The effects of minocycline on spinal root avulsion injury in rodent model : a histological study by Yew Chin, Tan

“…Minocycline has been proven to show its neuroprotective effect in stroke and demyelination disease. It is a widely available, cost effective antibiotic with anti-inflammatory and anti-apoptotic properties. …”
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AQP4-IgG NMOSD, MOGAD, and double-seronegative NMOSD: is it possible to depict the antibody subtype using magnetic resonance imaging? by Diego Cardoso Fragoso, Luana Michelli Oliveira de Paula Salles, Samira Luisa Apóstolos Pereira, Dagoberto Callegaro, Douglas Kazutoshi Sato, Carolina de Medeiros Rimkus

“…Background There is clinical and radiological overlap among demyelinating diseases. However, their pathophysiological mechanisms are different and carry distinct prognoses and treatment demands. …”
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Comparing myelin-sensitive magnetic resonance imaging measures and resulting g-ratios in healthy and multiple sclerosis brains by Ronja C. Berg, Aurore Menegaux, Thomas Amthor, Guillaume Gilbert, Maria Mora, Sarah Schlaeger, Viola Pongratz, Markus Lauerer, Christian Sorg, Mariya Doneva, Irene Vavasour, Mark Mühlau, Christine Preibisch

“…Magnetic resonance imaging (MRI) of myelin-sensitive parameters can help to non-invasively evaluate demyelinating diseases such as multiple sclerosis (MS). Several different myelin-sensitive MRI methods have been proposed to determine measures of the degree of myelination, in particular the g-ratio. …”
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Dietary protection against the visual and motor deficits induced by experimental autoimmune encephalomyelitis by Katarzyna Zyla-Jackson, Katarzyna Zyla-Jackson, Dorothy A. Walton, Kendra S. Plafker, Susan Kovats, Susan Kovats, Constantin Georgescu, Richard S. Brush, Madison Tytanic, Martin-Paul Agbaga, Martin-Paul Agbaga, Scott M. Plafker, Scott M. Plafker

“…Despite multiple immune modulatory therapies for autoimmune demyelinating diseases of the central nervous system, these treatments can be limiting for subsets of patients due to adverse effects and expense. …”
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Quantitative Imaging of White and Gray Matter Remyelination in the Cuprizone Demyelination Model Using the Macromolecular Proton Fraction by Marina Khodanovich, Anna Pishchelko, Valentina Glazacheva, Edgar Pan, Andrey Akulov, Mikhail Svetlik, Yana Tyumentseva, Tatyana Anan’ina, Vasily Yarnykh

“…This study provides immunohistological validation of fast MPF mapping as a non-invasive tool for quantitative assessment of de- and remyelination in white and gray matter and indicates the feasibility of using MPF as a surrogate marker of reparative processes in demyelinating diseases.…”
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Neural cell membrane-coated nanoparticles for targeted and enhanced uptake by central nervous system cells by Zhang, Na, Lin, Junquan, Chew, Sing Yian

“…Targeted drug delivery to specific neural cells within the central nervous system (CNS) plays important roles in treating neurological disorders, such as neurodegenerative (e.g. targeting neurons) and demyelinating diseases (e.g. targeting oligodendrocytes (OLs)). …”
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Distribution Patterns and Publishing Rates of Oral Presentations Presented in National Neurology Congresses According to Diseases Between 2000-2017 by Ferda İlgen Uslu, Alişan Bayrakoğlu, Sultan Meşe, Gülşen Babacan Yıldız

“…Of the OPs, 318 were in the field of demyelinating diseases (DMD), 305 on cerebrovascular diseases (CVD), 205 on epilepsy, 202 on neuromuscular diseases (NMD), 199 on headache, 183 on movement disorders, 112 on behavioral neurology, 20 on sleep disorders, 13 on pediatric neurology, and 119 on other diseases. …”
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Experience and perception of utilizing virtual clinic in neurological assessment in Saudi Arabia by Mohammed Hmoud, Mohammed Hmoud, Mohammed Hmoud, Hassan K. Salamatullah, Hassan K. Salamatullah, Dania E. Faidah, Dania E. Faidah, Seraj Makkawi, Seraj Makkawi, Seraj Makkawi

