Cholera toxin and O-specific polysaccharide immune responses after oral cholera vaccination with Dukoral in different age groups of Bangladeshi participants by Pinki Dash, Al Hakim, Aklima Akter, Hasan Al Banna, M. Hasanul Kaisar, Amena Aktar, Sultana Rownok Jahan, Jannatul Ferdous, Salima Raiyan Basher, Mohammad Kamruzzaman, Fahima Chowdhury, Afroza Akter, Imam Tauheed, Ana A. Weil, Richelle C. Charles, Stephen B. Calderwood, Edward T. Ryan, Regina C. LaRocque, Jason B. Harris, Taufiqur Rahman Bhuiyan, Firdausi Qadri

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Evaluation of Heterologous Effects of Travel Vaccines in Colorectal Cancer: A Database Study and a Cautionary Tale by Eva Herweijer, Klaus Schwamborn, Kaatje Bollaerts, Adrian Spillmann, Tom Cattaert, Thomas Verstraeten, Janet Hoogstraate

Subjects: “…Dukoral…”
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Mechanisms Underlying the Immune Response Generated by an Oral Vibrio cholerae Vaccine by Danylo Sirskyj, Ashok Kumar, Ali Azizi

“…We investigated the involvement of Toll-like receptor signaling in the induction of humoral immune responses following oral immunization with Dukoral, comparing wild type mice with TLR-2-, TLR-4-, MyD88- and Trif-deficient mice. …”
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Determination of bactericidal activity of serum against Vibrio cholerae outer membrane vesicles in BALB/c mice by M Sedaghat, SD Siadat, E Mirabzadeh Ardakani, M Keramati, F Vaziri, F Shahcheraghi

“…The vaccine formulas included V. cholerae OMVs, killed whole cells of V. cholerae (WC), combination of WC-OMV and licensed cholera vaccine (Dukoral).The serum vibriocidal activity of mice sera was determined by measuring the complement-mediated lysis. …”
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Assessment of Mouse Ileal loop Protection against Clinically Isolated Vibrio cholerae Outer Membrane Vesicles as a Vaccine Candidate by M. Sedaghat, S. D. Siadat, F. Shahcheraghi, E. Mirabzadeh Ardakani, M. Keramati, F. Vaziri, S. A. Nojoumi

“…In addition, fluid accumulation (FA) assay regarding the resistance to live strain of V. cholerae in ligated ileal loops was carried out to determine immunogenicity by OMV or combination of OMV and WC in comparison to that reported for Dukoral vaccine. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis of purified OMVs indicated protein profiles within the range of 34-52 kDa. …”
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Therapeutic Potential of Cholera Toxin B Subunit for the Treatment of Inflammatory Diseases of the Mucosa by Joshua M. Royal, Nobuyuki Matoba

“…This well-known biological activity has been exploited in cholera prevention (as a component of Dukoral® vaccine) and vaccine development for decades. …”
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A Systems Biology Approach Identifies B Cell Maturation Antigen (BCMA) as a Biomarker Reflecting Oral Vaccine Induced IgA Antibody Responses in Humans by Lynda Mottram, Anna Lundgren, Ann-Mari Svennerholm, Susannah Leach, Susannah Leach

“…We then assess the ability of BCMA to reflect oral vaccine induced primary and memory IgA responses using an ELISA BCMA assay on a larger number of samples collected in clinical trials with Dukoral® and the oral enterotoxigenic Escherichia coli vaccine candidate ETVAX. …”
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An Update on Cholera Immunity and Current and Future Cholera Vaccines by Jan Holmgren

“…Oral cholera vaccines (OCVs), based on inactivated <i>Vibrio cholerae</i> whole-cell components, either together with the cholera toxin B subunit (Dukoral™) or administered alone (Shanchol™/Euvichol-Plus™) were shown to be consistently safe and effective in large field trials in all settings. …”
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Immunogenicity of cholera vaccination in children with inflammatory bowel disease by Łukasz Dembiński, Anna Stelmaszczyk-Emmel, Katarzyna Sznurkowska, Agnieszka Szlagatys-Sidorkiewicz, Andrzej Radzikowski, Aleksandra Banaszkiewicz

