Myelopathy: Retrospective Evaluation of Twenty-Eight Cases by Yüksel Erdal, Ufuk Emre, Zeynep Selcen Dartıcı, Osman Özgür Yalın, Nuri Özgür Kılıçkesmez

“…The most common initial symptoms were sensorial deficits and motor weakness. Demyelinating diseases were the most common diseases and multiple sclerosis was the most frequent etiology among demiyelinating diseases. …”
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Significance of Autoantibodies in Autoimmune Encephalitis in Relation to Antigen Localization: An Outline of Frequently Reported Autoantibodies with a Non-Systematic Review by Keiko Tanaka, Meiko Kawamura, Kenji Sakimura, Nobuo Kato

“…It has also improved our understanding of intractable epilepsy, atypical psychosis, and some demyelinating diseases that are ameliorated with immune therapies. …”
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Rewiring of Glucose and Lipid Metabolism Induced by G Protein-Coupled Receptor 17 Silencing Enables the Transition of Oligodendrocyte Progenitors to Myelinating Cells by Davide Marangon, Matteo Audano, Silvia Pedretti, Marta Fumagalli, Nico Mitro, Davide Lecca, Donatella Caruso, Maria P. Abbracchio

“…Globally, this study unveils a functional link between GPR17 expression, lactate release and myelin composition, and suggests that innovative interventions targeting GPR17 may help to foster endogenous myelination in demyelinating diseases.…”
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Neurological manifestations of COVID-19 in a five-year-old child by L. A. Balykova, I. V. Boynova, V. N. Ignatyev, O. I. Ignatieva

“…In children under 16 years of age infected with SARS-CoV-2, the vast majority of cases were mild, without marked neurological manifestations.This paper describes a case of acute disseminated encephalomyelitis in a five-year-old child associated with SARS-CoV-2, which caused difficulties in the differential diagnosis with demyelinating diseases and hereditary pathology. The disease was diagnosed in a family where both parentswere diagnosedwith COVID-19 by polymerase chain reaction (PCR).The CNSlesionwasrepresented by severe central hemiparesis, involvement of some cranial nerves, with impaired pelvic organ function. …”
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High Dose Pharmaceutical Grade Biotin (MD1003) Accelerates Differentiation of Murine and Grafted Human Oligodendrocyte Progenitor Cells In Vivo by Marion J. F. Levy, Beatriz Garcia-Diaz, Frédéric Sedel, Anne Baron-Van Evercooren, Sabah Mozafari

“…Accumulating evidences suggest a strong correlation between metabolic changes and neurodegeneration in CNS demyelinating diseases such as multiple sclerosis (MS). Biotin, an essential cofactor for five carboxylases, is expressed by oligodendrocytes and involved in fatty acid synthesis and energy production. …”
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Nogo-A and LINGO-1: Two Important Targets for Remyelination and Regeneration by Ilias Kalafatakis, Fevronia Papagianni, Konstantinos Theodorakis, Domna Karagogeos

“…Inhibiting the actions of Nogo-A or LINGO-1 promotes remyelination both in vitro and in vivo, while Nogo-A or LINGO-1 antagonists have been suggested as promising therapeutic approaches for demyelinating diseases. In this review, we focus on these two negative regulators of myelination while also providing an overview of the available data on the effects of Nogo-A and LINGO-1 inhibition on oligodendrocyte differentiation and remyelination.…”
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A framework for optimal whole-sample histological quantification of neurite orientation dispersion in the human spinal cord by Grussu, F, Schneider, T, Yates, R, Zhang, H, Wheeler-Kingshott, C, DeLuca, G, Alexander, D

“…Segmentation of neurites prior to OD quantification is recommended.Our framework can potentially provide OD even in demyelinating diseases, where myelin-based histology is not suitable. …”

Overlapping CNS inflammatory diseases: differentiating features of NMO and MS. by Juryńczyk, M, Craner, M, Palace, J

“…We review the value of these discriminators and discuss the compelling need for new diagnostic markers in these two autoimmune demyelinating diseases of the central nervous system.…”

Case report: A novel case of COVID-19 triggered tumefactive demyelinating lesions in one multiple sclerosis patient by Jinghan Hu, Leiyun Huang, Zengyun Qiu, Yongzhen Liu, Kaiming Shen, Bin Tang, Jing Qian, Jing Qian

“…The case also gave us a hint that SARS-CoV-2 has a potential contributory role in inducing or exacerbating demyelinating diseases of the central nervous system that warrants further investigation.…”
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EGF-Coupled Gold Nanoparticles Increase the Expression of CNPase and the Myelin-Associated Proteins MAG, MOG, and MBP in the Septal Nucleus Demyelinated by Cuprizone by Eduardo Lira-Diaz, Jesus Monroy-Rodriguez, Maria G. Gonzalez-Pedroza, Raul A. Morales-Luckie, Luis Castro-Sánchez, Oscar Gonzalez-Perez

