Hyperferritinemic sepsis, macrophage activation syndrome, and mortality in a pediatric research network: a causal inference analysis by Zhenziang Fan, Kate F. Kernan, Yidi Qin, Scott Canna, Robert A. Berg, David Wessel, Murray M. Pollack, Kathleen Meert, Mark Hall, Christopher Newth, John C. Lin, Allan Doctor, Tom Shanley, Tim Cornell, Rick E. Harrison, Athena F. Zuppa, Katherine Sward, J. Michael Dean, H. J. Park, Joseph A. Carcillo

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Machine learning derivation of four computable 24-h pediatric sepsis phenotypes to facilitate enrollment in early personalized anti-inflammatory clinical trials by Yidi Qin, Kate F. Kernan, Zhenjiang Fan, Hyun-Jung Park, Soyeon Kim, Scott W. Canna, John A. Kellum, Robert A. Berg, David Wessel, Murray M. Pollack, Kathleen Meert, Mark Hall, Christopher Newth, John C. Lin, Allan Doctor, Tom Shanley, Tim Cornell, Rick E. Harrison, Athena F. Zuppa, Russell Banks, Ron W. Reeder, Richard Holubkov, Daniel A. Notterman, J. Michael Dean, Joseph A. Carcillo

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Novel Genetic Risk and Metabolic Signatures of Insulin Signaling and Androgenesis in the Anovulation of Polycystic Ovary Syndrome by Xiaoke Wu, Chi Chiu Wang, Yijuan Cao, Jian Li, Zhiqiang Li, Hongli Ma, Jingshu Gao, Hui Chang, Duojia Zhang, Jing Cong, Yu Wang, Qi Wu, Xiaoxiao Han, Pui Wah Jacqueline Chung, Yiran Li, Xu Zheng, Lingxi Chen, Lin Zeng, Astrid Borchert, Hartmut Kuhn, Zi-Jiang Chen, Ernest Hung Yu Ng, Elisabet Stener-Victorin, Heping Zhang, Richard S. Legro, Ben Willem J. Mol, Yongyong Shi

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Class imbalance should not throw you off balance: Choosing the right classifiers and performance metrics for brain decoding with imbalanced data by Philipp Thölke, Yorguin-Jose Mantilla-Ramos, Hamza Abdelhedi, Charlotte Maschke, Arthur Dehgan, Yann Harel, Anirudha Kemtur, Loubna Mekki Berrada, Myriam Sahraoui, Tammy Young, Antoine Bellemare Pépin, Clara El Khantour, Mathieu Landry, Annalisa Pascarella, Vanessa Hadid, Etienne Combrisson, Jordan O’Byrne, Karim Jerbi

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Identification and validation of a machine learning model of complete response to radiation in rectal cancer reveals immune infiltrate and TGFβ as key predictorsResearch in context... by Enric Domingo, Sanjay Rathee, Andrew Blake, Leslie Samuel, Graeme Murray, David Sebag-Montefiore, Simon Gollins, Nicholas West, Rubina Begum, Susan Richman, Phil Quirke, Keara Redmond, Aikaterini Chatzipli, Alessandro Barberis, Sylvana Hassanieh, Umair Mahmood, Michael Youdell, Ultan McDermott, Viktor Koelzer, Simon Leedham, Ian Tomlinson, Philip Dunne, Francesca M. Buffa, Timothy S. Maughan, Andrew Blake, Francesca Buffa, Enric Domingo, Geoffrey Higgins, Christopher Holmes, Viktor Koelzer, Simon Leedham, Timothy Maughan, Gillies McKenna, James Robineau, Ian Tomlinson, Michael Youdell, Philip Quirke, Susan Richman, David Sebag-Montefiore, Matthew Seymour, Nicholas West, Philip Dunne, Richard Kennedy, Mark Lawler, Keara Redmond, Manuel Salto-Tellez, Peter Campbell, Aikaterini Chatzipli, Claire Hardy, Ultan McDermott, Simon Bach, Andrew Beggs, Jean-Baptiste Cazier, Gary Middleton, Dion Morton, Celina Whalley, Louise Brown, Richard Kaplan, Graeme Murray, Richard Wilson, Richard Adams, Richard Sullivan, Leslie Samuel, Paul Harkin, Steven Walker, Jim Hill, Chieh-Hsi Wu, Dennis Horgan

