Effects of a Mobile-Based Intervention for Parents of Children With Crying, Sleeping, and Feeding Problems: Randomized Controlled Trial by Michaela Augustin, Maria Licata-Dandel, Linda D Breeman, Mathias Harrer, Ayten Bilgin, Dieter Wolke, Volker Mall, Margret Ziegler, David Daniel Ebert, Anna Friedmann

“… BackgroundExcessive crying, sleeping, and feeding problems in early childhood are major stressors that can result in parents feeling socially isolated and having low self-efficacy. …”
Get full text

A fast and robust hippocampal subfields segmentation: HSF revealing lifespan volumetric dynamics by Clement Poiret, Clement Poiret, Clement Poiret, Antoine Bouyeure, Antoine Bouyeure, Antoine Bouyeure, Sandesh Patil, Sandesh Patil, Sandesh Patil, Antoine Grigis, Antoine Grigis, Edouard Duchesnay, Edouard Duchesnay, Matthieu Faillot, Matthieu Faillot, Michel Bottlaender, Michel Bottlaender, Frederic Lemaitre, Frederic Lemaitre, Marion Noulhiane, Marion Noulhiane, Marion Noulhiane

“…Studying the structure of hippocampal subfields in vivo is crucial to understand volumetric trajectories across the lifespan, from the emergence of episodic memory during early childhood to memory impairments found in older adults. …”
Get full text

Model-estimated impacts of pediatric respiratory syncytial virus prevention programs in Mali on asthma prevalence by Justin R. Ortiz, MD, Rachel S. Laufer, MPH, Steven M. Brunwasser, PhD, Flanon Coulibaly, MD, Fatoumata Diallo, MD, Moussa Doumbia, MD, Amanda J. Driscoll, PhD, Deshayne B. Fell, PhD, Fadima C. Haidara, MD, Tina V. Hartert, MD, Adama M. Keita, MD, Kathleen M. Neuzil, MD, Brittney M. Snyder, PhD, Samba Sow, MD, Meagan C. Fitzpatrick, PhD

“…We used World Health Organization (WHO) Preferred Product Characteristics for RSV prevention, demographic and RSV epidemiologic data from Mali, regional recurrent wheeze/asthma prevalence, and relative risk of recurrent wheeze/asthma given early childhood RSV LRTI. Results: Among the simulated cohort of 778,680 live births, 10.0% had RSV LRTI by 2 years and 89.6% survived to 6 years. …”
Get full text

Long-Term Motor Cortical Electrical Stimulation Ameliorates 6-Hydroxydopamine-Induced Motor Dysfunctions and Exerts Neuroprotective Effects in a Rat Model of Parkinson’s Disease by Chi-Wei Kuo, Chi-Wei Kuo, Ming-Yuan Chang, Ming-Yuan Chang, Ming-Yuan Chang, Ming-Yi Chou, Chien-Yuan Pan, Chih-Wei Peng, Hui-Chiun Tseng, Tsu-Yi Jen, Xiao-Kuo He, Hui-Hua Liu, Thi Xuan Dieu Nguyen, Pi-Kai Chang, Tsung-Hsun Hsieh, Tsung-Hsun Hsieh, Tsung-Hsun Hsieh

Get full text

Maternal multiple micronutrient supplementation and other biomedical and socioenvironmental influences on children's cognition at age 9–12 years in Indonesia: follow-up of the SUMM... by Elizabeth L Prado, PhD, Susy K Sebayang, PhD, Mandri Apriatni, MA, Siti R Adawiyah, BS, Nina Hidayati, BS, Ayuniarti Islamiyah, BS, Sudirman Siddiq, BS, Benyamin Harefa, BS, Jarrad Lum, PhD, Katherine J Alcock, DPhil, Michael T Ullman, PhD, Husni Muadz, PhD, Dr. Anuraj H Shankar, DSc

“…Interpretation: Maternal MMN had long-term benefits for child cognitive development at 9–12 years of age, thereby supporting its role in early childhood development, and policy change toward MMN. …”
Get full text

Incidence of respiratory virus illness and hospitalizations in a Panama and El Salvador birth cohort, 2014–2018 by Eduardo Azziz-Baumgartner, Lindsey M Duca, Rosalba González, Arlene Calvo, S. Cornelia Kaydos-Daniels, Natalie Olson, Adam MacNeil, Vic Veguilla, Rhina Domínguez, Andrea Vicari, Rafael Rauda, Nga Vuong, Alba María Ropero, Julio Armero, Rachael Porter, Danilo Franco, Juan Miguel Pascale