“…Current pharmacological therapies against demyelinating diseases are not quite satisfactory to promote remyelination. …”
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Nimodipine Exerts Beneficial Effects on the Rat Oligodendrocyte Cell Line OLN-93 by Felix Boltz, Michael Enders, Andreas Feigenspan, Philipp Kirchner, Arif Ekici, Stefanie Kuerten

“…Taking into consideration previous studies that demonstrated a beneficial effect of nimodipine on microglia, our data support the notion that nimodipine is an interesting drug candidate for the treatment of MS and other demyelinating diseases.…”
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Anti-MOG antibody-positive ADEM following infectious mononucleosis due to a primary EBV infection: a case report by Yoshitsugu Nakamura, Hideto Nakajima, Hiroki Tani, Takafumi Hosokawa, Shimon Ishida, Fumiharu Kimura, Kimihiko Kaneko, Toshiyuki Takahashi, Ichiro Nakashima

“…Abstract Background Anti-Myelin oligodendrocyte glycoprotein (MOG) antibodies are detected in various demyelinating diseases, such as pediatric acute disseminated encephalomyelitis (ADEM), recurrent optic neuritis, and aquaporin-4 antibody-seronegative neuromyelitis optica spectrum disorder. …”
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Cuprizone-Induced Neurotoxicity in Human Neural Cell Lines Is Mediated by a Reversible Mitochondrial Dysfunction: Relevance for Demyelination Models by Eva Martínez-Pinilla, Núria Rubio-Sardón, Sandra Villar-Conde, Gemma Navarro, Eva del Valle, Jorge Tolivia, Rafael Franco, Ana Navarro

“…This reversible cell-based model may help to further investigate the role of mitochondria in the disease, and study the molecular intricacies underlying the pathophysiology of the MS and other demyelinating diseases.…”
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A_2B Adenosine Receptors: When Outsiders May Become an Attractive Target to Treat Brain Ischemia or Demyelination by Elisabetta Coppi, Ilaria Dettori, Federica Cherchi, Irene Bulli, Martina Venturini, Daniele Lana, Maria Grazia Giovannini, Felicita Pedata, Anna Maria Pugliese

“…In conclusion, data in the literature indicate the A_2BRs as putative therapeutic targets for the still unmet treatment of stroke or demyelinating diseases.…”
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Acid-Sensing Ion Channels in Glial Cells by Victoria Cegielski, Rohan Chakrabarty, Shinghua Ding, Michael J. Wacker, Paula Monaghan-Nichols, Xiang-Ping Chu

“…In oligodendrocytes, constitutive activation of ASIC1a participates in demyelinating diseases. ASIC1a, ASIC2a, and ASIC3, found in microglial cells, could mediate the inflammatory response. …”
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MOG antibody associated disease (MOGAD) presenting with extensive brain stem encephalitis: A case report by Elisabeth Olbert, Cornelia Brunner, Naela Alhani, Christian Našel, Walter Struhal

“…Background: Myelin oligodendrocyte glycoprotein antibody disease (MOGAD) is a relatively new entity of demyelinating diseases, clinically presenting with optic neuritis, transverse myelitis, or encephalic symptoms. …”
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TMEM106B Puncta Is Increased in Multiple Sclerosis Plaques, and Reduced Protein in Mice Results in Delayed Lipid Clearance Following CNS Injury by Bridget Shafit-Zagardo, Simone Sidoli, James E. Goldman, Juwen C. DuBois, John R. Corboy, Stephen M. Strittmatter, Hillary Guzik, Ukuemi Edema, Anita G. Arackal, Yair M. Botbol, Emilio Merheb, Rashed M. Nagra, Sarah Graff

“…During inflammatory, demyelinating diseases such as multiple sclerosis (MS), inflammation and axonal damage are prevalent early in the course. …”
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The Dectin-1 Receptor Signaling Pathway Mediates the Remyelination Effect of Lentinan through Suppression of Neuroinflammation and Conversion of Microglia by Dandan Zhang, Yue Jia, Xingzong Sun, Haoran Li, Min Yin, Hongliang Li, Lili Dai, Li Han, Lei Wang, Menghan Qian, Jing Du, Keming Zhu, Hongkun Bao

“…Demyelinating diseases such as multiple sclerosis (MS) are chronic inflammatory autoimmune diseases and involve demyelination and axonal degeneration. …”
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The effect of probiotic supplementation on the clinical and para-clinical findings of multiple sclerosis: a randomized clinical trial by Kimia Motlagh Asghari, Neda Dolatkhah, Hormoz Ayromlou, Fatemeh Mirnasiri, Taher Dadfar, Maryam Hashemian

“…Abstract Multiple Sclerosis (MS) is a chronic demyelination disease of the central nervous system (CNS). …”
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Transition clinic in pediatric onset multiple sclerosis: Opinions of pediatric neurologists and neurologists by Ismail Solmaz

“…The majority of pediatric neurologists (n=22, 71%) had been involved in central nervous system demyelinating diseases for 0-9 years. Among neurologists, the largest group 17 (n=17, 51.5%) was those who had been caring for these patients for 10-19 years. …”
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