In-silico studies of glutathione peroxidase4 activators as candidate for multiple sclerosis management by Alaa Alnoor Alameen, Mohnad Abdalla, Hanan M. Alshibl, Monerah R. AlOthman, Manal M. Alkhulaifi, Tabyan O. Mirgany, Rasha Elsayim

“…The study was carried out through various computational methods using Autodock Vina for docking of the protein and ligand and Desmond for MD simulation. The four tested compounds used to activate GPx4 are as follows: ferrostatin, lapatinib, liproxstatin-1, and PKUMDL-LDL-102. …”
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‘Il topo, le piante, i vermi. Giacomo Leopardi, ed Erasmus e Charles Darwin’ by Angioy, A

“…He was also one of the most important ‘lunar man’, as Jenny Uglow recorded in Lunar Men, who anticipated many evolutionary ideas, a committed campaigner against slavery (as was his grandson Charles, see Adrian Desmond and James Moore’s Darwin’s Sacred Cause). …”

Safety, Tolerability, and Pharmacokinetics of Benralizumab: A Phase 1, Randomized, Single-Blind Study of Healthy Chinese Participants by Cheung TT, Mai TH, Chia YL, Yap DYH, Lee CH, Chen CC, Huang Y, Jin Y, Johnston J, Werkström V, Yao Y, Ge X, Zheng W

“…Tommy Tsang Cheung,1,* Tu H Mai,2,* Yen Lin Chia,2 Desmond YH Yap,1 Chi-Ho Lee,1 Cecil Chi-Keung Chen,2 Ying Huang,3 Yuwen Jin,3 James Johnston,4 Viktoria Werkström,5 Yuhui Yao,6 Xiaoyun Ge,7 Wenying Zheng8 1Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, People’s Republic of China; 2Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology & Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, South San Francisco, CA, USA; 3Clinical Pharmacology, R&D China, AstraZeneca, Shanghai, People’s Republic of China; 4Late-stage Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK; 5Late-Stage Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden; 6Respiratory & Immunology, R&D China, AstraZeneca, Shanghai, People’s Republic of China; 7Clinical Safety, R&D China, AstraZeneca, Shanghai, People’s Republic of China; 8Biometrics, R&D China, AstraZeneca, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yen Lin Chia, Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology & Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, 701 Gateway Blvd, South San Francisco, CA, 9408, USA, Tel +1 425 5272574, Email yenlin@gmail.comPurpose: Biological therapies targeting eosinophils have been shown to be effective in treating patients with severe eosinophilic asthma. …”
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How a menu of adherence support strategies facilitated high adherence to HIV prevention products among adolescent girls and young women in sub‐Saharan Africa: a mixed methods analy... by Sarah T. Roberts, Noah Mancuso, Kristin Williams, Hadijah Kalule Nabunya, Hlengiwe Mposula, Caroline Mugocha, Priscilla Mvinjelwa, Morgan Garcia, Daniel W. Szydlo, Lydia Soto‐Torres, Kenneth Ngure, Sybil Hosek

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Investigating the verbal working memory network in children with Dyslexia : an effective connectivity study by Kwok, Fu Yu

“…Study 1 set the stage for the dissertation by extending the verbal working memory network established by Chen and Desmond (2005a) to elucidate the effective network connectivity in typical adults during verbal working memory. …”
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Assessing the therapeutic potential of agomelatine, ramelteon, and melatonin against SARS-CoV-2 by Pradeep Kumar Yadalam, Thodur Madapusi Balaji, Saranya Varadarajan, Khalid J. Alzahrani, Mohammad S. Al-Ghamdi, Hosam Ali Baeshen, Mohammed Farhan A. Alfarhan, Zohaib Khurshid, Shilpa Bhandi, Raghunathan Jagannathan, Vikrant R. Patil, A. Thirumal Raj, Jithendra Ratnayake, Shankargouda Patil

“…AutoDock version 4.2.6 docking program and AutoDock Tools (ADT) version 1.5.6 were used for molecular docking. Desmond, a Package of Schrödinger LLC was used to simulate molecular dynamics for hundred nanoseconds using. …”
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Time Trend Analysis of Tuberculosis Treatment While Using Digital Adherence Technologies—An Individual Patient Data Meta-Analysis of Eleven Projects across Ten High Tuberculosis-Bu... by Liza M. de Groot, Masja Straetemans, Noriah Maraba, Lauren Jennings, Maria Tarcela Gler, Danaida Marcelo, Mirchaye Mekoro, Pieter Steenkamp, Riccardo Gavioli, Anne Spaulding, Edwin Prophete, Margarette Bury, Sayera Banu, Sonia Sultana, Baraka Onjare, Egwuma Efo, Jason Alacapa, Jens Levy, Mona Lisa L. Morales, Achilles Katamba, Aleksey Bogdanov, Kateryna Gamazina, Dzhumagulova Kumarkul, Orechova-Li Ekaterina, Adithya Cattamanchi, Amera Khan, Mirjam I. Bakker