“…Summary: Background: Respiratory viruses remain a key cause of early childhood illness, hospitalization, and death globally.The recent pandemic has rekindled interest in the control of respiratory viruses among paediatric populations. …”
Get full text

「反思性對話」運用於在職教保服務人員專業成長之探究 Inquiry of Reflective Conversations Applied to In-service Preschool Teachers’ Professional Development by 張素貞 Su-Chen Chang

Get full text

Dandy-Walker Syndrome – review of patients’ health situation in Poland by Ewa Teresa Guz, Krzysztof Turowski, Marta Czekirda, Elżbieta Bartoń

“…Symptoms of the disease can develop slowly since the early childhood and will result in developing both hydrocephalus and anomalies related to the structure of the cerebellum. …”
Get full text

Longitudinal neurological analysis of moderate and severe pediatric cerebral visual impairment by Andres Jimenez-Gomez, Kristen S. Fisher, Kristen S. Fisher, Kevin X. Zhang, Kevin X. Zhang, Chunyan Liu, Qin Sun, Veeral S. Shah, Veeral S. Shah, Veeral S. Shah, Veeral S. Shah, Veeral S. Shah

“…After controlling for significant confounders, receiving any type of therapy [early childhood intervention (ECI), physical and occupational therapy (PT/OT), refractive error correction or glasses] was significantly associated with longitudinal improvement in CVI grade compared to patients who did not receive any therapy, with glasses yielding the largest benefit.ConclusionThis study offers extensive insights into neurologic, developmental and ophthalmologic features in patients with moderate to severe CVI. …”
Get full text

Corpus callosum and cerebellar vermis size in very preterm infants: Relationship to long-term neurodevelopmental outcome by Po-Ming Wu, Hsin-I. Shih, Wen-Hao Yu, Li-Wen Chen, Lie-Chuan Wang, Chao-Ching Huang, Yi-Fang Tu

“…Background: The neonatal changes of corpus callosum or cerebellar volume in preterm infants have been shown to link with abnormal mentality and motor disability in early childhood. This study aims to predict the long-term neurological outcomes by measuring these changes on neonatal brain ultrasound in preterm infants. …”
Get full text

Clinical and Neurodevelopmental Characteristics of Enterovirus and Parechovirus Meningitis in Neonates by Silvia Bucci, Luana Coltella, Ludovica Martini, Alessandra Santisi, Domenico Umberto De Rose, Livia Piccioni, Francesca Campi, Maria Paola Ronchetti, Daniela Longo, Giulia Lucignani, Andrea Dotta, Cinzia Auriti

“…Data on neurodevelopmental outcome of children who contract enterovirus meningitis in early childhood are still limited in the literature.AimsTo evaluate the neurodevelopmental outcome of newborns with documented enterovirus and parechovirus meningitis contracted within the first months of life.MethodsEnterovirus and parechovirus were detected on cerebrospinal fluid (CSF) and plasma by RT-PCR. …”
Get full text

TPC2 rescues lysosomal storage in mucolipidosis type IV, Niemann–Pick type C1, and Batten disease by Anna Scotto Rosato, Einar K Krogsaeter, Dawid Jaślan, Carla Abrahamian, Sandro Montefusco, Chiara Soldati, Barbara Spix, Maria Teresa Pizzo, Giuseppina Grieco, Julia Böck, Amanda Wyatt, Daniela Wünkhaus, Marcel Passon, Marc Stieglitz, Marco Keller, Guido Hermey, Sandra Markmann, Doris Gruber‐Schoffnegger, Susan Cotman, Ludger Johannes, Dennis Crusius, Ulrich Boehm, Christian Wahl‐Schott, Martin Biel, Franz Bracher, Elvira De Leonibus, Elena Polishchuk, Diego L Medina, Dominik Paquet, Christian Grimm

“…LSDs manifest often with neurodegenerative symptoms, typically starting in early childhood, and going along with a strongly reduced life expectancy and quality of life. …”
Get full text

Perinatal and postnatal exposure to phthalates and early neurodevelopment at 6 months in healthy infants born at term by Laura Lucaccioni, Lucia Palandri, Lucia Palandri, Erica Passini, Viola Trevisani, Filippo Calandra Buonaura, Natascia Bertoncelli, Giovanna Talucci, Angela Ferrari, Eleonora Ferrari, Barbara Predieri, Fabio Facchinetti, Lorenzo Iughetti, Lorenzo Iughetti, Elena Righi

“…The exposure during sensible temporal windows as pregnancy and early childhood, may influence physiological neurodevelopment.Aims and ScopeThe aim of this study is to analyze the relationship between the urinary levels of phthalate metabolites in newborn and infants and the global development measured by the Griffiths Scales of Children Development (GSCD) at six months.MethodsLongitudinal cohort study in healthy Italian term newborn and their mothers from birth to the first 6 months of life. …”
Get full text

