Lipid-mediated activation of plasma membrane-localized deubiquitylating enzymes modulate endosomal trafficking by Karin Vogel, Tobias Bläske, Marie-Kristin Nagel, Christoph Globisch, Shane Maguire, Lorenz Mattes, Christian Gude, Michael Kovermann, Karin Hauser, Christine Peter, Erika Isono

“…The endocytic degradation of plasma membrane proteins can be modulated by deubiquitylating enzymes (DUBs). Here, the authors describe two plasma membrane localized Arabidopsis DUBs that can be activated by binding to anionic lipids and influence the endocytic transport of plasma membrane proteins.…”
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Usp5, Usp34, and Otu1 deubiquitylases mediate DNA repair in Drosophila melanogaster by Zoltán G. Páhi, Levente Kovács, Diána Szűcs, Barbara N. Borsos, Péter Deák, Tibor Pankotai

“…To elucidate the role of DUBs in DNA repair in Drosophila melanogaster, systematic siRNA screening was applied to identify DUBs with a reduced survival rate following exposure to ultraviolet and X-ray radiations. …”
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Role of Deubiquitinases in Parkinson’s Disease—Therapeutic Perspectives by Pernille Y. Ø. Nielsen, Justyna Okarmus, Morten Meyer

“…DUBs with a known association to PD are described in this paper, along with their function. …”
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Deubiquitinating Enzyme Inhibitors Block Chikungunya Virus Replication by Lady S. López, Eliana P. Calvo, Jaime E. Castellanos

“…Therefore, DUB activity may be a pharmacological target for blocking CHIKV infection.…”
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Discovery and characterization of ZUFSP/ZUP1, a distinct deubiquitinase class important for genome stability by Kwasna, D, Rehman, SA, Natarajan, J, Matthews, S, Madden, R, De Cesare, V, Weidlich, S, Virdee, S, Ahel, I, Gibbs-Seymour, I, Kulathu, Y

“…Our analyses reveal that ZUFSP is a novel DUB with no homology to any known DUBs, leading us to classify ZUFSP as the seventh DUB family. …”

Phosphoribosyl-linked serine ubiquitination of USP14 by the SidE family effectors of Legionella excludes p62 from the bacterial phagosome by Jinli Ge, Ying Wang, Xindi Chen, Kaiwen Yu, Zhao-Qing Luo, Xiaoyun Liu, Jiazhang Qiu

“…In the present study, we demonstrate that the host DUB USP14 is PR-ubiquitinated by SidEs at multiple serine residues, which impairs its DUB activity and its interactions with p62. …”
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Interplay between bacterial deubiquitinase and ubiquitin E3 ligase regulates ubiquitin dynamics on Legionella phagosomes by Shuxin Liu, Jiwei Luo, Xiangkai Zhen, Jiazhang Qiu, Songying Ouyang, Zhao-Qing Luo

“…Many of its virulence factors function as ubiquitin ligases or deubiquitinases (DUBs). Here, we identify Lem27 as a DUB that displays a preference for diubiquitin formed by K6, K11, or K48. …”
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Remodeling of the ribosomal quality control and integrated stress response by viral ubiquitin deconjugases by Jiangnan Liu, Noemi Nagy, Carlos Ayala-Torres, Francisco Aguilar-Alonso, Francisco Morais-Esteves, Shanshan Xu, Maria G. Masucci

“…The vDUB participates in protein complexes that include the RQC ubiquitin ligases ZNF598 and LTN1. …”
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The Functional Deubiquitinating Enzymes in Control of Innate Antiviral Immunity by Zhi Zong, Zhengkui Zhang, Liming Wu, Long Zhang, Fangfang Zhou

“…Insights into the role of viral DUBs in counteracting host immune responses are also provided. …”
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Neutron-encoded diubiquitins to profile linkage selectivity of deubiquitinating enzymes by Bianca D. M. van Tol, Bjorn R. van Doodewaerd, Guinevere S. M. Lageveen-Kammeijer, Bas C. Jansen, Cami M. P. Talavera Ormeño, Paul J. M. Hekking, Aysegul Sapmaz, Robbert Q. Kim, Angeliki Moutsiopoulou, David Komander, Manfred Wuhrer, Gerbrand J. van der Heden van Noort, Huib Ovaa, Paul P. Geurink

