Electrophysiological Profile Remodeling via Selective Suppression of Voltage-Gated Currents by CLN1/PPT1 Overexpression in Human Neuronal-Like Cells by Gian Carlo Demontis, Francesco Pezzini, Elisa Margari, Marzia Bianchi, Biancamaria Longoni, Stefano Doccini, Maciej Maurycy Lalowski, Filippo Maria Santorelli, Alessandro Simonati

“…CLN1 disease (OMIM #256730) is an inherited neurological disorder of early childhood with epileptic seizures and premature death. …”
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Advancing scalability and impacts of a teacher training program for promoting child mental health in Ugandan primary schools: protocol for a hybrid-type II effectiveness-implementa... by Keng-Yen Huang, Janet Nakigudde, Elizabeth Nsamba Kisakye, Hafsa Sentongo, Tracy A. Dennis-Tiwary, Yesim Tozan, Hyung Park, Laurie Miller Brotman

“…Through a cross-sector collaboration, we are carrying out a second-generation investigation of implementation and effectiveness of a school-based mental health EBI, ParentCorps Professional Development (PD), to scale-up and sustain the EBI in Uganda to promote early childhood students’ mental health. Our previous studies in Uganda supported that culturally adapted PD resulted in short-term benefits for classrooms, children, and families. …”
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Dandy-Walker Syndrome – review of patients’ health situation in Poland by Ewa Teresa Guz, Krzysztof Turowski, Marta Czekirda, Elżbieta Bartoń

“…Symptoms of the disease can develop slowly since the early childhood and will result in developing both hydrocephalus and anomalies related to the structure of the cerebellum. …”
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ANATOMICAL AND GENETIC PREDISPOSITION FOR CARIES IN PERMANENT DENTITION. REVIEW by K.A. Udaltsova, E.O. Pisarenko

“…Fermentable carbohydrates enrich cariogenic bacteria, including Streptococus mutans, S. sobrinus, and Lactobacillus species, in the biofilm leading to dental decalcification. Severe-early childhood caries, affecting multiple smooth tooth surfaces before age 5, can lead to pain, abscess formation, and loss of teeth; associated with more new carious lesions and emergency room visits, increased treatment costs, delayed development, and diminished ability to learn. …”
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Stunting and lead: using causal mediation analysis to better understand how environmental lead exposure affects cognitive outcomes in children by Kelsey M. Gleason, Linda Valeri, Anuraj H. Shankar, John F. Obrycki, Md Omar Sharif Ibne Hasan, Golam Mostofa, Quazi Quamruzzaman, Robert O. Wright, David C. Christiani, David C. Bellinger, Maitreyi Mazumdar

“…Methods Participants were 734 children from a longitudinal birth cohort established in rural Bangladesh to study the health effects of prenatal and early childhood environmental metal exposures. Lead exposure was estimated using umbilical cord blood samples obtained at birth and blood obtained via venipuncture at age 20–40 months. …”
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Development, Reliability, and Validity of the Preschool Learning Skills Scale: A Tool for Early Identification of Preschoolers at Risk of Learning Disorder in Mainland China by Mengmeng Yao, Mengmeng Yao, Jing Wang, Jing Wang, Panting Liu, Yanru Guo, Yachun Xie, Yachun Xie, Lei Zhang, Nan Su, Yanwei Li, Dongchuan Yu, Qin Hong, Xia Chi, Xia Chi

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A hybrid digital parenting program delivered within the Malaysian preschool system: protocol for a feasibility study of a small-scale factorial cluster randomized trial by Cooper, Hal, Mohd Nadzri, Farah Zeehan, Vyas, Seema, Juhari, Rumaya, Ismail, Nellie, Arshat, Zarinah, Rajandiran, Durgesh, Markle, Laurie, Calderon, Francisco, Vallance, Inge, Melendez-Torres, G.J., Facciolà, Chiara, Senesathith, Vanisa, Gardner, Frances, Lachman, Jamie M.

“…Background: The United Nations’ Sustainable Development Goal 4, and particularly target 4.2, which seeks to ensure that, by 2030, all children have access to quality early childhood development, care, and preprimary education so that they are ready for primary education, is far from being achieved. …”
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Structural and biophysical characterisations of MeCP2 MBD mutants that correlate with Rett syndrome by Chia, Jyh Yea

“…Mutations in MECP2 lead to Rett syndrome (RTT), which is characterised by progressive neuro-developmental disorder in early childhood of females. Previous studies revealed that most RTT missense mutations alter the protein conformation and subsequently interferes the methyl-CpG recognition. …”
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The SAGE Handbook of Comparative Studies in Education / by Suter, Larry E., editor, Smith, Emma, editor, Denman, Brian D., editor

Respuesta inmune para la vacuna heberbiovac-hb y factores de riesgo Consolación del Sur, año 2004 Immnune response to the Heberbiovac-HB and risk factors, Consolación del Sur 2004... by Emilia Rosa Rieumont, José Fco Martínez Gutiérrez, Tania Cruz Gónzalez, María Gloria Lugo Rosa

“…The individuals which results were between =10 UI/L and < 100 UI/L, Hyperresponsers = 100 UI/L are considered protected and sero-unprotected when the titers were < 10 UI/L; in 498 children of 10 years old that were vaccinated in the early childhood having the schedule (0-16 months) of negative mothers for HBsAg, belonging to Consolacion del Sur in Pinar del Rio province. …”
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Adult GAMT deficiency: A literature review and report of two siblings by Bhavi P. Modi, Haq Nawaz Khan, Robin van der Lee, Muhammad Wasim, Charlotte A. Haaxma, Phillip A. Richmond, Britt Drögemöller, Suleman Shah, Gajja Salomons, Frans M. van der Kloet, Fred M. Vaz, Saskia N. van der Crabben, Colin J. Ross, Wyeth W. Wasserman, Clara D.M. van Karnebeek, Fazli Rabbi Awan

