Bioavailability of three novel oral, sustained‐release pellets, relative to an immediate‐release tablet containing 500 mg flucytosine: A randomized, open‐label, crossover study in... by Vishal Goyal, Edrich Krantz, Francois Simon, Anouk Neven, Johanna Eriksson, Amaria Saayman, Nabila Ibnou Zekri Lassout, Mathieu Louis, Stephen Robinson, Abhijit Deshmukh, Amit Antarkar, Carol Ruffell, Sarika Victor, Marylore Chenel, Aljosa Celebic, Henri Caplain, Jean‐Yves Gillon, Isabela Ribeiro

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Comparative evaluation of immunoassays to improve access to diagnosis for Chagas disease in Colombia by Ricardo Andrés Caicedo Díaz, Colin Forsyth, Oscar Alberto Bernal, Andrea Marchiol, Mauricio Beltrán Duran, Carolina Batista, Rafael Herazo, Mauricio Javier Vera, Eduin Pachón Abril, Carlos Andres Valencia-Hernández, Astrid Carolina Flórez Sánchez

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A four-step process for building sustainable access to diagnosis and treatment of Chagas disease by Carolina Batista, Colin J. Forsyth, Rafael Herazo, Marina Pereira Certo, Andrea Marchiol

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The oral protease inhibitor (PF-07321332) protects Syrian hamsters against infection with SARS-CoV-2 variants of concern by Rana Abdelnabi, Caroline S. Foo, Dirk Jochmans, Laura Vangeel, Steven De Jonghe, Patrick Augustijns, Raf Mols, Birgit Weynand, Thanaporn Wattanakul, Richard M. Hoglund, Joel Tarning, Charles E. Mowbray, Peter Sjö, Fanny Escudié, Ivan Scandale, Eric Chatelain, Johan Neyts

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Oral fexinidazole for stage 1 or early stage 2 African Trypanosoma brucei gambiense trypanosomiasis: a prospective, multicentre, open-label, cohort study by Victor Kande Betu Ku Mesu, DPH, Wilfried Mutombo Kalonji, MD, Clélia Bardonneau, MSc, Olaf Valverde Mordt, MSc, Digas Ngolo Tete, MPH, Séverine Blesson, MSc, François Simon, MSc, Sophie Delhomme, MSc, Sonja Bernhard, PhD, Hélène Mahenzi Mbembo, MD, Christian Mpia Moke, MD, Steven Lumeya Vuvu, MMed, Junior Mudji E'kitiak, MD, Felix Akwaso Masa, MD, Melchias Mukendi Ilunga, MD, Dieudonné Mpoyi Muamba Nzambi, MD, Tim Mayala Malu, MD, Serge Kapongo Tshilumbwa, MD, Franck Botalema Bolengi, MD, Mathieu Nkieri Matsho, MD, Crispin Lumbala, MPH, Bruno Scherrer, PhD, Nathalie Strub-Wourgaft, MD, Antoine Tarral, MD

“…Funding: Through the Drugs for Neglected Diseases initiative: the Bill & Melinda Gates Foundation, the Republic and Canton of Geneva (Switzerland), the Dutch Ministry of Foreign Affairs (also known as DGIS; Netherlands), the Norwegian Agency for Development Cooperation (also known as Norad; Norway), the Federal Ministry of Education and Research (also known as BMBF) through KfW (Germany), the Brian Mercer Charitable Trust (UK), and other private foundations and individuals from the HAT campaign. …”
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Pre-clinical evaluation of antiviral activity of nitazoxanide against SARS-CoV-2 by Jean-Sélim Driouich, Maxime Cochin, Franck Touret, Paul-Rémi Petit, Magali Gilles, Grégory Moureau, Karine Barthélémy, Caroline Laprie, Thanaporn Wattanakul, Palang Chotsiri, Richard M. Hoglund, Joel Tarning, Laurent Fraisse, Peter Sjö, Charles E. Mowbray, Fanny Escudié, Ivan Scandale, Eric Chatelain, Xavier de Lamballerie, Caroline Solas, Antoine Nougairède

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How Clinical Research Can Contribute to Strengthening Health Systems in Low Resource Countries by Florent Mbo, Wilfried Mutombo, Digas Ngolo, Patrice Kabangu, Olaf Valverde Mordt, Nathalie Strub Wourgaft, Erick Mwamba

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Bioluminescence imaging reveals enhanced SARS-CoV-2 clearance in mice with combinatorial regimens by Irfan Ullah, Fanny Escudie, Ivan Scandale, Zoela Gilani, Gabrielle Gendron-Lepage, Fleur Gaudette, Charles Mowbray, Laurent Fraisse, Renée Bazin, Andrés Finzi, Walther Mothes, Priti Kumar, Eric Chatelain, Pradeep D. Uchil