“…All patients were administered two doses of the oral cholera vaccine (Dukoral®). Anti-cholera toxin B subunit IgA and IgG seroconversion rates were evaluated in a group with immunosuppressive (IS) treatment and a group without IS treatment (NIS). …”
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Efficacy and Safety of Cholera Vaccines by A. A. Goryaev, L. V. Sayapina, Yu. I. Obukhov, V. P. Bondarev

“…The paper compares active  ingredients and excipients used in Dukoral®, mORC-VAX®, Shanchol®, Euvichol®, Vaxchora®, Oravacs® and the cholera bivalent chemical vaccine. …”
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Vaccination strategies to combat an infectious globe: Oral cholera vaccines by Rosa M López-Gigosos, Elena Plaza, Rosa M Díez-Díaz, Maria J Calvo

“…The two vaccines currently available in worldwide are: (1) The killed oral vaccine (Dukoral, licensed by SBL-Sweden to Crucell-Holland) is recommended since 1999 by WHO and consists of a mixture of four preparations of heat or formalin killed whole cell Vibrio cholera O1 (Inaba and Ogaba serotypes, and classical and El Tor biotypes) that are then added with purified recombinant cholera toxin (CT) B subunit. …”
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Costs of illness due to cholera, costs of immunization and cost-effectiveness of an oral cholera mass vaccination campaign in Zanzibar. by Christian Schaetti, Mitchell G Weiss, Said M Ali, Claire-Lise Chaignat, Ahmed M Khatib, Rita Reyburn, Radboud J Duintjer Tebbens, Raymond Hutubessy

“…BACKGROUND: The World Health Organization (WHO) recommends oral cholera vaccines (OCVs) as a supplementary tool to conventional prevention of cholera. Dukoral, a killed whole-cell two-dose OCV, was used in a mass vaccination campaign in 2009 in Zanzibar. …”
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Oral cholera vaccine use in Zanzibar: socioeconomic and behavioural features affecting demand and acceptance by Chaignat Claire-Lise, Weiss Mitchell G, Pach Al, Ali Said M, Hutubessy Raymond, Schaetti Christian, Khatib Ahmed M

“…To assess this new approach in endemic settings, a project was launched in Zanzibar to vaccinate 50,000 individuals living in communities at high risk of cholera with an oral two-dose vaccine (Dukoral^®).</p> <p>Immunisation programmes in low-income countries have suffered a reduced coverage or were even brought to a halt because of an ignorance of local realities. …”
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Type II NKT Cell Agonist, Sulfatide, Is an Effective Adjuvant for Oral Heat-Killed Cholera Vaccines by Aqel Albutti, Stephanie Longet, Craig P. McEntee, Shauna Quinn, Alex Liddicoat, Cristiana Rîmniceanu, Nils Lycke, Lydia Lynch, Susanna Cardell, Ed C. Lavelle

“…Specifically, administration of sulfatide with the oral cholera vaccine Dukoral^® resulted in enhancement of intestinal antigen-specific IgA in addition to Th1 and Th17 immune responses. …”
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SSSCPreds: Deep Neural Network-Based Software for the Prediction of Conformational Variability and Application to SARS-CoV‑2 by Hiroshi Izumi, Laurence A. Nafie, Rina K. Dukor

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Conformational Variability Correlation Prediction of Transmissibility and Neutralization Escape Ability for Multiple Mutation SARS-CoV‑2 Strains using SSSCPreds by Hiroshi Izumi, Laurence A. Nafie, Rina K. Dukor

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Chiroptical Properties and Conformation of Four Lasiocepsin-Related Antimicrobial Peptides: Structural Role of Disulfide Bridges by Markéta Pazderková, Václav Profant, Petr Maloň, Rina K. Dukor, Václav Čeřovský, Vladimír Baumruk, Lucie Bednárová

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