Locating macromolecular assemblies in cells by 2D template matching with cisTEM by Bronwyn A Lucas, Benjamin A Himes, Liang Xue, Timothy Grant, Julia Mahamid, Nikolaus Grigorieff

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CDK7/12/13 inhibition targets an oscillating leukemia stem cell network and synergizes with venetoclax in acute myeloid leukemia by Lixiazi He, Christian Arnold, Judith Thoma, Christian Rohde, Maksim Kholmatov, Swati Garg, Cheng‐Chih Hsiao, Linda Viol, Kaiqing Zhang, Rui Sun, Christina Schmidt, Maike Janssen, Tara MacRae, Karin Huber, Christian Thiede, Josée Hébert, Guy Sauvageau, Julia Spratte, Herbert Fluhr, Gabriela Aust, Carsten Müller‐Tidow, Christof Niehrs, Gislene Pereira, Jörg Hamann, Motomu Tanaka, Judith B Zaugg, Caroline Pabst

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S274: A NOVEL SUBTYPE OF ANEMIA CAUSED BY MUTATIONS IN TFRC GENE by S. Colucci, V. Venturi, F. Nicole, D. Jové Solavera, M. Zimon, P. Richter-Pechanska, G. Hernandez, S. Unal, F. Gumruk, A. Diaz-Conradi, L. Romero-Cortadellas, X. Ferrer-Cortès, M. Olivella, M. Erlacher, C. Niemeyer, T. Wiesel, R. Pepperkok, M. D. Fleming, A. E. Kulozik, M. Sanchez, M. U. Muckenthaler

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Structural basis for sequence-independent substrate selection by eukaryotic wobble base tRNA deaminase ADAT2/3 by Luciano G. Dolce, Aubree A. Zimmer, Laura Tengo, Félix Weis, Mary Anne T. Rubio, Juan D. Alfonzo, Eva Kowalinski

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Bioinformatics goes to school--new avenues for teaching contemporary biology. by Louisa Wood, Philipp Gebhardt

“…Since 2010, the European Molecular Biology Laboratory's (EMBL) Heidelberg laboratory and the European Bioinformatics Institute (EMBL-EBI) have jointly run bioinformatics training courses developed specifically for secondary school science teachers within Europe and EMBL member states. …”
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SMART: a web-based tool for the study of genetically mobile domains. by Schultz, J, Copley, R, Doerks, T, Ponting, C, Bork, P

“…SMART (a Simple Modular Architecture Research Tool) allows the identification and annotation of genetically mobile domains and the analysis of domain architectures (http://SMART.embl-heidelberg.de ). More than 400 domain families found in signalling, extra-cellular and chromatin-associated proteins are detectable. …”

Stroma Transcriptomic and Proteomic Profile of Prostate Cancer Metastasis Xenograft Models Reveals Prognostic Value of Stroma Signatures by Sofia Karkampouna, Maria R. De Filippo, Charlotte K. Y. Ng, Irena Klima, Eugenio Zoni, Martin Spahn, Frank Stein, Per Haberkant, George N. Thalmann, Marianna Kruithof-de Julio

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BipA exerts temperature-dependent translational control of biofilm-associated colony morphology in Vibrio cholerae by Teresa del Peso Santos, Laura Alvarez, Brandon Sit, Oihane Irazoki, Jonathon Blake, Benjamin R Warner, Alyson R Warr, Anju Bala, Vladimir Benes, Matthew K Waldor, Kurt Fredrick, Felipe Cava

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P630: TARGETING NEGATIVE REGULATION OF MAPK SIGNALING IN CHRONIC LYMPHOCYTIC LEUKEMIA by M. Stumpf, V. Ecker, P. Giansanti, J. Lu, T. Zenz, I. Ringshausen, B. Küster, J. Ruland, M. Buchner

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On the current status of Phakopsora pachyrhizi genome sequencing by Marco eLoehrer, Alexander eVogel, Bruno eHuettel, Richard eReinhardt, Vladimir eBenes, Sébastien eDuplessis, Bjoern eUsadel, Bjoern eUsadel, Ulrich eSchaffrath

