Evolution and assembly of ESCRTs. by Ghazi-Tabatabai, S, Obita, T, Pobbati, A, Perisic, O, Samson, R, Bell, S, Williams, R

“…The mechanism of Vps4-catalysed disassembly of ESCRT networks is unknown; however, it requires interaction between Vps4 and ESCRT-III subunits. …”

AKTIP interacts with ESCRT I and is needed for the recruitment of ESCRT III subunits to the midbody by Merigliano, Chiara, Burla, Romina, La Torre, Mattia, Del Giudice, Simona, Teo, Hsiang Ling, Liew, Chong Wai, Chojnowski, Alexandre, Goh, Wah Ing, Olmos, Yolanda, Maccaroni, Klizia, Giubettini, Maria, Chiolo, Irene, Carlton, Jeremy G., Raimondo, Domenico, Vernì, Fiammetta, Stewart, Colin L., Rhodes, Daniela, Wright, Graham D., Burke, Brian E., Saggio, Isabella

“…This step is carried out by the endosomal sorting complex required for transport (ESCRT) machinery. AKTIP, a protein discovered to be associated with telomeres and the nuclear membrane in interphase cells, shares sequence similarities with the ESCRT I component TSG101. …”
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Ancient ESCRTs and the evolution of binary fission. by Samson, R, Bell, S

“…Thus, two distinct machineries to drive binary fission have evolved in prokaryotes - one dependent on tubulin-like proteins and one dependent on the ESCRT system.…”

A role for the ESCRT system in cell division in archaea. by Samson, R, Obita, T, Freund, S, Williams, R, Bell, S

“…We found that Sulfolobus ESCRT-III and Vps4 homologs underwent regulation of their expression during the cell cycle. …”

Cortical constriction during abscission involves helices of ESCRT-III-dependent filaments. by Guizetti, J, Schermelleh, L, Mäntler, J, Maar, S, Poser, I, Leonhardt, H, Müller-Reichert, T, Gerlich, D

“…The endosomal sorting complex required for transport (ESCRT)-III co-localized with constriction zones and was required for assembly of 17-nanometer-diameter filaments. …”

Toxoplasma gondii exploits the host ESCRT machinery for parasite uptake of host cytosolic proteins by Rivera-Cuevas, Yolanda, Mayoral, Joshua, Di Cristina, Manlio, Lawrence, Anna-Lisa E, Olafsson, Einar B, Patel, Romir K, Thornhill, Dishari, Waldman, Benjamin S, Ono, Akira, Sexton, Jonathan Z, Lourido, Sebastian, Weiss, Louis M, Carruthers, Vern B

“…<jats:italic>gondii</jats:italic> by disrupting host ESCRT function. We identified the transmembrane dense granule protein TgGRA14, which contains motifs homologous to the late domain motifs of HIV-1 Gag, as a candidate for the recruitment of the host ESCRT machinery to the PV membrane. …”
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Molecular and structural basis of ESCRT-III recruitment to membranes during archaeal cell division by Samson, R, Obita, T, Hodgson, B, Shaw, M, Chong, P, Williams, R, Bell, S

“…Recent work has established that <em>Sulfolobus</em> homologs of the eukaryotic ESCRT-III and Vps4 components of the ESCRT machinery play an important role in <em>Sulfolobus</em> cell division. …”

Molecular and structural basis of ESCRT-III recruitment to membranes during archaeal cell division. by Samson, R, Obita, T, Hodgson, B, Shaw, M, Chong, P, Williams, R, Bell, S

“…Recent work has established that Sulfolobus homologs of the eukaryotic ESCRT-III and Vps4 components of the ESCRT machinery play an important role in Sulfolobus cell division. …”

Accessory ESCRT-III proteins are conserved and selective regulators of Rab11a-exosome formation by Marie, PP, Fan, S-J, Mason, J, Wells, A, Mendes, CC, Wainwright, SM, Scott, S, Fischer, R, Harris, AL, Wilson, C, Goberdhan, DCI

“…Accessory ESCRT-III components have reported roles in ESCRT-III-mediated vesicle scission, but their precise functions are poorly defined. …”

A role for Vps13-mediated lipid transfer at the ER-endosome contact site in ESCRT-mediated sorting by Suzuki, Sho W., West, Matthew, Zhang, Yichen, Fan, Jenny S., Roberts, Rachel T., Odorizzi, Greg, Emr, Scott D.