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Persistent, Asymptomatic Colonization with Candida is Associated with Elevated Frequencies of Highly Activated Cervical Th17-Like Cells and Related Cytokines in the Reproductive Tr... by Anna-Ursula Happel, Melanie Gasper, Christina Balle, Iyaloo Konstantinus, Hoyam Gamieldien, Smritee Dabee, Katherine Gill, Linda-Gail Bekker, Jo-Ann S. Passmore, Heather B. Jaspan

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In silico evaluation of the compounds of the ayurvedic drug, AYUSH-64, for the action against the SARS-CoV-2 main protease by Thrigulla Saketh Ram, Manne Munikumar, Vankudavath Naik Raju, Parasannanavar Devaraj, Naveen Kumar Boiroju, Rajkumar Hemalatha, P.V.V. Prasad, Manohar Gundeti, Brijesh S. Sisodia, Sharad Pawar, G.P. Prasad, Mukesh Chincholikar, Sumeet Goel, Anupam Mangal, Sudesh Gaidhani, N. Srikanth, K.S. Dhiman

“…We also conducted 100 ns period of molecular dynamics simulations with Desmond and further MM/GBSA for the best complex of AYUSH-64 with Mpro of SARS-CoV-2. …”
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Associations of inter-annual rainfall decreases with subsequent HIV outcomes for persons with HIV on antiretroviral therapy in Southern Africa: a collaborative analysis of cohort s... by Adam Trickey, Leigh F. Johnson, Fai Fung, Rogerio Bonifacio, Collins Iwuji, Samuel Biraro, Samuel Bosomprah, Linda Chirimuta, Jonathan Euvrard, Geoffrey Fatti, Matthew P. Fox, Per Von Groote, Joe Gumulira, Guy Howard, Lauren Jennings, Agnes Kiragga, Guy Muula, Frank Tanser, Thorsten Wagener, Andrea Low, Peter Vickerman

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Nations and nationalisms

“…<em>John Toland, tolerance and the nation</em> <br/> Pierre Lurbe, John Toland, cosmopolitanism, and the concept of nation <br/> Desmond M. Clarke, Locke and Toland on toleration <br/> VII. …”

Adaption of an ongoing clinical trial to quickly respond to gaps in changing international recommendations: the experience of D2EFT by Emmanuelle Papot, Simone Jacoby, Dona Arlinda, Anchalee Avihingsanon, Iskandar Azwa, Margaret Borok, Dannae Brown, Mohamed Cissé, Sounkalo Dao, Nnakelu Eriobu, Richard Kaplan, Muhammad Karyana, Nagalingeswaran Kumarasamy, Johnnie Lee, Marcelo H. Losso, Gail V. Matthews, Leonardo Perelis, Carmen Perez-Casas, Kiat Ruxrungtham, Melynda Watkins, H. Clifford Lane, Anthony Kelleher, Matthew Law, Mark N. Polizzotto

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A pilot study to show that asymptomatic sexually transmitted infections alter the foreskin epithelial proteome by Nyaradzo T. L. Chigorimbo-Murefu, Matthys Potgieter, Matthys Potgieter, Sonwabile Dzanibe, Zikhona Gabazana, Gershom Buri, Aditya Chawla, Bokani Nleya, Abraham J. Olivier, Rushil Harryparsad, Bridget Calder, Shaun Garnett, Lungile Maziya, David A. Lewis, David A. Lewis, Heather Jaspan, Heather Jaspan, Heather Jaspan, Doug Wilson, Jo-Ann S. Passmore, Nicola Mulder, Jonathan Blackburn, Linda-Gail Bekker, Clive M. Gray, Clive M. Gray

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Adherence challenges with daily oral pre‐exposure prophylaxis during pregnancy and the postpartum period in South African women: a cohort study by Dvora Joseph Davey, Dorothy C. Nyemba, Jose Castillo‐Mancilla, Lubbe Wiesner, Jennifer Norman, Rufaro Mvududu, Nyiko Mashele, Leigh F. Johnson, Linda‐Gail Bekker, Pamina Gorbach, Thomas J. Coates, Landon Myer