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Significance of the ARIMA epidemiological modeling to predict the rate of HIV and AIDS in the Kumba Health District of Cameroon by Arrey Emmanuel Besong, Odette Dzemo Kibu, Odette Dzemo Kibu, Odette Dzemo Kibu, Odette Dzemo Kibu, Elvis Asangbeng Tanue, Elvis Asangbeng Tanue, Elvis Asangbeng Tanue, Elvis Asangbeng Tanue, Besong Agbor Obinkem, Ginyu Innocentia Kwalar, Ginyu Innocentia Kwalar, Ginyu Innocentia Kwalar, Ginyu Innocentia Kwalar, Fabrice Chethkwo, Valentine Ndze Ngum, Maurice Marcel Sandeu, Maurice Marcel Sandeu, Maurice Marcel Sandeu, Maurice Marcel Sandeu, Patrick Jolly Ngono Ema, Patrick Jolly Ngono Ema, Patrick Jolly Ngono Ema, Patrick Jolly Ngono Ema, Nkweteyim Denis, Nkweteyim Denis, Nkweteyim Denis, Nkweteyim Denis, Onduo Moise, Onduo Moise, Onduo Moise, Onduo Moise, Ayana Gelan, Ayana Gelan, Ayana Gelan, Ayana Gelan, Jude Dzevela Kong, Jude Dzevela Kong, Jude Dzevela Kong, Dickson Shey Nsagha, Dickson Shey Nsagha, Dickson Shey Nsagha, Dickson Shey Nsagha

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Genetic determinants of telomere length from 109,122 ancestrally diverse whole-genome sequences in TOPMed by Margaret A. Taub, Matthew P. Conomos, Rebecca Keener, Kruthika R. Iyer, Joshua S. Weinstock, Lisa R. Yanek, John Lane, Tyne W. Miller-Fleming, Jennifer A. Brody, Laura M. Raffield, Caitlin P. McHugh, Deepti Jain, Stephanie M. Gogarten, Cecelia A. Laurie, Ali Keramati, Marios Arvanitis, Albert V. Smith, Benjamin Heavner, Lucas Barwick, Lewis C. Becker, Joshua C. Bis, John Blangero, Eugene R. Bleecker, Esteban G. Burchard, Juan C. Celedón, Yen Pei C. Chang, Brian Custer, Dawood Darbar, Lisa de las Fuentes, Dawn L. DeMeo, Barry I. Freedman, Melanie E. Garrett, Mark T. Gladwin, Susan R. Heckbert, Bertha A. Hidalgo, Marguerite R. Irvin, Talat Islam, W. Craig Johnson, Stefan Kaab, Lenore Launer, Jiwon Lee, Simin Liu, Arden Moscati, Kari E. North, Patricia A. Peyser, Nicholas Rafaels, Christine Seidman, Daniel E. Weeks, Fayun Wen, Marsha M. Wheeler, L. Keoki Williams, Ivana V. Yang, Wei Zhao, Stella Aslibekyan, Paul L. Auer, Donald W. Bowden, Brian E. Cade, Zhanghua Chen, Michael H. Cho, L. Adrienne Cupples, Joanne E. Curran, Michelle Daya, Ranjan Deka, Celeste Eng, Tasha E. Fingerlin, Xiuqing Guo, Lifang Hou, Shih-Jen Hwang, Jill M. Johnsen, Eimear E. Kenny, Albert M. Levin, Chunyu Liu, Ryan L. Minster, Take Naseri, Mehdi Nouraie, Muagututi‘a Sefuiva Reupena, Ester C. Sabino, Jennifer A. Smith, Nicholas L. Smith, Jessica Lasky-Su, James G. Taylor, VI, Marilyn J. Telen, Hemant K. Tiwari, Russell P. Tracy, Marquitta J. White, Yingze Zhang, Kerri L. Wiggins, Scott T. Weiss, Ramachandran S. Vasan, Kent D. Taylor, Moritz F. Sinner, Edwin K. Silverman, M. Benjamin Shoemaker, Wayne H.-H. Sheu, Frank Sciurba, David A. Schwartz, Jerome I. Rotter, Daniel Roden, Susan Redline, Benjamin A. Raby, Bruce M. Psaty, Juan M. Peralta, Nicholette D. Palmer, Sergei Nekhai, Courtney G. Montgomery, Braxton D. Mitchell, Deborah A. Meyers, Stephen T. McGarvey, Angel C.Y. Mak, Ruth J.F. Loos, Rajesh Kumar, Charles Kooperberg, Barbara A. Konkle, Shannon Kelly, Sharon L.R. Kardia, Robert Kaplan, Jiang He, Hongsheng Gui, Frank D. Gilliland, Bruce D. Gelb, Myriam Fornage, Patrick T. Ellinor, Mariza de Andrade, Adolfo Correa, Yii-Der Ida Chen, Eric Boerwinkle, Kathleen C. Barnes, Allison E. Ashley-Koch, Donna K. Arnett, Christine Albert, Cathy C. Laurie, Goncalo Abecasis, Deborah A. Nickerson, James G. Wilson, Stephen S. Rich, Daniel Levy, Ingo Ruczinski, Abraham Aviv, Thomas W. Blackwell, Timothy Thornton, Jeff O’Connell, Nancy J. Cox, James A. Perry, Mary Armanios, Alexis Battle, Nathan Pankratz, Alexander P. Reiner, Rasika A. Mathias

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