“…Physicians deemed it more suitable to conduct teleconsultations for patients with headaches and epilepsy than for those with neuromuscular and demyelinating diseases/multiple sclerosis. Furthermore, they agreed that patients' experiences (55.6%) and physicians' acceptance (55.6%) were the two main limitations to implementing virtual clinics.DiscussionThis study revealed that neurologists were more confident in performing history-taking in virtual clinics than in physical exams. …”
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Effect of β-hydroxybutyrate on behavioral alterations, molecular and morphological changes in CNS of multiple sclerosis mouse model by Wei Sun, Min Wen, Min Liu, Qingpeng Wang, Quiqin Liu, Lanjie Li, Hans-Christian Siebert, Gabriele Loers, Ruiyan Zhang, Ning Zhang, Ning Zhang

“…Thus, our results demonstrate that BHB treatment efficiently supports OPC differentiation and decreases the OLs apoptosis in CPZ-intoxicated mice, partly by down-regulating the expression of TRPA1 and PARP, which is associated with the inhibition of the p38-MAPK/JNK/JUN pathway and the activation of ERK1/2, PI3K/AKT/mTOR signaling, supporting BHB treatment adjunctive nutritional therapy for the treatment of chronic demyelinating diseases, such as multiple sclerosis (MS).…”
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Overexpression of <i>OLIG2</i> and <i>MYT1L</i> Transcription Factors Enhance the Differentiation Potential of Human Mesenchymal Stem Cells into Oligodendrocytes by Ifrah Fahim, Aisha Ishaque, Faiza Ramzan, Shamsul Azlin Bin Ahmad Shamsuddin, Anwar Ali, Asmat Salim, Irfan Khan

“…Background: Demyelinating diseases represent a broad spectrum of disorders and are characterized by the loss of specialized glial cells (oligodendrocytes), which eventually leads to neuronal degeneration. …”
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Clinical Features of Patients with Myelin Oligodendrocyte Glycoprotein Antibody&ndash;Associated Disease and Isolated Seizure Symptoms by Yang Y, Zhang C, Cao C, Su W, Zhao N, Yue W

“…Yun Yang,1,2 Chao Zhang,1 Chen Cao,3 Wenhua Su,1 Na Zhao,1 Wei Yue1,4 1Department of Neurology, Clinical College of Neurology, Neurosurgery, and Neurorehabilitation, Tianjin Medical University, Tianjin Huanhu Hospital, Tianjin, People’s Republic of China; 2Department of Neurology, The Second Hospital of Tianjin Medical University, Tianjin, People’s Republic of China; 3Department of Medical Imageology, Tianjin Huanhu Hospital, Tianjin, People’s Republic of China; 4Department of Biomedical Engineering, Tianjin University, Tianjin, People’s Republic of ChinaCorrespondence: Wei Yue, Department of Neurology, Tianjin Huanhu Hospital, 6 Jizhao Road, Tianjin, 300350, People’s Republic of China, Fax +862259065662, Email hhyuewei2021@163.comBackground: Myelin oligodendrocyte glycoprotein (MOG) antibody–associated encephalitis is a new clinical phenotype of inflammatory demyelinating diseases. Some MOG antibody–positive patients with central nervous system demyelinating events present with isolated seizures. …”
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神经酸的来源、提取分离工艺及生理功能研究进展Progress on the source, extraction and separation processes, and physiological function of nervonic acid by 王菊花1，许佳敏1，佟祎鑫1，马赛买1，白万明2，白小勇2，孔维宝1 WANG Juhua1, XU Jiamin1, TONG Yixin1, MA Saimai1, BAI Wanming2, BAI Xiaoyong2, KONG Weibao1

“…In order to promote the high yield of nervonic acid and the large-scale development and application of related products, the sources, extraction and separation processes, and physiological function of nervonic acid were reviewed.Nervonic acid exists in a variety of animals, plants, and microorganisms, and its extraction and separation processes include low-temperature crystallization, supercritical CO2 extraction, urea inclusion fractionation, molecular distillation, etc. , and it has physiological functions of treating brain diseases, central nervous system demyelinating diseases, cardiovascular and cerebrovascular diseases and enhancing immunity and other functions.In order to obtain abundant and high purity nervonic acid, genetic engineering also can be used to construct high-yield nervonic acid transgenic plants besides breeding high-yield nervonic acid plant varieties. …”
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High-Dose Intravenous Steroid Treatment Seems to Have No Long-Term Negative Effect on Bone Mineral Density of Young and Newly Diagnosed Multiple Sclerosis Patients: A Pilot Study by George Simeakis, Maria Anagnostouli, Nikolaos Fakas, John Koutsikos, Athanasios Papatheodorou, Konstantinos Chanopoulos, Kwnstantinos Athanasiou, George Papatheodorou, Evangelia Zapanti, Maria Alevizaki, Gregory Kaltsas, Evangelos Terpos

