Efficacy of an extensively hydrolyzed formula with the addition of synbiotics in infants with cow's milk protein allergy: a real-world evidence study by Ramiro Soria, Mónica Del Compare, Marisa Sallaberry, Graciela Martín, Gustavo Aprigliano, Verónica Hermida, Mabel Carosella, Martín Gruenberg, Silvana Monsell, Paula Micone, Eugenia Maciero, Norberto Giglio

“…IntroductionCow's milk protein allergy (CMPA) is the most frequent food allergy in early childhood. For those infants requiring breastmilk substitutes, formulas with extensively hydrolyzed proteins (EHF), should be the treatment of choice. …”
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Genomic, Proteomic, and Phenotypic Spectrum of Novel O-Sialoglycoprotein Endopeptidase Variant in Four Affected Individuals With Galloway-Mowat Syndrome by Malak Ali Alghamdi, Malak Ali Alghamdi, Hicham Benabdelkamel, Afshan Masood, Narjes Saheb Sharif-Askari, Mahmood Y. Hachim, Hamad Alsheikh, Muddathir H. Hamad, Mustafa A. Salih, Fahad A. Bashiri, Fahad A. Bashiri, Khalid Alhasan, Khalid Alhasan, Khalid Alhasan, Tarek Kashour, Pilar Guatibonza Moreno, Sabine Schröder, Vasiliki Karageorgou, Aida M. Bertoli-Avella, Hisham Alkhalidi, Dima Z. Jamjoom, Ibrahim A. Alorainy, Assim A. Alfadda, Assim A. Alfadda, Assim A. Alfadda, Rabih Halwani

“…Most patients die during early childhood. Here, we identified a novel homozygous O-sialoglycoprotein endopeptidase (OSGEP) variant, NM_017807.3:c.973C>G (p.Arg325Gly), in four affected individuals in an extended consanguineous family from Saudi Arabia. …”
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O registro do crescimento e desenvolvimento da criança na caderneta de saúde [The record of children’s growth and development in the health booklet] [El registro del crecimiento y... by Abner Pereira Almeida, Luciana Carvalho Ceballos, Alice Regina Costa Barbosa, Denismar Alves Nogueira, Denis Silva Moreira

“…Methods: in this quantitative, cross-sectional, descriptive study, documentary analysis was carried out with 229 health booklets collected at 10 Municipal Early Childhood Education Centers in a municipality in south Minas Gerais, from January to June 2015, using a purpose-designed form. …”
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Hábitos alimentares e fatores de risco para aterosclerose em estudantes de Bento Gonçalves (RS) Dietary habits and risk factors for atherosclerosis in students from Bento Gonçalves... by Hosana Maria Speranza Cimadon, Renata Geremia, Lucia Campos Pellanda

“…<br>BACKGROUND: Atherosclerotic cardiovascular disease begins its process in early childhood and is influenced throughout life by genetic factors and environmental exposure to potentially modifiable risk factors. …”
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Retraso de la adquisición de la succión-deglución-respiración en el pretérmino: efectos de una estimulación precoz Delay in the acquisition of sucking-swallowing-breathing in the p... by E. La Orden Izquierdo, E. Salcedo Lobato, I. Cuadrado Pérez, M. S. Herráez Sánchez, L. Cabanillas Vilaplana

“…Its delay extends hospital stay and increases the incidence of oral motor disorders in early childhood. Aims: To analyze the transition from enteral to oral nutrition, the comorbidity associated with its delay and the impact of an early suction stimulation in a cohort of premature babies. …”
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Ultra-processed and fast food consumption, exposure to phthalates during pregnancy, and socioeconomic disparities in phthalate exposures by Brennan H. Baker, Melissa M. Melough, Alison G. Paquette, Emily S. Barrett, Drew B. Day, Kurunthachalam Kannan, Ruby HN Nguyen, Nicole R. Bush, Kaja Z. LeWinn, Kecia N. Carroll, Shanna H. Swan, Qi Zhao, Sheela Sathyanarayana