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Heterologous vaccination of BNT162b2 in Ad26. COV2.S-vaccinated healthcare workers elicits long-term humoral immune response by B Jacobson, A Khan, AH Shulman, B Segal, E Mayne, L-G Bekker, I Sanne, G Gray

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Preferences and acceptability for long‐acting PrEP agents among pregnant and postpartum women with experience using daily oral PrEP in South Africa and Kenya by Nafisa J. Wara, Rufaro Mvududu, Mary M. Marwa, Laurén Gómez, Nyiko Mashele, Catherine Orrell, Corrina Moucheraud, John Kinuthia, Grace John‐Stewart, Landon Myer, Risa Hoffman, Jillian Pintye, Dvora L. Joseph Davey

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Delamanid-containing regimens and multidrug-resistant tuberculosis: A systematic review and meta-analysis by Mohammad Javad Nasiri, Moein Zangiabadian, Erfan Arabpour, Sirus Amini, Farima Khalili, Rosella Centis, Lia D'Ambrosio, Justin T. Denholm, H. Simon Schaaf, Martin van den Boom, Xhevat Kurhasani, Margareth Pretti Dalcolmo, Seif Al-Abri, Jeremiah Chakaya, Jan-Willem Alffenaar, Onno Akkerman, Denise Rossato Silva, Marcela Muňoz-Torrico, Barbara Seaworth, Emanuele Pontali, Laura Saderi, Simon Tiberi, Alimuddin Zumla, Giovanni Battista Migliori, Giovanni Sotgiu

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Emergence and phenotypic characterization of the global SARS-CoV-2 C.1.2 lineage by Cathrine Scheepers, Josie Everatt, Daniel G. Amoako, Houriiyah Tegally, Constantinos Kurt Wibmer, Anele Mnguni, Arshad Ismail, Boitshoko Mahlangu, Bronwen E. Lambson, Darren P. Martin, Eduan Wilkinson, James Emmanuel San, Jennifer Giandhari, Nelia Manamela, Noxolo Ntuli, Prudence Kgagudi, Sandile Cele, Simone I. Richardson, Sureshnee Pillay, Thabo Mohale, Upasana Ramphal, Yeshnee Naidoo, Zamantungwa T. Khumalo, Gaurav Kwatra, Glenda Gray, Linda-Gail Bekker, Shabir A. Madhi, Vicky Baillie, Wesley C. Van Voorhis, Florette K. Treurnicht, Marietjie Venter, Koleka Mlisana, Nicole Wolter, Alex Sigal, Carolyn Williamson, Nei-yuan Hsiao, Nokukhanya Msomi, Tongai Maponga, Wolfgang Preiser, Zinhle Makatini, Richard Lessells, Penny L. Moore, Tulio de Oliveira, Anne von Gottberg, Jinal N. Bhiman

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Evaluating the use of oral pre-exposure prophylaxis among pregnant and postpartum adolescent girls and young women in Cape Town, South Africa by Nehaa Khadka, Pamina M. Gorbach, Dorothy C. Nyemba, Dorothy C. Nyemba, Rufaro Mvududu, Nyiko Mashele, Marjan Javanbakht, Roch A. Nianogo, Grace M. Aldrovandi, Linda-Gail Bekker, Thomas J. Coates, Landon Myer, Dvora L. Joseph Davey, Dvora L. Joseph Davey, Dvora L. Joseph Davey

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Quantifying how single dose Ad26.COV2.S vaccine efficacy depends on Spike sequence features by Craig A. Magaret, Li Li, Allan C. deCamp, Morgane Rolland, Michal Juraska, Brian D. Williamson, James Ludwig, Cindy Molitor, David Benkeser, Alex Luedtke, Brian Simpkins, Fei Heng, Yanqing Sun, Lindsay N. Carpp, Hongjun Bai, Bethany L. Dearlove, Elena E. Giorgi, Mandy Jongeneelen, Boerries Brandenburg, Matthew McCallum, John E. Bowen, David Veesler, Jerald Sadoff, Glenda E. Gray, Sanne Roels, An Vandebosch, Daniel J. Stieh, Mathieu Le Gars, Johan Vingerhoets, Beatriz Grinsztejn, Paul A. Goepfert, Leonardo Paiva de Sousa, Mayara Secco Torres Silva, Martin Casapia, Marcelo H. Losso, Susan J. Little, Aditya Gaur, Linda-Gail Bekker, Nigel Garrett, Carla Truyers, Ilse Van Dromme, Edith Swann, Mary A. Marovich, Dean Follmann, Kathleen M. Neuzil, Lawrence Corey, Alexander L. Greninger, Pavitra Roychoudhury, Ollivier Hyrien, Peter B. Gilbert

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