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Is There a Need to Differentiate Atypical Multiple Sclerosis from Neuromyelitis Optica Spectrum Disorders (NMOSD)? The Pros and Cons: A Systematic Review (PP-21) by Sepideh Paybast, Fatemeh Baghalha, Ali Emami, Abdorreza Naser Moghadasi

“…Introduction: Most atypical inflammatory demyelinating diseases (IDD) exhibit pathological characteristics comparable to multiple sclerosis (MS). …”
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An analytical longitudinal observational study on the association of Vitamin D insufficiency in subjects with primary (idiopathic) demyelinating optic neuritis using visual evoked... by Nirja Agasti, Amar Kumar Misra, Manamita Mandal, Bijendra Mohanty, Soumit Roy, Joydeep Mukherjee, Jasodhara Chaudhuri

“…Visual evoked potential (VEP) and optical coherence tomography (OCT) are emerging tools for demyelinating diseases. Aims and Objectives: We tried to correlate between Vitamin D insufficiency and acute demyelinating ON using different parameters such as VEP, ganglion cell layer (GCL) thickness, and retinal nerve fiber layer (RNFL) thickness. …”
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Alpha4 beta7 integrin controls Th17 cell trafficking in the spinal cord leptomeninges during experimental autoimmune encephalomyelitis by Barbara Rossi, Silvia Dusi, Gabriele Angelini, Alessandro Bani, Nicola Lopez, Vittorina Della Bianca, Enrica Caterina Pietronigro, Elena Zenaro, Carlotta Zocco, Gabriela Constantin, Gabriela Constantin

“…Altogether, our data suggest that a better knowledge of the molecular mechanisms controlling myelin-specific Th1 and Th17 cell trafficking during EAE delevopment may help to identify new therapeutic strategies for CNS inflammatory and demyelinating diseases.…”
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Consensus of expert advices on routing, diagnosis, and management of patients with neuromyelitis optica spectrum disorders by A. N. Boyko, K. Z. Bakhtiyarova, L. V. Brylev, M. N. Zakharova, D. S. Kasatkin, D. S. Korobko, S. V. Kotov, V. S. Krasnov, N. A. Malkova, E. V. Popova, S. A. Sivertseva, T. O. Simaniv, A. A. Sokolova, N. A. Totolyan, T. N. Trushnikova, F. A. Khabirov, N. V. Khachanova

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Granzyme B in circulating CD8+ T cells as a biomarker of immunotherapy effectiveness and disability in neuromyelitis optica spectrum disorders by Ziyan Shi, Qin Du, Xiaofei Wang, Jianchen Wang, Hongxi Chen, Yanling Lang, Lingyao Kong, Wenqin Luo, Mu Yang, Mu Yang, Hongyu Zhou

“…Background and objectiveNeuromyelitis optica spectrum disorders (NMOSD) are chronical inflammatory demyelinating diseases of the central nervous system (CNS) and the underlying mechanism remains unclear. …”
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Longitudinal evaluation of demyelinated lesions in a multiple sclerosis model using ultrashort echo time magnetization transfer (UTE-MT) imaging by Caroline Guglielmetti, Tanguy Boucneau, Peng Cao, Annemie Van der Linden, Peder E.Z. Larson, Myriam M. Chaumeil

“…Alterations in myelin integrity are involved in many neurological disorders and demyelinating diseases, such as multiple sclerosis (MS). Although magnetic resonance imaging (MRI) is the gold standard method to diagnose and monitor MS patients, clinically available MRI protocols show limited specificity for myelin detection, notably in cerebral grey matter areas. …”
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Phenotypic Characteristics and Recurrence Factors of MOG-IgG Associated Disorders in Children by WANG Xin, ZHAO Ruibin, YANG Huafang, LIU Chong, LIU Tian, LU Cui, CHEN Didi

“…Objective To examine the phenotypic features and recurrence factors of MOG-IgG positivity in central nervous system inflammatory demyelinating diseases in children. Methods A follow-up study on 54 children with MOGAD diagnosed in Children&apos;s Hospital of Hebei Province from December 2017 to December 2021 was performed. …”
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