Impacto de la caries de la infancia temprana en la calidad de vida relacionada a la salud bucal en niños peruanos menores de 71 meses de edad by Gilmer Torres-Ramos, Daniel Blanco-Victorio, Manuel Chávez-Sevillano, Sonia Apaza-Ramos, Virginia Antezana –Vargas

“…La percepción de las madres de la CVRSB fue recogida a través del cuestionario ECOHIS (Early Childhood Oral Health Impact Scale). Los datos de CIT fueron recolectados a través de un examen clínico por dos examinadores previamente calibrados (kappa˃0.81) usando los criterios ICDASII. …”
Get full text

Rescue of infant progressive familial intrahepatic cholestasis type 3 mice by repeated dosing of AAV gene therapy by Nicholas D. Weber, Leticia Odriozola, Irene Ros-Gañán, Guillermo García-Porrero, David Salas, Josepmaria Argemi, Jean-Philippe Combal, Takashi K. Kishimoto, Gloria González-Aseguinolaza

“…Background & Aims: Gene therapy using recombinant adeno-associated virus (rAAV) vector carrying multidrug resistance protein 3 (MDR3) coding sequence (AAV8-MDR3) represents a potential curative treatment for progressive familial intrahepatic cholestasis type 3 (PFIC3), which presents in early childhood. However, patients with the severest form of PFIC3 should receive treatment early after detection to prevent irreversible hepatic fibrosis leading ultimately to liver transplantation or death. …”
Get full text

The Relative Reinforcing Value of Cookies Is Higher Among Head Start Preschoolers With Obesity by Sally G. Eagleton, Sally G. Eagleton, Jennifer L. Temple, Kathleen L. Keller, Kathleen L. Keller, Michele E. Marini, Jennifer S. Savage, Jennifer S. Savage

“…Further, the development of individual differences in the RRV of food in early childhood is poorly understood. This cross-sectional study tested the hypothesis that the RRV of HED (cookies) to low-energy-dense (LED; fruit) food would be greater in children with obesity compared to children without obesity in a sample of 130 low-income 3- to 5-year-olds enrolled in Head Start classrooms in Central Pennsylvania. …”
Get full text

Neuraxial analgesia in a parturient with the VACTERL association undergoing labor and vaginal delivery by Juan A. Ramos, Shashank S. Shettar, Christopher F. James

“…Past medical history included VACTERL association with an imperforate anus and a partial endocardial cushion defect, both repaired in early childhood. She also had significant dorso-lumbar scoliosis with an extra lumbar vertebra. …”
Get full text

Canadian dentists' views on the first dental visit for children by Hamideh Alai-Towfigh, Robert J. Schroth, Robert J. Schroth, Robert J. Schroth, Robert J. Schroth, Ralph Hu, Ralph Hu, Victor H. K. Lee, Victor H. K. Lee, Olubukola Olatosi, Olubukola Olatosi, Olubukola Olatosi

“…Findings from this study may inform educational campaigns on early childhood oral health targeted toward dentists.…”
Get full text

Estudo clínico-radiológico de crianças e adolescentes indígenas Suruí, Região Amazônica Clinical and radiological study of Suruí indigenous children and adolescents, Amazon Region,... by Paulo Cesar Basta, Diana Patrícia Giraldo Rios, Luiz Carlos Corrêa Alves, Clemax Couto Sant´Anna, Carlos Everaldo Alvares Coimbra Junior

“…The X-rays showed high frequencies of infiltrates and calcifications, which are compatible with primary infection in early childhood. However, these lesions are not different from those observed among other groups and do not suggest immune deficiencies. …”
Get full text

Retinal Degeneration Associated With RPGRIP1: A Review of Natural History, Mutation Spectrum, and Genotype–Phenotype Correlation in 228 Patients by Avigail Beryozkin, Hamzah Aweidah, Roque Daniel Carrero Valenzuela, Myriam Berman, Oscar Iguzquiza, Frans P. M. Cremers, Muhammad Imran Khan, Anand Swaroop, Radgonde Amer, Samer Khateb, Tamar Ben-Yosef, Dror Sharon, Eyal Banin

“…Age of onset was during early childhood (n = 133, average of 1.7 years). All patients but 6 had moderate hyperopia (n = 59, mean of 4.8D), and average BCVA was 0.06 Snellen (n = 124; only 10 patients had visual acuity [VA] > 0.10 Snellen). …”
Get full text