“…Most insights into deubiquitinase (DUB) substrate specificity originate from studies with isolated di-ubiquitins (diUb), but in cells diUbs with different linkage types coexist. …”
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LUCIFER'S HAMMER / by Niven, Larry

“…The Hamner-Brown comet, dubbed by the press as "Lucifer's Hammer", is due to strike earth within a few minutes…”

Regulation of the Hippo signaling pathway by deubiquitinating enzymes in cancer by Ashley Mussell, Costa Frangou, Jianmin Zhang

“…In this review, we discuss the roles that DUBs play in the regulation of the Hippo signaling pathway for homeostasis and disease. …”
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Enzymatic Blockade of the Ubiquitin-Proteasome Pathway by Ernst, Robert, Claessen, Jasper H. L., Mueller, Britta, Sanyal, Sumana, Spooner, Eric, van der Veen, Annemarthe G., Kirak, Oktay, Schlieker, Christian D., Weihofen, Wilhelm A., Ploegh, Hidde

“…Our data underscore the necessity of a DUB activity for completion of the dislocation reaction and provide a new means of inhibition of proteasomal proteolysis with reduced cytotoxicity.…”
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In the moonlight: non-catalytic functions of ubiquitin and ubiquitin-like proteases by Marta Campos Alonso, Klaus-Peter Knobeloch, Klaus-Peter Knobeloch

“…Traditionally, observed effects resulting from deficiencies in deubiquitinases (DUBs) and UBL proteases have often been attributed to the misregulation of substrate modification by ubiquitin or UBLs. …”
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Is Incidence of Hysterectomy Increased in Post Tubal Ligated Patients due to Dysfunctional Uterine Bleeding? by Iram Munawar

“…Among them, 89 patients were operated due to DUB. Of these 89 patients, 28 (31.4%) had history of BTL (Case group) while 61 (68.5) had no history of BTL (Control group). …”
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Histopathology-like categories based on endometrial imprint cytology in dysfunctional uterine bleeding by Seema N Baxi, Nirav S Panchal

“…Only few studies have used cytology in the diagnosis of dysfunctional uterine bleeding (DUB). Endometrial imprint cytology has been rarely used except for application of immunocytochemistry in diagnosis of endometrial carcinoma. …”
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Detection of ubiquitin-proteasome enzymatic activities in cells: application of activity-based probes to inhibitor development. by Kramer, H, Nicholson, B, Kessler, B, Altun, M

“…A family of reagents has been developed that specifically label deubiquitylating enzymes (DUBs) and facilitate characterization of their inhibitors. …”

Investigating the regulation of ZUP1, a novel deubiquitinating enzyme involved in DNA repair, by coupled monoubiquitination by Schützenhofer, K

“…Ubiquitination, a major post-translational modification, is reversed through the action of a large family of specialised proteases termed deubiquitinating enzymes (DUBs). Due to their involvement in key cellular pathways, such as inflammation, the cell cycle and DNA repair, as well as their potential as targets for therapeutic intervention, DUBs are critical to investigate. …”

Detection of ubiquitin-proteasome enzymatic activities in cells: Application of activity-based probes to inhibitor development by Kramer, H, Nicholson, B, Kessler, B, Altun, M

“…A family of reagents has been developed that specifically label deubiquitylating enzymes (DUBs) and facilitate characterization of their inhibitors. …”

Communicative language teaching: Structure-Based or Dynamic Usage-Based? by Audrey Rousse-Malpat, Rasmus Steinkrauss, Martijn Wieling, Marjolijn Verspoor

“…However, a small group of teachers in the Netherlands started teaching French as a second language with a strong CLT program in line with Dynamic Usage-Based (DUB) principles. Rather than focusing on rule learning and explicit grammar teaching to avoid errors, the DUB program takes the dynamics of second-language development into consideration and focuses on the three key elements of usage-based theory: frequency, salience and contingency. …”
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