“…Methods: In a socioeconomically diverse sample of 1031 pregnant women from the Conditions Affecting Neurocognitive Development and Learning in Early Childhood (CANDLE) Study in the urban South, the Block Food Frequency Questionnaire was administered and urinary phthalate metabolites were measured in the second trimester. …”
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Relationship Between Weight Status and Self-Image Mediated by Pubertal Timing and Athletic Competence: A Cohort Study With Taiwanese Adolescents by Jen-Hao Kuo, Josue Jaru Ubeda Herrera, Josue Jaru Ubeda Herrera, Chia-Yi Liu, Ting-Hsuan Lee, Carol Strong, Chung-Ying Lin, Yun-Hsuan Chang, Yun-Hsuan Chang, Yun-Hsuan Chang, Yun-Hsuan Chang, Yi-Ching Lin, Yi-Ping Hsieh, Meng-Che Tsai, Meng-Che Tsai

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Prevalence and risk factors of anemia in children by Cristie Regine Klotz Zuffo, Mônica Maria Osório, Cesar Augusto Taconeli, Suely Teresinha Schmidt, Bruno Henrique Corrêa da Silva, Cláudia Choma Bettega Almeida

“…Objective: To identify the prevalence and factors associated with anemia in children attending Municipal Early Childhood Education Day Care Center (Centros Municipais de Educação Infantil [CMEI]) nurseries in Colombo-PR. …”
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Assessing the Inequality of Early Child Development in China - A Population-Based Study by Yunting Zhang, PhD, Le Kang, PhD, Jin Zhao, PhD, Prof. Yingquan Song, PhD, Prof. Fan Jiang, MD, PhD, Chunling Lu, PhD

“…Background: As a country with the second largest child population in the world, China has little population-level evidence on who has been left behind in early childhood development (ECD). Knowledge of inequalities in ECD will inform the Chinese government in policies on promoting ECD and guide global-level monitoring on ECD progress. …”
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Longitudinal changes in body mass index Z-scores during infancy and risk of childhood allergies by Wei-Hsuan Sung, Kuo-Wei Yeh, Jing-Long Huang, Kuan-Wen Su, Kuan-Fu Chen, Chin-Chieh Wu, Ming-Han Tsai, Man-Chin Hua, Sui-Ling Liao, Shen-Hao Lai, Chih-Yung Chiu

“…Conclusions: A decreasing trend of BMI Z-scores during infancy is determined to be inversely associated with IgE and allergen sensitization, which may potentially increase the risk of allergies in early childhood.…”
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Deciduous tooth biomarkers reveal atypical fetal inflammatory regulation in autism spectrum disorder by Dani Dumitriu, Elena Baldwin, Roozie J.J. Coenen, Luke A. Hammond, Darcy S. Peterka, Lynne Heilbrun, Richard E. Frye, Raymond Palmer, Hjalmar Nobel Norrman, Anna Fridell, Karl Lundin Remnelius, Johan Isaksson, Christine Austin, Paul Curtin, Sven Bölte, Manish Arora

“…Here, we present a method to generate approximately daily profiles of prenatal and early childhood inflammation as measured by developmentally archived C-reactive protein (CRP) in incremental layers of deciduous tooth dentin. …”
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Diagnosis of human herpesvirus 6B primary infection by polymerase chain reaction in young children with exanthematic disease Diagnóstico de infecção primária pelo herpesvírus human... by Ivna de Melo Magalhães, Rebeca Vasquez Novo Martins, Renata Oliveira Vianna, Solange Artimos Oliveira, Silvia Maria Baeta Cavalcanti

“…INTRODUCTION: Exanthem subitum is a classical rash disease of early childhood caused by human herpesvirus 6B (HHV-6B). …”
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Oral health-related quality of life, impaired physical health and orofacial pain in children and adolescents with juvenile idiopathic arthritis – a prospective multicenter cohort s... by Josefine M. Halbig, Birgitta Jönsson, Elisabeth G. Gil, Anne N. Åstrøm, Veronika Rypdal, Paula Frid, Thomas A. Augdal, Johannes Fischer, Lena Cetrelli, Marite Rygg, Anette Lundestad, Karin Tylleskär, Ellen Nordal, For the Norwegian JIA Study – Temporo-mandibular Involvement, Oral Health, Uveitis, Bone Health, Quality of Life in Children with Juvenile Idiopathic Arthritis

“…We aimed to describe OHRQoL in children and adolescents with JIA compared to controls, and to explore the validity and internal consistency of the Early Childhood Oral Health Impact Scale (ECOHIS) and the Child Oral Impact on Daily Performance (Child-OIDP). …”
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Self‐control interventions for children under age 10 for improving self‐control and delinquency and problem behaviors by Alex R. Piquero, Wesley G. Jennings, David P. Farrington