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ZOONET: perspectives on the evolution of animal form. Meeting report. by Fischer, A, Arboleda, E, Egger, B, Hilbrant, M, McGregor, A, Cole, A, Daley, A

“…The meeting marked the conclusion of ZOONET, an EU-funded Marie-Curie Research Training Network comprising nine research groups from all over Europe (Max Telford, University College London; Michael Akam, University of Cambridge; Detlev Arendt, EMBL Heidelberg; Maria Ina Arnone, Stazione Zoologica Anton Dohrn Napoli; Michalis Averof, IMBB Heraklion; Graham Budd, Uppsala University; Richard Copley, University of Oxford; Wim Damen, University of Cologne; Ernst Wimmer, University of Göttingen). …”

Recent improvements to the SMART domain-based sequence annotation resource. by Letunic, I, Goodstadt, L, Dickens, N, Doerks, T, Schultz, J, Mott, R, Ciccarelli, F, Copley, R, Ponting, C, Bork, P

“…SMART (Simple Modular Architecture Research Tool, http://smart.embl-heidelberg.de) is a web-based resource used for the annotation of protein domains and the analysis of domain architectures, with particular emphasis on mobile eukaryotic domains. …”

Pre-analytical processing of plasma and serum samples for combined proteome and metabolome analysis by Hagen M. Gegner, Thomas Naake, Aurélien Dugourd, Torsten Müller, Torsten Müller, Felix Czernilofsky, Georg Kliewer, Georg Kliewer, Evelyn Jäger, Barbara Helm, Nina Kunze-Rohrbach, Ursula Klingmüller, Carsten Hopf, Carsten Müller-Tidow, Sascha Dietrich, Julio Saez-Rodriguez, Wolfgang Huber, Rüdiger Hell, Gernot Poschet, Jeroen Krijgsveld, Jeroen Krijgsveld

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Estimating the cumulative incidence of SARS-CoV-2 infection in Costa Rica: modelling seroprevalence data in a population-based cohortResearch in context by Romain Fantin, Neha Agarwala, Amada Aparicio, Ruth Pfeiffer, Tim Waterboer, Arturo Abdelnour, Julia Butt, Julia Flock, Kim Remans, D. Rebecca Prevots, Carolina Porras, Allan Hildesheim, Viviana Loria, Mitchell H. Gail, Rolando Herrero, Alejandro Calderón, Karla Moreno, Melvin Morera, Roy Wong, Roberto Castro, Bernal Cortés, Rebecca Ocampo, Michael Zúñiga, Juan Carlos Vanegas, Kaiyuan Sun, Cristina Barboza-Solís, Marco Binder

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Single-cell Bayesian deconvolution by Gabriel Torregrosa-Cortés, David Oriola, Vikas Trivedi, Jordi Garcia-Ojalvo

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Structural conservation of HBV-like capsid proteins over hundreds of millions of years despite the shift from non-enveloped to enveloped life-style by Sara Pfister, Julius Rabl, Thomas Wiegand, Simone Mattei, Alexander A. Malär, Lauriane Lecoq, Stefan Seitz, Ralf Bartenschlager, Anja Böckmann, Michael Nassal, Daniel Boehringer, Beat H. Meier

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A timer gene network is spatially regulated by the terminal system in the Drosophila embryo by Erik Clark, Margherita Battistara, Matthew A Benton

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S285: DISSECTING THE ROLE OF THE IMMUNOPHILIN FKBP12 IN HEPCIDIN REGULATION by Mariateresa Pettinato, Alessandro Dulja, Silvia Colucci, Valeria Furiosi, Franca Fette, Andrea Steinbicker, Martina Muckenthaler, Antonella Nai, Alessia Pagani, Laura Silvestri

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Single‐cell RNA sequencing of motoneurons identifies regulators of synaptic wiring in Drosophila embryos by Jessica Velten, Xuefan Gao, Patrick Van Nierop y Sanchez, Katrin Domsch, Rashi Agarwal, Lena Bognar, Malte Paulsen, Lars Velten, Ingrid Lohmann

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2FAST2Q: a general-purpose sequence search and counting program for FASTQ files by Afonso M. Bravo, Athanasios Typas, Jan-Willem Veening

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