-
721
Patient with CADASIL – a diagnostic challenge
Published 2023-09-01“…CONCLUSIONS: It is relevant to pay attention to radiological findings and family history in the diagnostic process of a patient presenting symptoms which may suggest CADASIL to differentiate this genetic condition from demyelinating diseases.…”
Get full text
Article -
722
Increased expression of cystine/glutamate antiporter in multiple sclerosis
Published 2011-06-01“…</p> <p>Conclusions</p> <p>Together, these results reveal that increased expression of the cystine/glutamate antiporter system x<sub>c</sub><sup>- </sup>in MS provides a link between inflammation and excitotoxicity in demyelinating diseases.</p>…”
Get full text
Article -
723
Reaction-diffusion models in weighted and directed connectomes.
Published 2022-10-01“…The implemented reaction-diffusion systems were applied to a subconnectome which shapes the mechanosensitive pathway that is strongly affected in the multiple sclerosis demyelination disease. It was found that demyelination modeling by connectivity weight modulation changes the oscillations of the target region, i.e. the primary somatosensory cortex, of the mechanosensitive pathway. …”
Get full text
Article -
724
Dor na esclerose múltipla: caracterização de uma população Portuguesa de 85 doentes.
Published 2009-06-01“…A sample of 85 MS patients of the Outpatient Clinic of Demyelinating Diseases of the Neurology Department of São João Hospital, Oporto, Portugal, was studied. …”
Get full text
Article -
725
Tuning PAK Activity to Rescue Abnormal Myelin Permeability in HNPP.
Published 2016-09-01“…We call it "functional demyelination", a novel mechanism upstream to the actual stripping of myelin that is relevant to many demyelinating diseases. This observation also provides a potential therapeutic approach for HNPP.…”
Get full text
Article -
726
Decoding unusual MR findings: Spinal cord edema in atypical cervical spondylotic myelopathy—A case report and literature review
Published 2023-12-01“…Neurological and radiological diagnoses tend to favor demyelinating diseases, which interfere with the diagnosis of CSM. …”
Get full text
Article -
727
Hormonal Regulation of Oligodendrogenesis II: Implications for Myelin Repair
Published 2021-02-01“…Alterations in myelin, the protective and insulating sheath surrounding axons, affect brain function, as is evident in demyelinating diseases where the loss of myelin leads to cognitive and motor dysfunction. …”
Get full text
Article -
728
Protocol of a prospective multicenter study on comorbidity impact on multiple sclerosis and antibody-mediated diseases of the central nervous system (COMMIT)
Published 2024“…The goal is to evaluate the impact of comorbidities on MS, NMOSD, and MOGAD which may lead to development of treatment approaches to improve outcomes of inflammatory demyelinating diseases of the CNS.…”
Journal article -
729
Autoantibody biomarkers in childhood-acquired demyelinating syndromes: results from a national surveillance cohort.
