BALO’S CONCENTRIC SCLEROSIS: CLINICAL CASE ОF REMISSION by L. V. Lorina, A. O. Burshinov

“…MRI conclusion: brain demyelination disease with large foci in the right post-frontal lobe region, typical of Balo’s concentric sclerosis. …”
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Signaling underlying kappa opioid receptor-mediated behaviors in rodents by Lee-Yuan Liu-Chen, Peng Huang

“…Kappa opioid receptor (KOR) agonists are potentially useful as analgesic and anti-pruritic agents, for prevention and treatment of substance use disorders, and for treatment of demyelinating diseases. However, side effects of KOR agonists, including psychotomimesis, dysphoria, and sedation, have caused early termination of clinical trials. …”
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Pediatric neuroimaging findings and clinical presentations of COVID-19: A systematic review by Irene(Tai-Lin) Lee, Po-Jen Lin, Ho-Hsian Yen

“…Neuroradiology findings of 114 children from 50 case reports included splenial or acute disseminated encephalomyelitis (ADEM)-like lesions, cytotoxic brain edema, autoimmune demyelinating diseases, ischemic stroke and arteritis, venous thrombosis, intracranial hemorrhage, meningitis, posterior reversible encephalopathy syndrome, anti-N-methyl-D-aspartate receptor autoimmune encephalitis, acute hemorrhagic leukoencephalitis, hydrocephalus, olfactory bulb atrophy, cerebellitis, and acute necrotizing encephalitis. …”
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IFP35 Is a Relevant Factor in Innate Immunity, Multiple Sclerosis, and Other Chronic Inflammatory Diseases: A Review by Roberto De Masi, Stefania Orlando, Francesco Bagordo, Tiziana Grassi

“…The considered data indicate IFP35 as a pleiotropic factor, suggesting it as biologically relevant in the innate immunity, general pathology, and human demyelinating diseases of the central nervous system.…”
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Astrocytes in oligodendrocyte lineage development and white matter pathology by Jiasi eLi, Lei eZhang, Yongxin eChu, Micheal eNamaka, Micheal eNamaka, Benqiang eDeng, Jiming eKong, Xiaoying eBi

“…White matter injury has been associated with the development of many demyelinating diseases. Despite a variety of scientific advances aimed at promoting re-myelination, their benefit has proven at best to be marginal. …”
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Angle-Angle Diagrams in the Assessment of Locomotion in Persons with Multiple Sclerosis: A Preliminary Study by Riccardo Di Giminiani, Davide Di Lorenzo, Stefano La Greca, Luca Russo, Francesco Masedu, Rocco Totaro, Elvira Padua

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Neural stem cells and oligodendrocyte progenitor cells compete for remyelination in the corpus callosum by Sarah Moyon, Mara Holloman, James L. Salzer, James L. Salzer

“…A major therapeutic goal in demyelinating diseases, such as Multiple Sclerosis, is to improve remyelination, thereby restoring effective axon conduction and preventing neurodegeneration. …”
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MRI techniques for quantitative and microstructure imaging by Dong, Zijing

“…The second part of this thesis presents a novel acquisition method for myelin water imaging with >10× acceleration compared to current approaches, that can potentially be used for a fast examination of demyelination diseases. The work also demonstrates the first submillimeter myelin water imaging in vivo at 600-um isotropic resolution to study cortical myeloarchitecture. …”
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Reported changes in dietary behavior following a first clinical diagnosis of central nervous system demyelination by Russell, R, Lucas, R, Brennan, V, Sherriff, J, Begley, A, Black, L, Dwyer, T, The Ausimmune Investigator Group

“…Further research is warranted to investigate the reasons behind any dietary changes adopted by people with a FCD or with MS, and whether making a dietary change has benefits for the progression of demyelinating diseases, e.g., to a diagnosis of MS, as well as for general health and well-being.…”

Variation within MBP gene predicts disease course in multiple sclerosis by Zhou, Y, Simpson, S, Charlesworth, J, Van Der Mei, I, Lucas, R, Ponsonby, A, Auslong Investigators Group, Taylor, B, Dwyer, T

“…Myelin basic protein (MBP) is a major component of the myelin sheath of CNS neurons and may play a central role in demyelinating diseases such as MS. However, genetic variation in MBP has not been implicated in MS onset risk in large genome‐wide association studies. …”

EBI2 Is Temporarily Upregulated in MO3.13 Oligodendrocytes during Maturation and Regulates Remyelination in the Organotypic Cerebellar Slice Model by Maria Velasco-Estevez, Nina Koch, Ilona Klejbor, Stephane Laurent, Kumlesh K. Dev, Andrzej Szutowicz, Andreas W. Sailer, Aleksandra Rutkowska

“…The work reported here provides new information on the expression and role of EBI2 in oligodendrocytes and myelination and provides new tools for modulation of oligodendrocyte biology and therapeutic approaches for demyelinating diseases.…”
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Myelin Measurement Using Quantitative Magnetic Resonance Imaging: A Correlation Study Comparing Various Imaging Techniques in Patients with Multiple Sclerosis by Laetitia Saccenti, Akifumi Hagiwara, Christina Andica, Kazumasa Yokoyama, Shohei Fujita, Shimpei Kato, Tomoko Maekawa, Koji Kamagata, Alice Le Berre, Masaaki Hori, Akihiko Wada, Ukihide Tateishi, Nobutaka Hattori, Shigeki Aoki