“…SEARCH STRATEGY Several strategies were used to perform an exhaustive search for literature fitting the eligibility criteria: (1) A keyword search was conducted across a number of online abstract databases; (2) The reference lists of previous reviews of early childhood prevention/intervention programs in general and self‐control improvement programs specifically were consulted; (3) Hand searches were carried out on leading journals in the field; (4) The publications of research and professional agencies were searched; and (5) Recognized scholars (experts) in various disciplines who were knowledgeable in the specific area of self‐control improvement programs were contacted. …”
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A vivência no processo formativo do projeto Educanvisa: relato de uma experiência de formação permanente | The Experience in Process Formation Project Educanvisa: Report of a Perma... by Ivanilde Alves Borba Rigo, Solimara Ligia Moura

“…-----------------------------------------------------------------------------------------------This report aims to present the experience of educators in the training process in Educanvisa Project, developed in the municipality of Lucas do Rio Verde/MT in 2012, with the public educators of the Municipal Network for Teaching units of Early Childhood Education and Education Basic. The report is focused on the continuing education of teachers, in order to enable them to become the mediators and multipliers of the subject in classrooms. …”
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Improved Metabolite Prediction Using Microbiome Data-Based Elastic Net Models by Jialiu Xie, Hunyong Cho, Bridget M. Lin, Malvika Pillai, Lara H. Heimisdottir, Dipankar Bandyopadhyay, Fei Zou, Fei Zou, Jeffrey Roach, Kimon Divaris, Kimon Divaris, Di Wu, Di Wu

“…We investigate the metabolite prediction performance of ENVIM using metagenomic and metatranscriptomic data in a supragingival biofilm multi-omics dataset of 289 children ages 3–5 who were participants of a community-based study of early childhood oral health (ZOE 2.0) in North Carolina, United States. …”
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Epidemiological profile of 39 cases of microcephaly caused by congenital infections diagnosed in the state of Rio Grande do Sul between 2015-2017 by Luciana Friedrich, Silvani Herber, Anna Pires Terra, André Anjos da Silva, Maria Teresa Viera Sanseverino, Lucas Rosa Fraga, Fernanda Sales Luiz Vianna, Ida Vanessa Doederlein Schwartz, Lavínia Schuler-Faccini

“…Conclusion: Most cases of congenital infection had severe neurological lesions, particularly the cases of ZIKV, which can cause neurodevelopmental delays and sequelae in these infants throughout early childhood. Keywords: Microcephaly; Congenital Infection; Zika Virus…”
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Transfusion regimens in thalassemia intermedia by Z. Karakas

“…Some TI patients are asymptomatic until adult life, whereas others are symptomatic from early childhood. In contrast with patients with Thalassemia major (TM), the severity of anemia is less and the patients do not require transfusions during at least the first few years of life. …”
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Habitudes alimentaires des enfants en maternelle : Et si nous les éduquons à la nutrition ? [Eating habits of children in kindergarten : What if we educate them on nutrition?] by Nour El-Houda KHABOUZA, Sarah MOUISSAT

“…While the family environment plays a predominant role in early childhood, the widening of the relational circle also directs children eating behaviour. …”
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Pancreatic family history does not predict disease progression but connotes alcohol consumption in adolescents and young adults with acute pancreatitis: Analysis of an internationa... by Márk Félix Juhász, Márk Félix Juhász, Nelli Farkas, Andrea Szentesi, Andrea Szentesi, Andrea Szentesi, Andrzej Wedrychowicz, Andreia Florina Nita, Natália Lásztity, Alexandra Tészás, István Tokodi, Áron Vincze, Bálint Eross, Bálint Eross, Bálint Eross, Ferenc Izbéki, László Czakó, Mária Papp, Péter Hegyi, Péter Hegyi, Péter Hegyi, Andrea Párniczky, Andrea Párniczky, Andrea Párniczky

“…The prevalence of diabetes and hyperlipidemia steadily rose with age in both groups.ConclusionPositive family history most likely signifies genetic background in early childhood. During adolescence and early adulthood, alcohol consumption and smoking emerge—clinicians should be aware and turn to intervention in such cases. …”
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