“…As most cases are identified and treated in early childhood, adult phenotypes that can help in understanding the natural history of the disorder are rare. …”
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Evaluation of a long day care intervention targeting the mealtime environment and curriculum to increase children’s vegetable intake: a cluster randomised controlled trial using th... by Samantha Morgillo, Lucinda K Bell, Claire Gardner, Shabnam Kashef, Karen Stafford, Dorota Zarnowiecki, Astrid AM Poelman, Maeva O Cochet-Broch, Brittany J Johnson, Aarti Gulyani, David N Cox, Rebecca K Golley

“…Children’s vegetable intake and variety was measured at follow-up using a modified Short Food Survey for early childhood education and care and analysed using a two-part mixed model for non-vegetable and vegetable consumers. …”
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The "healthy lifestyle guide pyramid" for children and adolescents La piramide del estilo de vida saludable para niños y adolescentes by M. González-Gross, J. J. Gómez-Lorente, J. Valtueña, J. C. Ortiz, A. Meléndez

“…Consensus about the need to increase prevention efforts makes the adoption of a healthy lifestyle seem desirable from early childhood onwards. After reviewing educational tools for children and adolescents aimed at promoting a healthy lifestyle, it was recognized that there was a need to develop a simple educational tool specifically designed for these age groups. …”
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Application of diffusion kurtosis imaging in neonatal brain development by Xueyuan Wang, Xueyuan Wang, Xianglong Liu, Meiying Cheng, Meiying Cheng, Desheng Xuan, Desheng Xuan, Xin Zhao, Xin Zhao, Xiaoan Zhang, Xiaoan Zhang

“…BackgroundDeviations from the regular pattern of growth and development could lead to early childhood diseases, suggesting the importance of evaluating early brain development. …”
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A new mutation in the CAVIN1/PTRF gene in two siblings with congenital generalized lipodystrophy type 4: case reports and review of the literature by Valentina Mancioppi, Tommaso Daffara, Martina Romanisio, Giovanni Ceccarini, Caterina Pelosini, Ferruccio Santini, Simonetta Bellone, Simonetta Bellone, Simona Mellone, Alessio Baricich, Ivana Rabbone, Gianluca Aimaretti, Baris Akinci, Mara Giordano, Mara Giordano, Flavia Prodam, Flavia Prodam, Flavia Prodam

“…We herein describe the clinical phenotypes of two siblings in their early childhood, with a phenotype characterized by a generalized reduction of subcutaneous fat, muscular hypertrophy, distinct facial features, myopathy, and atlantoaxial instability. …”
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Increased maternal non-oxidative energy metabolism mediates association between prenatal di-(2-ethylhexyl) phthalate (DEHP) exposure and offspring autism spectrum disorder symptoms... by Sarah Thomson, Katherine Drummond, Martin O'Hely, Christos Symeonides, Chitra Chandran, Toby Mansell, Richard Saffery, Peter Sly, Jochen Mueller, Peter Vuillermin, Anne-Louise Ponsonby

“…Counterfactual mediation analyses indicated that part of the mechanism by which higher prenatal DEHP exposure influences the development of ASD symptoms in early childhood is through a maternal metabolic shift in pregnancy towards non-oxidative energy pathways, which are inefficient compared to oxidative metabolism. …”
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European Network for blood pressure research in children and adolescents (COST Action CA 19115) by Empar Lurbe, Fernando Fernandez-Aranda, Elke Wühl

“…While few would dispute the importance of taking effective steps to identify and manage this condition in middle-aged and elderly individuals, relatively little attention has been paid to the problem of high BP in children and adolescents.Therefore, the development of actions focused on early childhood, childhood and adolescence and the investigation of the underlying causes of this epidemic are of utmost importance. …”
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PERKEMBANGAN KREATIVITAS ANAK TAMAN KANAK-KANAK ( STUDI KOMPARATIF TK SEKAR JEPARA & RA DARUL HIKMAH JEPARA ) by Amir Gufron

“…Parents assume that early childhood as the age of containing the problem , - the age is difficult , Educators believe that childhood is a pre-school or kindergarten age / RA - a consequence of education provided to children is very different from what was experienced at the time of start formal education in the classroom (and beyond). …”
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Peran Keluarga dalam Menumbuhkan Jiwa Wirausaha Sejak Usia Dini by Mallevi Agustin Ningrum

“…Of course, here the role of a very large family because the family is the first and primary educators for children. Early childhood is a crucial time in the formation of the pattern of life for children in the future. …”
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Cow's milk and hen's egg anaphylaxis: A comprehensive data analysis from the European Anaphylaxis Registry by Ewa Cichocka‐Jarosz, Sabine Dölle‐Bierke, Urszula Jedynak‐Wąsowicz, Dominique Sabouraud‐Leclerc, Alice Köhli, Lars Lange, Nikolaos G. Papadopoulos, Jonathan Hourihane, Katja Nemat, Kathrin Scherer Hofmeier, Stephanie Hompes, Hagen Ott, Lucila Lopes de Oliveira, Thomas Spindler, Christian Vogelberg, Margitta Worm

“…Abstract Background Cow's milk (CM) and hen's egg (HE) are leading triggers of anaphylaxis in early childhood. The aim of this study was to identify clinical phenotypes and therapeutic measures for CM anaphylaxis (CMA) compared to HE anaphylaxis (HEA) in children up to 12 years of age, based on a large pan‐European dataset from the European Anaphylaxis Registry. …”
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