla Taveggia, Ye Zhang

“…Oligodendrocytes and myelin are essential for the function of the central nervous system, as evidenced by the severe neurological symptoms that arise in demyelinating diseases such as multiple sclerosis and leukodystrophy. …”
Get full text

Genetics behind Cerebral Disease with Ocular Comorbidity: Finding Parallels between the Brain and Eye Molecular Pathology by Kao-Jung Chang, Hsin-Yu Wu, Aliaksandr A. Yarmishyn, Cheng-Yi Li, Yu-Jer Hsiao, Yi-Chun Chi, Tzu-Chen Lo, He-Jhen Dai, Yi-Chiang Yang, Ding-Hao Liu, De-Kuang Hwang, Shih-Jen Chen, Chih-Chien Hsu, Chung-Lan Kao

“…By revisiting the genome-wide and phenome-wide association studies (GWAS and PheWAS), we clustered a handful of renowned CVIs into five ontology groups, namely ciliopathies (Joubert syndrome, Bardet–Biedl syndrome, Alstrom syndrome), demyelination diseases (multiple sclerosis, Alexander disease, Pelizaeus–Merzbacher disease), transcriptional deregulation diseases (Mowat–Wilson disease, Pitt–Hopkins disease, Rett syndrome, Cockayne syndrome, X-linked alpha-thalassaemia mental retardation), compromised peroxisome disorders (Zellweger spectrum disorder, Refsum disease), and channelopathies (neuromyelitis optica spectrum disorder), and reviewed several mutation hotspots currently found to be associated with the CVIs. …”
Get full text

C1q is essential for myelination in the central nervous system (CNS) by Qiang Yu, Nan Zhang, Teng Guan, Ying Guo, Hassan Marzban, Benjamin Lindsey, Jiming Kong

“…This study uncovers the pivotal role of microglia-derived C1q in developmental myelination and could potentially pave the way for new therapeutic strategies for treating demyelinating diseases.…”
Get full text

Deficiency of microglial Hv1 channel is associated with activation of autophagic pathway and ROS production in LPC-induced demyelination mouse model by Man Chen, Lin-Lin Yang, Zi-Wei Hu, Chuan Qin, Luo-Qi Zhou, Ya-ling Duan, Dale B. Bosco, Long-Jun Wu, Ke-Bin Zhan, Sha-Bei Xu, Dai-Shi Tian

“…Abstract Background Multiple sclerosis (MS) is an immune-mediated demyelinated disease of the central nervous system. Activation of microglia is involved in the pathogenesis of myelin loss. …”
Get full text

Vertebral artery dissection stroke in evolution presented with postural headache as initial manifestation by Yen-Chung Chen, Yang-Hao Ou, Ming-Che Chang, Wei-Liang Chen, Chih-Ming Lin

“…Nevertheless, with the aid of single photon emission computed tomography, we are confident the patient was afflicted with ischemic/hemorrhagic lesion, instead of neoplasm or demyelinating diseases. Lateral medullary syndrome was confirmed on the repeated brain MRI. …”
Get full text