“…Here, we reveal that Vps13-mediated lipid transfer at ER-endosome contact sites is required for the ESCRT pathway. We propose that Vps13 may play a critical role in supplying lipids to the endosome, ensuring continuous ESCRT-mediated sorting during MVB biogenesis.…”
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Three-dimensional analysis of budding sites and released virus suggests a revised model for HIV-1 morphogenesis. by Carlson, L, Briggs, J, Glass, B, Riches, J, Simon, M, Johnson, M, Müller, B, Grünewald, K, Kräusslich, H

“…In contrast, late-budding sites lacking functional ESCRT exhibited a nearly closed Gag sphere. The results lead us to propose that budding is initiated by Gag assembly, but is completed in an ESCRT-dependent manner before the Gag sphere is complete. …”

Type I Interferon Imposes a TSG101/ISG15 Checkpoint at the Golgi for Glycoprotein Trafficking during Influenza Virus Infection by Sanyal, Sumana, Ashour, Joseph, Maruyama, Takeshi, Altenburg, Arwen F., Cragnolini, Juan Jose, Bilate, Angelina, Avalos, Ana M., Kundrat, Lenka, García-Sastre, Adolfo, Ploegh, Hidde

“…The influenza A virus (IAV) matrix protein binds to the ESCRT-I complex, although the involvement of early ESCRT proteins such as Tsg101 in IAV trafficking remain to be established. …”
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Evolution of diverse cell division and vesicle formation systems in Archaea. by Makarova, K, Yutin, N, Bell, S, Koonin, E

“…Recently a novel cell division system comprised of homologues of eukaryotic ESCRT-III (endosomal sorting complex required for transport III) proteins was discovered in the hyperthermophilic crenarchaeote Sulfolobus acidocaldarius. …”

EGAD! There is an ERAD doppelganger in the Golgi by Fonseca, D, Carvalho, P

“…Disposal of membrane proteins in the late secretory pathway is thought to be exclusively facilitated by ESCRT‐dependent lysosomal degradation. In this issue of The EMBO Journal, Schmidt et al define a previously uncharacterized endosome and Golgi‐associated degradation (EGAD) pathway. …”

A presynaptic endosomal trafficking pathway controls synaptic growth signaling by Rodal, Avital A., Blunk, Aline Dorret, Akbergenova, Yulia, Jorquera, Ramon, Buhl, Lauren Kaye, Littleton, J. Troy

“…Our results define a presynaptic trafficking pathway mediated by SNX16, NWK, and the ESCRT complex that functions to control synaptic growth signaling at the interface between endosomal compartments.…”
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Redundant late domain functions of tandem VP2 YPX3L motifs in nonlytic cellular egress of quasi-enveloped hepatitis A virus by González-López, O, Rivera-Serrano, E, Hu, F, Hensley, L, McKnight, K, Ren, J, Stuart, D, Fry, E, Lemon, S

“…The endosomal sorting complexes required for transport (ESCRT) are key to this process, as is the ESCRT-III-associated protein, ALIX, which also contributes to membrane budding of conventional enveloped viruses. …”

Clathrin mediates both internalization and vesicular release of triggered T cell receptor at the immunological synapse by Kvalvaag, A, Valvo, S, Céspedes, PF, Saliba, DG, Kurz, E, Korobchevskaya, K, Dustin, ML

“…Here, we show that clathrin is first recruited to TCR microclusters by HRS and STAM2 to initiate release of TCR in extracellular vesicles through clathrin- and ESCRT-mediated ectocytosis directly from the plasma membrane. …”

Monitoring α-synuclein ubiquitination dynamics reveals key endosomal effectors mediating its trafficking and degradation by Zenko, D, Marsh, J, Castle, AR, Lewin, R, Fischer, R, Tofaris, GK

“…This is mediated by NBR1 binding and entry into endosomes in a process that involves ESCRT I-III for subsequent lysosomal degradation. …”

Regulation of synaptic structure and function at the Drosophila neuromuscular junction by Blunk, Aline D. (Aline Dorret)

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T-cells play the classics with a different spin. by Dustin, M

“…Finally, we showed recently that T-cells use endosomal sorting complexes required for transport (ESCRTs) at the plasma membrane to generate T-cell antigen receptor-enriched microvesicles. …”