“…Evaluation of myelin by magnetic resonance imaging (MRI) is a difficult challenge, but holds promise in demyelinating diseases, such as multiple sclerosis (MS). Although multiple techniques have been developed, no gold standard has been established. …”
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Teriflunomide as a therapeutic means for myelin repair by Peter Göttle, Janos Groh, Laura Reiche, Joel Gruchot, Nicole Rychlik, Luisa Werner, Iria Samper Agrelo, Rainer Akkermann, Annika Zink, Alessandro Prigione, Hans-Peter Hartung, Rudolf Martini, Patrick Küry

“…Abstract Background Promotion of myelin repair in the context of demyelinating diseases such as multiple sclerosis (MS) still represents a clinical unmet need, given that this disease is not only characterized by autoimmune activities but also by impaired regeneration processes. …”
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Transdifferentiation of Human Dental Pulp Stem Cells Into Oligoprogenitor Cells by Ardeshir Moayeri, Maryam Nazm Bojnordi, Sara Haratizadeh, Amir Esmaeilnejad-Moghadam, Rafieh Alizadeh, Hatef Ghasemi Hamidabadi

“…Cell therapy based on oligodendrocytes and their precursors transplantation can hold a promising alternative treatment for myelin sheet repair in demyelinating diseases. Methods: Human Dental Pulp Stem Cells (hDPSCs) are noninvasive, autologous and easy available source with multipotency characteristics, so they are in focus of interest in regenerative medicine. …”
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Rapid Discrimination of Neuromyelitis Optica Spectrum Disorder and Multiple Sclerosis Using Machine Learning on Infrared Spectra of Sera by Youssef El Khoury, Marie Gebelin, Jérôme de Sèze, Christine Patte-Mensah, Gilles Marcou, Alexandre Varnek, Ayikoé-Guy Mensah-Nyagan, Petra Hellwig, Nicolas Collongues

“…Neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS) are both autoimmune inflammatory and demyelinating diseases of the central nervous system. NMOSD is a highly disabling disease and rapid introduction of the appropriate treatment at the acute phase is crucial to prevent sequelae. …”
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Case report: MOG-IgG-associated encephalitis with Epstein-Barr virus infection and Alzheimer's pathologic change in cerebrospinal fluid by Lin Li, Chuan Li, Dan Yao, Yun-feng Hao, Chao Zhao, Qi Yan, Jun-tong Liu, Jun-tong Liu, Shu-yu Liu, Shu-yu Liu, Wen-ping Zhu, Wen-ping Zhu, Ying Du, Wei Zhang

“…Immunoglobulin G antibodies to myelin oligodendrocyte glycoprotein (MOG-IgG) associated disease is a rare, demyelinated disease in the central nerve system (CNS) predominately involving optic nerve, spinal cord, and brain leading to optic neuritis (ON), transverse myelitis (TM), encephalitis. …”
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Erinacine S, a small active component derived from Hericium erinaceus, protects oligodendrocytes and alleviates mood abnormalities in cuprizone-exposed rodents by Jing-Ting Fu, Chih-Jou Yang, Li-Ya Lee, Wan-Ping Chen, Yu-Wen Chen, Chin-Chu Chen, Yuan-Ting Sun, Chung-Shi Yang, Shun-Fen Tzeng

“…This study presents compelling evidence supporting the potential of HeS as a promising small active compound for protecting OLs and preserving myelin in demyelinating diseases associated with emotional disorders.…”
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Pregestational neurological disorders among women of childbearing age—Nationwide data from a 13-year period in Hungary by Dániel Bereczki, Mónika Bálint, András Ajtay, Ferenc Oberfrank, Ildikó Vastagh

“…The most prevalent diagnoses following headaches were dizziness and giddiness (15 589 patients [2.1%]; nerve, nerve root and plexus disorders (10 375 patients [1.4%]); epileptic disorders (7028 patients [0.9%]); neurological diseases of vascular origin (6091 patients [0.8%]); other disorders of the nervous system (5358 patients [0.7%]); and demyelinating diseases of the central nervous system (2129 patients [0.3%]). …”
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Features of the diagnosis and treatment of patients with AQP-4-positive neuromyelitis optica and MOG antibody disease by V. E. Avdeeva, A. S. Kotov

“…As the amount of knowledge about multiple sclerosis increases, there is an interest in other forms of demyelinating diseases, among which neuromyelitis optica spectrum disorder and MOG (myelin oligodendrocyte glycoprotein) antibody disease can be distinguished.Objective: to improve the efficiency of diagnosis and treatment, to assess the long-term outcome in patients with AQP-4-positive neuromyelitis optica and MOG antibody disease.Materials and methods. …”
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Impact of Intraventricular Human Adipose-Derived Stem Cells Transplantation with Pregnenolone Treatment on Remyelination of Corpus Callosum in A Rat Model of Multiple Sclerosis by Mohammad Mardani, Rasoul Ganji, Nazem Ghasemi, Mohammad Kazemi, Shahnaz Razavi

“…Cell-based treatment is a novel strategy for the treatment of demyelinating diseases such asMS. Adipose-derived stem cells (ADSCs) have neuroprotective and neuroregenerative effects and pregnenolone as aneurosteroid has remarkable roles in neurogenesis. …”
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