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Need for a Standardized Translational Drug Development Platform: Lessons Learned from the Repurposing of Drugs for COVID-19 by Frauke Assmus, Jean-Sélim Driouich, Rana Abdelnabi, Laura Vangeel, Franck Touret, Ayorinde Adehin, Palang Chotsiri, Maxime Cochin, Caroline S. Foo, Dirk Jochmans, Seungtaek Kim, Léa Luciani, Grégory Moureau, Soonju Park, Paul-Rémi Pétit, David Shum, Thanaporn Wattanakul, Birgit Weynand, Laurent Fraisse, Jean-Robert Ioset, Charles E. Mowbray, Andrew Owen, Richard M. Hoglund, Joel Tarning, Xavier de Lamballerie, Antoine Nougairède, Johan Neyts, Peter Sjö, Fanny Escudié, Ivan Scandale, Eric Chatelain

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Tackling antimicrobial resistance in neonatal sepsis by Laura Folgori, Sally J Ellis, Julia A Bielicki, Paul T Heath, Mike Sharland, Manica Balasegaram

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Preclinical data do not support the use of amiodarone or dronedarone as antiparasitic drugs for Chagas disease at the approved human dosing regimen by Amanda F. Francisco, Gong Chen, Wen Wang, Melissa L. Sykes, Fanny Escudié, Ivan Scandale, Francisco Olmo, David M. Shackleford, Bilal Zulfiqar, Jadel M. Kratz, Thao Pham, Jessica Saunders, Meiyu Hu, Vicky M. Avery, Susan A. Charman, John M. Kelly, Eric Chatelain

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The drug and vaccine landscape for neglected diseases (2000–11): a systematic assessment by Dr. Belen Pedrique, MD, Nathalie Strub-Wourgaft, MD, Claudette Some, PharmD, Piero Olliaro, MD, Patrice Trouiller, PharmD, Nathan Ford, PhD, Bernard Pécoul, MD, Jean-Hervé Bradol, MD

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Mandatory Notification of Chronic Chagas Disease: Confronting the Epidemiological Silence in the State of Goiás, Brazil by Liliane da Rocha Siriano, Andrea Marchiol, Marina Pereira Certo, Juan-Carlos Cubides, Colin Forsyth, Fabrício Augusto de Sousa

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Clinical use of molecular methods for Trypanosoma cruzi infection in endemic and non-endemic countries: Benefits, limitations and challenges by Maria-Jesus Pinazo, Maria-Jesus Pinazo, Maria-Jesus Pinazo, Colin J. Forsyth, Colin J. Forsyth, Constanza Lopez-Albizu, Margarita María Catalina Bisio, Margarita María Catalina Bisio, Adriana González-Martínez, Adriana González-Martínez, Adriana González-Martínez, Laura Bohorquez, Jimy Pinto, Israel Molina, Israel Molina, Andrea Marchiol, Rafael Herazo, Irene Losada Galván, Irene Losada Galván, Irene Losada Galván, Tayná Marques, Fabiana Barreira, Juan Carlos Villar, Juan Carlos Villar, Yanina Sguassero, Maria Soledad Santini, Maria Soledad Santini, Maria Soledad Santini, Jaime Altcheh, Belkisyolé Alarcón de Noya, Belkisyolé Alarcón de Noya, Sergio Sosa-Estani, Sergio Sosa-Estani, Sergio Sosa-Estani

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Towards the elimination of visceral leishmaniasis as a public health problem in east Africa: reflections on an enhanced control strategy and a call for action by Jorge Alvar, MD, Margriet den Boer, PharmD, Daniel Argaw Dagne, MD

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Evaluación del cambio del algoritmo de diagnóstico serológico para la enfermedad de Chagas en Colombia by Andrea Rosana Marchiol, Rafael Herazo, Carolina Flórez Sánchez, Martha Stella Ayala Sotelo, Maryi Lorena Segura, Liliana Jazmín Cortés Cortés, Ricardo Andrés Caicedo Díaz

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Drug discovery and development for neglected diseases: the DNDi model by Eric Chatelain, Jean-Robert Ioset

“…Eric Chatelain, Jean-Robert IosetDrugs for Neglected Diseases Initiative (DNDi), Geneva, SwitzerlandAbstract: New models of drug discovery have been developed to overcome the lack of modern and effective drugs for neglected diseases such as human African trypanosomiasis (HAT; sleeping sickness), leishmaniasis, and Chagas disease, which have no financial viability for the pharmaceutical industry. …”
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Ravidasvir: equitable access through an alternative drug development pathway by Mark Wing Loong Cheong, Jean-Michel Piedagnel, Swee Kheng Khor

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Target Product Profile for a point-of-care diagnostic test for dermal leishmaniases by Israel Cruz, Audrey Albertini, Mady Barbeitas, Byron Arana, Albert Picado, Jose A. Ruiz-Postigo, Joseph M. Ndung'u

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In Vitro Susceptibility to Miltefosine of <i>Leishmania infantum</i> (syn. <i>L.</i> <i>chagasi</i>) Isolates from Different Geographical Areas in Brazil by Caroline Ricce Espada, Erica V. de Castro Levatti, Mariana Côrtes Boité, Dorcas Lamounier, Jorge Alvar, Elisa Cupolillo, Carlos Henrique Nery Costa, Joelle Rode, Silvia R. B. Uliana

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