Published 2014“…Although these antibodies are clinically relevant when associated with the specific neurological syndromes that have been described, further studies are required to evaluate their roles and clinical relevance in demyelinating diseases.…”
Journal article -
730
Autoantibody biomarkers in childhood-acquired demyelinating syndromes: results from a national surveillance cohort
Published 2014“…Although these antibodies are clinically relevant when associated with the specific neurological syndromes that have been described, further studies are required to evaluate their roles and clinical relevance in demyelinating diseases.…”
Journal article -
731
Association between incidence of white matter hyperintensities in magnetic resonance imaging of the brain and smoking
Published 2021“…Patients with gross brain lesions, structural abnormalities, and history suggestive ongoing intracranial infection, inflammatory or demyelinating diseases were excluded. Demographic data regarding pack-years, age of initiation/cessation, duration of smoking, type of cigarettes (nonfiltered, filtered, e-cigarette) was collected and analysed using Pearson’s correlation method, Fisher exact test, and Independent T-test as necessary. …”
Get full text
Thesis -
732
High Yield of Adult Oligodendrocyte Lineage Cells Obtained from Meningeal Biopsy
Published 2017-10-01“…This oligodendrocyte lineage cell population derives from an accessible and adult source, being therefore a promising candidate for autologous cell therapy of demyelinating diseases. In addition, the described method to differentiate meningeal-derived neural stem cells into oligodendrocyte lineage cells may represent a valid in vitro model to dissect oligodendrocyte differentiation and to screen for drugs capable to promote oligodendrocyte regeneration.…”
Get full text
Article -
733
Myeloid cell-associated aromatic amino acid metabolism facilitates CNS myelin regeneration
Published 2024-01-01“…Abstract Regulation of myeloid cell activity is critical for successful myelin regeneration (remyelination) in demyelinating diseases, such as multiple sclerosis (MS). Here, we show aromatic alpha-keto acids (AKAs) generated from the amino acid oxidase, interleukin-4 induced 1 (IL4I1), promote efficient remyelination in mouse models of MS. …”
Get full text
Article -
734
Icaritin Promotes Myelination by Simultaneously Enhancing the Proliferation and Differentiation of Oligodendrocyte Precursor Cells
Published 2023-08-01“…However, simultaneously promoting the differentiation and proliferation of oligodendrocyte precursor cells in lesions remains an unmet challenge and might affect demyelinating diseases. Kidney-tonifying herbs of traditional Chinese medicine (TCM) are effective in improving the symptoms of degenerative patients. …”
Get full text
Article -
735
NRF2 and PPAR-γ Pathways in Oligodendrocyte Progenitors: Focus on ROS Protection, Mitochondrial Biogenesis and Promotion of Cell Differentiation
Published 2020-09-01“…An adequate protection from oxidative and inflammatory reactions, together with the promotion of oligodendrocyte progenitor (OP) differentiation, is needed to recover from myelin damage in demyelinating diseases. Mitochondria are targets of inflammatory and oxidative insults and are essential in oligodendrocyte differentiation. …”
Get full text
Article -
736
The Effect of Levothyroxine on Lysolecithin-Induced Local Demyelination in Optic Chiasm of Male Rats
Published 2017-08-01“…Studies have suggested a link between central nervous system demyelinating diseases and thyroid disorders, and probably the treatments that increase the level of thyroid hormones are beneficial in multiple sclerosis. …”
Get full text
Article -
737
Phenotyping variants of tumefactive demyelinating lesions according to clinical and radiological features—A case series
Published 2023-02-01“…They are identified in a range of demyelinating diseases including massive demyelination due to Marburg's acute MS, Schilder's Disease, Balo's concentric sclerosis, and Tumefactive MS. …”
Get full text
Article -
738
Microglia/macrophage polarization regulates spontaneous remyelination in intermittent cuprizone model of demyelination
Published 2024-03-01“…Central nervous system (CNS) lesions can repeatedly be de-and remyelinated during demyelinating diseases such as multiple sclerosis (MS). Here, we designed an intermittent demyelination model by 0.3 % Cuprizone feeding in C57/BL6 mice followed by two weeks recovery. …”
Get full text
Article -
739
Plasma exchange in inflammatory demyelinating disorders of the central nervous system: reasonable use in the clinical practice
Published 2023-03-01“…Plasma exchange is well established for various neurological disorders, and it is applied successfully in central nervous system inflammatory demyelinating diseases (CNS-IDD). It mainly modulates the humoral immune system; thus, it has a greater theoretical effect in diseases with prominent humoral mechanisms, such as neuromyelitis optica (NMO). …”
Get full text
Article -
740
Topographical effects on fiber-mediated microRNA delivery to control oligodendroglial precursor cells development
Published 2016“…Effective remyelination in the central nervous system (CNS) facilitates the reversal of disability in patients with demyelinating diseases such as multiple sclerosis. Unfortunately until now, effective strategies of controlling oligodendrocyte (OL) differentiation and maturation remain limited. …”
Get full text
Get full text
Journal Article