Structural, biochemical and inhibition studies on hypoxia-inducible factor (HIF) prolyl hydroxylases by Lippl, K

“…Further, evolutionary links between human HIF prolyl hydroxylases and Skp1-mediated oxygen-sensing mechanisms in lower organisms, such as <em>Dictyostelium discoideum</em> and <em>Toxoplasma gondii</em>, were investigated.…”

Proteasomes of Autophagy-Deficient Cells Exhibit Alterations in Regulatory Proteins and a Marked Reduction in Activity by Qiuhong Xiong, Rong Feng, Sarah Fischer, Malte Karow, Maria Stumpf, Susanne Meßling, Leonie Nitz, Stefan Müller, Christoph S. Clemen, Ning Song, Ping Li, Changxin Wu, Ludwig Eichinger

“…We previously found that autophagy 9 (ATG9) and 16 (ATG16) proteins are crucial for full proteasomal activity in the unicellular amoeba <i>Dictyostelium discoideum</i>. In comparison to AX2 wild-type cells, ATG9⁻and ATG16⁻ cells displayed a 60%, and ATG9⁻/16⁻ cells a 90%, decrease in proteasomal activity. …”
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