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701
Myelopathy: Retrospective Evaluation of Twenty-Eight Cases
Published 2017-12-01“…The most common initial symptoms were sensorial deficits and motor weakness. Demyelinating diseases were the most common diseases and multiple sclerosis was the most frequent etiology among demiyelinating diseases. …”
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702
Significance of Autoantibodies in Autoimmune Encephalitis in Relation to Antigen Localization: An Outline of Frequently Reported Autoantibodies with a Non-Systematic Review
Published 2020-07-01“…It has also improved our understanding of intractable epilepsy, atypical psychosis, and some demyelinating diseases that are ameliorated with immune therapies. …”
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703
Rewiring of Glucose and Lipid Metabolism Induced by G Protein-Coupled Receptor 17 Silencing Enables the Transition of Oligodendrocyte Progenitors to Myelinating Cells
Published 2022-08-01“…Globally, this study unveils a functional link between GPR17 expression, lactate release and myelin composition, and suggests that innovative interventions targeting GPR17 may help to foster endogenous myelination in demyelinating diseases.…”
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704
Neurological manifestations of COVID-19 in a five-year-old child
Published 2022-09-01“…In children under 16 years of age infected with SARS-CoV-2, the vast majority of cases were mild, without marked neurological manifestations.This paper describes a case of acute disseminated encephalomyelitis in a five-year-old child associated with SARS-CoV-2, which caused difficulties in the differential diagnosis with demyelinating diseases and hereditary pathology. The disease was diagnosed in a family where both parentswere diagnosedwith COVID-19 by polymerase chain reaction (PCR).The CNSlesionwasrepresented by severe central hemiparesis, involvement of some cranial nerves, with impaired pelvic organ function. …”
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705
High Dose Pharmaceutical Grade Biotin (MD1003) Accelerates Differentiation of Murine and Grafted Human Oligodendrocyte Progenitor Cells In Vivo
Published 2022-12-01“…Accumulating evidences suggest a strong correlation between metabolic changes and neurodegeneration in CNS demyelinating diseases such as multiple sclerosis (MS). Biotin, an essential cofactor for five carboxylases, is expressed by oligodendrocytes and involved in fatty acid synthesis and energy production. …”
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706
Nogo-A and LINGO-1: Two Important Targets for Remyelination and Regeneration
Published 2023-02-01“…Inhibiting the actions of Nogo-A or LINGO-1 promotes remyelination both in vitro and in vivo, while Nogo-A or LINGO-1 antagonists have been suggested as promising therapeutic approaches for demyelinating diseases. In this review, we focus on these two negative regulators of myelination while also providing an overview of the available data on the effects of Nogo-A and LINGO-1 inhibition on oligodendrocyte differentiation and remyelination.…”
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707
A framework for optimal whole-sample histological quantification of neurite orientation dispersion in the human spinal cord
Published 2016“…Segmentation of neurites prior to OD quantification is recommended.Our framework can potentially provide OD even in demyelinating diseases, where myelin-based histology is not suitable. …”
Journal article -
708
Overlapping CNS inflammatory diseases: differentiating features of NMO and MS.
Published 2015“…We review the value of these discriminators and discuss the compelling need for new diagnostic markers in these two autoimmune demyelinating diseases of the central nervous system.…”
Journal article -
709
Case report: A novel case of COVID-19 triggered tumefactive demyelinating lesions in one multiple sclerosis patient
Published 2023-11-01“…The case also gave us a hint that SARS-CoV-2 has a potential contributory role in inducing or exacerbating demyelinating diseases of the central nervous system that warrants further investigation.…”
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710
EGF-Coupled Gold Nanoparticles Increase the Expression of CNPase and the Myelin-Associated Proteins MAG, MOG, and MBP in the Septal Nucleus Demyelinated by Cuprizone
Published 2022-02-01“…Current pharmacological therapies against demyelinating diseases are not quite satisfactory to promote remyelination. …”
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711
Nimodipine Exerts Beneficial Effects on the Rat Oligodendrocyte Cell Line OLN-93
Published 2022-04-01“…Taking into consideration previous studies that demonstrated a beneficial effect of nimodipine on microglia, our data support the notion that nimodipine is an interesting drug candidate for the treatment of MS and other demyelinating diseases.…”
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712
Anti-MOG antibody-positive ADEM following infectious mononucleosis due to a primary EBV infection: a case report
Published 2017-04-01“…Abstract Background Anti-Myelin oligodendrocyte glycoprotein (MOG) antibodies are detected in various demyelinating diseases, such as pediatric acute disseminated encephalomyelitis (ADEM), recurrent optic neuritis, and aquaporin-4 antibody-seronegative neuromyelitis optica spectrum disorder. …”
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713
Cuprizone-Induced Neurotoxicity in Human Neural Cell Lines Is Mediated by a Reversible Mitochondrial Dysfunction: Relevance for Demyelination Models
Published 2021-02-01“…This reversible cell-based model may help to further investigate the role of mitochondria in the disease, and study the molecular intricacies underlying the pathophysiology of the MS and other demyelinating diseases.…”
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714
A<sub>2B</sub> Adenosine Receptors: When Outsiders May Become an Attractive Target to Treat Brain Ischemia or Demyelination
Published 2020-12-01“…In conclusion, data in the literature indicate the A<sub>2B</sub>Rs as putative therapeutic targets for the still unmet treatment of stroke or demyelinating diseases.…”
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715
Acid-Sensing Ion Channels in Glial Cells
Published 2022-01-01“…In oligodendrocytes, constitutive activation of ASIC1a participates in demyelinating diseases. ASIC1a, ASIC2a, and ASIC3, found in microglial cells, could mediate the inflammatory response. …”
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716
MOG antibody associated disease (MOGAD) presenting with extensive brain stem encephalitis: A case report
Published 2022-12-01“…Background: Myelin oligodendrocyte glycoprotein antibody disease (MOGAD) is a relatively new entity of demyelinating diseases, clinically presenting with optic neuritis, transverse myelitis, or encephalic symptoms. …”
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717
TMEM106B Puncta Is Increased in Multiple Sclerosis Plaques, and Reduced Protein in Mice Results in Delayed Lipid Clearance Following CNS Injury
Published 2023-06-01“…During inflammatory, demyelinating diseases such as multiple sclerosis (MS), inflammation and axonal damage are prevalent early in the course. …”
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718
The Dectin-1 Receptor Signaling Pathway Mediates the Remyelination Effect of Lentinan through Suppression of Neuroinflammation and Conversion of Microglia
Published 2022-01-01“…Demyelinating diseases such as multiple sclerosis (MS) are chronic inflammatory autoimmune diseases and involve demyelination and axonal degeneration. …”
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719
The effect of probiotic supplementation on the clinical and para-clinical findings of multiple sclerosis: a randomized clinical trial
Published 2023-10-01“…Abstract Multiple Sclerosis (MS) is a chronic demyelination disease of the central nervous system (CNS). …”
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720
Transition clinic in pediatric onset multiple sclerosis: Opinions of pediatric neurologists and neurologists
Published 2022-06-01“…The majority of pediatric neurologists (n=22, 71%) had been involved in central nervous system demyelinating diseases for 0-9 years. Among neurologists, the largest group 17 (n=17, 51.5%) was those who had been caring for these patients for 10-19 years. …”
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Article